@article{MTMT:35146543, title = {Targeted Screening and Quantification of Characteristic Sesquiterpene Lactones in Ambrosia artemisiifolia L. at Different Growth Stages}, url = {https://m2.mtmt.hu/api/publication/35146543}, author = {Kovács, Balázs and Püski, Péter and Bajtel, Ákos and Ferencz, Elek and Csupor-Löffler, Boglárka and Csupor, Dezső and Kiss, Tivadar}, doi = {10.3390/plants13152053}, journal-iso = {PLANTS-BASEL}, journal = {PLANTS-BASEL}, volume = {13}, unique-id = {35146543}, year = {2024}, eissn = {2223-7747}, orcid-numbers = {Kovács, Balázs/0009-0002-0541-4192; Püski, Péter/0000-0001-8426-0456; Bajtel, Ákos/0000-0003-2128-6522; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Csupor, Dezső/0000-0002-4088-3333; Kiss, Tivadar/0000-0003-3538-377X} } @article{MTMT:34501021, title = {Chemical composition, antimicrobial and antiproliferative activity of the essential oil from Ambrosia artemisiifolia L}, url = {https://m2.mtmt.hu/api/publication/34501021}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Csikós, Orsolya and Kiss, Tivadar and Veres, Katalin and Spengler, Gabriella and Csupor-Löffler, Boglárka and Csupor, Dezső}, doi = {10.1080/10412905.2024.2303449}, journal-iso = {J ESSENT OIL RES}, journal = {JOURNAL OF ESSENTIAL OIL RESEARCH}, volume = {36}, unique-id = {34501021}, issn = {1041-2905}, abstract = {The aim of our study was to characterize the composition and certain bioactivities of the essential oil of Ambrosia artemisiifolia. Eighty organic compounds were identified in the essential oils obtained by hydrodistillation and microwave-assisted isolation. Germacrene D was the main component in both oils. The essential oil obtained by hydrodistillation exerted antibacterial activity against two S. aureus strains, with MIC values of 0.015% for the methicillin-susceptible strain and 0.25% for the methicillin-resistant strain. In the biofilm formation assay, a dose-dependent inhibition was observed in case of the K. pneumoniae ATCC 600,703. In the ethidium bromide accumulation assay, a dose-dependent inhibition activity was observed against the bacterial efflux pump of the Gram-negative bacteria E. coli ATCC 25,922. The essential oil displayed strong in vitro cytotoxicity against the multidrug-resistant (MDR) Colo 320 cancer cell line with an IC50 value of 0.0103%. The essential oil showed strong inhibition on the proliferation of the doxorubicin-sensitive Colo 205 cells (IC50 values of 0.054%) and in the case of MDR Colo 320 colonic adenocarcinoma cells (IC50 values of 0.008%). This is the first report of the cytotoxic and antiproliferative activities of the essential oil from these species.}, keywords = {Ambrosia artemisiifolia; ANTIBIOTIC-RESISTANCE; Chemistry, Applied; hydrodistillation; ACHILLEA-MILLEFOLIUM; microwave-assisted isolation}, year = {2024}, eissn = {2163-8152}, pages = {30-42}, orcid-numbers = {Kovács, Balázs/0009-0002-0541-4192; Kiss, Tivadar/0000-0003-3538-377X; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:34496994, title = {The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence : a systematic review and meta-analysis of randomized clinical trials}, url = {https://m2.mtmt.hu/api/publication/34496994}, author = {Laczkó-Zöld, Eszter and Csupor-Löffler, Boglárka and Kolcsár, Edina-Blanka and Ferenci, Tamás and Nan, Monica and Tóth, Barbara and Csupor, Dezső}, doi = {10.3389/fnut.2023.1200801}, journal-iso = {FRONT NUTR}, journal = {FRONTIERS IN NUTRITION}, volume = {10}, unique-id = {34496994}, issn = {2296-861X}, abstract = {Several studies have shown that Momordica charantia L. (Cucurbitaceae, bitter melon) has beneficial effects on metabolic syndrome (MetS) parameters and exerts antidiabetic, anti-hyperlipidemic, and anti-obesity activities. Since the findings of these studies are contradictory, the goal of this systematic review and meta-analysis was to assess the efficacy of bitter melon in the treatment of metabolic syndrome, with special emphasis on the anti-diabetic effect. Embase, Cochrane, PubMed, and Web of Science databases were searched for randomized controlled human trials (RCTs). The meta-analysis was reported according to the PRISMA statement. The primary outcomes of the review are body weight, BMI, fasting blood glucose, glycated hemoglobin A1c, systolic blood pressure, diastolic blood pressure, serum triglyceride, HDL, LDL, and total cholesterol levels. Nine studies were included in the meta-analysis with 414 patients in total and 4–16 weeks of follow-up. In case of the meta-analysis of change scores, no significant effect could be observed for bitter melon treatment over placebo on fasting blood glucose level (MD = −0.03; 95% CI: −0.38 to 0.31; I 2 = 34%), HbA1c level (MD = −0.12; 95% CI: −0.35 to 0.11; I 2 = 56%), HDL (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%), LDL (MD = −0.10; 95% CI: −0.28 to 0.08; I 2 = 37%), total cholesterol (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%,), body weight (MD = −1.00; 95% CI: −2.59–0.59; I 2 = 97%), BMI (MD = −0.42; 95% CI: −0.99–0.14; I 2 = 95%), systolic blood pressure (MD = 1.01; 95% CI: −1.07–3.09; I 2 = 0%) and diastolic blood pressure levels (MD = 0.24; 95% CI: −1.04–1.53; I 2 = 0%). Momordica treatment was not associated with a notable change in ALT, AST, and creatinine levels compared to the placebo, which supports the safety of this plant. However, the power was overall low and the meta-analyzed studies were also too short to reliably detect long-term metabolic effects. This highlights the need for additional research into this plant in carefully planned clinical trials of longer duration.}, keywords = {[Meta-analysis]}, year = {2024}, eissn = {2296-861X}, orcid-numbers = {Csupor-Löffler, Boglárka/0000-0003-3751-2520; Ferenci, Tamás/0000-0001-6791-3080; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:33742452, title = {Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines}, url = {https://m2.mtmt.hu/api/publication/33742452}, author = {Ferencz, Elek and Spengler, Gabriella and Zupkó, István and Vollár, Martin and Zomborszki, Zoltán Péter and Kúsz, Norbert and Hohmann, Judit and Kovács, Balázs and Csupor, Dezső and Laczkó-Zöld, Eszter and Csupor-Löffler, Boglárka}, doi = {10.1515/znc-2022-0239}, journal-iso = {Z NATURFORSCH C}, journal = {ZEITSCHRIFT FÜR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES}, volume = {78}, unique-id = {33742452}, issn = {0939-5075}, abstract = {Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe with spreading use in the contemporary folk medicine. The chemical composition of the above-ground parts is extensively studied, however, the metabolites of the roots are less discovered. By multiple chromatographic purification of the root extracts, we isolated thiophene A (1), n-dodecene (2), taraxerol-3-O-acetate (3), α-linoleic acid (4), (+)-pinoresinol (5), and thiophene E (7,10-epithio-7,9-tridecadiene-3,5,11-triyne-1,2-diol) (6). The 1H NMR data published earlier for 1 were supplemented together with the assignment of 13C NMR data. Thiophene E (6), which is reported for the first time from this species, exerted cytotoxic and antiproliferative effects on A-431 epidermoid skin cancer cells, whereas taraxerol-3-O-acetate (3) and α-linoleic acid (4) had slight antiproliferative effect on gynecological cancer cell lines. Thiophene E (6) and taraxerol-3-O-acetate (3) displayed antiproliferative and cytotoxic effects on MRC-5 fibroblast cells. Thiophene E (6) exerted weak antibacterial activity (MIC 25 μg/mL) on MRSA ATCC 43300, on Staphylococcus aureus ATCC 25923, Escherichia coli AG100 and E. coli ATCC 25922 both thiophenes were inactive. Although the isolated compounds exerted no remarkable cytotoxic or antiproliferative activities, the effects on MRC-5 fibroblast cells highlight the necessity of further studies to support the safety of ragweed root.}, keywords = {lignan; RAGWEED; Thiophene; Ambrosia artemisiifolia; sterol}, year = {2023}, eissn = {1865-7125}, pages = {299-305}, orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Zupkó, István/0000-0003-3243-5300; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Kovács, Balázs/0009-0002-0541-4192; Csupor, Dezső/0000-0002-4088-3333; Csupor-Löffler, Boglárka/0000-0003-3751-2520} } @article{MTMT:32604937, title = {The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials}, url = {https://m2.mtmt.hu/api/publication/32604937}, author = {Bajtel, Ákos and Kiss, Tivadar and Tóth, Barbara and Kiss, Szabolcs and Hegyi, Péter and Vörhendi, Nóra and Csupor-Löffler, Boglárka and Gede, Noémi and Hohmann, Judit and Csupor, Dezső}, doi = {10.3390/ph15010100}, journal-iso = {PHARMACEUTICALS-BASE}, journal = {PHARMACEUTICALS}, volume = {15}, unique-id = {32604937}, keywords = {[Meta-analysis]}, year = {2022}, eissn = {1424-8247}, orcid-numbers = {Bajtel, Ákos/0000-0003-2128-6522; Kiss, Tivadar/0000-0003-3538-377X; Tóth, Barbara/0000-0002-6086-8819; Hegyi, Péter/0000-0003-0399-7259; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:33117614, title = {Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat}, url = {https://m2.mtmt.hu/api/publication/33117614}, author = {Bali, Zsolt Kristóf and Bruszt, Nóra and Kőszegi, Zsombor and Nagy, Lili Veronika and Atlasz, Tamás and Kovács, Péter and Csupor, Dezső and Csupor-Löffler, Boglárka and Hernádi, István}, doi = {10.3390/pharmaceutics14102067}, journal-iso = {PHARMACEUTICS}, journal = {PHARMACEUTICS}, volume = {14}, unique-id = {33117614}, issn = {1999-4923}, abstract = {Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats. First, we investigated the effects of microiontophoretically applied SON alone and combined with GABA-receptor agents picrotoxin and saclofen on neuronal firing activity in various brain areas. Next, putative anxiolytic effects of SON (1.0–3.0 mg/kg) were tested against the GABA-receptor positive allosteric modulator reference compound diazepam (1.0–5.0 mg/kg) in the elevated zero maze (EOM). Furthermore, basic cognitive effects were assessed in a rodent version of the psychomotor vigilance task (PVT). Local application of SON predominantly inhibited the firing activity of neurons. This inhibitory effect of SON was successfully blocked by GABA(A)-receptor antagonist picrotoxin but not by GABA(B)-receptor antagonist saclofen. Similar to GABA(A)-receptor positive allosteric modulator diazepam, SON increased the time spent by animals in the open quadrants of the EOM without any signs of adverse psychomotor and cognitive effects observed in the PVT. We showed that, under in vivo conditions, SON acts as a potent GABA(A)-receptor agonist and effectively decreases anxiety without observable side effects. The present findings facilitate the deeper understanding of the mechanism of action and the widespread pharmacological use of diterpene alkaloids in various CNS indications.}, year = {2022}, eissn = {1999-4923}, orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Kőszegi, Zsombor/0000-0003-2192-0159; Atlasz, Tamás/0000-0002-8112-8633; Kovács, Péter/0000-0001-5732-7432; Csupor, Dezső/0000-0002-4088-3333; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Hernádi, István/0000-0001-7882-4817} } @article{MTMT:33684363, title = {Antiproliferative sesquiterpene lactones from Ambrosia artemisiifolia L}, url = {https://m2.mtmt.hu/api/publication/33684363}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Y-C and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1055/s-0042-1759242}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {88}, unique-id = {33684363}, issn = {0032-0943}, year = {2022}, eissn = {1439-0221}, pages = {1533-1533}, orcid-numbers = {Kovács, Balázs/0009-0002-0541-4192; Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:33049439, title = {Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines}, url = {https://m2.mtmt.hu/api/publication/33049439}, author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Yu-Chi and Rácz, Bálint and Spengler, Gabriella and Csupor, Dezső}, doi = {10.1080/13880209.2022.2103574}, journal-iso = {PHARM BIOL}, journal = {PHARMACEUTICAL BIOLOGY}, volume = {60}, unique-id = {33049439}, issn = {1388-0209}, abstract = {Ambrosia artemisiifolia L. (Asteraceae) contains sesquiterpene lactones as characteristic secondary metabolites. Many of these compounds exert antiproliferative and cytotoxic effects.To isolate the sesquiterpene lactones from the aerial part of A. artemisiifolia and to elucidate their cytotoxic, antiproliferative and antibacterial effects.The compounds were identified by one-dimensional (1D) and 2D NMR, HR-MS spectroscopy from the methanol extract. Isolated compounds were investigated for their cytotoxic and antiproliferative effects on human colonic adenocarcinoma cell lines and human embryonal lung fibroblast cell line using MTT assay. The selectivity of the sesquiterpenes was calculated towards the normal cell line. To check the effect of drug interactions between compounds and doxorubicin, multidrug-resistant Colo 320 cells were used.A new seco-psilostachyinolide derivative, 1,10-dihydro-1'-noraltamisin, and seven known compounds were isolated from the methanol extract. Acetoxydihydrodamsin had the most potent cytotoxic effect on sensitive (Colo205) cell line (IC50 = 7.64 µM), also the strongest antiproliferative effect on Colo205 (IC50 = 5.14 µM) and Colo320 (IC50 = 3.67 µM) cell lines. 1'-Noraltamisin (IC50 = 8.78 µM) and psilostachyin (IC50 = 5.29 µM) showed significant antiproliferative effects on the multidrug-resistant Colo320 cell line and had moderate selectivity against human embryonal lung fibroblast cell line. Psilostachyin C exhibited cytotoxic effects on Colo205 cells (IC50 = 26.60 µM). None of the isolated compounds inhibited ABCB1 efflux pump (EP; P-glycoprotein) or the bacterial EPs.Acetoxydihydrodamsin, 1'-noraltamisin, and psilostachyin showed the most remarkable cytotoxic and antiproliferative activity on tumour cell lines and exerted selectivity towards MRC-5 cell line.}, keywords = {ASTERACEAE; RAGWEED; 1,10-dihydro-1′-noraltamisin; human colonic}, year = {2022}, eissn = {1744-5116}, pages = {1511-1519}, orcid-numbers = {Kovács, Balázs/0009-0002-0541-4192; Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333} } @article{MTMT:32948511, title = {A comprehensive phytochemical and pharmacological review on sesquiterpenes from the genus Ambrosia}, url = {https://m2.mtmt.hu/api/publication/32948511}, author = {Kovács, Balázs and Hohmann, Judit and Csupor-Löffler, Boglárka and Kiss, Tivadar and Csupor, Dezső}, doi = {10.1016/j.heliyon.2022.e09884}, journal-iso = {HELIYON}, journal = {HELIYON}, volume = {8}, unique-id = {32948511}, year = {2022}, eissn = {2405-8440}, orcid-numbers = {Kovács, Balázs/0009-0002-0541-4192; Hohmann, Judit/0000-0002-2887-6392; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Kiss, Tivadar/0000-0003-3538-377X; Csupor, Dezső/0000-0002-4088-3333} } @{MTMT:33267338, title = {8.4 Gyógynövények/drogok a betegségek megelőzésében és terápiájában - 1. rész}, url = {https://m2.mtmt.hu/api/publication/33267338}, author = {Roza, Orsolya and Csupor-Löffler, Boglárka and Tóth, Barbara}, booktitle = {Gyógyszertári ismeretek (szak)asszisztensek részére 7. kötet}, unique-id = {33267338}, year = {2022}, pages = {44}, orcid-numbers = {Roza, Orsolya/0000-0001-7928-0305; Csupor-Löffler, Boglárka/0000-0003-3751-2520; Tóth, Barbara/0000-0002-6086-8819} }