https://m2.mtmt.hu/ hun 2026-10-25 00:57 JournalArticle 37376400 VALIDATED true 0 false 2026-10-20T09:34:15.228+0000 2026-10-20T09:29:27.780+0000 2026-07-08T15:56:21.192+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin true 10026589 2026-10-20T09:29:23.832+0000 2026-10-20T09:29:24.015+0000 true 521 Szuper Admin /api/admin/521 Admin true false true true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lian, T. Nonsyndromic familial type B aortic dissection exhibits distinct clinical profiles and operative outcomes true true /api/journal/2932 REVIEWED true false 2932 false 2932 true 0741-5214 1097-6809 Journal FOREIGN In press 2026 Background: Although a heritable nature of type A aortic dissection is well established, the contribution of family history to type B aortic dissection (TBAD) remains less clearly characterized. This analysis evaluates the prevalence, clinical characteristics, and outcomes of familial TBAD (FTBAD) compared with sporadic TBAD and Marfan syndrome (MFS)-related TBAD to determine whether FTBAD exhibits features consistent with increased underlying aortic vulnerability. Methods: This is a retrospective analysis of TBAD patients enrolled in the International Registry of Acute Aortic Dissection between 1996 and 2024. Based on standardized clinical abstraction, patients were categorized as FTBAD, sporadic TBAD, or MFS-associated TBAD. Baseline characteristics, imaging features, surgical management, in-hospital outcomes, and postdischarge events across groups using bivariate and time-to-event analyses for ≤4 years after discharge were compared. Time-to-event analysis included reintervention, rupture, and survival. Results: Among 2726 patients (mean age, 63.0 ± 14.6 years; 64.2% male), 223 (8.2%) had FTBAD and 128 (4.7%) had MFS. Patients with FTBAD presented at a younger age than those with sporadic TBAD (60.8 years vs 64.3 years; P <. 001), but were older than patients with MFS (42.4 years). Compared with patients with sporadic TBAD, patients with FTBAD were more frequently normotensive at presentation and had higher rates of prior aortic dissection and prior cardiac or aortic surgery. Patent false lumen was more frequent in patients with FTBAD (60.0%) and patients with MFS (66.7%) than in patients with sporadic TBAD (49.8%) and patients with FTBAD had more extensive dissections despite a similar aortic diameter at the time of dissection compared with patients with sporadic TBAD. The indication for endovascular intervention was more frequently visceral ischemia in FTBAD compared with sporadic TBAD (23.5% vs 10.9%; P <. 05). Thoracic endovascular aortic repair was less frequently performed in FTBAD compared with sporadic TBAD (23.8% vs 29.7%; P =. 081), and least common in MFS (15.6%). Postdischarge data were available for 56.9% of those discharged. The 3-year incidence of late surgical intervention was 23.78% for patients with FTBAD, higher than for patients with sporadic TBAD (15.7%; P =. 023). The 1-year survival exceeded 93% in all groups, and the 4-year survival exceeded 83%. Conclusions: Nonsyndromic FTBAD is present in a meaningful proportion of patients and is associated with distinct clinical features consistent with increased underlying aortic vulnerability compared with sporadic TBAD. Systematic assessment of family history may improve risk stratification, longitudinal surveillance, and patient shared decision-making in the management of TBAD. © 2026 2026 true true true false false false NONE 2026-10-20 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 D1 false false false false 2026-10-06T15:59:10.776+0000 12 57 0 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 140258733 /api/authorship/140258733 1 0.05882353 true false false Lian T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258734 /api/authorship/140258734 2 0.05882353 false false false Pai C.-W. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258735 /api/authorship/140258735 3 0.05882353 false false false Woznicki E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258736 /api/authorship/140258736 4 0.05882353 false false false Ouzounian M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258737 /api/authorship/140258737 5 0.05882353 false false false Bossone E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258738 /api/authorship/140258738 6 0.05882353 false false false Harris K.M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258739 /api/authorship/140258739 7 0.05882353 false false false O'Gara P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258740 /api/authorship/140258740 8 0.05882353 false false false Bismuth J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258741 /api/authorship/140258741 9 0.05882353 false false false Bhan A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258742 /api/authorship/140258742 10 0.05882353 false false false Kaiser C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258743 /api/authorship/140258743 11 0.05882353 false false false Chen E.P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258744 /api/authorship/140258744 12 0.05882353 false false false Nienaber C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258745 /api/authorship/140258745 13 0.05882353 false false false Isselbacher E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258746 /api/authorship/140258746 14 0.05882353 false false false Lindsay M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258747 /api/authorship/140258747 15 0.05882353 false false false Eagle K. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258748 /api/authorship/140258748 16 0.05882353 false false false Evangelista A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 140258749 /api/authorship/140258749 17 0.05882353 false true false Shalhub S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 32610914 /api/publicationidentifier/32610914 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/j.jvs.2026.04.022 https://doi.org/10.1016/j.jvs.2026.04.022 false true PublicationIdentifier 33390498 /api/publicationidentifier/33390498 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001849146200001 https://www.webofscience.com/wos/woscc/full-record/001849146200001 false true PublicationIdentifier 32610913 /api/publicationidentifier/32610913 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 105041495749 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105041495749 false true SjrRating 11713178 /api/sjrrating/11713178 15 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true D1 FROM_LAST_YEAR true true /api/publication/37376400 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lian T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pai C.-W. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Woznicki E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ouzounian M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bossone E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harris K.M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >O'Gara P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bismuth J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bhan A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaiser C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chen E.P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nienaber C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Isselbacher E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lindsay M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Eagle K. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Evangelista A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shalhub S. </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37376400" target="_blank">Nonsyndromic familial type B aortic dissection exhibits distinct clinical profiles and operative outcomes</a></div> <div> <span class="journal-title">JOURNAL OF VASCULAR SURGERY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0741-5214">0741-5214</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1097-6809">1097-6809</a>)</span>: <span class="journal-volume">In press</span> <span class="page"> </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/j.jvs.2026.04.022" target="_blank" href="https://doi.org/10.1016/j.jvs.2026.04.022"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001849146200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001849146200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105041495749" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105041495749"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37376400&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37376400</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2026.10.20. 11:29 Szuper Admin (admin) </div> </div></div>