@article{MTMT:34728728, title = {Storage Conditions Influence the Quality of Ginger – A Stability Study Inspired by Clinical Trials}, url = {https://m2.mtmt.hu/api/publication/34728728}, author = {Tóth, Barbara and Horváth, Attila and Jójártné Laczkovich, Orsolya and Biró, Dalma and Matuz, Mária and Csupor, Dezső}, doi = {10.1055/a-2283-8147}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, unique-id = {34728728}, issn = {0032-0943}, abstract = {Ginger has traditionally been used to treat and prevent nausea and vomiting; however, the results of clinical trials are ambiguous. The efficacy of ginger is attributed to gingerols and their metabolites, shogaols. Since these compounds have different pharmacological profiles, the clinical efficacy of ginger products is largely dependent on their chemical composition. The goal of our study was to examine the stability of ginger determining the 6-gingerol contents in order to assess the effects of different storage conditions. We have performed a 6-month stability test with dry ginger rhizome samples stored in a constant climate chamber in three different storage containers (uncovered glass container, glass container sealed with rubber stopper, plastic container). 6-gingerol contents were measured by HPLC method. The concentration of 6-gingerol decreased in all samples. In the sealed glass container, the decrease of 6-gingerol content was significantly lower than in the unsealed glass container and in the plastic container. These results demonstrate that storage conditions have a significant impact on the quality of ginger, which may also affect efficacy.}, year = {2024}, eissn = {1439-0221}, orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Matuz, Mária/0000-0002-7877-2399; Csupor, Dezső/0000-0002-4088-3333} } @{MTMT:34556245, title = {Gyomorfekély ellenes hatással rendelkező, hagyma leveléből kivont poliszacharidok, eljárás előállításukra és alkalmazásuk}, url = {https://m2.mtmt.hu/api/publication/34556245}, author = {Csupor, Dezső and Zupkó, István and Hohmann, Judit and Kiss, Tivadar and Horváth, Attila}, unique-id = {34556245}, year = {2023}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333; Zupkó, István/0000-0003-3243-5300; Hohmann, Judit/0000-0002-2887-6392; Kiss, Tivadar/0000-0003-3538-377X} } @CONFERENCE{MTMT:33941008, title = {Chemical composition and antiproliferative properties of Peganum harmala}, url = {https://m2.mtmt.hu/api/publication/33941008}, author = {Nasibova, Tohfa and Hohmann, Judit and Schelz, Zsuzsanna and Zupkó, István and Horváth, Attila and Barta, Anita and Abdallah, Hiba Faroug Muddather}, booktitle = {4th Symposium of Young Researchers on Pharmacognosy}, doi = {10.14232/syrmpnpr.2023.9}, unique-id = {33941008}, year = {2023}, pages = {15-15}, orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Schelz, Zsuzsanna/0000-0002-8519-4830; Zupkó, István/0000-0003-3243-5300; Abdallah, Hiba Faroug Muddather/0000-0001-8472-330X} } @article{MTMT:32843331, title = {NHE-1 plays a central role in the smoke-induced proliferation in barrett's esophageal cell line}, url = {https://m2.mtmt.hu/api/publication/32843331}, author = {Becskeházi, Eszter and Korsós, Marietta Margaréta and Gál, Eleonóra and Tiszlavicz, László and Hoyk, Z and Deli, M and Köhler, Zoltán Márton and Keller-Pintér, Anikó and Horváth, Attila and Csekő, K and Helyes, Z and Hegyi, Péter and Venglovecz, Viktória}, journal-iso = {CENT EUR J GASTRO HEPATOL}, journal = {CENTRAL EUROPEAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY / GASZTROENTEROLÓGIAI ÉS HEPATOLÓGIAI SZEMLE}, volume = {8}, unique-id = {32843331}, year = {2022}, eissn = {2415-9107}, pages = {65-65}, orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Köhler, Zoltán Márton/0000-0002-8299-105X; Keller-Pintér, Anikó/0000-0002-4105-8458; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:33135629, title = {Coumarins, furocoumarins and limonoids of Citrus trifoliata and their effects on human colon adenocarcinoma cell lines}, url = {https://m2.mtmt.hu/api/publication/33135629}, author = {Kerekes, Diána and Horváth, Attila and Kúsz, Norbert and Borcsa, Botond Lajos and Szemerédi, Nikoletta and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1016/j.heliyon.2022.e10453}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {8}, unique-id = {33135629}, year = {2022}, eissn = {2405-8440}, orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:32258572, title = {Inhibition of NHE-1 Increases Smoke-Induced Proliferative Activity of Barrett’s Esophageal Cell Line}, url = {https://m2.mtmt.hu/api/publication/32258572}, author = {Becskeházi, Eszter and Korsós, Marietta Margaréta and Gál, Eleonóra and Tiszlavicz, László and Hoyk, Zsófia and Deli, Mária Anna and Köhler, Zoltán Márton and Keller-Pintér, Anikó and Horváth, Attila and Csekő, Kata and Helyes, Zsuzsanna and Hegyi, Péter and Venglovecz, Viktória}, doi = {10.3390/ijms221910581}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {22}, unique-id = {32258572}, issn = {1661-6596}, year = {2021}, eissn = {1422-0067}, orcid-numbers = {Tiszlavicz, László/0000-0003-1134-6587; Deli, Mária Anna/0000-0001-6084-6524; Köhler, Zoltán Márton/0000-0002-8299-105X; Keller-Pintér, Anikó/0000-0002-4105-8458; Hegyi, Péter/0000-0003-0399-7259; Venglovecz, Viktória/0000-0002-2316-7247} } @article{MTMT:32182543, title = {Development and validation of a RP-HPLC-DAD method for quantification of charantin in Momordica charantia products}, url = {https://m2.mtmt.hu/api/publication/32182543}, author = {Laczkó Zöld, Eszter and Bacsadi, Blanka and Horváth, Attila and Csupor, Dezső}, doi = {10.1016/j.jfca.2021.104161}, journal-iso = {J FOOD COMPOS ANAL}, journal = {JOURNAL OF FOOD COMPOSITION AND ANALYSIS}, volume = {104}, unique-id = {32182543}, issn = {0889-1575}, year = {2021}, eissn = {1096-0481}, orcid-numbers = {Laczkó Zöld, Eszter/0000-0002-8189-1129; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:31186422, title = {Comprehensive chemotaxonomic analysis of saffron crocus tepal and stamen samples, as raw materials with potential antidepressant activity}, url = {https://m2.mtmt.hu/api/publication/31186422}, author = {Mottaghipisheh, Javad and Mahmoodi Sourestani, Mohammad and Kiss, Tivadar and Horváth, Attila and Tóth, Barbara and Ayanmanesh, Mehdi and Khamushi, Amin and Csupor, Dezső}, doi = {10.1016/j.jpba.2020.113183}, journal-iso = {J PHARMACEUT BIOMED ANAL}, journal = {JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS}, volume = {184}, unique-id = {31186422}, issn = {0731-7085}, abstract = {Saffron crocus (Crocus sativus L.) has been widely grown in Iran. Its stigma is considered as the most valuable spice for which several pharmacological activities have been reported in preclinical and clinical studies, the antidepressant effect being the most thoroughly studied and confirmed. This plant part contains several characteristic secondary metabolites, including the carotenoids crocetin and crocin, and the monoterpenoid glucoside picrocrocin, and safranal. Since only the stigma is utilized industrially, huge amount of saffron crocus by-product remains unused. Recently, the number of papers dealing with the chemical and pharmacological analysis of saffron is increasing; however, there are no systematic studies on the chemical variability of the major by-products. In the present study, we harvested saffron crocus flowers from 40 different locations of Iran. The tepals and stamens were separated and subjected to qualitative and quantitative analysis by HPLC-DAD. The presence and amount of seven marker compounds, including crocin, crocetin, picrocrocin, safranal, kaempferol-3-O-sophoroside, kaempferol-3-O-glucoside, and quercetin-3-O-sophoroside were determined. The analytical method was validated for filter compatibility, stability, suitability, accuracy, precision, intermediate precision, and repeatability. Tepal and stamen samples contained three flavonol glycosides. The main constituent of the tepals was kaempferol-3-O-sophoroside (62.19–99.48 mg/g). In the stamen, the amount of flavonoids was lower than in the tepal. The amount of kaempferol-3-O-glucoside, as the most abundant compound, ranged between 1.72–7.44 mg/g. Crocin, crocetin, picrocrocin, and safranal were not detected in any of the analysed samples. Our results point out that saffron crocus by-products, particularly tepals might be considered as rich sources of flavonol glucosides. The data presented here can be useful in setting quality standards for plant parts of C. sativus that are currently considered as by-products of saffron production.}, year = {2020}, eissn = {1873-264X}, orcid-numbers = {Mottaghipisheh, Javad/0000-0002-4725-9189; Kiss, Tivadar/0000-0003-3538-377X; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:31262237, title = {Nitro-Oleic Acid in Seeds and Differently Developed Seedlings of Brassica napus L.}, url = {https://m2.mtmt.hu/api/publication/31262237}, author = {Vollár, Martin and Feigl, Gábor and Kondak, Dóra and Horváth, Attila and Molnár, Árpád and Kúsz, Norbert and Ördög, Attila and Csupor, Dezső and Kolbert, Zsuzsanna}, doi = {10.3390/plants9030406}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {9}, unique-id = {31262237}, abstract = {Similar to animals, it has recently been proven that nitro-fatty acids such as nitro-linolenic acid and nitro-oleic acid (NO2-OA) have relevant physiological roles as signalling molecules also in plants. Although NO2-OA is of great therapeutic importance, its presence in plants as a free fatty acid has not been observed so far. Since Brassica napus (oilseed rape) is a crop with high oleic acid content, the abundance of NO2-OA in its tissues can be assumed. Therefore, we quantified NO2-OA in B. napus seeds and differently developed seedlings. In all samples, NO2-OA was detectable at nanomolar concentrations. The seeds showed the highest NO2-OA content, which decreased during germination. In contrast, nitric oxide (●NO) levels increased in the early stages of germination and seedling growth. Exogenous NO2-OA treatment (100 µM, 24 h) of Brassica seeds resulted in significantly increased ●NO level and induced germination capacity compared to untreated seeds. The results of in vitro approaches (4-Amino-5-methylamino-2’,7’-difluorofluorescein (DAF-FM) fluorescence, ●NO -sensitive electrode) supported the ●NO liberating capacity of NO2-OA. We observed for the first time that Brassica seeds and seedlings contain free NO2-OA which may be involved in germination as an ●NO donor as suggested both by the results of exogenous NO2-OA treatment of seeds and in vitro approaches. Due to their high NO2- OA content, Brassica sprouts can be considered as a good source of dietary NO2-OA intake.}, year = {2020}, eissn = {2223-7747}, orcid-numbers = {Feigl, Gábor/0000-0001-6524-9147; Kúsz, Norbert/0000-0002-9973-6442; Ördög, Attila/0000-0002-1867-8237; Csupor, Dezső/0000-0002-4088-3333; Kolbert, Zsuzsanna/0000-0002-7819-4672} } @{MTMT:30718595, title = {Development and validation of a HPLC-UV method for the quantification of charantin in Momordica charantia products}, url = {https://m2.mtmt.hu/api/publication/30718595}, author = {Eszter, Laczkó Zöld and Horváth, Attila and Blanka, Bacsadi and Csupor, Dezső}, booktitle = {Trends in Natural Product Research - PSE Young Scientists’ Meeting on Biochemistry, Molecular Aspects and Pharmacology of Bioactive Natural Products}, doi = {10.14232/tnpr.2019.po37}, unique-id = {30718595}, abstract = {Momordica charantia L., also known as bitter melon, is widely cultivated as a vegetable crop in tropical and subtropical countries. It has been used in traditional medicine for various actions. Among them, the most studied is the hypoglycemic activity, attributed to different chemical compounds, like some triterpene glycosides and charatin. This work is part of a project which aims the comparison of chemical components of the greenhouse-grown plants in Romania and imported vegetable products (India). We measured the charantin content of 8 samples obtained from 3 different Romanian producers (fruits and leaves) and an import drug. In addition, we analyzed 2 tea products and 4 food supplements containing bitter gourd extracts. A HPLC-UV method was developed and validated for the determinination of charantin content. We found that greenhouse-grown plants of Romanian origin have similar charantin content (0.39-0.64 mg/g) to those from India (0.58 ± 0.01 mg/g). In food supplements, the charantin content was in expected range, except one product which had lower content (0.131 ± 0.008 mg/g) and in case of one of the teas, where the charantin content was below the LOD. The organoleptic analysis of this tea shown to contain only traces of bitter melon, and probably contains black tea. This assumption has been confirmed by TLC analysis. This proposed method is suitable and practical for comparison of the charantin content of herbal products of different origin and could be of use for analysis of charantin in food supplements.}, year = {2019}, pages = {119-119}, orcid-numbers = {Csupor, Dezső/0000-0002-4088-3333} }