{ "labelLang" : "hun", "responseDate" : "2024-03-29 13:22", "paging" : { "last" : false, "first" : false, "totalPages" : 15, "totalElements" : 147, "totalUncutElements" : 147, "totalEstimatedElements" : 110, "size" : 10, "number" : 2, "numberOfElements" : 10, "sort" : [ { "direction" : "DESC", "property" : "publishedYear", "ascending" : false }, { "direction" : "ASC", "property" : "firstAuthor", "ascending" : true } ] }, "content" : [ { "otype" : "JournalArticle", "mtid" : 30433954, "status" : "VALIDATED", "published" : true, "comment" : "Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of Szeged, Szeged, 6720, Hungary \n Interdisciplinary Centre of Natural Products, University of Szeged, Szeged, 6720, Hungary \n Department of Medical Microbiology and Immunobiology, University of Szeged, Szeged, 6720, Hungary \n Department of Organic Chemistry, University of Debrecen, Debrecen, 4032, Hungary \n Cited By :2 \n Export Date: 24 June 2020 \n CODEN: TETRA \n Correspondence Address: Hohmann, J.; Department of Pharmacognosy, Interdisciplinary Excellence Centre, University of SzegedHungary; email: hohmann@pharm.u-szeged.hu \n Chemicals/CAS: uvaol, 545-46-0 \n Funding details: Emberi Eroforrások Minisztériuma, EMMI, 20391-3/2018 /FEKUSTRAT \n Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI, K 120181, PD 121020 \n Funding text 1: Financial support from the Economic Development and Innovation Operative Programme GINOP -2.3.2-15-2016-00012 is gratefully acknowledged. Ministry of Human Capacities , Hungary grant 20391-3/2018 /FEKUSTRAT is acknowledged. D. R. is a grantee of the János Bolyai Research Fellowship of the Hungarian Academy of Sciences . T. K. and A. M. thank the National Research, Development and Innovation Office ( NKFI K 120181 and PD 121020 ) for financial support and the Governmental Information-Technology Development Agency ( KIFÜ ) for CPU time. 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false, "snippet" : true } ], "journal" : { "otype" : "Journal", "mtid" : 4246, "link" : "/api/journal/4246", "label" : "TETRAHEDRON 0040-4020 1464-5416", "pIssn" : "0040-4020", "eIssn" : "1464-5416", "reviewType" : "REVIEWED", "noIF" : false, "sciIndexed" : true, "scopusIndexed" : true, "lang" : "FOREIGN", "hungarian" : false, "published" : true, "oldId" : 4246, "snippet" : true }, "volume" : "75", "issue" : "10", "firstPage" : "1364", "lastPage" : "1370", "firstPageOrInternalIdForSort" : "1364", "pageLength" : 7, "publishedYear" : 2019, "abstractText" : "Two new 14-noreudesmane sesquiterpenes, one new phenylpropane heterodimer, caulilexin C, and uvaol were isolated from the 70% MeOH extract of the fruit peel of Elaeagnus rhamnoides. The structures of the compounds were elucidated by HRESIMS and advanced NMR methods. The absolute configuration of (R)-6,9-dihydroxy-1-oxo-14-noreudesm-5,7,9-triene was determined by the TDDFT-ECD method. The new compounds, together with structurally similar naphthalenes (musizin, musizin-8-O-glucoside, torachrysone-8-O-glucoside) and 1,4-naphthoquinone (2-methylstipandrone), isolated previously from Rumex aquaticus, were investigated for their antiviral activity against Herpes simplex virus type 2 (HSV-2) using two different methods. Applying the traditional virus yield reduction test, (R)-6,9-dihydroxy-1-oxo-14-noreudesm-5,7,9-triene, 1-[3-methoxy-4-(2-methoxy-4-(1E)-propenyl-phenoxy)-phenyl]-propane-1,2-diol, and musizin caused a 2.00 log10, 3.49 log10, and 2.33 log10 reduction of HSV-2 yield, respectively, at a concentration of 12.5 mM. 2-Hydroxy-1-methoxy-6,9-dioxo-14-noreudesm-1,3,5(10),7-tetraene exhibited an antiviral effect at concentration of 50 mM only. Similar results were obtained when the qPCR method was used to test the antiviral activity of the compounds.", "subjects" : [ { "otype" : "Classification", "mtid" : 12184, "link" : "/api/classification/12184", "label" : "Farmakológia és gyógyszerészet", "published" : true, "snippet" : true }, { "otype" : "Classification", "mtid" : 12187, "link" : "/api/classification/12187", "label" : "Gyógyszerismeret", "published" : true, "snippet" : true } ], "fundings" : [ { "otype" : "Funding", "mtid" : 1975344, "link" : "/api/funding/1975344", "label" : "(GINOP-2.3.2-15-2016-00012)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1975345, "link" : "/api/funding/1975345", "label" : "(Hungary grant 20391-3/2018/FEKUSTRAT)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1975346, "link" : "/api/funding/1975346", "label" : "NKFI(K120181)", "published" : false, "snippet" : true }, { "otype" : "Funding", "mtid" : 1975347, "link" : "/api/funding/1975347", "label" : "NKFI(PD121020)", "published" : false, "snippet" : true } ], "keywords" : [ { "otype" : "Keyword", "mtid" : 1248199, "link" : "/api/keyword/1248199", "label" : "Hippophae rhamnoides", "published" : true, "oldId" : 1248199, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1683084, "link" : "/api/keyword/1683084", "label" : "sea buckthorn", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1711963, "link" : "/api/keyword/1711963", "label" : "Elaeagnus rhamnoides", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1711964, "link" : "/api/keyword/1711964", "label" : "Noreudesmane", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1711965, "link" : "/api/keyword/1711965", "label" : "Phenylpropane dimer", "published" : true, "snippet" : true }, { "otype" : "Keyword", "mtid" : 1711966, "link" : "/api/keyword/1711966", "label" : "Anti-HSV2-activity", "published" : true, "snippet" : true } ], "digital" : true, "printed" : true, "sourceYear" : 2019, "foreignEdition" : true, "foreignLanguage" : true, "fullPublication" : true, "conferencePublication" : false, "nationalOrigin" : true, "missingAuthor" : false, "oaType" : "CLOSED", "oaCheckDate" : "2024-03-12", "oaFree" : false, "citationCount" : 14, "citationCountUnpublished" : 0, "citationCountWoOther" : 14, "independentCitCountWoOther" : 14, "nationalOriginCitationCount" : 1, "foreignEditionCitationCount" : 14, "doiCitationCount" : 14, "wosCitationCount" : 13, "scopusCitationCount" : 13, "wosScopusCitationCount" : 13, "wosScopusCitationCountWoOther" : 13, "wosScopusIndependentCitationCount" : 13, "wosScopusIndependentCitationCountWoOther" : 13, "independentCitationCount" : 14, "selfCitationCount" : 0, "unhandledCitationCount" : 0, "citingPubCount" : 14, "independentCitingPubCount" : 14, "citingPubCountWoOther" : 14, "independentCitingPubCountWoOther" : 14, "unhandledCitingPubCount" : 0, "citedPubCount" : 12, "citedCount" : 12, "ratings" : [ { "otype" : "SjrRating", "mtid" : 10782183, "link" : "/api/sjrrating/10782183", "label" : "sjr:Q2 (2019) Scopus - Drug Discovery TETRAHEDRON 0040-4020", "listPos" : 71, "rankValue" : 0.49, "type" : "journal", "ratingType" : { "otype" : "RatingType", "mtid" : 10002, "link" : "/api/ratingtype/10002", "label" : "sjr", "code" : "sjr", "published" : true, "snippet" : true }, "subject" : { "otype" : "ClassificationExternal", "mtid" : 3002, "link" : "/api/classificationexternal/3002", "label" : "Scopus - Drug Discovery", "published" : true, "oldId" : 3002, "snippet" : true }, "ranking" : "Q2", "calculation" : "DIRECT", "published" : true, "snippet" : true } ], "ratingsForSort" : "Q2", "hasCitationDuplums" : false, "inSelectedPubs" : "10056768", "userChangeableUntil" : "2019-02-12T20:48:28.384+0000", "publishDate" : "2019-02-13T20:48:28.380+0000", "directInstitutesForSort" : "Farmakognóziai Intézet (SZTE / GYTK); Orvosi Mikrobiológiai és Immunbiológiai Intézet (SZTE / ÁOK); Szerves Kémiai Tanszék (DE / TTK / KemI); Természetes Vegyületek Interdiszciplináris Központ (SZTE / KE)", "ownerAuthorCount" : 10, "ownerInstituteCount" : 38, "directInstituteCount" : 4, "authorCount" : 10, "contributorCount" : 0, "hasQualityFactor" : true, "tempLockerIds" : [ 10020110 ], "link" : "/api/publication/30433954", "label" : "Rédei Dóra et al. 14-Noreudesmanes and a phenylpropane heterodimer from sea buckthorn berry inhibit Herpes simplex type 2 virus replication. 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