@article{MTMT:34788747,
	title = {The Australian Traumatic Brain Injury Initiative: Systematic Review of Predictive Value of Biological Markers for People With Moderate-Severe Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/34788747},
	author = {Bagg, M.K. and Hellewell, S.C. and Keeves, J. and Antonic-Baker, A. and McKimmie, A. and Hicks, A.J. and Gadowski, A. and Newcombe, V.F.J. and Barlow, K.M. and Balogh, Z.J. and Ross, J.P. and Law, M. and Caeyenberghs, K. and Parizel, P.M. and Thorne, J. and Papini, M. and Gill, G. and Jefferson, A. and Ponsford, J.L. and Lannin, N.A. and O’Brien, T.J. and Cameron, P.A. and Jamie, Cooper D. and Rushworth, N. and Gabbe, B.J. and Fitzgerald, M.},
	doi = {10.1089/neu.2023.0464},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34788747},
	issn = {0897-7151},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34786218,
	title = {Emergency Department Risk Factors for Post-Concussion Syndrome After Mild Traumatic Brain Injury: A Systematic Review},
	url = {https://m2.mtmt.hu/api/publication/34786218},
	author = {Lubbers, V.F. and van, den Hoven D.J. and van, der Naalt J. and Jellema, K. and van, den Brand C. and Backus, B.},
	doi = {10.1089/neu.2023.0302},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34786218},
	issn = {0897-7151},
	abstract = {Approximately 16% of patients with mild traumatic brain injury (mTBI) develop a post-concussion syndrome (PCS) with persistent physical, neurological, and behavioral complaints. PCS has a great impact on a patient’s quality of life, often decreases the ability to return to work, and henceforth has a great economic impact. Recent studies suggest that early treatment can greatly improve prognosis and prevent long-term effects in these patients. However, early recognition of patients at high risk of PCS remains difficult. The objective of this systematic review is to assess risk factors associated with the development of PCS, primarily aimed at the group of non-hospitalized patients who were seen with mTBI at the emergency department (ED). We searched PubMed/MEDLINE, Cochrane Library and EMBASE on September 23, 2022, for prospective studies that assessed the risk factors for the development of PCS. Exclusion criteria were: retrospective studies; > 20% computed tomography (CT) abnormalities, <18 years of age, follow-up <4 weeks, severe trauma, and study population <100 patients. The search strategy identified 1628 articles, of which 17 studies met eligibility criteria. Risk factors found in this systematic review are pre-existing psychiatric history, headache at the ED, neurological symptoms at the ED, female sex, CT abnormalities, pre-existent sleeping problems, and neck pain at the ED. This systematic review identified seven risk factors for development of PCS in patients with mTBI. Future research should assess if implementation of these risk factors into a risk stratification tool will assist the emergency physician in the identification of patients at high risk of PCS. © Mary Ann Liebert, Inc.},
	keywords = {Risk Factors; Mild traumatic brain injury; Emergency department; Post-Concussion Syndrome},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34774211,
	title = {Phenotyping Depression After Mild Traumatic Brain Injury: Evaluating the Impact of Multiple Injury, Gender, and Injury Context},
	url = {https://m2.mtmt.hu/api/publication/34774211},
	author = {Kennedy, E. and Ozmen, M. and Bouldin, E.D. and Panahi, S. and Mobasher, H. and Troyanskaya, M. and Martindale, S.L. and Merritt, V.C. and O’Neil, M. and Sponheim, S.R. and Remigio-Baker, R.A. and Presson, A. and Swan, A.A. and Kent, Werner J. and Greene, T.H. and Wilde, E.A. and Tate, D.F. and Walker, W.C. and Pugh, M.J.},
	doi = {10.1089/neu.2023.0381},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {in press},
	unique-id = {34774211},
	issn = {0897-7151},
	abstract = {The chronic mental health consequences of mild traumatic brain injury (TBI) are a leading cause of disability. This is surprising given the expectation of significant recovery after mild TBI, which suggests that other injury-related factors may contribute to long-term adverse outcomes. The objective of this study was to determine how number of prior injuries, gender, and environment/context of injury may contribute to depressive symptoms after mild TBI among deployed United States service members and veterans (SMVs). Data from the Long-term Impact of Military-Relevant Brain Injury Consortium Prospective Longitudinal Study was used to assess TBI injury characteristics and depression scores previously measured on the Patient Health Questionnaire-9 (PHQ-9) among a sample of 1456 deployed SMVs. Clinical diagnosis of mild TBI was defined via a multi-step process centered on a structured face-to-face interview. Logistical and linear regressions stratified by gender and environment of injury were used to model depressive symptoms controlling for sociodemographic and combat deployment covariates. Relative to controls with no history of mild TBI (n = 280), the odds ratios (OR) for moderate/severe depression (PHQ-9 ‡ 10) were higher for SMVs with one mild TBI (n = 358) OR: 1.62 (95% confidence interval [CI] 1.09–2.40, p = 0.016) and two or more mild TBIs (n = 818) OR: 1.84 (95% CI 1.31–2.59, p < 0.001). Risk differences across groups were assessed in stratified linear models, which found that depression symptoms were elevated in those with a history of multiple mild TBIs compared with those who had a single mild TBI (p < 0.001). Combat deployment-related injuries were also associated with higher depression scores than injuries occurring in non-combat or civilian settings (p < 0.001). Increased rates of depression after mild TBI persisted in the absence of post-traumatic stress disorder. Both men and women SMVs separately exhibited significantly increased depressive symptom scores if they had had combat-related mild TBI. These results suggest that contextual information, gender, and prior injury history may influence long-term mental health outcomes among SMVs with mild TBI exposure. © Mary Ann Liebert, Inc.},
	keywords = {DEPRESSION; traumatic brain injury; DEPLOYMENT; mild TBI; veteran health},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34668120,
	title = {External Validation of the Post-Concussion Symptoms Rule for Predicting Mild Traumatic Brain Injury Outcome},
	url = {https://m2.mtmt.hu/api/publication/34668120},
	author = {Mikolic, Ana and Brasher, Penelope M. A. and Brubacher, Jeffrey R. and Panenka, William and Scheuermeyer, Frank X. and Archambault, Patrick and Khazei, Afshin and Silverberg, Noah D.},
	doi = {10.1089/neu.2023.0484},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34668120},
	issn = {0897-7151},
	keywords = {Mild traumatic brain injury; clinical decision rule; external validation; persistent post-concussion symptoms},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34615957,
	title = {Longitudinal Associations Between Persistent Post-Concussion Symptoms and Blood Biomarkers of Inflammation and CNS-Injury After Mild Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/34615957},
	author = {Clarke, Gerard Janez Brett and Skandsen, Toril and Zetterberg, Henrik and Follestad, Turid and Einarsen, Cathrine Elisabeth and Vik, Anne and Mollnes, Tom Eirik and Pischke, Soren Erik and Blennow, Kaj and Haberg, Asta Kristine},
	doi = {10.1089/neu.2023.0419},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34615957},
	issn = {0897-7151},
	abstract = {The aim of our study was to investigate the biological underpinnings of persistent post-concussion symptoms (PPCS) at 3 months following mild traumatic brain injury (mTBI). Patients (n = 192, age 16-60 years) with mTBI, defined as Glasgow Coma Scale (GCS) score between 13 and 15, loss of consciousness (LOC) <30 min, and post-traumatic amnesia (PTA) <24 h were included. Blood samples were collected at admission (within 72 h), 2 weeks, and 3 months. Concentrations of blood biomarkers associated with central nervous system (CNS) damage (glial fibrillary acidic protein [GFAP], neurofilament light [NFL], and tau) and inflammation (interferon gamma [IFN gamma], interleukin [IL]-8, eotaxin, macrophage inflammatory protein-1-beta [MIP]-1 beta, monocyte chemoattractant protein [MCP]-1, interferon-gamma-inducible protein [IP]-10, IL-17A, IL-9, tumor necrosis factor [TNF], basic fibroblast growth factor [FGF]-basic platelet-derived growth factor [PDGF], and IL-1 receptor antagonist [IL-1ra]) were obtained. Demographic and injury-related factors investigated were age, sex, GCS score, LOC, PTA duration, traumatic intracranial finding on magnetic resonance imaging (MRI; within 72 h), and extracranial injuries. Delta values, that is, time-point differences in biomarker concentrations between 2 weeks minus admission and 3 months minus admission, were also calculated. PPCS was assessed with the British Columbia Post-Concussion Symptom Inventory (BC-PSI). In single variable analyses, longer PTA duration and a higher proportion of intracranial findings on MRI were found in the PPCS group, but no single biomarker differentiated those with PPCS from those without. In multi-variable models, female sex, longer PTA duration, MRI findings, and lower GCS scores were associated with increased risk of PPCS. Inflammation markers, but not GFAP, NFL, or tau, were associated with PPCS. At admission, higher concentrations of IL-8 and IL-9 and lower concentrations of TNF, IL-17a, and MCP-1 were associated with greater likelihood of PPCS; at 2 weeks, higher IL-8 and lower IFN gamma were associated with PPCS; at 3 months, higher PDGF was associated with PPCS. Higher delta values of PDGF, IL-17A, and FGF-basic at 2 weeks compared with admission, MCP-1 at 3 months compared with admission, and TNF at 2 weeks and 3 months compared with admission were associated with greater likelihood of PPCS. Higher IL-9 delta values at both time-point comparisons were negatively associated with PPCS. Discriminability of individual CNS-injury and inflammation biomarkers for PPCS was around chance level, whereas the optimal combination of biomarkers yielded areas under the curve (AUCs) between 0.62 and 0.73. We demonstrate a role of biological factors on PPCS, including both positive and negative effects of inflammation biomarkers that differed based on sampling time-point after mTBI. PPCS was associated more with acute inflammatory processes, rather than ongoing inflammation or CNS-injury biomarkers. However, the modest discriminative ability of the models suggests other factors are more important in the development of PPCS.},
	keywords = {sex differences; concussion; Intracranial volume; complicated mild traumatic brain injury; extracranial injuries; mixed-mechanism mild traumatic brain injury},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34610764,
	title = {Exposure to Low-Intensity Blast Increases Clearance of Brain Amyloid Beta},
	url = {https://m2.mtmt.hu/api/publication/34610764},
	author = {Abutarboush, Rania and Reed, Eileen and Chen, Ye and Gu, Ming and Watson, Cameron and Kawoos, Usmah and Statz, Jonathan K. and Tschiffely, Anna E. and Ciarlone, Stephanie and Perez-Garcia, Georgina and Gama Sosa, Miguel A. and de Gasperi, Rita and Stone, James R. and Elder, Gregory A. and Ahlers, Stephen T.},
	doi = {10.1089/neu.2023.0284},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34610764},
	issn = {0897-7151},
	abstract = {The long-term effects of exposure to blast overpressure are an important health concern in military personnel. Increase in amyloid beta (A beta) has been documented after non-blast traumatic brain injury (TBI) and may contribute to neuropathology and an increased risk for Alzheimer's disease. We have shown that A beta levels decrease following exposure to a low-intensity blast overpressure event. To further explore this observation, we examined the effects of a single 37 kPa (5.4 psi) blast exposure on brain A beta levels, production, and clearance mechanisms in the acute (24 h) and delayed (28 days) phases post-blast exposure in an experimental rat model. A beta and, notably, the highly neurotoxic detergent soluble A beta 42 form, was reduced at 24 h but not 28 days after blast exposure. This reduction was not associated with changes in the levels of A beta oligomers, expression levels of amyloid precursor protein (APP), or increase in enzymes involved in the amyloidogenic cleavage of APP, the beta- and Gamma-secretases BACE1 and presenilin-1, respectively. The levels of ADAM17 alpha-secretase (also known as tumor necrosis factor alpha-converting enzyme) decreased, concomitant with the reduction in brain A beta. Additionally, significant increases in brain levels of the endothelial transporter, low-density related protein 1 (LRP1), and enhancement in co-localization of aquaporin-4 (AQP4) to perivascular astrocytic end-feet were observed 24 h after blast exposure. These findings suggest that exposure to low-intensity blast may enhance endothelial clearance of A beta by LRP1-mediated transcytosis and alter AQP4-aided glymphatic clearance. Collectively, the data demonstrate that low-intensity blast alters enzymatic, transvascular, and perivascular clearance of A beta.},
	keywords = {CEREBRAL VASCULATURE; TBI; AQP4; A beta clearance; low-intensity blast},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34561074,
	title = {Concussion-Related Disruptions to Hub Connectivity in the Default Mode Network Are Related to Symptoms and Cognition},
	url = {https://m2.mtmt.hu/api/publication/34561074},
	author = {Bouchard, H.C. and Higgins, K.L. and Amadon, G.K. and Laing-Young, J.M. and Maerlender, A. and Al-Momani, S. and Neta, M. and Savage, C.R. and Schultz, D.H.},
	doi = {10.1089/neu.2023.0089},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	unique-id = {34561074},
	issn = {0897-7151},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34482706,
	title = {Trigeminal Sensitization in a Closed Head Model for Mild Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/34482706},
	author = {Tashiro, Akimasa and Bereiter, David A. and Ohta, Hiroyuki and Kawauchi, Satoko and Sato, Shunichi and Morimoto, Yuji},
	doi = {10.1089/neu.2023.0328},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {2024-1},
	unique-id = {34482706},
	issn = {0897-7151},
	year = {2024},
	eissn = {1557-9042}
}

@article{MTMT:34477399,
	title = {Screening Performance of S100B, GFAP and UCH-L1 For Intracranial Injury Within 6 hours of Injury and beyond},
	url = {https://m2.mtmt.hu/api/publication/34477399},
	author = {Trivedi, Dhanisha Trivedi and Forssten, Maximilian Peter and Cao, Yang and Mohammad Ismail, Ahmad and Czeiter, Endre and Amrein, Krisztina and Kobeissy, Firas and Wang, Kevin K W and DeSoucy, Erik and Büki, András and Mohseni, Shahin},
	doi = {10.1089/neu.2023.0322},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {41},
	unique-id = {34477399},
	issn = {0897-7151},
	abstract = {The Scandinavian NeuroTrauma Committee (SNC) guidelines recommend S100B as a screening tool for early detection of Traumatic brain injury (TBI) in patients presenting with an initial Glasgow coma scale (GCS) of 14-15. The objective of the current study was to compare S100B's diagnostic performance within the recommended 6-hour window after injury, compared to GFAP and UCH-L1. The secondary outcome of interest was the ability of these biomarkers in detecting traumatic intracranial pathology beyond the 6-hour mark.The Center-TBI core database (2014-2017) was queried for data pertaining to all TBI patients with an initial GCS of 14-15 who had a blood sample taken within 6 hours of injury in which the levels of S100B, GFAP, and UCH-L1 were measured. As a subgroup analysis, data involving patients with blood samples taken within 6-9 hours, and 9-12 hours were analyzed separately for diagnostic ability. The diagnostic ability of these biomarkers for detecting any intracranial injury was evaluated based on the area under the receiver operating characteristic curve (AUC). Each biomarker's sensitivity, specificity, and accuracy were also reported at the cutoff that maximized Youden's index.A total of 531 TBI patients with GCS 14-15 on admission had a blood sample taken within 6 hours, of whom 24.9% (N = 132) had radiologically confirmed intracranial injury. The AUCs of GFAP (0.86, 95% confidence interval (CI): 0.82-0.90) and UCH-L1 (0.81, 95% CI: 0.76-0.85) were statistically significantly higher than that of S100B (0.74, 95% CI: 0.69-0.79) during this time. There was no statistically significant difference in the predictive ability of S100B when sampled within 6 hours, 6-9 hours, and 9-12 hours of injury, as the p-values were >0.05 when comparing the AUCs. Overlapping AUC 95% CI suggests no benefit of a combined GFAP and UCH-L1 screening tool over GFAP during the time periods studied [ 0.87 (0.83-0.90) vs 0.86 (0.82-0.90) when sampled within 6 hours of injury, 0.83 (0.78-0.88) vs 0.83 (0.78-0.89) within 6-to-9 hours and 0.81 (0.73-0.88) vs 0.79 (0.72-0.87) within 9-12 hours].Targeted analysis of the CENTER-TBI core database, with focus on the patient category for which biomarker testing is recommended by the SNC guidelines, revealed that GFAP and UCH-L1 perform superior to S100B in predicting CT-positive intracranial lesions within 6 hours of injury. GFAP continued to exhibit superior predictive ability to S100B during the time periods studied. S100B displayed relatively unaltered screening performance beyond the diagnostic timeline provided by SNC guidelines. These findings suggest the need for a re-evaluation of the current SNC TBI guidelines.},
	keywords = {Biomarkers; traumatic brain injury; Head trauma; adult brain injury},
	year = {2024},
	eissn = {1557-9042},
	pages = {349-358},
	orcid-numbers = {Czeiter, Endre/0000-0002-9578-6944}
}

@article{MTMT:34562183,
	title = {Lysophospholipids Are Associated With Outcomes in Hospitalized Patients With Mild Traumatic Brain Injury},
	url = {https://m2.mtmt.hu/api/publication/34562183},
	author = {Gusdon, A.M. and Savarraj, J.P.J. and Redell, J.B. and Paz, A. and Hinds, S. and Burkett, A. and Torres, G. and Ren, X. and Badjatia, N. and Hergenroeder, G.W. and Moore, A.N. and Choi, H.A. and Dash, P.K.},
	doi = {10.1089/neu.2023.0046},
	journal-iso = {J NEUROTRAUM},
	journal = {JOURNAL OF NEUROTRAUMA},
	volume = {41},
	unique-id = {34562183},
	issn = {0897-7151},
	year = {2024},
	eissn = {1557-9042},
	pages = {59-72}
}