TY  - JOUR
AU  - Hunyadi, Attila
AU  - Herke, I
AU  - Lengyel, K
AU  - Báthori, Mária
AU  - Kele, Zoltán
AU  - Simon, András
AU  - Tóth, Gábor
AU  - Szendrei, Kálmán
TI  - Ecdysteroid-containing food supplements from Cyanotis arachnoidea on the European market: evidence for spinach product counterfeiting
JF  - SCIENTIFIC REPORTS
J2  - SCI REP
VL  - 6
PY  - 2016
PG  - 8
SN  - 2045-2322
DO  - 10.1038/srep37322
UR  - https://m2.mtmt.hu/api/publication/3073484
ID  - 3073484
N1  - Institute of Pharmacognosy, University of Szeged, Eötvös str. 6, Szeged, H-6720, Hungary            
            Department of Medical Chemistry, University of Szeged, Dóm Sq. 8, Szeged, H-6720, Hungary            
            NMR Group, Department of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics, Szt. Gellért Sq. 4, Budapest, H-1111, Hungary            
            Cited By :11            
            Export Date: 21 October 2020            
            Correspondence Address: Hunyadi, A.; Institute of Pharmacognosy, University of Szeged, Eötvös str. 6, Hungary; email: hunyadi.a@pharm.u-szeged.hu
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hunyadi, Attila
AU  - Katalin, Lengyel
AU  - Ibolya, Herke
AU  - Báthori, Mária
AU  - Tóth, Gábor
AU  - Szendrei, Kálmán
TI  - A curious case of dietary supplement adulteration: Cyanotis arachnoidea as fake spinach on the European market
JF  - PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH
J2  - PLANTA MED
VL  - 80
PY  - 2014
IS  - 16
SN  - 0032-0943
DO  - 10.1055/s-0034-1394859
UR  - https://m2.mtmt.hu/api/publication/2726746
ID  - 2726746
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Seres, Adrienn
AU  - Ducza, Eszter
AU  - Báthori, Mária
AU  - Hunyadi, Attila
AU  - Béni, Zoltán
AU  - Dékány, M
AU  - Hajagos-Tóth, Judit
AU  - Verli, Judit
AU  - Gáspár, Róbert
TI  - Androgenic effect of honeybee drone milk in castrated rats: roles of methyl palmitate and methyl oleate
JF  - JOURNAL OF ETHNOPHARMACOLOGY
J2  - J ETHNOPHARMACOL
VL  - 153
PY  - 2014
IS  - 2
SP  - 446
EP  - 453
PG  - 8
SN  - 0378-8741
DO  - 10.1016/j.jep.2014.02.050
UR  - https://m2.mtmt.hu/api/publication/2552412
ID  - 2552412
AB  - ETHNOPHARMACOLOGICAL RELEVANCE:

Numerous honeybee (Apis mellifera) products have been used in traditional medicine to treat infertility and to increase vitality in both men and women. Drone milk (DM) is a relatively little-known honeybee product with a putative sexual hormone effect. The oestrogenic effect of a fraction of DM has recently been reported in rats. However, no information is available on the androgenic effects of DM. The purpose of the present study was to determine the androgen-like effect of DM in male rats and to identify effective compounds.
MATERIALS AND METHODS:

A modified Hershberger assay was used to investigate the androgenic effect of crude DM, and the plasma level of testosterone was measured. The prostatic mRNA and protein expression of Spot14-like androgen-inducible protein (SLAP) were also examined with real-time PCR and Western blot techniques. GC-MS and NMR spectroscopic investigations were performed to identify the active components gained by bioactivity-guided fractionation.
RESULTS:

The crude DM increased the relative weights of the androgen-dependent organs and the plasma testosterone level in castrated rats and these actions were flutamide-sensitive. DM increased the tissue mRNA and protein level of SLAP, providing further evidence of its androgen-like character. After bioactivity-guided fractionation, two fatty acid esters, methyl palmitate (MP) and methyl oleate (MO), were identified as active compounds. MP alone showed an androgenic effect, whereas MO increased the weight of androgen-sensitive tissues and the plasma testosterone level only in combination.
CONCLUSION:

The experimental data of DM and its active compounds (MO and MP) show androgenic activity confirming the traditional usage of DM. DM or MP or/and MO treatments may project a natural mode for the therapy of male infertility.
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Hunyadi, Attila
AU  - Liktor-Busa, Erika
AU  - Márki, Árpád
AU  - Martins, Ana
AU  - Jedlinszki, Nikoletta
AU  - Hsieh, TJ
AU  - Báthori, Mária
AU  - Hohmann, Judit
AU  - Zupkó, István
TI  - Metabolic effects of mulberry leaves: Exploring potential benefits in type 2 diabetes and hyperuricemia
JF  - EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
J2  - EVID-BASED COMPL ALT
VL  - 2013
PY  - 2013
PG  - 10
SN  - 1741-427X
DO  - 10.1155/2013/948627
UR  - https://m2.mtmt.hu/api/publication/2443587
ID  - 2443587
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Seres, Adrienn
AU  - Ducza, Eszter
AU  - Báthori, Mária
AU  - Hunyadi, Attila
AU  - Béni, Zoltán
AU  - Dekany, M
AU  - Gáspár, Róbert
TI  - Raw Drone Milk of Honeybees Elicits Uterotrophic Effect in Rats: Evidence for Estrogenic Activity
JF  - JOURNAL OF MEDICINAL FOOD
J2  - J MED FOOD
VL  - 16
PY  - 2013
IS  - 5
SP  - 404
EP  - 409
PG  - 6
SN  - 1096-620X
DO  - 10.1089/jmf.2012.0232
UR  - https://m2.mtmt.hu/api/publication/2114165
ID  - 2114165
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Cossuta, Dániel
AU  - Vatai, T
AU  - Báthori, Mária
AU  - Hohmann, Judit
AU  - Keve, T
AU  - Simándi, Béla
TI  - Extraction of hyperforin and hypericin from St. John's wort (Hypericum perforatum L.) with different solvents
JF  - JOURNAL OF FOOD PROCESS ENGINEERING
J2  - J FOOD PROCESS ENG
VL  - 35
PY  - 2012
IS  - 2
SP  - 222
EP  - 235
PG  - 14
SN  - 0145-8876
DO  - 10.1111/j.1745-4530.2010.00583.x
UR  - https://m2.mtmt.hu/api/publication/1952030
ID  - 1952030
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Martins, Ana
AU  - Báthori, Mária
AU  - Amaral, L
AU  - Molnár, József
AU  - Hunyadi, Attila
TI  - Ecdysteroids as modulators of multi-drug resistance: structure-activity relationship study
JF  - BIOMEDICAL PAPERS-OLOMOUC
J2  - BIOMED PAP
VL  - 156
PY  - 2012
IS  - Suppl 1.
SP  - S39
EP  - S40
SN  - 1213-8118
UR  - https://m2.mtmt.hu/api/publication/2236491
ID  - 2236491
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Martins, Ana
AU  - Báthori, Mária
AU  - Amaral, L.
AU  - Molnár, József
AU  - Hunyadi, Attila
TI  - Structure-activity relationship study of ecdysteroids on multi-drug resistant mouse lymphoma cell line
T2  - Workshop of COST Action CM0804, The University of Bucharest, The Romanian Catalysis Society and The Romanian Academy
PY  - 2012
SP  - 67
EP  - 68
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/2236486
ID  - 2236486
LA  - English
DB  - MTMT
ER  - 

TY  - CONF
AU  - Martins, Ana
AU  - Dankó, Balázs Ödön
AU  - Molnár, József
AU  - Báthori, Mária
AU  - Pascu, ML.
AU  - Amaral, L.
AU  - Hunyadi, Attila
TI  - Significant activity of ecdysteroids on the multi-drug resistance of mammalian cancer cells – discovery and state of the art
T2  - Workshop of COST Action CM0804, The University of Bucharest, The Romanian Catalysis Society and The Romanian Academy
PY  - 2012
SP  - 44
EP  - 45
PG  - 2
UR  - https://m2.mtmt.hu/api/publication/2236482
ID  - 2236482
LA  - English
DB  - MTMT
ER  - 

TY  - JOUR
AU  - Martins, Ana
AU  - Crul-Tóth, Noémi
AU  - Ványolós, Attila
AU  - Béni, Zoltán
AU  - Zupkó, István
AU  - Molnár, József
AU  - Báthori, Mária
AU  - Hunyadi, Attila
TI  - Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter
JF  - JOURNAL OF MEDICINAL CHEMISTRY
J2  - J MED CHEM
VL  - 55
PY  - 2012
IS  - 11
SP  - 5034
EP  - 5043
PG  - 10
SN  - 0022-2623
DO  - 10.1021/jm300424n
UR  - https://m2.mtmt.hu/api/publication/1989835
ID  - 1989835
AB  - Multidrug resistance (MDR) is a major cause of failure of cancer chemotherapy. Fifty-eight ecdysteroids, herbal analogues of the insect molting hormone and their semisynthetic derivatives, were tested for their activity against L5178 mouse T-cell lymphoma cells (non-MDR) and their subcell line transfected with pHa MDR1/A retrovirus overexpressing the human ABCB1 efflux pump (MDR cell line). The compounds showed very low antiproliferative activities but modulated the efflux of rhodamine 123 mediated by the ABCB1 transporter. Roughly depending on the polarity, mild to strong synergism or antagonism was observed by combining ecdysteroids with doxorubicin, and specific structure-activity relationships were also found. Our results show the effect of ecdysteroids on MDR cancer cells for the first time. Less polar derivatives may serve as valuable leads toward a potent and safe resistance modulator. Biological significance of the resistance-increasing activity of the most abundant phytoecdysteroids including 20-hydroxyecdysone is yet to be clarified.
LA  - English
DB  - MTMT
ER  -