@misc{MTMT:3083137, title = {Sustainable synthesis of N-methylated cyclic model peptides}, url = {https://m2.mtmt.hu/api/publication/3083137}, author = {Szloszár, Aliz and Mándity, István and Ferenc, Fülöp}, unique-id = {3083137}, year = {2015}, orcid-numbers = {Szloszár, Aliz/0000-0002-2126-2849; Mándity, István/0000-0003-2865-6143} } @article{MTMT:31647897, title = {ConjuPepDB: a database of peptide–drug conjugates}, url = {https://m2.mtmt.hu/api/publication/31647897}, author = {Balogh, Balázs and Ivánczi, Márton and Nizami, Bilal and Beke-Somfai, Tamás and Mándity, István}, doi = {10.1093/nar/gkaa950}, journal-iso = {NUCLEIC ACIDS RES}, journal = {NUCLEIC ACIDS RESEARCH}, volume = {49}, unique-id = {31647897}, issn = {0305-1048}, abstract = {Peptide–drug conjugates are organic molecules composed of (i) a small drug molecule, (ii) a peptide and (iii) a linker. The drug molecule is mandatory for the biological action, however, its efficacy can be enhanced by targeted delivery, which often also reduces unwanted side effects. For site-specificity the peptide part is mainly responsible. The linker attaches chemically the drug to the peptide, but it could also be biodegradable which ensures controlled liberation of the small drug. Despite the importance of the field, there is no public comprehensive database on these species. Herein we describe ConjuPepBD, a freely available, fully annotated and manually curated database of peptide drug conjugates. ConjuPepDB contains basic information about the entries, e.g. CAS number. Furthermore, it also implies their biomedical application and the type of chemical conjugation employed. It covers more than 1600 conjugates from ∼230 publications. The web-interface is user-friendly, intuitive, and useable on several devices, e.g. phones, tablets, PCs. The webpage allows the user to search for content using numerous criteria, chemical structure and a help page is also provided. Besides giving quick insight for newcomers, ConjuPepDB is hoped to be also helpful for researchers from various related fields. The database is accessible at: https://conjupepdb.ttk.hu/.}, year = {2021}, eissn = {1362-4962}, pages = {D1102-D1112}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Mándity, István/0000-0003-2865-6143} } @book{MTMT:34186753, title = {Szerves kémia tesztfeladatok}, url = {https://m2.mtmt.hu/api/publication/34186753}, isbn = {9786155722288}, author = {Balogh, Balázs and Bogdán, Dóra and Czompa, Andrea and Deme, Ruth and Dunkel, Petra and Ivánczi, Márton and Kárpáti, Levente and Krajsovszky, Gábor and Mándity, István and Tétényi, Péter}, publisher = {Semmelweis Egyetem}, unique-id = {34186753}, year = {2023}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Krajsovszky, Gábor/0000-0002-3224-4566; Mándity, István/0000-0003-2865-6143} } @book{MTMT:34315226, title = {Organic chemistry test questions - Másodközlés angol nyelven}, url = {https://m2.mtmt.hu/api/publication/34315226}, isbn = {9786155722295}, author = {Balogh, Balázs and Bogdán, Dóra and Czompa, Andrea and Deme, Ruth and Dunkel, Petra and Ivánczi, Márton and Kárpáti, Levente and Krajsovszky, Gábor and Mándity, István and Tétényi, Péter}, publisher = {Semmelweis Egyetem}, unique-id = {34315226}, year = {2023}, orcid-numbers = {Balogh, Balázs/0000-0001-7282-7283; Bogdán, Dóra/0000-0003-4455-8914; Czompa, Andrea/0000-0001-8442-8554; Deme, Ruth/0000-0002-0798-6912; Dunkel, Petra/0000-0001-5445-8357; Kárpáti, Levente/0000-0002-9091-3027; Krajsovszky, Gábor/0000-0002-3224-4566; Mándity, István/0000-0003-2865-6143} } @article{MTMT:31996377, title = {Statin‐boosted cellular uptake and endosomal escape of penetratin due to reduced membrane dipole potential}, url = {https://m2.mtmt.hu/api/publication/31996377}, author = {Batta, Gyula Gábor (Ifj.) and Kárpáti, Levente and Henrique, Gabriela Fulaneto and Tóth, Gabriella and Tarapcsák, Szabolcs and Kovács, Tamás and Zákány, Florina and Mándity, István and Nagy, Péter}, doi = {10.1111/bph.15509}, journal-iso = {BR J PHARMACOL}, journal = {BRITISH JOURNAL OF PHARMACOLOGY}, volume = {178}, unique-id = {31996377}, issn = {0007-1188}, year = {2021}, eissn = {1476-5381}, pages = {3667-3681}, orcid-numbers = {Batta, Gyula Gábor (Ifj.)/0000-0001-8735-6920; Kárpáti, Levente/0000-0002-9091-3027; Kovács, Tamás/0000-0002-1084-9847; Mándity, István/0000-0003-2865-6143; Nagy, Péter/0000-0002-7466-805X} } @article{MTMT:34034694, title = {Conformational diversity of membrane active beta[sup]3[/sup]-peptide foldamers}, url = {https://m2.mtmt.hu/api/publication/34034694}, author = {Beke-Somfai, Tamás and El Battioui, Kamal and Juhász, Tünde and Quemé Peña, Mayra and Szigyártó, Imola Csilla and Molnár, Dániel and Toth, Judit and Szabo, Lilla and Bodor, Andrea and Wacha, András Ferenc and Mándity, István}, journal-iso = {J PEPT SCI}, journal = {JOURNAL OF PEPTIDE SCIENCE}, volume = {28}, unique-id = {34034694}, issn = {1075-2617}, keywords = {Biochemistry & Molecular Biology}, year = {2022}, eissn = {1099-1387}, orcid-numbers = {Bodor, Andrea/0000-0002-7422-298X; Wacha, András Ferenc/0000-0002-9609-0893; Mándity, István/0000-0003-2865-6143} } @article{MTMT:1926671, title = {Unique α,β- and α,α,β,β-peptide foldamers based on cis-β-aminocyclopentanecarboxylic acid}, url = {https://m2.mtmt.hu/api/publication/1926671}, author = {Berlicki, Ł and Pilsl, L and Wéber, Edit and Mándity, István and Cabrele, C and Martinek, Tamás and Fülöp, Ferenc and Reiser, O}, doi = {10.1002/anie.201107702}, journal-iso = {ANGEW CHEM INT EDIT}, journal = {ANGEWANDTE CHEMIE-INTERNATIONAL EDITION}, volume = {51}, unique-id = {1926671}, issn = {1433-7851}, abstract = {Waterproof: cis-β-Aminocylopentanecarboxylic acid is a highly suitable building block for the synthesis of α,β- and α,α,β, β-peptides that have unique helical structures with high stability in methanol and aqueous media. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.}, keywords = {PEPTIDES; METHANOL; FOLDAMERS; amino acids; helical structures; aqueous media; Building blockes; High stability; cis-pentacine; β-amino acids}, year = {2012}, eissn = {1521-3773}, pages = {2208-2212}, orcid-numbers = {Wéber, Edit/0000-0002-5904-0619; Mándity, István/0000-0003-2865-6143; Martinek, Tamás/0000-0003-3168-8066; Fülöp, Ferenc/0000-0003-1066-5287} } @{MTMT:33096693, title = {Toward the green synthesis of peptides and peptidic drugs}, url = {https://m2.mtmt.hu/api/publication/33096693}, author = {Bogdán, Dóra and Kárpáti, Levente and Mándity, István}, booktitle = {Contemporary Chemical Approaches for Green and Sustainable Drugs}, doi = {10.1016/B978-0-12-822248-5.00002-4}, unique-id = {33096693}, year = {2022}, pages = {421-456}, orcid-numbers = {Bogdán, Dóra/0000-0003-4455-8914; Mándity, István/0000-0003-2865-6143} } @misc{MTMT:3082886, title = {Organocatalysis in flow: solid supported peptide catalyzed enantioselective synthesis of γ-nitroaldehydes}, url = {https://m2.mtmt.hu/api/publication/3082886}, author = {B Ötvös, Sándor and Mándity, István and Fülöp, Ferenc}, unique-id = {3082886}, year = {2011}, orcid-numbers = {Mándity, István/0000-0003-2865-6143} } @misc{MTMT:3082920, title = {Safe; efficient and scalable synthesis of novel potentially bioactive 1;2;3-triazoles in flow}, url = {https://m2.mtmt.hu/api/publication/3082920}, author = {B Ötvös, Sándor and Mándity, István and Georgiádes, Ádám and Kiss, Loránd and Fülöp, Ferenc}, unique-id = {3082920}, year = {2012}, orcid-numbers = {Mándity, István/0000-0003-2865-6143} } @article{MTMT:37019304, title = {An ATP‐Mediated Antibiotic β‐Peptide Nanofiber That Kills Multidrug‐Resistant Bacteria via a Multistage Mechanism}, url = {https://m2.mtmt.hu/api/publication/37019304}, author = {Chakraborty, Sohini and El Battioui, Kamal and Molnár, Dániel and Jezsó, Bálint and Daruka, Lejla and Tasvilla, Sonallya and Juhász, Tünde and Hirmondó, Rita and Szigyártó, Imola Csilla and Románszki, Loránd and Tőkési, Natália and Pinkas, Daniel and Házy, Eszter and Pavela, Olivér and Bodor, Andrea and Varga, Zoltán and Mándity, István and Kovács, Mihály and Pál, Csaba and Horváti, Kata and Tóth, Judit and Beke-Somfai, Tamás}, doi = {10.1002/advs.202522269}, journal-iso = {ADV SCI}, journal = {ADVANCED SCIENCE}, volume = {13}, unique-id = {37019304}, abstract = {Artificial bioinspired supramolecular assemblies hold great potential to alter modern medicine. Organic tissue‐like nanomaterials built from foldamer peptidomimetics and natural biomolecules could expand our boundaries toward new biocompounds that are able to address global health challenges. Related, antimicrobial resistance against conventional antibiotics motivates search for new compounds with orthogonal mechanisms. Here we designed an antibacterial system where natural adenosine phosphates (APs) trigger supramolecular co‐assemblies from a lipopolysaccharide‐targeting (LPS) antimicrobial β 3 ‐peptide (3K). Cryo‐EM and confocal microscopy images on E. coli confirmed that real‐time action of 3K‐APs progresses via a multiscale mechanism. Initially, entangled nanofibers capture bacteria resulting in agglutination. Further, individual cells become enwrapped, undergoing a reduction in cell height, as observed by AFM. Finally, in situ cryo‐EM observations, offering insight into their structural state in solution, suggest an association between the presence of extracellular vesicles and loss of cell integrity, which may contribute to cell death. 3K‐ATP was tested on multidrug resistant bacterial strains which adapted to membrane‐targeting antibiotics, where only limited cross‐resistance was observed. Resistant strains modifying their LPS even showed increased sensitivity. Besides induced disassembly by target membranes, degradation could also be reached through enzymatic hydrolysis of APs, altogether resulting in supramolecular bactericides with controllable build‐up and clearance.}, year = {2026}, eissn = {2198-3844}, orcid-numbers = {Jezsó, Bálint/0000-0002-1306-4797; Hirmondó, Rita/0000-0002-0393-3290; Bodor, Andrea/0000-0002-7422-298X; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143; Kovács, Mihály/0000-0002-1200-4741; Horváti, Kata/0000-0003-4092-6011} } @article{MTMT:30931910, title = {Scope and limitation of propylene carbonate as a sustainable solvent in the Suzuki–Miyaura reaction}, url = {https://m2.mtmt.hu/api/publication/30931910}, author = {Czompa, Andrea and Pásztor, Balázs László and Sahar, Jennifer Alizadeh and Mucsi, Zoltán and Bogdán, Dóra and Ludányi, Krisztina and Varga, Zoltán and Mándity, István}, doi = {10.1039/C9RA07044C}, journal-iso = {RSC ADV}, journal = {RSC ADVANCES}, volume = {9}, unique-id = {30931910}, year = {2019}, eissn = {2046-2069}, pages = {37818-37824}, orcid-numbers = {Czompa, Andrea/0000-0001-8442-8554; Mucsi, Zoltán/0000-0003-3224-8847; Bogdán, Dóra/0000-0003-4455-8914; Ludányi, Krisztina/0000-0002-2380-9529; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143} } @misc{MTMT:33338279, title = {Propylene carbonate in Suzuki-Miyaura reaction}, url = {https://m2.mtmt.hu/api/publication/33338279}, author = {Czompa, Andrea and Mándity, István}, unique-id = {33338279}, abstract = {11th Edition of International Conference on Catalysis, Chemical Engineering and Technology, Magnus Group, USA– Tokyo, Japan (hybrid event)}, year = {2022}, orcid-numbers = {Czompa, Andrea/0000-0001-8442-8554; Mándity, István/0000-0003-2865-6143} } @article{MTMT:34864485, title = {Sustainable and Safe N-alkylation of N-heterocycles by Propylene Carbonate under Neat Reaction Conditions}, url = {https://m2.mtmt.hu/api/publication/34864485}, author = {Czompa, Andrea and Bogdán, Dóra and Balogh, Balázs and Erdei, Eszter and Selymes, Patrik and Csomos, Attila and Mándity, István}, doi = {10.3390/ijms25105523}, journal-iso = {INT J MOL SCI}, journal = {INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES}, volume = {25}, unique-id = {34864485}, issn = {1661-6596}, abstract = {A new, eco-friendly process utilising the green solvent propylene carbonate (PC) has been developed to perform N-alkylation of N-, O- and/or S-containing heterocyclic compounds. PC in these reactions served as both the reagent and solvent. Importantly, no genotoxic alkyl halides were required. No auxiliary was necessary when using anhydrous PC. Product formation includes nucleophilic substitution with the concomitant loss of water and carbon dioxide. Substrates prepared, including the newly invented PROTAC drugs, are widely used.}, year = {2024}, eissn = {1422-0067}, orcid-numbers = {Czompa, Andrea/0000-0001-8442-8554; Bogdán, Dóra/0000-0003-4455-8914; Balogh, Balázs/0000-0001-7282-7283; Csomos, Attila/0000-0002-4955-5002; Mándity, István/0000-0003-2865-6143} } @article{MTMT:34124792, title = {Evaluation of the therapeutic efficacy of 213Bi-labelled DOTA-conjugated alpha-melanocyte stimulating hormone peptide analogues in melanocortin-1 receptor positive preclinical melanoma model}, url = {https://m2.mtmt.hu/api/publication/34124792}, author = {Csikos, Csaba and Képes, Zita and Fekete, Anikó and Vágner, Adrienn and Nagy, Gábor and Gyuricza, Barbara and Arató, Viktória Zsófia and Kárpáti, Levente and Mándity, István and Bruchertseifer, Frank and Halmos, Gábor and Szikra, Dezső and Trencsényi, György}, doi = {10.1016/j.ijpharm.2023.123344}, journal-iso = {INT J PHARM}, journal = {INTERNATIONAL JOURNAL OF PHARMACEUTICS}, volume = {644}, unique-id = {34124792}, issn = {0378-5173}, year = {2023}, eissn = {1873-3476}, orcid-numbers = {Csikos, Csaba/0000-0003-3338-340X; Képes, Zita/0000-0003-2889-8521; Nagy, Gábor/0000-0002-9842-0315; Kárpáti, Levente/0000-0002-9091-3027; Mándity, István/0000-0003-2865-6143; Trencsényi, György/0000-0001-6456-6212} } @article{MTMT:118384, title = {An efficient route for the synthesis of 2-arylthiazino[5,6-b]indole derivatives}, url = {https://m2.mtmt.hu/api/publication/118384}, author = {Csomós, Péter and Fodor, Lajos and Mándity, István and Bernáth, Gábor}, doi = {10.1016/j.tet.2007.03.132}, journal-iso = {TETRAHEDRON}, journal = {TETRAHEDRON}, volume = {63}, unique-id = {118384}, issn = {0040-4020}, year = {2007}, eissn = {1464-5416}, pages = {4983-4989}, orcid-numbers = {Mándity, István/0000-0003-2865-6143} } @misc{MTMT:33191182, title = {Synthesis and characterisation of water soluble membrane active foldamers}, url = {https://m2.mtmt.hu/api/publication/33191182}, author = {Szigyártó, Imola Csilla and el Battioui, Kamal and Udyavara Nagaraj, Vignesh and Quemé Peña, Mayra and Mihály, Judith and Wacha, András Ferenc and Bogdán, Dóra and Zsila, Ferenc and Varga, Zoltán and Mándity, István and Beke-Somfai, Tamás}, unique-id = {33191182}, year = {2019}, orcid-numbers = {Udyavara Nagaraj, Vignesh/0000-0002-7063-1022; Wacha, András Ferenc/0000-0002-9609-0893; Bogdán, Dóra/0000-0003-4455-8914; Varga, Zoltán/0000-0002-5741-2669; Mándity, István/0000-0003-2865-6143} } @article{MTMT:32764077, title = {Close correlation between thiolate basicity and certain NMR parameters in cysteine and cystine microspecies}, url = {https://m2.mtmt.hu/api/publication/32764077}, author = {Ferreira de Santana, Juliana and Mirzahosseini, Arash and Mándity, B. and Bogdán, Dóra and Mándity, István and Noszál, Béla}, doi = {10.1371/journal.pone.0264866}, journal-iso = {PLOS ONE}, journal = {PLOS ONE}, volume = {17}, unique-id = {32764077}, year = {2022}, eissn = {1932-6203}, orcid-numbers = {Mirzahosseini, Arash/0000-0002-3281-8435; Bogdán, Dóra/0000-0003-4455-8914; Mándity, István/0000-0003-2865-6143; Noszál, Béla/0000-0003-3898-3084} } @{MTMT:36287605, title = {Continuous Flow Synthesis}, url = {https://m2.mtmt.hu/api/publication/36287605}, author = {Dormán, György and Mándity, István and Deme, Ruth and Mándoki, András}, booktitle = {Encyclopedia of Green Chemistry, Volume 1}, doi = {10.1016/B978-0-443-15742-4.00075-2}, unique-id = {36287605}, year = {2025}, pages = {199-217}, orcid-numbers = {Dormán, György/0000-0001-7702-2206; Mándity, István/0000-0003-2865-6143; Deme, Ruth/0000-0002-0798-6912} } @article{MTMT:1809240, title = {Rapid, simple, and efficient deprotection of benzyl/benzylidene protected carbohydrates by utilization of flow chemistry}, url = {https://m2.mtmt.hu/api/publication/1809240}, author = {Ekholm, FS and Mándity, István and Fülöp, Ferenc and Leino, R}, doi = {10.1016/j.tetlet.2010.12.109}, journal-iso = {TETRAHEDRON LETT}, journal = {TETRAHEDRON LETTERS}, volume = {52}, unique-id = {1809240}, issn = {0040-4039}, abstract = {A rapid, simple, and efficient deprotection procedure for the deprotection of benzyl- and/or benzylidene protected carbohydrates is described utilizing a continuous flow hydrogenation reactor. The method tolerates both acid- and base sensitive functional groups. The high efficiency, simple work-up, and short reaction time should make this method appealing to researchers working in the fields of carbohydrate chemistry and total synthesis. (C) 2011 Elsevier Ltd. All rights reserved.}, keywords = {PRODUCTS; SERIES; VACCINE; carbohydrates; Heterogenous catalysis; Flow chemistry; hydrogenolysis; OLIGOSACCHARIDE SYNTHESIS; CHEMICAL-SYNTHESIS; GLYCOSYLATION REACTIONS; Benzyl/benzylidene; Protective groups}, year = {2011}, eissn = {1873-3581}, pages = {1839-1841}, orcid-numbers = {Mándity, István/0000-0003-2865-6143; Fülöp, Ferenc/0000-0003-1066-5287} }