@article{MTMT:34795611, title = {Effect of ultrasound-guided stellate ganglion block on cerebral oxygen metabolism and S100B protein during carotid endarterectomy}, url = {https://m2.mtmt.hu/api/publication/34795611}, author = {Yang, Fen}, doi = {10.62347/RXRN7802}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {16}, unique-id = {34795611}, issn = {1943-8141}, year = {2024}, eissn = {1943-8141}, pages = {1018-1028} } @article{MTMT:34657623, title = {LncRNA AL645608.3 mediates malignant progression of acute myeloid leukemia}, url = {https://m2.mtmt.hu/api/publication/34657623}, author = {Yan, Jin-Hua and Liao, Kai-Qiong and Yao, Ling and Chen, Jian-Lan and Xiong, Li-Fang and Tao, Xu-Zhang}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {16}, unique-id = {34657623}, issn = {1943-8141}, keywords = {Acute myeloid leukemia; LncRNA; MMP-9; IRF6; Cbl; AL645608.3; IFNB1}, year = {2024}, eissn = {1943-8141}, pages = {342-355} } @article{MTMT:34665764, title = {Comparative analysis of ankle injury kinematics and dynamics in basketball players: forefoot landing vs. rearfoot landing modes}, url = {https://m2.mtmt.hu/api/publication/34665764}, author = {Wang, Tongling and Zhao, Cuiqing and Guo, Zhangjian}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34665764}, issn = {1943-8141}, keywords = {Biomechanics; Ankle; Basketball; Injury risk factor; landing mode}, year = {2023}, eissn = {1943-8141}, pages = {5843-5849} } @article{MTMT:34636173, title = {Ulinastatin combined with somatostatin enhances disease control and modulates serum inflammatory factors in patients with severe pancreatitis}, url = {https://m2.mtmt.hu/api/publication/34636173}, author = {Chen, Fuying and Xu, Yan and Wang, Zhen}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34636173}, issn = {1943-8141}, keywords = {SOMATOSTATIN; Clinical symptoms; Severe pancreatitis; ulinastatin; serum inflammatory factors}, year = {2023}, eissn = {1943-8141}, pages = {5797-5807} } @article{MTMT:34506165, title = {Pan-cancer analysis of the oncogenic role of the core osteosarcoma gene VCAN in human tumors}, url = {https://m2.mtmt.hu/api/publication/34506165}, author = {Zhou, Haidong and Lu, Dinggui and Yu, Dianbo and Luo, Changtai and Xie, Kangqi and Ma, Huade and Li, Shanlang and Liang, Jiyun and Wei, Fengxu and Chen, Luchang and Luo, Dong and Wang, Wei and Wei, Jihua}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34506165}, issn = {1943-8141}, abstract = {Objective: Versican (VCAN), a member of the multifunctional glycoprotein family, is involved in various aspects of cancer progression. However, the role of VCAN in diverse cancers remains poorly defined. This research aimed to investigate the correlation between VCAN expression and the oncogenic role, as well as visualize its prognostic landscape in pan-cancer. Methods: Raw data in regard to VCAN expression in cancer patients were acquired from GEO GeneChip public database in NCBI. Besides, we selected microarray data GSE16088 for analysis. We retrieved the genes associated with osteosarcoma (OS) from the OMIM database and identified their intersection with the core module. VCAN was suggested to be a potential marker gene for OS. Subsequently, we conducted Gene Set Enrichment Analysis (GSEA) to explore gene functional enrichment. Moreover, we performed pan-cancer analysis on VCAN to gain a comprehensive understanding of its implications across various cancer types. Results: The VCAN expression in the tumor tissue was higher than that in normal tissue. Elevated expression of VCAN was associated with high the tumor stage and poor long-term survival. There was a significant positive correlation between VCAN and cancer fibroblasts in all pan cancers. Moreover, FBN1 was the intersection gene of VCAN-related genes and linker genes. ANTXR1, COL5A2, CSGALNACT2, and SPARC were the target genes of VCAN genes. GSEA analysis showed that VCAN was mainly enriched in the extracellular matrix (ECM) signaling pathway. Conclusion: VCAN can be used as a marker molecule for the early diagnosis of OS and holds significance as a molecule in cases of OS with distant metastasis. The ECM signaling pathway may be a core pathway in OS development and distant metastasis. These findings shed new light on therapeutics of cancers.}, keywords = {CELLS; DIFFERENTIATION; TGF-BETA; INVASION; EXTRACELLULAR-MATRIX; MIGRATION; Oncology; Progression; Osteosarcoma; PROMOTES; versican; VCAN; Pan cancer; ECM signaling pathway}, year = {2023}, eissn = {1943-8141}, pages = {5556-5573} } @article{MTMT:34323706, title = {Levosimendan improves cardiac function, hemodynamics, and body inflammation in patients with acute myocardial infarction and heart failure}, url = {https://m2.mtmt.hu/api/publication/34323706}, author = {Sun, Xiaoxia and Wei, Congying and Li, Lei and Qu, Chao}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34323706}, issn = {1943-8141}, abstract = {Objective: To examine the effects of levosimendan on cardiac function, hemodynamics, and body inflammation of patients with acute myocardial infarction and heart failure. Methods: A retrospective analysis was conducted on 113 acute myocardial infarction patients with heart failure (admitted to Xianyang First People's Hospital from September 2018 to January 2022). According to the treatment plan, patients were categorized into a control group (n = 53) (treated with conventional diuresis and vasodilation) and observation group (n = 60) (treated with levosimendan in addition to the treatment of the control group). Indexes were compared between the two groups before and after treatment, including effectiveness rate, mean pulmonary arterial pressure (PAMP) and pulmonary eter (LVESD) and left ventricular ejection fraction (LVEF) were monitored before and after treatment by color Doppler ultrasonography. Serum high-sensitivity C-reactive protein (hs-CRP) levels were measured before and after treatment. Logistic analysis was applied to screen independent factors affecting treatment efficacy. Adverse reactions and life quality after 6 months of treatment were compared between the two groups. Results: The overall response rate of the observation group was higher than that of the control group (P<0.05). Changes in PAMP and PCWP in the two groups before and after treatment were significantly different. Patients in the observation group had improved indicators compared with the control group (all P<0.05). After treatment, the cardiac function indexes and inflammation-related factors of the observation group were improved more than those of the control group (P<0.05). Patients in the observation group had a lower incidence of adverse reactions and a higher life quality 6 months after treatment compared to the control group (P<0.05). Diabetes and treatment regimen were independent risk factors affecting treatment efficacy by logistic regression analysis. Conclusion: The administration of levosimendan helps improve cardiac function, hemodynamics, and body inflammation in patients with acute myocardial infarction and heart failure, with fewer adverse reactions and higher safety.}, keywords = {Hemodynamics; heart failure; Acute myocardial infarction; LEVOSIMENDAN; Cardiac function; body inflammation level}, year = {2023}, eissn = {1943-8141}, pages = {5624-5632} } @article{MTMT:34640715, title = {PCSK9 inhibitors suppress oxidative stress and inflammation in atherosclerotic development by promoting macrophage autophagy}, url = {https://m2.mtmt.hu/api/publication/34640715}, author = {Yang, Jinjing and Ma, Xiurui and Niu, Dan and Sun, Yu and Chai, Xiaohong and Deng, Yongzhi and Wang, Jingping and Dong, Jin}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34640715}, issn = {1943-8141}, keywords = {Inflammation; ATHEROSCLEROSIS; Autophagy; proprotein convertase subtilisin/kexin type 9; Oxidative stress}, year = {2023}, eissn = {1943-8141}, pages = {5129-+} } @article{MTMT:34592257, title = {Particulate matter promotes the epithelial to mesenchymal transition in human lung epithelial cells via the ROS pathway}, url = {https://m2.mtmt.hu/api/publication/34592257}, author = {Zhang, Jun and Xu, Xiaoyan and Liang, Ying and Wu, Xiaomin and Qian, Zhongqing and Zhang, Liming and Wang, Ting}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34592257}, issn = {1943-8141}, abstract = {Objects: Epidemiologic studies have linked exposure to airborne pollutant particulate matter (PM) with increased rates of chronic cardiopulmonary diseases, including asthma and idiopathic pulmonary fibrosis (IPF). Several investigations have suggested that the epithelial-to-mesenchymal transition (EMT) may contribute to the complex pathobiology of environmental exposure-mediated pulmonary fibrosis. The present study was designed to characterize the mechanisms of PM-mediated EMT in human lung epithelial cells (HBECs). Methods and results: PM induced significant dose (0-100 mu g/ml) and time (0-72 h)-dependent increases in transforming growth factor beta (TGF beta) and fibronectin (FN) protein levels in HBECs lysates. PM-activated TGF beta and FN protein production in HBECs was prevented by the antioxidant N-acetyl-cysteine (NAC, 5 mM). Furthermore, the NF-KB inhibitor BAY11-7082 (5 mu M) abolished PM-induced FN production in HBECs. Biomarkers of EMT (ACTA2, SNAIL1 and SNAIL2) in PM-treated HBECs were significantly increased at the mRNA level compared to control cells. Conclusions: These results demonstrate that PM increases protein levels of TGF beta and FN via reactive oxygen species (ROS)-dependent pathways. In addition, PM exposure induces EMT in human lung epithelial cells, supporting a novel mechanism for PM-induced pulmonary fibrosis.}, keywords = {particulate matter; Reactive oxygen species; lung epithelial cells; Epithelial-to-mesenchymal transition}, year = {2023}, eissn = {1943-8141}, pages = {5159-+} } @article{MTMT:34503769, title = {Safety and effectiveness of recombinant human erythropoietin coupled with different doses of Roxadustat for treatment of renal anemia in patients on maintenance hemodialysis}, url = {https://m2.mtmt.hu/api/publication/34503769}, author = {Wei, Shanzhai and Sun, Jie and Xu, Kangchun and Li, Yibei and Zhang, Yilai}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34503769}, issn = {1943-8141}, abstract = {Objective: To investigate the safety and efficacy of recombinant human erythropoietin (rHuEPO) in com-bination with different doses of Roxadustat in treating renal anemia in patients on maintenance hemodialysis. Methods: Eighty patients with renal anemia on maintenance hemodialysis treated in Shuyang Hospital of Traditional Chinese Medicine from January 2020 to December 2021 were selected as study subjects, and they were divided into a study group (n=40, high-dose Roxadustat + rHuEPO therapy) and a control group (Con) (n=40, low-dose Roxadustat + rHuEPO therapy) in accordance with different therapies. The effects of anemia therapy, changes in anemia indicators (hemoglobin (Hb), hematocrit (Hct)), changes in iron metabolism indicators (transferrin saturation (TSAT), serum ferritin (SF)), changes in oxidative stress indicators Malondialdehyde (MDA), Superoxide Dismutase (SOD), and changes in microinflammatory indicators IL6, CRP were compared between the two groups. The occur-rences of adverse effects during therapy were counted and compared between the two groups. Results: The therapy efficiency of the study group was 97.50% (39/40), which was higher than 85.00% (34/40) in the control group (P=0.048). The contents of Hb, Hct, TSAT, and SF were higher in the study group than the Con after therapy (all P<0.001 or P=0.001). The contents of MDA, IL6, and CRP were significantly lower in the study group than the Con after therapy (all P<0.001). The occurrence of adverse effects was 10.00% in the study group, which was higher than 5.00% in the Con, but the difference was not significant (P=0.396). Conclusion: The combination of rHuEPO and high-dose Roxadustat (120 mg/time) has a better effect on improving anemia symptoms in maintenance he-modialysis patients than in those who take low dose Roxadustat (100 mg/time). It can significantly improve anemia and iron metabolism indicators and alleviate patients' inflammation and oxidative stress levels.}, keywords = {Oncology; CHRONIC KIDNEY-DISEASE; Maintenance hemodialysis; PHASE-3; Therapeutic effect; Recombinant human erythropoietin; renal anemia; roxadustat; CKD-RELATED ANEMIA}, year = {2023}, eissn = {1943-8141}, pages = {5120-5128} } @article{MTMT:34366804, title = {Down-regulation of Jun induces senescence through destabilizing chromatin in osteoarthritis chondrocytes}, url = {https://m2.mtmt.hu/api/publication/34366804}, author = {Xie, Ting and Ren, Xunshan and Zhuang, Huangming and Jiang, Fuze and Zhang, Yuelong and Zhou, Panghu}, journal-iso = {AM J TRANSL RES}, journal = {AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH}, volume = {15}, unique-id = {34366804}, issn = {1943-8141}, abstract = {Objective: Osteoarthritis (OA) is the most common degenerative joint disease leading to disability worldwide. Cellular senescence is considered to be a fundamental pathogenic mechanism in the development of OA and has attracted increasing attention. However, regulatory mechanisms underlying chondrocyte senescence in OA remain unclear. Methods: Bioinformatic methods were used to screen key genes. Immunohistochemistry and the quantitative reverse transcription polymerase chain reaction were used to evaluate gene expression. RNA intervention experiments were performed to explore the functions of key genes. Results: We used 494 aging-associated genes provided by the Aging Atlas to identify the co-expression modules associated with age and OA. Thirty age-associated differentially expressed genes (ASDEGs) were identified. Using cytoHubba in Cytoscape, we identified Jun as the hub-ASDEG for OA chondrocytes. We confirmed the downregulation of Jun in OA rats and senescent chondrocytes by immunohistochemistry and quantitative reverse transcription polymerase chain reaction, respectively. Inhibition of proliferation and accelerated senescence were observed in chondrocytes treated with siRNA against Jun. Mechanistically, we observed micronuclei formation and reduced expression of H3K9me3 and heterochromatin protein 1gamma in siRNA-Jun-treated chondrocytes, indicating that destabilization of chromatin occurred during this treatment. Conclusion: Jun plays a crucial role in OA development and causes senescence by destabilizing chromatin in chondrocytes. These findings provide new insights into OA progression and suggest promising therapeutic targets.}, keywords = {senescence; osteoarthritis; JUN; chondrocyte}, year = {2023}, eissn = {1943-8141}, pages = {4873-+} }