@article{MTMT:34501021,
	title = {Chemical composition, antimicrobial and antiproliferative activity of the essential oil from Ambrosia artemisiifolia L},
	url = {https://m2.mtmt.hu/api/publication/34501021},
	author = {Kovács, Balázs and Szemerédi, Nikoletta and Csikós, Orsolya and Kiss, Tivadar and Veres, Katalin and Spengler, Gabriella and Csupor-Löffler, Boglárka and Csupor, Dezső},
	doi = {10.1080/10412905.2024.2303449},
	journal-iso = {J ESSENT OIL RES},
	journal = {JOURNAL OF ESSENTIAL OIL RESEARCH},
	volume = {36},
	unique-id = {34501021},
	issn = {1041-2905},
	year = {2024},
	eissn = {2163-8152},
	pages = {30-42},
	orcid-numbers = {Kiss, Tivadar/0000-0003-3538-377X; Veres, Katalin/0000-0001-7108-3622; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:34496994,
	title = {The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence : a systematic review and meta-analysis of randomized clinical trials},
	url = {https://m2.mtmt.hu/api/publication/34496994},
	author = {Laczkó-Zöld, Eszter and Csupor-Löffler, Boglárka and Kolcsár, Edina-Blanka and Ferenci, Tamás and Nan, Monica and Tóth, Barbara and Csupor, Dezső},
	doi = {10.3389/fnut.2023.1200801},
	journal-iso = {FRONT NUTR},
	journal = {FRONTIERS IN NUTRITION},
	volume = {10},
	unique-id = {34496994},
	issn = {2296-861X},
	abstract = {Several studies have shown that Momordica charantia L. (Cucurbitaceae, bitter melon) has beneficial effects on metabolic syndrome (MetS) parameters and exerts antidiabetic, anti-hyperlipidemic, and anti-obesity activities. Since the findings of these studies are contradictory, the goal of this systematic review and meta-analysis was to assess the efficacy of bitter melon in the treatment of metabolic syndrome, with special emphasis on the anti-diabetic effect. Embase, Cochrane, PubMed, and Web of Science databases were searched for randomized controlled human trials (RCTs). The meta-analysis was reported according to the PRISMA statement. The primary outcomes of the review are body weight, BMI, fasting blood glucose, glycated hemoglobin A1c, systolic blood pressure, diastolic blood pressure, serum triglyceride, HDL, LDL, and total cholesterol levels. Nine studies were included in the meta-analysis with 414 patients in total and 4–16 weeks of follow-up. In case of the meta-analysis of change scores, no significant effect could be observed for bitter melon treatment over placebo on fasting blood glucose level (MD = −0.03; 95% CI: −0.38 to 0.31; I 2 = 34%), HbA1c level (MD = −0.12; 95% CI: −0.35 to 0.11; I 2 = 56%), HDL (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%), LDL (MD = −0.10; 95% CI: −0.28 to 0.08; I 2 = 37%), total cholesterol (MD = −0.04; 95% CI: −0.17 to 0.09; I 2 = 66%,), body weight (MD = −1.00; 95% CI: −2.59–0.59; I 2 = 97%), BMI (MD = −0.42; 95% CI: −0.99–0.14; I 2 = 95%), systolic blood pressure (MD = 1.01; 95% CI: −1.07–3.09; I 2 = 0%) and diastolic blood pressure levels (MD = 0.24; 95% CI: −1.04–1.53; I 2 = 0%). Momordica treatment was not associated with a notable change in ALT, AST, and creatinine levels compared to the placebo, which supports the safety of this plant. However, the power was overall low and the meta-analyzed studies were also too short to reliably detect long-term metabolic effects. This highlights the need for additional research into this plant in carefully planned clinical trials of longer duration.},
	keywords = {[Meta-analysis]},
	year = {2024},
	eissn = {2296-861X},
	orcid-numbers = {Ferenci, Tamás/0000-0001-6791-3080; Tóth, Barbara/0000-0002-6086-8819; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:33742452,
	title = {Isolation of compounds from the roots of Ambrosia artemisiifolia and their effects on human cancer cell lines},
	url = {https://m2.mtmt.hu/api/publication/33742452},
	author = {Ferencz, Elek and Spengler, Gabriella and Zupkó, István and Vollár, Martin and Zomborszki, Zoltán Péter and Kúsz, Norbert and Hohmann, Judit and Kovács, Balázs and Csupor, Dezső and Laczkó-Zöld, Eszter and Csupor-Löffler, Boglárka},
	doi = {10.1515/znc-2022-0239},
	journal-iso = {Z NATURFORSCH C},
	journal = {ZEITSCHRIFT FÜR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES},
	volume = {78},
	unique-id = {33742452},
	issn = {0939-5075},
	abstract = {Common ragweed (Ambrosia artemisiifolia L.) is an invasive plant in Europe with spreading use in the contemporary folk medicine. The chemical composition of the above-ground parts is extensively studied, however, the metabolites of the roots are less discovered. By multiple chromatographic purification of the root extracts, we isolated thiophene A (1), n-dodecene (2), taraxerol-3-O-acetate (3), α-linoleic acid (4), (+)-pinoresinol (5), and thiophene E (7,10-epithio-7,9-tridecadiene-3,5,11-triyne-1,2-diol) (6). The 1H NMR data published earlier for 1 were supplemented together with the assignment of 13C NMR data. Thiophene E (6), which is reported for the first time from this species, exerted cytotoxic and antiproliferative effects on A-431 epidermoid skin cancer cells, whereas taraxerol-3-O-acetate (3) and α-linoleic acid (4) had slight antiproliferative effect on gynecological cancer cell lines. Thiophene E (6) and taraxerol-3-O-acetate (3) displayed antiproliferative and cytotoxic effects on MRC-5 fibroblast cells. Thiophene E (6) exerted weak antibacterial activity (MIC 25 μg/mL) on MRSA ATCC 43300, on Staphylococcus aureus ATCC 25923, Escherichia coli AG100 and E. coli ATCC 25922 both thiophenes were inactive. Although the isolated compounds exerted no remarkable cytotoxic or antiproliferative activities, the effects on MRC-5 fibroblast cells highlight the necessity of further studies to support the safety of ragweed root.},
	keywords = {lignan; RAGWEED; Thiophene; Ambrosia artemisiifolia; sterol},
	year = {2023},
	eissn = {1865-7125},
	pages = {299-305},
	orcid-numbers = {Spengler, Gabriella/0000-0001-8085-0950; Zupkó, István/0000-0003-3243-5300; Zomborszki, Zoltán Péter/0000-0002-7412-9793; Kúsz, Norbert/0000-0002-9973-6442; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:32604937,
	title = {The Safety of Dronabinol and Nabilone: A Systematic Review and Meta-Analysis of Clinical Trials},
	url = {https://m2.mtmt.hu/api/publication/32604937},
	author = {Bajtel, Ákos and Kiss, Tivadar and Tóth, Barbara and Kiss, Szabolcs and Hegyi, Péter and Vörhendi, Nóra and Csupor-Löffler, Boglárka and Gede, Noémi and Hohmann, Judit and Csupor, Dezső},
	doi = {10.3390/ph15010100},
	journal-iso = {PHARMACEUTICALS-BASE},
	journal = {PHARMACEUTICALS},
	volume = {15},
	unique-id = {32604937},
	keywords = {[Meta-analysis]},
	year = {2022},
	eissn = {1424-8247},
	orcid-numbers = {Bajtel, Ákos/0000-0003-2128-6522; Kiss, Tivadar/0000-0003-3538-377X; Tóth, Barbara/0000-0002-6086-8819; Hegyi, Péter/0000-0003-0399-7259; Hohmann, Judit/0000-0002-2887-6392; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:33117614,
	title = {Aconitum Alkaloid Songorine Exerts Potent Gamma-Aminobutyric Acid-A Receptor Agonist Action In Vivo and Effectively Decreases Anxiety without Adverse Sedative or Psychomotor Effects in the Rat},
	url = {https://m2.mtmt.hu/api/publication/33117614},
	author = {Bali, Zsolt Kristóf and Bruszt, Nóra and Kőszegi, Zsombor and Nagy, Lili Veronika and Atlasz, Tamás and Kovács, Péter and Csupor, Dezső and Csupor-Löffler, Boglárka and Hernádi, István},
	doi = {10.3390/pharmaceutics14102067},
	journal-iso = {PHARMACEUTICS},
	journal = {PHARMACEUTICS},
	volume = {14},
	unique-id = {33117614},
	issn = {1999-4923},
	abstract = {Songorine (SON) is a diterpenoid alkaloid from Aconitum plants. Preparations of Aconitum roots have been employed in traditional oriental herbal medicine, however, their mechanisms of action are still unclear. Since GABA-receptors are possible brain targets of SON, we investigated which subtypes of GABA-receptors contribute to the effects of SON, and how SON affects anxiety-like trait behavior and psychomotor cognitive performance of rats. First, we investigated the effects of microiontophoretically applied SON alone and combined with GABA-receptor agents picrotoxin and saclofen on neuronal firing activity in various brain areas. Next, putative anxiolytic effects of SON (1.0–3.0 mg/kg) were tested against the GABA-receptor positive allosteric modulator reference compound diazepam (1.0–5.0 mg/kg) in the elevated zero maze (EOM). Furthermore, basic cognitive effects were assessed in a rodent version of the psychomotor vigilance task (PVT). Local application of SON predominantly inhibited the firing activity of neurons. This inhibitory effect of SON was successfully blocked by GABA(A)-receptor antagonist picrotoxin but not by GABA(B)-receptor antagonist saclofen. Similar to GABA(A)-receptor positive allosteric modulator diazepam, SON increased the time spent by animals in the open quadrants of the EOM without any signs of adverse psychomotor and cognitive effects observed in the PVT. We showed that, under in vivo conditions, SON acts as a potent GABA(A)-receptor agonist and effectively decreases anxiety without observable side effects. The present findings facilitate the deeper understanding of the mechanism of action and the widespread pharmacological use of diterpene alkaloids in various CNS indications.},
	year = {2022},
	eissn = {1999-4923},
	orcid-numbers = {Bali, Zsolt Kristóf/0000-0003-0712-0788; Kőszegi, Zsombor/0000-0003-2192-0159; Atlasz, Tamás/0000-0002-8112-8633; Kovács, Péter/0000-0001-5732-7432; Csupor, Dezső/0000-0002-4088-3333; Hernádi, István/0000-0001-7882-4817}
}

@article{MTMT:33684363,
	title = {Antiproliferative sesquiterpene lactones from Ambrosia artemisiifolia L},
	url = {https://m2.mtmt.hu/api/publication/33684363},
	author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Y-C and Spengler, Gabriella and Csupor, Dezső},
	doi = {10.1055/s-0042-1759242},
	journal-iso = {PLANTA MED},
	journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH},
	volume = {88},
	unique-id = {33684363},
	issn = {0032-0943},
	year = {2022},
	eissn = {1439-0221},
	pages = {1533-1533},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:33049439,
	title = {Antiproliferative and cytotoxic effects of sesquiterpene lactones isolated from Ambrosia artemisiifolia on human adenocarcinoma and normal cell lines},
	url = {https://m2.mtmt.hu/api/publication/33049439},
	author = {Kovács, Balázs and Szemerédi, Nikoletta and Kúsz, Norbert and Kiss, Tivadar and Csupor-Löffler, Boglárka and Tsai, Yu-Chi and Rácz, Bálint and Spengler, Gabriella and Csupor, Dezső},
	doi = {10.1080/13880209.2022.2103574},
	journal-iso = {PHARM BIOL},
	journal = {PHARMACEUTICAL BIOLOGY},
	volume = {60},
	unique-id = {33049439},
	issn = {1388-0209},
	abstract = {Ambrosia artemisiifolia L. (Asteraceae) contains sesquiterpene lactones as characteristic secondary metabolites. Many of these compounds exert antiproliferative and cytotoxic effects.To isolate the sesquiterpene lactones from the aerial part of A. artemisiifolia and to elucidate their cytotoxic, antiproliferative and antibacterial effects.The compounds were identified by one-dimensional (1D) and 2D NMR, HR-MS spectroscopy from the methanol extract. Isolated compounds were investigated for their cytotoxic and antiproliferative effects on human colonic adenocarcinoma cell lines and human embryonal lung fibroblast cell line using MTT assay. The selectivity of the sesquiterpenes was calculated towards the normal cell line. To check the effect of drug interactions between compounds and doxorubicin, multidrug-resistant Colo 320 cells were used.A new seco-psilostachyinolide derivative, 1,10-dihydro-1'-noraltamisin, and seven known compounds were isolated from the methanol extract. Acetoxydihydrodamsin had the most potent cytotoxic effect on sensitive (Colo205) cell line (IC50 = 7.64 µM), also the strongest antiproliferative effect on Colo205 (IC50 = 5.14 µM) and Colo320 (IC50 = 3.67 µM) cell lines. 1'-Noraltamisin (IC50 = 8.78 µM) and psilostachyin (IC50 = 5.29 µM) showed significant antiproliferative effects on the multidrug-resistant Colo320 cell line and had moderate selectivity against human embryonal lung fibroblast cell line. Psilostachyin C exhibited cytotoxic effects on Colo205 cells (IC50 = 26.60 µM). None of the isolated compounds inhibited ABCB1 efflux pump (EP; P-glycoprotein) or the bacterial EPs.Acetoxydihydrodamsin, 1'-noraltamisin, and psilostachyin showed the most remarkable cytotoxic and antiproliferative activity on tumour cell lines and exerted selectivity towards MRC-5 cell line.},
	keywords = {ASTERACEAE; RAGWEED; 1,10-dihydro-1′-noraltamisin; human colonic},
	year = {2022},
	eissn = {1744-5116},
	pages = {1511-1519},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Kiss, Tivadar/0000-0003-3538-377X; Rácz, Bálint/0000-0003-0088-3408; Spengler, Gabriella/0000-0001-8085-0950; Csupor, Dezső/0000-0002-4088-3333}
}

@article{MTMT:32948511,
	title = {A comprehensive phytochemical and pharmacological review on sesquiterpenes from the genus Ambrosia},
	url = {https://m2.mtmt.hu/api/publication/32948511},
	author = {Kovács, Balázs and Hohmann, Judit and Csupor-Löffler, Boglárka and Kiss, Tivadar and Csupor, Dezső},
	doi = {10.1016/j.heliyon.2022.e09884},
	journal-iso = {HELIYON},
	journal = {HELIYON},
	volume = {8},
	unique-id = {32948511},
	year = {2022},
	eissn = {2405-8440},
	orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392; Kiss, Tivadar/0000-0003-3538-377X; Csupor, Dezső/0000-0002-4088-3333}
}

@{MTMT:33267338,
	title = {8.4 Gyógynövények/drogok a betegségek megelőzésében és terápiájában - 1. rész},
	url = {https://m2.mtmt.hu/api/publication/33267338},
	author = {Roza, Orsolya and Csupor-Löffler, Boglárka and Tóth, Barbara},
	booktitle = {Gyógyszertári ismeretek (szak)asszisztensek részére 7. kötet},
	unique-id = {33267338},
	year = {2022},
	pages = {44},
	orcid-numbers = {Roza, Orsolya/0000-0001-7928-0305; Tóth, Barbara/0000-0002-6086-8819}
}

@article{MTMT:32911943,
	title = {Bearberry in the treatment of acute uncomplicated cystitis (BRUMI) : protocol of a multicentre, randomised double-blind clinical trial},
	url = {https://m2.mtmt.hu/api/publication/32911943},
	author = {Tóth, Barbara and Jávorházy, András and Nyirády, Péter and Csupor-Löffler, Boglárka and Birinyi, Péter and Zhanel, George and Naber, Kurt and Länger, Reinhard and Vörhendi, Nóra and Gede, Noémi and Váncsa, Szilárd and Hegyi, Péter and Csupor, Dezső},
	doi = {10.1136/bmjopen-2021-057982},
	journal-iso = {BMJ OPEN},
	journal = {BMJ OPEN},
	volume = {12},
	unique-id = {32911943},
	issn = {2044-6055},
	abstract = {Bearberry (Arctostaphylos uva-ursi) leaf is available as a treatment of uncomplicated cystitis in several European countries. The antimicrobial activity of its extracts and some of its individual constituents has been observed in vitro; however, the efficacy of bearberry compared with standard antimicrobial therapy has not been assessed yet.The objective of the study is to assess the safety and non-inferiority of bearberry as an alternative therapy in the treatment of acute uncomplicated cystitis in comparison with standard antibiotic therapy (fosfomycin).This is a randomised controlled double-blinded multicentre trial. Eligible patients will be premenopausal women with a sum score of ≥6 for the typical acute uncomplicated cystitis symptoms (frequency, urgency, painful urination, incomplete emptying, suprapubic pain and visible haematuria) reported on the Acute Cystitis Symptom Score (ACSS) typical domain and pyuria. Patients will be randomly assigned to receive 3 g single dose of fosfomycin powder and two placebo tablets three times a day for 7 days or B a single dose of placebo powder and two tablets containing a dry extract of Uvae ursi folium. At least 504 patients (allocated as 1:1) will need to be enrolled to access non-inferiority with a non-inferiority limit of 14% for the primary endpoint.Improvement of symptoms of uncomplicated cystitis (based on the ACSS score) at day 7 is defined as the primary endpoint, whereas several secondary endpoints such as the number and ratio of patients with bacteriuria at day 7, frequency and severity of side effects; recurrence of urinary tract infection, concurrent use of other over the counter (OTC) medications and food supplements will be determined to elucidate more detailed differences between the groups. The number of recurrences and medications taken for treatment will be monitored for a follow-up period of 90 days (80-100 days).This study has been approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (IV/4225-1/2021/EKU). The results will be disseminated by publication of peer-reviewed manuscripts.NCT05055544.},
	keywords = {Clinical Trials; Urinary Tract Infections; interstitial cystitis},
	year = {2022},
	eissn = {2044-6055},
	orcid-numbers = {Tóth, Barbara/0000-0002-6086-8819; Nyirády, Péter/0000-0002-7037-4919; Birinyi, Péter/0000-0001-9275-0092; Váncsa, Szilárd/0000-0002-9347-8163; Hegyi, Péter/0000-0003-0399-7259; Csupor, Dezső/0000-0002-4088-3333}
}