@CONFERENCE{MTMT:35150785,
	title = {French paradox},
	url = {https://m2.mtmt.hu/api/publication/35150785},
	author = {Agbadua, Orinamhe Godwin and Kúsz, Norbert and Berkecz, Róbert and Marton, András and Karancsi, Tamás and Gáti, Tamás and Tóth, Gábor and Balogh, György Tibor and Huber, Robin and Marcourt, Laurence and Wolfender, Jean-Luc and Queiroz, Emerson Ferreira and Hunyadi, Attila},
	booktitle = {5th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrpharmacognosy.2024.a3},
	unique-id = {35150785},
	year = {2024},
	pages = {8-9},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Balogh, György Tibor/0000-0001-8273-1760; Huber, Robin/0000-0001-9164-6584; Marcourt, Laurence/0000-0002-9614-1099; Wolfender, Jean-Luc/0000-0002-0125-952X; Queiroz, Emerson Ferreira/0000-0001-9567-1664; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34541373,
	title = {Thymoquinone-protoflavone hybrid molecules as potential antitumor agents},
	url = {https://m2.mtmt.hu/api/publication/34541373},
	author = {AHMED, Sara Hassan Hassan and Tayeb, Bizhar Ahmed and Gonda, Tímea and Girst, Gábor and Szőri, Kornél and Berkecz, Róbert and Zupkó, István and Minorics, Renáta and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0291567},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34541373},
	issn = {1932-6203},
	abstract = {We describe herein the synthesis of eight new ester-coupled hybrid compounds from thymoquinone and protoflavone building blocks, and their bioactivity testing against multiple cancer cell lines. Among the hybrids, compound 14 showed promising activities in all cell lines studied. The highest activities were recorded against breast cancer cell lines with higher selectivity to MDA-MB-231 as compared to MCF-7. Even though the hybrids were found to be completely hydrolysed in 24 h under cell culture conditions, compound 14 demonstrated a ca. three times stronger activity against U-87 glioblastoma cells than a 1:1 mixture of its fragments. Further, compound 14 showed good tumour selectivity: it acted 4.4-times stronger on U-87 cells than on MRC-5 fibroblasts. This selectivity was much lower, only ca. 1.3-times, when the cells were co-treated with a 1:1 mixture of its non-coupled fragments. Protoflavone-thymoquinone hybrids may therefore serve as potential new antitumor leads particularly against glioblastoma.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Szőri, Kornél/0000-0003-3337-8635; Berkecz, Róbert/0000-0002-9076-2177; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:35150781,
	title = {Ecdysteroids present in various insect meals},
	url = {https://m2.mtmt.hu/api/publication/35150781},
	author = {Asafotei, Oaklekie Enéh and Crul-Tóth, Noémi and Hunyadi, Attila},
	booktitle = {5th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrpharmacognosy.2024.a2},
	unique-id = {35150781},
	year = {2024},
	pages = {7-7},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:35156158,
	title = {Phytochemical Investigation of Carex praecox Schreb. and ACE-Inhibitory Activity of Oligomer Stilbenes of the Plant},
	url = {https://m2.mtmt.hu/api/publication/35156158},
	author = {Dávid, Csilla Zsuzsanna and Kúsz, Norbert and Agbadua, Orinamhe Godwin and Berkecz, Róbert and Kincses, Annamária and Spengler, Gabriella and Hunyadi, Attila and Hohmann, Judit and Vasas, Andrea},
	doi = {10.3390/molecules29143427},
	journal-iso = {MOLECULES},
	journal = {MOLECULES},
	volume = {29},
	unique-id = {35156158},
	issn = {1420-3049},
	abstract = {Phenolic compounds are the main special metabolites of Cyperaceae species from phytochemical, pharmacological, and chemotaxonomical points of view. The present study focused on the isolation, structure determination, and pharmacological investigation of constituents from Carex praecox. Twenty-six compounds, including lignans, stilbenes, flavonoids, megastigmanes, chromenes, and phenylpropanoids, were identified from the methanol extract of the plant. Five of these compounds, namely, carexines A–E, are previously undescribed natural products. All compounds were isolated for the first time from C. praecox. The ACE-inhibitory activity of seven stilbenoid compounds was tested, and (–)-hopeaphenol proved to be the most active (IC50 7.7 ± 0.9 μM). The enzyme–kinetic studies revealed a mixed-type inhibition; therefore, domain-specific studies were also conducted. The in silico docking of (–)-hopeaphenol to the ACE affirmed some favorable interactions. In addition, the antiproliferative and antibacterial effects of some compounds were also evaluated.},
	year = {2024},
	eissn = {1420-3049},
	orcid-numbers = {Kúsz, Norbert/0000-0002-9973-6442; Berkecz, Róbert/0000-0002-9076-2177; Kincses, Annamária/0000-0002-1591-1419; Spengler, Gabriella/0000-0001-8085-0950; Hunyadi, Attila/0000-0003-0074-3472; Hohmann, Judit/0000-0002-2887-6392; Vasas, Andrea/0000-0002-1818-7702}
}

@article{MTMT:35078258,
	title = {Preparation of dearomatized p‐coumaric acid derivatives as DNA damage response inhibitors with potent in vitro antitumor effect},
	url = {https://m2.mtmt.hu/api/publication/35078258},
	author = {Fási, Laura and Gonda, Tímea and Crul-Tóth, Noémi and Vass, Máté and Gyovai, András and Nagy, Viktória and Ocsovszki, Imre and Zupkó, István and Kúsz, Norbert and Nové, Márta and Spengler, Gabriella and Berkecz, Róbert and Wang, Hui-Chun and Chang, Fang-Rong and Hunyadi, Attila},
	doi = {10.1002/cmdc.202300675},
	journal-iso = {CHEMMEDCHEM},
	journal = {CHEMMEDCHEM},
	unique-id = {35078258},
	issn = {1860-7179},
	abstract = {Our research group previously identified graviquinone (1) as a promising antitumor metabolite that is formed in situ when the antioxidant methyl caffeate scavenges free radicals. Furthermore, it exerted a DNA damaging effect on cancer cells and a DNA protective effect on normal keratinocytes. To expand and explore chemical space around qraviquinone, in the current work we synthesized 9 new alkyl‐substituted derivatives and tested their in vitro antitumor potential. All new compounds bypassed ABCB1‐mediated multidrug resistance and showed highly different cell line specificity compared with 1. All compounds were more potent in MDA‐MB‐231 than on MCF‐7 cells. The n‐butyl‐substituted derivatives 2 and 8 modulated the cell cycle and inhibited the ATR‐mediated phosphorylation of checkpoint kinase‐1 in MCF‐7 cells. As a significant expansion of our previous findings, our results highlight the potential antitumor value of alkyl‐substituted graviquinone derivatives.},
	year = {2024},
	eissn = {1860-7187},
	orcid-numbers = {Gyovai, András/0000-0003-2316-2160; Ocsovszki, Imre/0000-0003-1290-996X; Zupkó, István/0000-0003-3243-5300; Kúsz, Norbert/0000-0002-9973-6442; Spengler, Gabriella/0000-0001-8085-0950; Berkecz, Róbert/0000-0002-9076-2177; Hunyadi, Attila/0000-0003-0074-3472}
}

@article{MTMT:34779108,
	title = {Diterpenes Isolated from Three Different Plectranthus Sensu Lato Species and Their Antiproliferative Activities against Gynecological and Glioblastoma Cancer Cells},
	url = {https://m2.mtmt.hu/api/publication/34779108},
	author = {Gáborová, Mária and Vágvölgyi, Máté and Tayeb, Bizhar Ahmed and Minorics, Renáta and Zupkó, István and Jurček, Ondřej and Béni, Szabolcs and Kubínová, Renata and Balogh, György Tibor and Hunyadi, Attila},
	doi = {10.1021/acsomega.4c00800},
	journal-iso = {ACS OMEGA},
	journal = {ACS OMEGA},
	volume = {9},
	unique-id = {34779108},
	issn = {2470-1343},
	year = {2024},
	eissn = {2470-1343},
	pages = {18495-18504},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Minorics, Renáta/0000-0001-9685-813X; Zupkó, István/0000-0003-3243-5300; Béni, Szabolcs/0000-0001-7056-6825; Balogh, György Tibor/0000-0003-3347-1880; Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:34895940,
	title = {Investigation of Antitrypanosomal Ecdysteroids’ Positions in Biologically Relevant Chemical Space},
	url = {https://m2.mtmt.hu/api/publication/34895940},
	author = {Háznagy, Márton Benedek and Anders, Backlund and Hunyadi, Attila},
	booktitle = {Congressus Pharmaceuticus Hungaricus XVII. and EUFEPS Annual Meeting 2024},
	unique-id = {34895940},
	year = {2024},
	pages = {285-286},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472}
}

@CONFERENCE{MTMT:35152074,
	title = {Preparation and investigation of B-ring modified nitrogen-containing calonysterone derivatives},
	url = {https://m2.mtmt.hu/api/publication/35152074},
	author = {Papdi, Glória and Girst, Gábor and Hunyadi, Attila and Vágvölgyi, Máté},
	booktitle = {5th Symposium of Young Researchers on Pharmacognosy},
	doi = {10.14232/syrpharmacognosy.2024.a7},
	unique-id = {35152074},
	year = {2024},
	pages = {13-13},
	orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Vágvölgyi, Máté/0000-0002-2233-9422}
}

@article{MTMT:35321478,
	title = {Euphane and Tirucallane Triterpenes with Trypanocidal Activity from Euphorbia desmondii},
	url = {https://m2.mtmt.hu/api/publication/35321478},
	author = {Saidu, Muhammad Bello and Krstić, Gordana and Barta, Anita and Hunyadi, Attila and Berkecz, Róbert and Gallah, Umar Shehu and Cholke, Kaushavi and Gertsch, Jürg and Rédei, Dóra and Hohmann, Judit},
	doi = {10.1021/acs.jnatprod.4c00730},
	journal-iso = {J NAT PROD},
	journal = {JOURNAL OF NATURAL PRODUCTS},
	unique-id = {35321478},
	issn = {0163-3864},
	year = {2024},
	eissn = {1520-6025},
	orcid-numbers = {Krstić, Gordana/0000-0001-6945-6178; Hunyadi, Attila/0000-0003-0074-3472; Berkecz, Róbert/0000-0002-9076-2177; Gertsch, Jürg/0000-0003-0978-1555; Rédei, Dóra/0000-0002-5013-247X; Hohmann, Judit/0000-0002-2887-6392}
}

@article{MTMT:34691003,
	title = {17-Oxime ethers of oxidized ecdysteroid derivatives modulate oxidative stress in human brain endothelial cells and dose-dependently might protect or damage the blood-brain barrier},
	url = {https://m2.mtmt.hu/api/publication/34691003},
	author = {Vágvölgyi, Máté and Laczkó, Dávid and Santa Maria, Anaraquel and Vigh, Judit Piroska and Walter, Fruzsina and Berkecz, Róbert and Deli, Mária Anna and Tóth, Gábor and Hunyadi, Attila},
	doi = {10.1371/journal.pone.0290526},
	journal-iso = {PLOS ONE},
	journal = {PLOS ONE},
	volume = {19},
	unique-id = {34691003},
	issn = {1932-6203},
	abstract = {20-Hydroxyecdysone and several of its oxidized derivatives exert cytoprotective effect in mammals including humans. Inspired by this bioactivity of ecdysteroids, in the current study it was our aim to prepare a set of sidechain-modified derivatives and to evaluate their potential to protect the blood-brain barrier (BBB) from oxidative stress. Six novel ecdysteroids, including an oxime and five oxime ethers, were obtained through regioselective synthesis from a sidechain-cleaved calonysterone derivative 2 and fully characterized by comprehensive NMR techniques revealing their complete 1 H and 13 C signal assignments. Surprisingly, several compounds sensitized hCMEC/D3 brain microvascular endothelial cells to tert -butyl hydroperoxide (tBHP)-induced oxidative damage as recorded by impedance measurements. Compound 8 , containing a benzyloxime ether moiety in its sidechain, was the only one that exerted a protective effect at a higher, 10 μM concentration, while at lower (10 nM– 1 μM) concentrations it promoted tBHP-induced cellular damage. Brain endothelial cells were protected from tBHP-induced barrier integrity decrease by treatment with 10 μM of compound 8 , which also mitigated the intracellular reactive oxygen species production elevated by tBHP. Based on our results, 17-oxime ethers of oxidized ecdysteroids modulate oxidative stress of the BBB in a way that may point towards unexpected toxicity. Further studies are needed to evaluate any possible risk connected to dietary ecdysteroid consumption and CNS pathologies in which BBB damage plays an important role.},
	year = {2024},
	eissn = {1932-6203},
	orcid-numbers = {Vágvölgyi, Máté/0000-0002-2233-9422; Santa Maria, Anaraquel/0000-0003-3505-5477; Walter, Fruzsina/0000-0001-8145-2823; Berkecz, Róbert/0000-0002-9076-2177; Deli, Mária Anna/0000-0001-6084-6524; Hunyadi, Attila/0000-0003-0074-3472}
}