@article{MTMT:34541373, title = {Thymoquinone-protoflavone hybrid molecules as potential antitumor agents}, url = {https://m2.mtmt.hu/api/publication/34541373}, author = {AHMED, Sara Hassan Hassan and Tayeb, Bizhar Ahmed and Gonda, Tímea and Girst, Gábor and Szőri, Kornél and Berkecz, Róbert and Zupkó, István and Minorics, Renáta and Hunyadi, Attila}, doi = {10.1371/journal.pone.0291567}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {19}, unique-id = {34541373}, issn = {1932-6203}, abstract = {We describe herein the synthesis of eight new ester-coupled hybrid compounds from thymoquinone and protoflavone building blocks, and their bioactivity testing against multiple cancer cell lines. Among the hybrids, compound 14 showed promising activities in all cell lines studied. The highest activities were recorded against breast cancer cell lines with higher selectivity to MDA-MB-231 as compared to MCF-7. Even though the hybrids were found to be completely hydrolysed in 24 h under cell culture conditions, compound 14 demonstrated a ca. three times stronger activity against U-87 glioblastoma cells than a 1:1 mixture of its fragments. Further, compound 14 showed good tumour selectivity: it acted 4.4-times stronger on U-87 cells than on MRC-5 fibroblasts. This selectivity was much lower, only ca. 1.3-times, when the cells were co-treated with a 1:1 mixture of its non-coupled fragments. Protoflavone-thymoquinone hybrids may therefore serve as potential new antitumor leads particularly against glioblastoma.}, year = {2024}, eissn = {1932-6203}, orcid-numbers = {Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Szőri, Kornél/0000-0003-3337-8635; Berkecz, Róbert/0000-0002-9076-2177; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:33947701, title = {Thymoquinone-protoflavone hybrids}, url = {https://m2.mtmt.hu/api/publication/33947701}, author = {AHMED, Sara Hassan Hassan and Tayeb, Bizhar Ahmed and Gonda, Tímea and Girst, Gábor and Szőri, Kornél and Berkecz, Róbert and Zupkó, István and Minorics, Renáta and Hunyadi, Attila}, booktitle = {4th Symposium of Young Researchers on Pharmacognosy}, doi = {10.14232/syrmpnpr.2023.7}, unique-id = {33947701}, year = {2023}, pages = {13-13}, orcid-numbers = {AHMED, Sara Hassan Hassan/0000-0002-6642-7256; Tayeb, Bizhar Ahmed/0000-0001-5197-564X; Szőri, Kornél/0000-0003-3337-8635; Berkecz, Róbert/0000-0002-9076-2177; Zupkó, István/0000-0003-3243-5300; Minorics, Renáta/0000-0001-9685-813X; Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:3428258, title = {Effect of particle restructuring during reduction processes over polydopamine-supported Pd nanoparticles}, url = {https://m2.mtmt.hu/api/publication/3428258}, author = {Gazdag, Tamás and Baróthi, Á and Juhász, Koppány Levente and Kunfi, Attila and Németh, Péter and Sápi, András and Kukovecz, Ákos and Kónya, Zoltán and Szőri, Kornél and London, Gábor}, doi = {10.1166/jnn.2019.15770}, journal-iso = {J NANOSCI NANOTECHNO}, journal = {JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY}, volume = {19}, unique-id = {3428258}, issn = {1533-4880}, year = {2019}, eissn = {1533-4899}, pages = {484-491}, orcid-numbers = {Németh, Péter/0000-0001-5592-5877; Sápi, András/0000-0001-6557-0731; Kukovecz, Ákos/0000-0003-0716-9557; Kónya, Zoltán/0000-0002-9406-8596; Szőri, Kornél/0000-0003-3337-8635} } @article{MTMT:30452962, title = {Application of hydroxyproline derivatives in enantioselective α-amination reactions in organic and aqueous environments: a structure-activity relationship study}, url = {https://m2.mtmt.hu/api/publication/30452962}, author = {Gurka, András Attila and Szőri, Kornél and Szőri, Milán and Bartók, Mihály and London, Gábor}, doi = {10.1007/s11224-016-0873-z}, journal-iso = {STRUCT CHEM}, journal = {STRUCTURAL CHEMISTRY}, volume = {28}, unique-id = {30452962}, issn = {1040-0400}, abstract = {We examined the activity of a series of L-hydroxyproline derivatives in enantioselective alpha-amination reaction between diethyl azodicarboxylate and propanal both in organic and aqueous media. In organic media most of the catalysts showed high activity and enantioselectivities comparable to that accessible with L-proline that is among the best catalysts in the reaction. The catalysts showed good activity under aqueous conditions as well; however, only low enantioselectivities were obtained in this case, primarily due to the racemisation of the product under the reaction conditions. Thus, the attempted achiral acid/base additive-driven stereocontrol was not feasible on a practical level.}, keywords = {WATER; asymmetric; hydroxyproline; alpha-Amination; Dual stereocontrol}, year = {2017}, eissn = {1572-9001}, pages = {415-421}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635; Szőri, Milán/0000-0003-4895-0999} } @article{MTMT:3230643, title = {Exploring Pd/Al2O3 Catalysed Redox Isomerisation of Allyl Alcohol as a Platform to Create Structural Diversity}, url = {https://m2.mtmt.hu/api/publication/3230643}, author = {Dékány, Attila Ádám and Lázár, Enikő and Szabó, Bálint and Havasi, Viktor and Halasi, Gyula and Sápi, András and Kukovecz, Ákos and Kónya, Zoltán and Szőri, Kornél and London, Gábor}, doi = {10.1007/s10562-017-2087-4}, journal-iso = {CATAL LETT}, journal = {CATALYSIS LETTERS}, volume = {147}, unique-id = {3230643}, issn = {1011-372X}, year = {2017}, eissn = {1572-879X}, pages = {1834-1843}, orcid-numbers = {Szabó, Bálint/0000-0002-9865-6336; Halasi, Gyula/0000-0003-0195-9400; Sápi, András/0000-0001-6557-0731; Kukovecz, Ákos/0000-0003-0716-9557; Kónya, Zoltán/0000-0002-9406-8596; Szőri, Kornél/0000-0003-3337-8635} } @article{MTMT:3106409, title = {Dual stereocontrol in aldol reactions catalysed by hydroxyproline derivatives in the presence of a large amount of water}, url = {https://m2.mtmt.hu/api/publication/3106409}, author = {Gurka, András Attila and Szőri, Kornél and Bartók, Mihály and London, Gábor}, doi = {10.1016/j.tetasy.2016.08.009}, journal-iso = {TETRAHEDRON ASYMMETR}, journal = {TETRAHEDRON-ASYMMETRY}, volume = {27}, unique-id = {3106409}, issn = {0957-4166}, year = {2016}, eissn = {1362-511X}, pages = {936-942}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635} } @article{MTMT:2987536, title = {Pd/Al2O3-catalysed redox isomerisation of allyl alcohol: application in aldol condensation and oxidative heterocyclization reactions}, url = {https://m2.mtmt.hu/api/publication/2987536}, author = {Dániel, Zsolnai and Mayer, Péter József and Szőri, Kornél and London, Gábor}, doi = {10.1039/C5CY01722J}, journal-iso = {CATAL SCIENCE & TECHNOLOGY}, journal = {CATALYSIS SCIENCE & TECHNOLOGY}, volume = {6}, unique-id = {2987536}, issn = {2044-4753}, year = {2016}, eissn = {2044-4761}, pages = {3814-3820}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635} } @article{MTMT:3129581, title = {Comparative Study of Graphite-Oxide and Graphene-Oxide Supported Proline Organocatalysts in Asymmetric Aldol Addition}, url = {https://m2.mtmt.hu/api/publication/3129581}, author = {Szőri, Kornél and Réti, Balázs and Szőllősi, György and Hernádi, Klára and Bartók, Mihály}, doi = {10.1007/s11244-016-0643-6}, journal-iso = {TOP CATAL}, journal = {TOPICS IN CATALYSIS}, volume = {59}, unique-id = {3129581}, issn = {1022-5528}, abstract = {Graphite oxide (GrO), graphene oxide (GnO) and their sulphated derivatives (GrOs, GrOo, GnOs, GnOo) were prepared from graphite (Gr) and graphene (Gn) as starting materials, using various methods. Previous experience suggests that in the course of sulphation relatively few functional groups get incorporated, which are mainly located along the edges of the layers. In the course of oxidation the layers are also converted to a significant extent, although aromatic regions are also retained, depending on the strength of the oxidative conditions. Proline impregnation of the functionalized catalyst supports obtained in this way enables the synthesis of Pro-GrO and Pro-GnO chiral catalysts. Proline interacts with the functional groups building up on the layers in a mostly reversible fashion and is relatively easily removed therefrom, whereas over sulphated materials groups forming on the edges allowed stronger bonding of proline. An asymmetric aldol reaction between 2-nitrobenzaldehyde and acetone with a selectivity of 90 % and an enantioselectivity of 77 % can be catalysed using these materials. The catalysts lifetime, however, is still limited at the present stage of our studies. Catalysts prepared from graphenes usually proved to be more active than those prepared from graphite, which was suggested to be due to the accessibility and amount of the functional groups created on the edges of the graphene sheets.}, year = {2016}, eissn = {1572-9028}, pages = {1227-1236}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635; Réti, Balázs/0000-0003-3398-1266; Szőllősi, György/0000-0003-4418-9530; Hernádi, Klára/0000-0001-9419-689X} } @article{MTMT:2982196, title = {Tuning the sense of product stereochemistry in aldol reactions of acetone and aromatic aldehydes in the presence of water with a single chiral catalyst}, url = {https://m2.mtmt.hu/api/publication/2982196}, author = {Gurka, András Attila and Szőri, Kornél and Szőllősi, György and Bartók, Mihály and London, Gábor}, doi = {10.1016/j.tetlet.2015.11.051}, journal-iso = {TETRAHEDRON LETT}, journal = {TETRAHEDRON LETTERS}, volume = {56}, unique-id = {2982196}, issn = {0040-4039}, year = {2015}, eissn = {1873-3581}, pages = {7201-7205}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635; Szőllősi, György/0000-0003-4418-9530} } @article{MTMT:2318100, title = {Palladium Nanoparticle-Graphene Catalysts for Asymmetric Hydrogenation}, url = {https://m2.mtmt.hu/api/publication/2318100}, author = {Szőri, Kornél and Puskás, Róbert and Szőllősi, György and Bertóti, Imre and Szépvölgyi, János and Bartók, Mihály}, doi = {10.1007/s10562-013-1006-6}, journal-iso = {CATAL LETT}, journal = {CATALYSIS LETTERS}, volume = {143}, unique-id = {2318100}, issn = {1011-372X}, year = {2013}, eissn = {1572-879X}, pages = {539-546}, orcid-numbers = {Szőri, Kornél/0000-0003-3337-8635; Szőllősi, György/0000-0003-4418-9530; Szépvölgyi, János/0000-0003-3727-4745} }