@article{MTMT:34416562, title = {Piroptózis, PANoptózis és ferroptózis a szív iszkémia/reperfúziós károsodásában}, url = {https://m2.mtmt.hu/api/publication/34416562}, author = {Pipicz, Márton and Demján, Virág and Csonka, Csaba and Csont, Tamás Bálint}, doi = {10.26430/CHUNGARICA.2023.53.5.451}, journal-iso = {CARDIOL HUNG}, journal = {CARDIOLOGIA HUNGARICA}, volume = {53}, unique-id = {34416562}, issn = {0133-5596}, abstract = {Az intenzív kutatások ellenére továbbra sem rendelkezünk olyan kardioprotektív gyógyszerekkel, amelyek a szív iszkémia/reperfúziós (I/R) károsodásával járó infarktusméretet hatásosan csökkentenék. Ennek egyik magyarázata, hogy az I/R-t kísérő sejtelhalás összetett folyamata teljesen még nem tisztázott. A mechanizmus részletesebb megismerése javíthatja a kardioprotektív gyógyszerfejlesztések transzlálhatóságát. A klasszikus szabályozott (apoptózis, autofágia-mediálta sejthalál) és nem szabályozott (nekrózis) sejthalálfolyamatok mellett olyan programozott sejthalálformákat és mechanizmusokat ismertünk meg az elmúlt években, mint például a piroptózis, a PANoptózis vagy a ferroptózis. Jelen összefoglaló közleményünkben ezen folyamatokat kívánjuk röviden bemutatni a szív I/R károsodásában, valamint kitérünk a lehetséges modulálási stratégiákra is.}, year = {2023}, eissn = {1588-0230}, pages = {451-458}, orcid-numbers = {Pipicz, Márton/0000-0002-0944-1684; Demján, Virág/0000-0002-6792-3024; Csonka, Csaba/0000-0003-2532-6261; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:34167864, title = {Effect of Eccentric Exercise on Metabolic Health in Diabetes and Obesity}, url = {https://m2.mtmt.hu/api/publication/34167864}, author = {Szűcs, Gergő and Pipicz, Márton and Szabó, Márton Richárd and Csont, Tamás Bálint and Török, László and Csonka, Csaba}, doi = {10.1186/s40798-023-00596-2}, journal-iso = {SPORT MED-OPEN}, journal = {SPORTS MEDICINE-OPEN}, volume = {9}, unique-id = {34167864}, issn = {2199-1170}, abstract = {There is a growing body of evidence showing the importance of physical activity against civilization-induced metabolic diseases, including type 2 diabetes (T2DM) and obesity. Eccentric contraction, when skeletal muscles generate force by lengthening, is a unique type of skeletal muscle activity. Eccentric contraction may lead to better power production characteristics of the muscle because eccentric contraction requires less energy and can result in higher tension. Therefore, it is an ideal tool in the rehabilitation program of patients. However, the complex metabolic effect (i.e., fat mass reduction, increased lipid oxidation, improvement in blood lipid profile, and increased insulin sensitivity) of the eccentric contraction alone has scarcely been investigated. This paper aims to review the current literature to provide information on whether eccentric contraction can influence metabolic health and body composition in T2DM or obesity. We also discussed the potential role of myokines in mediating the effects of eccentric exercise. A better understanding of the mechanism of eccentric training and particularly their participation in the regulation of metabolic diseases may widen their possible therapeutic use and, thereby, may support the fight against the leading global risks for mortality in the world.}, year = {2023}, eissn = {2198-9761}, orcid-numbers = {Szűcs, Gergő/0000-0003-1874-2718; Pipicz, Márton/0000-0002-0944-1684; Szabó, Márton Richárd/0000-0003-0415-5192; Csont, Tamás Bálint/0000-0001-5792-2768; Csonka, Csaba/0000-0003-2532-6261} } @article{MTMT:32148359, title = {Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance}, url = {https://m2.mtmt.hu/api/publication/32148359}, author = {Demján, Virág and Apjok-Sója, Andrea and Kiss, Tivadar and Fejes, Alexandra and Gausz, Flóra Diána and Szűcs, Gergő and Siska, Andrea and Földesi, Imre and Tengölics, Roland and Darula, Zsuzsanna and Csupor, Dezső and Pipicz, Márton and Csont, Tamás Bálint}, doi = {10.1016/j.jtcme.2021.08.003}, journal-iso = {J TRADITIONAL COMP MED}, journal = {JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE}, volume = {12}, unique-id = {32148359}, issn = {2225-4110}, year = {2022}, eissn = {2225-4110}, pages = {250-259}, orcid-numbers = {Demján, Virág/0000-0002-6792-3024; Apjok-Sója, Andrea/0000-0003-3691-5889; Kiss, Tivadar/0000-0003-3538-377X; Fejes, Alexandra/0000-0002-2905-709X; Szűcs, Gergő/0000-0003-1874-2718; Földesi, Imre/0000-0002-3329-8136; Csupor, Dezső/0000-0002-4088-3333; Pipicz, Márton/0000-0002-0944-1684; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:32653862, title = {Kynurenine Pathway Metabolites as Potential Clinical Biomarkers in Coronary Artery Disease}, url = {https://m2.mtmt.hu/api/publication/32653862}, author = {Molnár-Gáspár, Renáta and Nógrádi-Halmi, Dóra and Demján, Virág and Berkecz, Róbert and Pipicz, Márton and Csont, Tamás Bálint}, doi = {10.3389/fimmu.2021.768560}, journal-iso = {FRONT IMMUNOL}, journal = {FRONTIERS IN IMMUNOLOGY}, volume = {12}, unique-id = {32653862}, issn = {1664-3224}, year = {2022}, eissn = {1664-3224}, orcid-numbers = {Molnár-Gáspár, Renáta/0000-0001-9673-4532; Nógrádi-Halmi, Dóra/0000-0001-9496-9354; Demján, Virág/0000-0002-6792-3024; Berkecz, Róbert/0000-0002-9076-2177; Pipicz, Márton/0000-0002-0944-1684; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:32924828, title = {Diet-Induced Hypercholesterolemia Leads to Cardiac Dysfunction and Alterations in the Myocardial Proteome}, url = {https://m2.mtmt.hu/api/publication/32924828}, author = {Szabó, Márton Richárd and Pipicz, Márton and Sárközy, Márta and Bruszel, Bella and Szabó, Zoltán and Csont, Tamás Bálint}, doi = {10.3390/ijms23137387}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {23}, unique-id = {32924828}, issn = {1661-6596}, abstract = {Elevated blood cholesterol is a major risk factor for coronary heart disease. Moreover, direct effects on the myocardium also contribute to the adverse effects of hypercholesterolemia. Here, we investigated the effect of hypercholesterolemia on the cardiac proteome. Male Wistar rats were fed with a laboratory rodent chow supplemented with 2% cholesterol for 8 weeks to induce hypercholesterolemia. The protein expression data obtained from the proteomic characterization of left ventricular samples from normo- and hypercholesterolemic animals were subjected to gene ontology (GO) and protein interaction analyses. Elevated circulating cholesterol levels were accompanied by diastolic dysfunction in cholesterol-fed rats. The proteomic characterization of left ventricular samples revealed altered expression of 45 proteins due to hypercholesterolemia. Based on the Gene Ontology analysis, hypercholesterolemia was associated with disturbed expression of cytoskeletal and contractile proteins. Beta-actin was downregulated in the hypercholesterolemic myocardium, and established a prominent hub of the protein interaction network. Analysis of the unfiltered dataset revealed concordant downregulated expression patterns in proteins associated with the arrangement of the contractile system (e.g., cardiac-specific troponins and myosin complex), and in subunits of the mitochondrial respiratory chain. We conclude that the observed changes in the cardiac proteome may contribute to the development of diastolic dysfunction in hypercholesterolemia.}, year = {2022}, eissn = {1422-0067}, orcid-numbers = {Szabó, Márton Richárd/0000-0003-0415-5192; Pipicz, Márton/0000-0002-0944-1684; Sárközy, Márta/0000-0002-5929-2146; Szabó, Zoltán/0000-0001-8278-8038; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:31903809, title = {Útmutató a gyermekek egészségének javítására megalakuló partneri együttműködés számára}, url = {https://m2.mtmt.hu/api/publication/31903809}, author = {Girán, János and Kollányi, Zsófia and Nemesrévi, Marcell and Pipicz, Márton and Sándor, János and Somhegyi, Annamária and Terebessy, András and Tóth, Gergely and Várfalvi, Marianna and Várfi, Melinda and Vitrai, József}, journal-iso = {EGÉSZSÉGFEJLESZTÉS}, journal = {EGÉSZSÉGFEJLESZTÉS}, volume = {62}, unique-id = {31903809}, issn = {1786-2434}, year = {2021}, eissn = {2498-6666}, pages = {95-200}, orcid-numbers = {Girán, János/0000-0002-4309-0013; Pipicz, Márton/0000-0002-0944-1684; Tóth, Gergely/0000-0001-8040-1899; Vitrai, József/0000-0001-9267-806X} } @article{MTMT:31902765, title = {Milyen legyen a népegészségügy legújabb iránya? Vitaindító az új népegészségügyi szemlélet sajátosságairól [What is the latest tendency of public health is? A debate on the characteristics of a new public health framework]}, url = {https://m2.mtmt.hu/api/publication/31902765}, author = {Vitrai, József and Bíró, Éva and Girán, János and Kollányi, Zsófia Katalin and Pipicz, Márton and Somhegyi, Annamária and Várfalvi, Marianna}, doi = {10.24365/ef.v62i1.716}, journal-iso = {EGÉSZSÉGFEJLESZTÉS}, journal = {EGÉSZSÉGFEJLESZTÉS}, volume = {62}, unique-id = {31902765}, issn = {1786-2434}, year = {2021}, eissn = {2498-6666}, pages = {81-94}, orcid-numbers = {Vitrai, József/0000-0001-9267-806X; Bíró, Éva/0000-0002-0131-8147; Girán, János/0000-0002-4309-0013; Kollányi, Zsófia Katalin/0000-0003-1261-6745; Pipicz, Márton/0000-0002-0944-1684} } @book{MTMT:31822928, title = {Oktatástechnikai kézikönyv családorvosok részére}, url = {https://m2.mtmt.hu/api/publication/31822928}, isbn = {9789634546085}, author = {Heim, Szilvia and Kolozsvári, László Róbert and Márkus, Bernadett and Mester, Lajos and Mészáros, Máté and Nánási, Anna and Pipicz, Márton and Rinfel, József and Kalmár, Zoltánné}, doi = {10.1556/9789634546085}, publisher = {Akadémiai Kiadó Zrt.}, unique-id = {31822928}, year = {2020}, orcid-numbers = {Márkus, Bernadett/0000-0002-3880-5168; Pipicz, Márton/0000-0002-0944-1684} } @{MTMT:31647861, title = {Development of diet-induced hypercholesterolemia is associated with alterations in cardiac gene expression profile}, url = {https://m2.mtmt.hu/api/publication/31647861}, author = {Szabó, Márton Richárd and Molnár-Gáspár, Renáta and Pipicz, Márton and Zsindely, Nóra and Diószegi, Petra and Sárközy, Márta and Bodai, László and Csont, Tamás Bálint}, booktitle = {Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project}, unique-id = {31647861}, year = {2020}, pages = {72-72}, orcid-numbers = {Szabó, Márton Richárd/0000-0003-0415-5192; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Pipicz, Márton/0000-0002-0944-1684; Zsindely, Nóra/0000-0002-6189-3100; Diószegi, Petra/0000-0001-8109-2266; Sárközy, Márta/0000-0002-5929-2146; Bodai, László/0000-0001-8411-626X; Csont, Tamás Bálint/0000-0001-5792-2768} } @article{MTMT:31330253, title = {Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts}, url = {https://m2.mtmt.hu/api/publication/31330253}, author = {Szabó, Márton Richárd and Molnár-Gáspár, Renáta and Pipicz, Márton and Zsindely, Nóra and Diószegi, Petra and Sárközy, Márta and Bodai, László and Csont, Tamás Bálint}, doi = {10.3390/ijms21113744}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {21}, unique-id = {31330253}, issn = {1661-6596}, year = {2020}, eissn = {1422-0067}, orcid-numbers = {Szabó, Márton Richárd/0000-0003-0415-5192; Molnár-Gáspár, Renáta/0000-0001-9673-4532; Pipicz, Márton/0000-0002-0944-1684; Zsindely, Nóra/0000-0002-6189-3100; Diószegi, Petra/0000-0001-8109-2266; Sárközy, Márta/0000-0002-5929-2146; Bodai, László/0000-0001-8411-626X; Csont, Tamás Bálint/0000-0001-5792-2768} }