TY - JOUR AU - Saidu, Muhammad Bello AU - Krstić, Gordana AU - Todorović, Nina AU - Berkecz, Róbert AU - Ali, Hazhmat AU - Zupkó, István AU - Hohmann, Judit AU - Rédei, Dóra TI - Monoterpenoid 5-methylcoumarins from Centrapalus pauciflorus with antiproliferative activity JF - ARABIAN JOURNAL OF CHEMISTRY J2 - ARAB J CHEM VL - 16 PY - 2023 IS - 6 PG - 12 SN - 1878-5352 DO - 10.1016/j.arabjc.2023.104777 UR - https://m2.mtmt.hu/api/publication/33695599 ID - 33695599 N1 - Department of Pharmacognosy, University of Szeged, Szeged, 6720, Hungary University of Belgrade, Faculty of Chemistry, Belgrade, 11000, Serbia University of Belgrade, Institute of Chemistry, Technology, and Metallurgy, Department of Chemistry, Belgrade, 11000, Serbia Institute of Pharmaceutical Analysis, University of Szeged, Szeged, 6720, Hungary Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, 6720, Hungary ELKH-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :1 Export Date: 19 October 2023 Correspondence Address: Hohmann, J.; Institute of Pharmacognosy, Hungary; email: hohmann.judit@szte.hu Funding details: TKP2021-EGA-32 Funding details: 5948 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K-143690 Funding details: National Research, Development and Innovation Office Funding text 1: This study was supported by National Research, Development and Innovation Office, Hungary (NKFIH; K-143690). The authors would like to thank the financial support provided by the Ministry of Innovation and Technology of Hungary from NKFIH Fund, project no. TKP2021-EGA-32. Publication was supported by University of Szeged Open Access Fund, grant number 5948. LA - English DB - MTMT ER - TY - JOUR AU - Krstić, Gordana AU - Saidu, Muhammad Bello AU - Barta, Anita AU - Vágvölgyi, Máté AU - Ali, Hazhmat AU - Zupkó, István AU - Berkecz, Róbert AU - Gallah, Umar Shehu AU - Rédei, Dóra AU - Hohmann, Judit TI - Anticancer Meroterpenoids from Centrapalus pauciflorus leaves: Chromone- and 2,4-Chromadione-Monoterpene Derivatives JF - ACS OMEGA J2 - ACS OMEGA VL - 8 PY - 2023 IS - 34 SP - 31389 EP - 31398 PG - 10 SN - 2470-1343 DO - 10.1021/acsomega.3c03884 UR - https://m2.mtmt.hu/api/publication/34103969 ID - 34103969 N1 - Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary University of Belgrade, Faculty of Chemistry, Studentski trg 12-16, Belgrade, 11158, Serbia Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Institute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, Szeged, 6720, Hungary Bioresource Department, National Research Institute for Chemical Technology (NARICT), Zaria, 1052, Nigeria ELKH-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Export Date: 19 October 2023 Correspondence Address: Rédei, D.; Department of Pharmacognosy, Eötvös u. 6, Hungary; email: redei.dora@szte.hu Correspondence Address: Hohmann, J.; Department of Pharmacognosy, Eötvös u. 6, Hungary; email: hohmann.judit@szte.hu Funding details: TKP2021-EGA-32 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K 143690, ÚNKP-22-4-SZTE-169 Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA Funding text 1: The authors thank the financial support provided by the Ministry of Innovation and Technology of Hungary from NKFIH Fund, project no. TKP2021-EGA-32. Support from Hungarian Research and Innovation Foundation (NKFI), grant number K 143690, is acknowledged. M. Vágvölgyi was supported by the ÚNKP-22-4-SZTE-169 New National Excellence Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. LA - English DB - MTMT ER - TY - JOUR AU - Krstić, Gordana AU - Saidu, Muhammad Bello AU - Bombicz, Petra AU - De, Sourav AU - Ali, Hazhmat AU - Zupkó, István AU - Berkecz, Róbert AU - Gallah, Umar Shehu AU - Rédei, Dóra AU - Hohmann, Judit TI - Pauciflorins A–E, Unexpected Chromone–Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus JF - JOURNAL OF NATURAL PRODUCTS J2 - J NAT PROD VL - 86 PY - 2023 IS - 4 SP - 891 EP - 896 PG - 6 SN - 0163-3864 DO - 10.1021/acs.jnatprod.2c01132 UR - https://m2.mtmt.hu/api/publication/33709446 ID - 33709446 N1 - Department of Pharmacognosy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade, 11158, Serbia Centre for Structural Science, Research Centre for Natural Sciences, Magyar Tudósok körútja 2, Budapest, 1117, Hungary Institute of Pharmacodynamics and Biopharmacy, University of Szeged, Eötvös u. 6, Szeged, 6720, Hungary Institute of Pharmaceutical Analysis, University of Szeged, Somogyi u. 4, Szeged, 6720, Hungary Bioresource Department, National Research Institute for Chemical Technology (NARICT), Zaria, 1052, Nigeria ELKH-USZ Biologically Active Natural Products Research Group, University of Szeged, Eötvös u. 6, Szeged, H-6720, Hungary Cited By :1 Export Date: 19 October 2023 CODEN: JNPRD Correspondence Address: Hohmann, J.; Department of Pharmacognosy, Eötvös u. 6, Hungary; email: Hohmann.judit@szte.hu Chemicals/CAS: Chromones; Monoterpenes Funding details: TKP2021-EGA-32 Funding details: Hungarian Scientific Research Fund, OTKA, K-124544 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFIH, K-143690 Funding details: National Research, Development and Innovation Office Funding text 1: This study was supported by the National Research, Development and Innovation Office, Hungary (NKFIH; K-143690). The authors would like to thank the financial support provided by the Ministry of Innovation and Technology of Hungary from the NKFIH Fund, project no. TKP2021-EGA-32. P.B. and S.D. are grateful to the Hungarian Scientific Research Fund (K-124544) for financial support. LA - English DB - MTMT ER - TY - CONF AU - Saidu, Muhammad Bello AU - Barta, Anita AU - Rédei, Dóra ED - Hohmann, Judit TI - Phytochemical investigations of Euphorbia desmondii T2 - 4th Symposium of Young Researchers on Pharmacognosy PB - Institute of Pharmacognosy, Faculty of Pharmacy, University of Szeged C1 - Szeged PY - 2023 SP - 22 EP - 22 PG - 1 DO - 10.14232/syrmpnpr.2023.15 UR - https://m2.mtmt.hu/api/publication/33963610 ID - 33963610 LA - English DB - MTMT ER - TY - BOOK ED - Rédei, Dóra TI - Fiatal Gyógynövénykutatók Fóruma: a Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztályának rendezvénye ET - 0 PB - Magyar Gyógyszerésztudományi Társaság Gyógynövény Szakosztálya C1 - Szeged PY - 2022 SP - 22 DO - 10.14232/fgykf.2022.af UR - https://m2.mtmt.hu/api/publication/32900661 ID - 32900661 LA - English DB - MTMT ER - TY - JOUR AU - Saidu, Muhammad Bello AU - Kúsz, Norbert AU - Berkecz, Róbert AU - Rácz, Bálint AU - Spengler, Gabriella AU - Hohmann, Judit AU - Rédei, Dóra TI - Ingol, ent-atisane, and stachane-type diterpenoids from Euphorbia deightonii with multidrug resistance reversing activity JF - PHYTOCHEMISTRY J2 - PHYTOCHEMISTRY VL - 204 PY - 2022 PG - 9 SN - 0031-9422 DO - 10.1016/j.phytochem.2022.113344 UR - https://m2.mtmt.hu/api/publication/33049861 ID - 33049861 N1 - Funding: This work was supported by the Economic Development and Innovation Operative Programme [GINOP-2.3.2-15-2016-00012]. M.B.S. was supported by the Stipendium Hungaricum scholarship program AB - Nine previously undescribed ingol-type diterpenoid polyesters with eighteen known ingol esters, two ent-atisane, and one stachane diterpenoid were isolated from the methanol extract of Euphorbia deightonii Croizat. The structures were established by extensive spectroscopic analysis involving 1D (1H, 13C J-modulation) and 2D NMR experiments, HRESIMS measurements, and the comparison of the spectroscopic data with reported literature values. The cytotoxic concentrations of 13 isolated compounds were determined, and the compounds were investigated for multidrug resistance modulating activity on an L5178 mouse lymphoma cell line using a rho-damin 123 accumulation assay. Six ingol esters demonstrated the significant inhibition of P-glycoprotein, while the two ent-atisane diterpenoids were found to be inactive. The measured activities allowed to establish some structure-activity relationships. Notably, lower and higher-type diterpenoids simultaneously occurred in E. deightonii. LA - English DB - MTMT ER - TY - JOUR AU - Saidu, Muhammad Bello AU - Kúsz, Norbert AU - Tsai, Yu-Chi AU - Vágvölgyi, Máté AU - Berkecz, Róbert AU - Kókai, Dávid AU - Burián, Katalin AU - Hohmann, Judit AU - Rédei, Dóra TI - Triterpenes and Phenolic Compounds from Euphorbia deightonii with Antiviral Activity against Herpes Simplex Virus Type-2 JF - PLANTS-BASEL J2 - PLANTS-BASEL VL - 11 PY - 2022 IS - 6 PG - 10 SN - 2223-7747 DO - 10.3390/plants11060764 UR - https://m2.mtmt.hu/api/publication/32765771 ID - 32765771 N1 - This research was funded by the Economic Development and Innovation Operative Programme (GINOP-2.3.2-15-2016-00012) and the National Research, Development and Innovation Fund (NKFI) under grant number K135845. M.B.S. was supported by the Stipendium Hungaricum scholarship program. AB - Two undescribed compounds, 3 beta,7 beta-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known compounds, namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), and 3,4,3'-tri-O-methylellagic acid (8). The structures of the isolated compounds were determined by HRESIMS, 1D (H-1, C-13 JMOD) and 2D NMR (HSQC, HMBC, H-1-H-1 COSY, NOESY) spectroscopic analysis, and by comparison of the assignments with literature data. The anti-herpes simplex virus type-2 activity of the isolated compounds were investigated by qRT-PCR assay on Vero cells after determining cytotoxic concentration 50% (CC50). Compounds 1, 3, 4, and 7 exhibited inhibitory effects with respective IC50 values of 7.05, 2.42, 11.73, and 0.032 mu M. Scoparon (7) showed the strongest anti-HSV activity with a selectivity index of 10.93. LA - English DB - MTMT ER - TY - JOUR AU - Tsai, Yu-Chi AU - Nell, Racheal A. AU - Buckendorf, Jonathan E. AU - Kúsz, Norbert AU - Mwangi, Peter Waweru AU - Berkecz, Róbert AU - Rédei, Dóra AU - Vasas, Andrea AU - Spivak, Adam M. AU - Hohmann, Judit TI - Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity JF - PHARMACEUTICALS J2 - PHARMACEUTICALS-BASE VL - 14 PY - 2021 IS - 7 PG - 22 SN - 1424-8247 DO - 10.3390/ph14070653 UR - https://m2.mtmt.hu/api/publication/32100393 ID - 32100393 N1 - Cited By :1 Export Date: 9 August 2022 LA - English DB - MTMT ER - TY - JOUR AU - Tóth, Barbara AU - Rédei, Dóra AU - Fekete, Orsolya AU - Csupor, Dezső TI - Bíbor kasvirág - az Év Gyógynövénye 2020-ban JF - GYÓGYSZERÉSZET J2 - GYÓGYSZERÉSZET VL - 2020 PY - 2020 IS - 11 SP - 643 EP - 648 PG - 6 SN - 0017-6036 UR - https://m2.mtmt.hu/api/publication/31784472 ID - 31784472 LA - Hungarian DB - MTMT ER - TY - JOUR AU - Tsai, Yu-Chi AU - Rédei, Dóra AU - Hohmann, Judit AU - Wu, Chin-Chung TI - 12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells via Activation of PKC-δ/PKD/ERK Signaling Pathway JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 21 PY - 2020 IS - 20 PG - 12 SN - 1661-6596 DO - 10.3390/ijms21207579 UR - https://m2.mtmt.hu/api/publication/31629692 ID - 31629692 LA - English DB - MTMT ER -