TY - GEN AU - Szloszár, Aliz AU - Mándity, István AU - Ferenc, Fülöp TI - Sustainable synthesis of N-methylated cyclic model peptides PY - 2015 UR - https://m2.mtmt.hu/api/publication/3083137 ID - 3083137 N1 - Város: Lisszabon Ország: Portugália Befejező dátum: 2015-07-16 Kezdő dátum: 2015-07-12 LA - English DB - MTMT ER - TY - JOUR AU - Balogh, Balázs AU - Ivánczi, Márton AU - Nizami, Bilal AU - Beke-Somfai, Tamás AU - Mándity, István TI - ConjuPepDB: a database of peptide–drug conjugates JF - NUCLEIC ACIDS RESEARCH J2 - NUCLEIC ACIDS RES VL - 49 PY - 2021 IS - D1 SP - D1102 EP - D1112 PG - 11 SN - 0305-1048 DO - 10.1093/nar/gkaa950 UR - https://m2.mtmt.hu/api/publication/31647897 ID - 31647897 AB - Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule, (ii) a peptide and (iii) a linker. The drug molecule is mandatory for the biological action, however, its efficacy can be enhanced by targeted delivery, which often also reduces unwanted side effects. For site-specificity the peptide part is mainly responsible. The linker attaches chemically the drug to the peptide, but it could also be biodegradable which ensures controlled liberation of the small drug. Despite the importance of the field, there is no public comprehensive database on these species. Herein we describe ConjuPepBD, a freely available, fully annotated and manually curated database of peptide drug conjugates. ConjuPepDB contains basic information about the entries, e.g. CAS number. Furthermore, it also implies their biomedical application and the type of chemical conjugation employed. It covers more than 1600 conjugates from ∼230 publications. The web-interface is user-friendly, intuitive, and useable on several devices, e.g. phones, tablets, PCs. The webpage allows the user to search for content using numerous criteria, chemical structure and a help page is also provided. Besides giving quick insight for newcomers, ConjuPepDB is hoped to be also helpful for researchers from various related fields. The database is accessible at: https://conjupepdb.ttk.hu/. LA - English DB - MTMT ER - TY - BOOK AU - Balogh, Balázs AU - Bogdán, Dóra AU - Czompa, Andrea AU - Deme, Ruth AU - Dunkel, Petra AU - Ivánczi, Márton AU - Kárpáti, Levente AU - Krajsovszky, Gábor AU - Mándity, István AU - Tétényi, Péter TI - Szerves kémia tesztfeladatok PB - Semmelweis Egyetem CY - Budapest PY - 2023 SP - 185 SN - 9786155722288 UR - https://m2.mtmt.hu/api/publication/34186753 ID - 34186753 N1 - Másodközlés: 34315226 LA - Hungarian DB - MTMT ER - TY - BOOK AU - Balogh, Balázs AU - Bogdán, Dóra AU - Czompa, Andrea AU - Deme, Ruth AU - Dunkel, Petra AU - Ivánczi, Márton AU - Kárpáti, Levente AU - Krajsovszky, Gábor AU - Mándity, István AU - Tétényi, Péter TI - Organic chemistry test questions - Másodközlés angol nyelven PB - Semmelweis Egyetem CY - Budapest PY - 2023 SP - 185 SN - 9786155722295 UR - https://m2.mtmt.hu/api/publication/34315226 ID - 34315226 N1 - Semmelweis University, Faculty of Pharmaceutical Sciences, Department of Organic Chemistry Eredeti közlemény: 34186753 LA - English DB - MTMT ER - TY - JOUR AU - Batta, Gyula Gábor (Ifj.) AU - Kárpáti, Levente AU - Henrique, Gabriela Fulaneto AU - Tóth, Gabriella AU - Tarapcsák, Szabolcs AU - Kovács, Tamás AU - Zákány, Florina AU - Mándity, István AU - Nagy, Péter TI - Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential JF - BRITISH JOURNAL OF PHARMACOLOGY J2 - BR J PHARMACOL VL - 178 PY - 2021 IS - 18 SP - 3667 EP - 3681 PG - 15 SN - 0007-1188 DO - 10.1111/bph.15509 UR - https://m2.mtmt.hu/api/publication/31996377 ID - 31996377 LA - English DB - MTMT ER - TY - JOUR AU - Beke-Somfai, Tamás AU - El Battioui, Kamal AU - Juhász, Tünde AU - Quemé Peña, Mayra AU - Szigyártó, Imola Csilla AU - Molnár, Dániel AU - Toth, Judit AU - Szabo, Lilla AU - Bodor, Andrea AU - Wacha, András Ferenc AU - Mándity, István TI - Conformational diversity of membrane active beta[sup]3[/sup]-peptide foldamers JF - JOURNAL OF PEPTIDE SCIENCE J2 - J PEPT SCI VL - 28 PY - 2022 IS - 3 PG - 2 SN - 1075-2617 UR - https://m2.mtmt.hu/api/publication/34034694 ID - 34034694 LA - English DB - MTMT ER - TY - JOUR AU - Berlicki, Ł AU - Pilsl, L AU - Wéber, Edit AU - Mándity, István AU - Cabrele, C AU - Martinek, Tamás AU - Fülöp, Ferenc AU - Reiser, O TI - Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid JF - ANGEWANDTE CHEMIE-INTERNATIONAL EDITION J2 - ANGEW CHEM INT EDIT VL - 51 PY - 2012 IS - 9 SP - 2208 EP - 2212 PG - 5 SN - 1433-7851 DO - 10.1002/anie.201107702 UR - https://m2.mtmt.hu/api/publication/1926671 ID - 1926671 AB - Waterproof: cis-β-Aminocylopentanecarboxylic acid is a highly suitable building block for the synthesis of α,β- and α,α,β, β-peptides that have unique helical structures with high stability in methanol and aqueous media. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. LA - English DB - MTMT ER - TY - CHAP AU - Bogdán, Dóra AU - Kárpáti, Levente AU - Mándity, István ED - Török, Marianna TI - Toward the green synthesis of peptides and peptidic drugs T2 - Contemporary Chemical Approaches for Green and Sustainable Drugs PB - Elsevier CY - Amsterdam SN - 9780128222485 PY - 2022 SP - 421 EP - 456 PG - 36 DO - 10.1016/B978-0-12-822248-5.00002-4 UR - https://m2.mtmt.hu/api/publication/33096693 ID - 33096693 LA - English DB - MTMT ER - TY - GEN AU - B Ötvös, Sándor AU - Mándity, István AU - Fülöp, Ferenc TI - Organocatalysis in flow: solid supported peptide catalyzed enantioselective synthesis of γ-nitroaldehydes PY - 2011 UR - https://m2.mtmt.hu/api/publication/3082886 ID - 3082886 N1 - Város: Bologna Ország: Olaszország Kezdő dátum: 2011-00-00 LA - English DB - MTMT ER - TY - GEN AU - B Ötvös, Sándor AU - Mándity, István AU - Georgiádes, Ádám AU - Kiss, Loránd AU - Fülöp, Ferenc TI - Safe; efficient and scalable synthesis of novel potentially bioactive 1;2;3-triazoles in flow PY - 2012 UR - https://m2.mtmt.hu/api/publication/3082920 ID - 3082920 N1 - Város: Budapest Ország: Magyarország Kezdő dátum: 2012-00-00 LA - English DB - MTMT ER - TY - JOUR AU - Chakraborty, Sohini AU - El Battioui, Kamal AU - Molnár, Dániel AU - Jezsó, Bálint AU - Daruka, Lejla AU - Tasvilla, Sonallya AU - Juhász, Tünde AU - Hirmondó, Rita AU - Szigyártó, Imola Csilla AU - Románszki, Loránd AU - Tőkési, Natália AU - Pinkas, Daniel AU - Házy, Eszter AU - Pavela, Olivér AU - Bodor, Andrea AU - Varga, Zoltán AU - Mándity, István AU - Kovács, Mihály AU - Pál, Csaba AU - Horváti, Kata AU - Tóth, Judit AU - Beke-Somfai, Tamás TI - An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism JF - ADVANCED SCIENCE J2 - ADV SCI VL - 13 PY - 2026 IS - 28 PG - 12 SN - 2198-3844 DO - 10.1002/advs.202522269 UR - https://m2.mtmt.hu/api/publication/37019304 ID - 37019304 N1 - Funding Agency and Grant Number: ELTE KMOP [4.2.1/B-10-2011-0002, NKFIH K-134595]; Hungary [TKP2021-EGA-31, 2020-1.1.2-PIACI-KFI-2020-00021, KKP_22, 144180, K138318]; European Union HORIZON WIDERA 2023 IDP2Biomed [101160233]; European Research Council [ERC-2023-ADG 101142626-FutureAntibiotics]; National Research, Development and Innovation Office [K146323]; Lendlet (Momentum) Programme of the Hungarian Academy of Sciences [LP2021-28]; National Research; National Laboratory of Biotechnology [2022-2.1.1-NL-2022-00008]; Development and Innovation Office Funding text: This work was funded by the National Research, Development and Innovation Office, Hungary (TKP2021-EGA-31, 2020-1.1.2-PIACI-KFI-2020-00021, KKP_22 Project n.o. 144180 and K138318). Support from Eotvos Lorand Research Network, Grant Nos. SA-87/2021 and KEP-5/2021 were also acknowledged. This work was supported by ELTE KMOP-4.2.1/B-10-2011-0002 and NKFIH K-134595 grants to M.K, NKFIH K-137940 and NKKP Advanced-150835, NKFIH K 137940 and Advanced 150838 to A.B. Funded by the European Union HORIZON WIDERA 2023 IDP2Biomed-grant agreement No. 101160233. K.H. acknowledges the support of the Lendulet (Momentum) Programme of the Hungarian Academy of Sciences (Grant No.: LP2021-28). Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Research Executive Agency (REA). Neither the European Union nor the granting authority can be held responsible for them. The work was supported by the HUN-REN Hungarian Research Network. The study was also supported by the following research grants: National Laboratory of Biotechnology Grant 2022-2.1.1-NL-2022-00008 (CP), National Research, Development and Innovation Office K146323 (CP), The European Research Council ERC-2023-ADG 101142626-FutureAntibiotics (CP). We acknowledge Cryo-electron microscopy and tomography core facility CEITEC MUof CIISB, Instruct-CZ Centre, supported by MEYS CR (LM2023042) and EuropeanRegional Development Fund-Project "Innovation of Czech Infrastructure forIntegrative Structural Biology" (No. CZ.02.01.01/00/23_015/0008175). AB - Artificial bioinspired supramolecular assemblies hold great potential to alter modern medicine. Organic tissue‐like nanomaterials built from foldamer peptidomimetics and natural biomolecules could expand our boundaries toward new biocompounds that are able to address global health challenges. Related, antimicrobial resistance against conventional antibiotics motivates search for new compounds with orthogonal mechanisms. Here we designed an antibacterial system where natural adenosine phosphates (APs) trigger supramolecular co‐assemblies from a lipopolysaccharide‐targeting (LPS) antimicrobial β 3 ‐peptide (3K). Cryo‐EM and confocal microscopy images on E. coli confirmed that real‐time action of 3K‐APs progresses via a multiscale mechanism. Initially, entangled nanofibers capture bacteria resulting in agglutination. Further, individual cells become enwrapped, undergoing a reduction in cell height, as observed by AFM. Finally, in situ cryo‐EM observations, offering insight into their structural state in solution, suggest an association between the presence of extracellular vesicles and loss of cell integrity, which may contribute to cell death. 3K‐ATP was tested on multidrug resistant bacterial strains which adapted to membrane‐targeting antibiotics, where only limited cross‐resistance was observed. Resistant strains modifying their LPS even showed increased sensitivity. Besides induced disassembly by target membranes, degradation could also be reached through enzymatic hydrolysis of APs, altogether resulting in supramolecular bactericides with controllable build‐up and clearance. LA - English DB - MTMT ER - TY - JOUR AU - Czompa, Andrea AU - Pásztor, Balázs László AU - Sahar, Jennifer Alizadeh AU - Mucsi, Zoltán AU - Bogdán, Dóra AU - Ludányi, Krisztina AU - Varga, Zoltán AU - Mándity, István TI - Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction JF - RSC ADVANCES J2 - RSC ADV VL - 9 PY - 2019 IS - 65 SP - 37818 EP - 37824 PG - 7 SN - 2046-2069 DO - 10.1039/C9RA07044C UR - https://m2.mtmt.hu/api/publication/30931910 ID - 30931910 LA - English DB - MTMT ER - TY - GEN AU - Czompa, Andrea AU - Mándity, István TI - Propylene carbonate in Suzuki-Miyaura reaction PY - 2022 UR - https://m2.mtmt.hu/api/publication/33338279 ID - 33338279 AB - 11th Edition of International Conference on Catalysis, Chemical Engineering and Technology, Magnus Group, USA– Tokyo, Japan (hybrid event) LA - English DB - MTMT ER - TY - JOUR AU - Czompa, Andrea AU - Bogdán, Dóra AU - Balogh, Balázs AU - Erdei, Eszter AU - Selymes, Patrik AU - Csomos, Attila AU - Mándity, István TI - Sustainable and Safe N-alkylation of N-heterocycles by Propylene Carbonate under Neat Reaction Conditions JF - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES J2 - INT J MOL SCI VL - 25 PY - 2024 IS - 10 PG - 14 SN - 1661-6596 DO - 10.3390/ijms25105523 UR - https://m2.mtmt.hu/api/publication/34864485 ID - 34864485 N1 - Funding Agency and Grant Number: Hungarian Research Foundation; National Research, Development and Innovation Office [TKP2021-EGA-31, RRF-2.3.1-21-2022-00015]; European Union [EFOP-3.6.3-VEKOP-16-2017-00009]; [OTKA ANN 139484] Funding text: We are grateful to the Hungarian Research Foundation (OTKA ANN 139484). The financial support of the National Research, Development and Innovation Office (TKP2021-EGA-31) is acknowledged. Project no. RRF-2.3.1-21-2022-00015 has been implemented with support provided by the European Union. E.E. acknowledges the grant of EFOP-3.6.3-VEKOP-16-2017-00009. AB - A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform N-alkylation of N-, O- and/or S-containing heterocyclic compounds. PC in these reactions served as both the reagent and solvent. Importantly, no genotoxic alkyl halides were required. No auxiliary was necessary when using anhydrous PC. Product formation includes nucleophilic substitution with the concomitant loss of water and carbon dioxide. Substrates prepared, including the newly invented PROTAC drugs, are widely used. LA - English DB - MTMT ER - TY - JOUR AU - Csikos, Csaba AU - Képes, Zita AU - Fekete, Anikó AU - Vágner, Adrienn AU - Nagy, Gábor AU - Gyuricza, Barbara AU - Arató, Viktória Zsófia AU - Kárpáti, Levente AU - Mándity, István AU - Bruchertseifer, Frank AU - Halmos, Gábor AU - Szikra, Dezső AU - Trencsényi, György TI - Evaluation of the therapeutic efficacy of 213Bi-labelled DOTA-conjugated alpha-melanocyte stimulating hormone peptide analogues in melanocortin-1 receptor positive preclinical melanoma model JF - INTERNATIONAL JOURNAL OF PHARMACEUTICS J2 - INT J PHARM VL - 644 PY - 2023 PG - 9 SN - 0378-5173 DO - 10.1016/j.ijpharm.2023.123344 UR - https://m2.mtmt.hu/api/publication/34124792 ID - 34124792 LA - English DB - MTMT ER - TY - JOUR AU - Csomós, Péter AU - Fodor, Lajos AU - Mándity, István AU - Bernáth, Gábor TI - An efficient route for the synthesis of 2-arylthiazino[5,6-b]indole derivatives JF - TETRAHEDRON J2 - TETRAHEDRON VL - 63 PY - 2007 IS - 23 SP - 4983 EP - 4989 PG - 7 SN - 0040-4020 DO - 10.1016/j.tet.2007.03.132 UR - https://m2.mtmt.hu/api/publication/118384 ID - 118384 LA - English DB - MTMT ER - TY - GEN AU - Szigyártó, Imola Csilla AU - el Battioui, Kamal AU - Udyavara Nagaraj, Vignesh AU - Quemé Peña, Mayra AU - Mihály, Judith AU - Wacha, András Ferenc AU - Bogdán, Dóra AU - Zsila, Ferenc AU - Varga, Zoltán AU - Mándity, István AU - Beke-Somfai, Tamás TI - Synthesis and characterisation of water soluble membrane active foldamers PY - 2019 UR - https://m2.mtmt.hu/api/publication/33191182 ID - 33191182 LA - English DB - MTMT ER - TY - JOUR AU - Ferreira de Santana, Juliana AU - Mirzahosseini, Arash AU - Mándity, B. AU - Bogdán, Dóra AU - Mándity, István AU - Noszál, Béla TI - Close correlation between thiolate basicity and certain NMR parameters in cysteine and cystine microspecies JF - PLOS ONE J2 - PLOS ONE VL - 17 PY - 2022 IS - 3 PG - 13 SN - 1932-6203 DO - 10.1371/journal.pone.0264866 UR - https://m2.mtmt.hu/api/publication/32764077 ID - 32764077 LA - English DB - MTMT ER - TY - CHAP AU - Dormán, György AU - Mándity, István AU - Deme, Ruth AU - Mándoki, András ED - Vaccaro, Luigi ED - Török, Béla TI - Continuous Flow Synthesis T2 - Encyclopedia of Green Chemistry, Volume 1 PB - Elsevier CY - Amsterdam PY - 2025 SP - 199 EP - 217 PG - 19 DO - 10.1016/B978-0-443-15742-4.00075-2 UR - https://m2.mtmt.hu/api/publication/36287605 ID - 36287605 LA - English DB - MTMT ER - TY - JOUR AU - Ekholm, FS AU - Mándity, István AU - Fülöp, Ferenc AU - Leino, R TI - Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry JF - TETRAHEDRON LETTERS J2 - TETRAHEDRON LETT VL - 52 PY - 2011 IS - 16 SP - 1839 EP - 1841 PG - 3 SN - 0040-4039 DO - 10.1016/j.tetlet.2010.12.109 UR - https://m2.mtmt.hu/api/publication/1809240 ID - 1809240 AB - A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved. LA - English DB - MTMT ER -