@article{MTMT:3073484, title = {Ecdysteroid-containing food supplements from Cyanotis arachnoidea on the European market: evidence for spinach product counterfeiting}, url = {https://m2.mtmt.hu/api/publication/3073484}, author = {Hunyadi, Attila and Herke, I and Lengyel, K and Báthori, Mária and Kele, Zoltán and Simon, András and Tóth, Gábor and Szendrei, Kálmán}, doi = {10.1038/srep37322}, journal-iso = {SCI REP}, journal = {SCIENTIFIC REPORTS}, volume = {6}, unique-id = {3073484}, issn = {2045-2322}, year = {2016}, eissn = {2045-2322}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Kele, Zoltán/0000-0002-4401-0302} } @article{MTMT:2726746, title = {A curious case of dietary supplement adulteration: Cyanotis arachnoidea as fake spinach on the European market}, url = {https://m2.mtmt.hu/api/publication/2726746}, author = {Hunyadi, Attila and Katalin, Lengyel and Ibolya, Herke and Báthori, Mária and Tóth, Gábor and Szendrei, Kálmán}, doi = {10.1055/s-0034-1394859}, journal-iso = {PLANTA MED}, journal = {PLANTA MEDICA: NATURAL PRODUCTS AND MEDICINAL PLANT RESEARCH}, volume = {80}, unique-id = {2726746}, issn = {0032-0943}, year = {2014}, eissn = {1439-0221}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:2552412, title = {Androgenic effect of honeybee drone milk in castrated rats: roles of methyl palmitate and methyl oleate}, url = {https://m2.mtmt.hu/api/publication/2552412}, author = {Seres, Adrienn and Ducza, Eszter and Báthori, Mária and Hunyadi, Attila and Béni, Zoltán and Dékány, M and Hajagos-Tóth, Judit and Verli, Judit and Gáspár, Róbert}, doi = {10.1016/j.jep.2014.02.050}, journal-iso = {J ETHNOPHARMACOL}, journal = {JOURNAL OF ETHNOPHARMACOLOGY}, volume = {153}, unique-id = {2552412}, issn = {0378-8741}, abstract = {ETHNOPHARMACOLOGICAL RELEVANCE: Numerous honeybee (Apis mellifera) products have been used in traditional medicine to treat infertility and to increase vitality in both men and women. Drone milk (DM) is a relatively little-known honeybee product with a putative sexual hormone effect. The oestrogenic effect of a fraction of DM has recently been reported in rats. However, no information is available on the androgenic effects of DM. The purpose of the present study was to determine the androgen-like effect of DM in male rats and to identify effective compounds. MATERIALS AND METHODS: A modified Hershberger assay was used to investigate the androgenic effect of crude DM, and the plasma level of testosterone was measured. The prostatic mRNA and protein expression of Spot14-like androgen-inducible protein (SLAP) were also examined with real-time PCR and Western blot techniques. GC-MS and NMR spectroscopic investigations were performed to identify the active components gained by bioactivity-guided fractionation. RESULTS: The crude DM increased the relative weights of the androgen-dependent organs and the plasma testosterone level in castrated rats and these actions were flutamide-sensitive. DM increased the tissue mRNA and protein level of SLAP, providing further evidence of its androgen-like character. After bioactivity-guided fractionation, two fatty acid esters, methyl palmitate (MP) and methyl oleate (MO), were identified as active compounds. MP alone showed an androgenic effect, whereas MO increased the weight of androgen-sensitive tissues and the plasma testosterone level only in combination. CONCLUSION: The experimental data of DM and its active compounds (MO and MP) show androgenic activity confirming the traditional usage of DM. DM or MP or/and MO treatments may project a natural mode for the therapy of male infertility.}, keywords = {testosterone; drone milk; apitherapy; SLAP; rat}, year = {2014}, eissn = {1872-7573}, pages = {446-453}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Béni, Zoltán/0000-0002-1275-4155; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:2443587, title = {Metabolic effects of mulberry leaves: Exploring potential benefits in type 2 diabetes and hyperuricemia}, url = {https://m2.mtmt.hu/api/publication/2443587}, author = {Hunyadi, Attila and Liktor-Busa, Erika and Márki, Árpád and Martins, Ana and Jedlinszki, Nikoletta and Hsieh, TJ and Báthori, Mária and Hohmann, Judit and Zupkó, István}, doi = {10.1155/2013/948627}, journal-iso = {EVID-BASED COMPL ALT}, journal = {EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE}, volume = {2013}, unique-id = {2443587}, issn = {1741-427X}, year = {2013}, eissn = {1741-4288}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Liktor-Busa, Erika/0000-0002-0495-8721; Márki, Árpád/0000-0002-6056-8891; Jedlinszki, Nikoletta/0000-0001-5070-9809; Hohmann, Judit/0000-0002-2887-6392; Zupkó, István/0000-0003-3243-5300} } @article{MTMT:2114165, title = {Raw Drone Milk of Honeybees Elicits Uterotrophic Effect in Rats: Evidence for Estrogenic Activity}, url = {https://m2.mtmt.hu/api/publication/2114165}, author = {Seres, Adrienn and Ducza, Eszter and Báthori, Mária and Hunyadi, Attila and Béni, Zoltán and Dekany, M and Gáspár, Róbert}, doi = {10.1089/jmf.2012.0232}, journal-iso = {J MED FOOD}, journal = {JOURNAL OF MEDICINAL FOOD}, volume = {16}, unique-id = {2114165}, issn = {1096-620X}, keywords = {Animals; Female; Male; Humans; RATS; ARTICLE; ESTROGEN; Rats, Sprague-Dawley; reverse transcription polymerase chain reaction; priority journal; controlled study; nonhuman; animal experiment; nuclear magnetic resonance imaging; Western blotting; Mass spectrometry; uterus; milk; fatty acids; protein expression; messenger rna; fatty acid; complement component C3; biological activity; fractionation; Column chromatography; Estrogens; Bees; honeybee; drone milk; apitherapy; drone; rat}, year = {2013}, eissn = {1557-7600}, pages = {404-409}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472; Béni, Zoltán/0000-0002-1275-4155; Gáspár, Róbert/0000-0002-1571-7579} } @article{MTMT:1952030, title = {Extraction of hyperforin and hypericin from St. John's wort (Hypericum perforatum L.) with different solvents}, url = {https://m2.mtmt.hu/api/publication/1952030}, author = {Cossuta, Dániel and Vatai, T and Báthori, Mária and Hohmann, Judit and Keve, T and Simándi, Béla}, doi = {10.1111/j.1745-4530.2010.00583.x}, journal-iso = {J FOOD PROCESS ENG}, journal = {JOURNAL OF FOOD PROCESS ENGINEERING}, volume = {35}, unique-id = {1952030}, issn = {0145-8876}, year = {2012}, eissn = {1745-4530}, pages = {222-235}, orcid-numbers = {Hohmann, Judit/0000-0002-2887-6392} } @article{MTMT:2236491, title = {Ecdysteroids as modulators of multi-drug resistance: structure-activity relationship study}, url = {https://m2.mtmt.hu/api/publication/2236491}, author = {Martins, Ana and Báthori, Mária and Amaral, L and Molnár, József and Hunyadi, Attila}, journal-iso = {BIOMED PAP}, journal = {BIOMEDICAL PAPERS-OLOMOUC}, volume = {156}, unique-id = {2236491}, issn = {1213-8118}, year = {2012}, eissn = {1804-7521}, pages = {S39-S40}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:2236486, title = {Structure-activity relationship study of ecdysteroids on multi-drug resistant mouse lymphoma cell line}, url = {https://m2.mtmt.hu/api/publication/2236486}, author = {Martins, Ana and Báthori, Mária and Amaral, L. and Molnár, József and Hunyadi, Attila}, booktitle = {Workshop of COST Action CM0804, The University of Bucharest, The Romanian Catalysis Society and The Romanian Academy}, unique-id = {2236486}, year = {2012}, pages = {67-68}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @CONFERENCE{MTMT:2236482, title = {Significant activity of ecdysteroids on the multi-drug resistance of mammalian cancer cells – discovery and state of the art}, url = {https://m2.mtmt.hu/api/publication/2236482}, author = {Martins, Ana and Dankó, Balázs Ödön and Molnár, József and Báthori, Mária and Pascu, ML. and Amaral, L. and Hunyadi, Attila}, booktitle = {Workshop of COST Action CM0804, The University of Bucharest, The Romanian Catalysis Society and The Romanian Academy}, unique-id = {2236482}, year = {2012}, pages = {44-45}, orcid-numbers = {Hunyadi, Attila/0000-0003-0074-3472} } @article{MTMT:1989835, title = {Significant activity of ecdysteroids on the resistance to doxorubicin in mammalian cancer cells expressing the human ABCB1 transporter}, url = {https://m2.mtmt.hu/api/publication/1989835}, author = {Martins, Ana and Crul-Tóth, Noémi and Ványolós, Attila and Béni, Zoltán and Zupkó, István and Molnár, József and Báthori, Mária and Hunyadi, Attila}, doi = {10.1021/jm300424n}, journal-iso = {J MED CHEM}, journal = {JOURNAL OF MEDICINAL CHEMISTRY}, volume = {55}, unique-id = {1989835}, issn = {0022-2623}, abstract = {Multidrug resistance (MDR) is a major cause of failure of cancer chemotherapy. Fifty-eight ecdysteroids, herbal analogues of the insect molting hormone and their semisynthetic derivatives, were tested for their activity against L5178 mouse T-cell lymphoma cells (non-MDR) and their subcell line transfected with pHa MDR1/A retrovirus overexpressing the human ABCB1 efflux pump (MDR cell line). The compounds showed very low antiproliferative activities but modulated the efflux of rhodamine 123 mediated by the ABCB1 transporter. Roughly depending on the polarity, mild to strong synergism or antagonism was observed by combining ecdysteroids with doxorubicin, and specific structure-activity relationships were also found. Our results show the effect of ecdysteroids on MDR cancer cells for the first time. Less polar derivatives may serve as valuable leads toward a potent and safe resistance modulator. Biological significance of the resistance-increasing activity of the most abundant phytoecdysteroids including 20-hydroxyecdysone is yet to be clarified.}, keywords = {Animals; Humans; MICE; ARTICLE; MOUSE; P-GLYCOPROTEIN; CYTOTOXICITY; multidrug resistance protein 1; nonhuman; animal cell; drug potentiation; Drug Synergism; Cell Line, Tumor; Drug Resistance; structure-activity relationship; Drug Antagonism; unclassified drug; unindexed drug; Antineoplastic Agents, Phytogenic; Antibiotics, Antineoplastic; drug structure; doxorubicin; ANTIPROLIFERATIVE ACTIVITY; structure activity relation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; rhodamine 123; drug activity; Drug Screening Assays, Antitumor; polypodine b; ecdysterone; ecdysteroid; ecdysone; 2 deoxyecdysone; Ecdysteroids; leukemia L 5178 Y; turkesterone; ponasterone A; muristerone A; integristerone A; dacryhainansterone; ajugasterone c; 5alpha 20 hydroxyecdysone; 22 deoxyintegristerone A; pterosterone; makisterone c; 3 epi beta ecdysone; 25,26 didehydrodacryhainansterone; 25 hydroxydacrihainansterone; 22 deoxy ecdysterone; 22 deoxy 20,21 didehydroecdysone; 2 deoxy ecdysterone 25 glucoside; 2 deoxy ecdysterone; 2 deoxy 5alpha polypodine b; 2 deoxy 5alpha integristerone a; 14 epi 20 hydroxyecdysone; 1 hydroxy 22 deoxy 20,21 didehydroecdysone}, year = {2012}, eissn = {1520-4804}, pages = {5034-5043}, orcid-numbers = {Ványolós, Attila/0000-0002-4710-0004; Béni, Zoltán/0000-0002-1275-4155; Zupkó, István/0000-0003-3243-5300; Hunyadi, Attila/0000-0003-0074-3472} }