https://m2.mtmt.hu/ eng 2026-10-23 10:39 JournalArticle 37322302 VALIDATED true 0 false 2026-10-23T03:01:07.304+0000 2026-10-20T01:05:11.433+0000 2026-06-04T12:35:44.377+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Márta Turek (KOKI admin 4) true 2026-10-23T02:59:42.202+0000 2026-10-20T01:05:11.382+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Gyurina, Katalin true true /api/journal/10051562 REVIEWED CELLS 2073-4409 true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 15 11 1000 1000 2026 Catecholamines are crucial signaling molecules that initiate thermogenesis in adipocytes through beta-adrenergic receptors (ADRBs). Adipocyte catecholamine resistance is a common feature of pediatric obesity, often impeding weight loss and the maintenance of a healthy body fat percentage. Our aim was to identify possible mechanisms that may be responsible for the development of catecholamine resistance in adipocytes. We demonstrate that Lim homeobox 8 (LHX8), a transcription factor previously known for its role in gametogenesis, is essential for catecholamine-induced thermogenesis in human adipocytes. LHX8 is expressed in developing human adipocytes throughout intrauterine and perinatal life, as well as in adulthood, and its expression levels positively correlate with the expression of key thermogenesis genes. Pediatric obesity diminished adipocyte expression of LHX8. Functionally, ADRB stimulation failed to induce thermogenesis in both mouse and human adipocytes when LHX8 was absent. Conversely, LHX8 overexpression enhanced thermogenesis in murine adipocytes. Mechanistically, LHX8 stimulated adipocyte interleukin-33 (IL-33) synthesis in response to ADRB activation, which subsequently increased thermogenic gene expression in both human and mouse adipocytes. In conclusion, adipocyte LHX8 is indispensable for catecholamine-responsive thermogenesis and represents a promising novel therapeutic target to overcome catecholamine resistance and promote effective weight management. Funding 2068045 /api/funding/2068045 János Bolyai Research Scholarship(BO/00227/23) false true Funding 2068046 /api/funding/2068046 National Research, Development and Innovation Office, Hungary(NKFIH-142939) false true Funding 2068047 /api/funding/2068047 National Research, Development and Innovation Office, Hungary(152378) false true true 2026 true true true false true false GOLD 2026-10-23 true https://doi.org/10.3390/cells15111000 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 5 5 Q1 false false false false 2026-09-02T12:39:11.837+0000 Gyermekgyógyászati Intézet (DE / ÁOK); Integratív Neuroendokrinológiai Kutatócsoport (HRN KOKI); Pathológiai Intézet (DE / ÁOK) 7 37 3 9 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 139377589 /api/authorship/139377589 Gyurina, Katalin [Gyurina, Katalin (gyermekkori elhíz...), author] Department of Pediatrics (UD) 1 0.11111111 true false false Author 10071216 /api/author/10071216 Katalin Gyurina (gyermekkori elhízás molekuláris biológiai vizsgálata) Gyurina Katalin true true Gyurina Katalin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377590 /api/authorship/139377590 Radványi, Ádám [Radványi, Ádám (gyermeksebészet, ...), author] Department of Pediatrics (UD) 2 0.111 false false false Author 10087195 /api/author/10087195 Ádám Radványi (gyermeksebészet, obesitológia) Radványi Ádám true true Radványi Ádám true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377591 /api/authorship/139377591 Sasi-Szabó, László [Sasi Szabó, László András (sebészet, gyermek...), author] Department of Pediatrics (UD) 3 0.11111111 false false false Author 10043792 /api/author/10043792 László András Sasi Szabó (sebészet, gyermeksebészet) Sasi Szabó László András true 10043792 true Sasi-Szabó László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377592 /api/authorship/139377592 Felszeghy, Enikő [Felszeghy, Enikő (Gyermekgyógyászat...), author] Department of Pediatrics (UD) 4 0.11111111 false false false Author 10038322 /api/author/10038322 Enikő Felszeghy (Gyermekgyógyászat, endokrinológia) Felszeghy Enikő true 10038322 true Felszeghy Enikő true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377593 /api/authorship/139377593 Rácz, Emese 5 0.11111111 false false false Rácz Emese true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377594 /api/authorship/139377594 Méhes, Gábor [Méhes, Gábor (haematopathologia...), author] Department of Pathology (UD) 6 0.11111111 false false false Author 10011299 /api/author/10011299 Gábor Méhes (haematopathologia, molekuláris genetika) Méhes Gábor true 10011299 true Méhes Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377595 /api/authorship/139377595 Kádár, Andrea [Kádár, Andrea (Integratív neuroe...), author] Integratív Neuroendokrinológiai Kutatócsoport 7 0.111 false false false Author 205 /api/author/205 Andrea Kádár (Integratív neuroendokrinológia) Kádár Andrea true 205 true Kádár Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377596 /api/authorship/139377596 Fekete, Csaba [Fekete, Csaba (Neuroendokrinológia), author] Integratív Neuroendokrinológiai Kutatócsoport 8 0.111 false false false Author 10012354 /api/author/10012354 Csaba Fekete (Neuroendokrinológia) Fekete Csaba true 10012354 true Fekete Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 139377597 /api/authorship/139377597 Röszer, Tamás 9 0.11111111 false true false Röszer Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 32468518 /api/publicationidentifier/32468518 DOI: 10.3390/cells15111000 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/cells15111000 https://doi.org/10.3390/cells15111000 false true PublicationIdentifier 32468569 /api/publicationidentifier/32468569 REAL: 239506 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 239506 https://real.mtak.hu/239506 false true PublicationIdentifier 32678731 /api/publicationidentifier/32678731 WoS: 001789843900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001789843900001 https://www.webofscience.com/wos/woscc/full-record/001789843900001 false true PublicationIdentifier 33395703 /api/publicationidentifier/33395703 Scopus: 105041275122 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105041275122 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105041275122 false true PublicationIdentifier 32678732 /api/publicationidentifier/32678732 PubMed: 42274594 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 42274594 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=42274594&dopt=Abstract false true PublicationIdentifier 32468519 /api/publicationidentifier/32468519 Other URL: https://www.mdpi.com/2073-4409/15/11/1000 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true GOLD true IDENTICAL https://www.mdpi.com/2073-4409/15/11/1000 https://www.mdpi.com/2073-4409/15/11/1000 false true SjrRating 11668570 /api/sjrrating/11668570 sjr:Q1 (2026) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELLS 2073-4409 38 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q1 FROM_LAST_YEAR true true Reference 75800520 /api/reference/75800520 1. Kerr 2025: Global, regional, and national prevalence of child and adolescent overweight and obesity, 1990–2021, with forecasts to 2050: A forecasting study for the Global Burden of Disease Study 2021., Lancet, 405, p. 785, DOI: 10.1016/S0140-6736(25)00397-6 1 10.1016/S0140-6736(25)00397-6 false true Reference 75800521 /api/reference/75800521 2. Marcus 2022: Pediatric obesity-Long-term consequences and effect of weight loss., J. Intern. Med., 292, p. 870, DOI: 10.1111/joim.13547 2 10.1111/joim.13547 false true Reference 75800522 /api/reference/75800522 3. Wolfrum 2022: Fueling the fire of adipose thermogenesis., Science, 375, p. 1229, DOI: 10.1126/science.abl7108 3 10.1126/science.abl7108 false true Reference 75800523 /api/reference/75800523 4. Hoang 2022: Mitochondrial RNA stimulates beige adipocyte development in young mice., Nat. Metab., 4, p. 1684, DOI: 10.1038/s42255-022-00683-w 4 10.1038/s42255-022-00683-w false true Reference 75800524 /api/reference/75800524 5. Rockstroh, D., Landgraf, K., Wagner, I.V., Gesing, J., Tauscher, R., Lakowa, N., Kiess, W., Bühligen, U., Wojan, M., and Till, H. (2015). Direct evidence of brown adipocytes in different fat depots in children. PLoS ONE, 10., DOI: 10.1371/journal.pone.0117841 5 10.1371/journal.pone.0117841 false true Reference 75800525 /api/reference/75800525 6. Cohen 2021: The cellular and functional complexity of thermogenic fat., Nat. Rev. Mol. Cell Biol., 22, p. 393, DOI: 10.1038/s41580-021-00350-0 6 10.1038/s41580-021-00350-0 false true Reference 75800526 /api/reference/75800526 7. Alcalá, M., Calderon-Dominguez, M., Serra, D., Herrero, L., and Viana, M. (2019). Mechanisms of Impaired Brown Adipose Tissue Recruitment in Obesity. Front. Physiol., 10., DOI: 10.3389/fphys.2019.00094 7 10.3389/fphys.2019.00094 false true Reference 75800527 /api/reference/75800527 8. Valentine 2022: β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity., J. Clin. Investig., 132, p. e153357, DOI: 10.1172/JCI153357 8 10.1172/JCI153357 false true Reference 75800528 /api/reference/75800528 9. Jespersen 2013: A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans., Cell Metab., 17, p. 798, DOI: 10.1016/j.cmet.2013.04.011 9 10.1016/j.cmet.2013.04.011 false true Reference 75800529 /api/reference/75800529 10. Timmons 2007: Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages., Proc. Natl. Acad. Sci. USA, 104, p. 4401, DOI: 10.1073/pnas.0610615104 10 10.1073/pnas.0610615104 false true Reference 75800530 /api/reference/75800530 11. Sharp, L.Z., Shinoda, K., Ohno, H., Scheel, D.W., Tomoda, E., Ruiz, L., Hu, H., Wang, L., Pavlova, Z., and Gilsanz, V. (2012). Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE, 7., DOI: 10.1371/journal.pone.0049452 11 10.1371/journal.pone.0049452 false true Reference 75800531 /api/reference/75800531 12. Kepple 2021: The transcriptional co-regulator LDB1 is required for brown adipose function., Mol. Metab., 53, p. 101284, DOI: 10.1016/j.molmet.2021.101284 12 10.1016/j.molmet.2021.101284 false true Reference 75800532 /api/reference/75800532 13. Breitfeld, J., Kehr, S., Müller, L., Stadler, P.F., Böttcher, Y., Blüher, M., Stumvoll, M., and Kovacs, P. (2020). Developmentally Driven Changes in Adipogenesis in Different Fat Depots Are Related to Obesity. Front. Endocrinol., 11., DOI: 10.3389/fendo.2020.00138 13 10.3389/fendo.2020.00138 false true Reference 75800533 /api/reference/75800533 14. Carey, A.L., Vorlander, C., Reddy-Luthmoodoo, M., Natoli, A.K., Formosa, M.F., Bertovic, D.A., Anderson, M.J., Duffy, S.J., and Kingwell, B.A. (2014). Reduced UCP-1 content in in vitro differentiated beige/brite adipocytes derived from preadipocytes of human subcutaneous white adipose tissues in obesity. PLoS ONE, 9., DOI: 10.1371/journal.pone.0091997 14 10.1371/journal.pone.0091997 false true Reference 75800534 /api/reference/75800534 15. Orzack 2015: The human sex ratio from conception to birth., Proc. Natl. Acad. Sci. USA, 112, p. E2102, DOI: 10.1073/pnas.1416546112 15 10.1073/pnas.1416546112 false true Reference 75800535 /api/reference/75800535 16. Morgado 2024: Inguinal hernias in children: Update on management guidelines., J. Paediatr. Child Health, 60, p. 648, DOI: 10.1111/jpc.16677 16 10.1111/jpc.16677 false true Reference 75800536 /api/reference/75800536 17. Boklage 2005: The epigenetic environment: Secondary sex ratio depends on differential survival in embryogenesis., Hum. Reprod., 20, p. 583, DOI: 10.1093/humrep/deh662 17 10.1093/humrep/deh662 false true Reference 75800537 /api/reference/75800537 18. Gyurina, K., Yarmak, M., Sasi-Szabó, L., Molnár, S., Méhes, G., and Röszer, T. (2023). Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity. Int. J. Mol. Sci., 24., DOI: 10.3390/ijms242316706 18 10.3390/ijms242316706 false true Reference 75800538 /api/reference/75800538 19. Plank 2009: Magnetofection: The Use of Magnetic Nanoparticles for Nucleic Acid Delivery., Cold Spring Harb. Protoc., 2009, p. pdb.prot5230, DOI: 10.1101/pdb.prot5230 19 10.1101/pdb.prot5230 false true Reference 75800539 /api/reference/75800539 20. Souto 2010: Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection., Nat. Med., 16, p. 708, DOI: 10.1038/nm.2156 20 10.1038/nm.2156 false true Reference 75800540 /api/reference/75800540 21. Livak 2001: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method., Methods, 25, p. 402, DOI: 10.1006/meth.2001.1262 21 10.1006/meth.2001.1262 false true Reference 75800541 /api/reference/75800541 22. Langmead 2012: Fast gapped-read alignment with Bowtie 2., Nat. Methods, 9, p. 357, DOI: 10.1038/nmeth.1923 22 10.1038/nmeth.1923 false true Reference 75800542 /api/reference/75800542 23. Kim 2015: HISAT: A fast spliced aligner with low memory requirements., Nat. Methods, 12, p. 357, DOI: 10.1038/nmeth.3317 23 10.1038/nmeth.3317 false true Reference 75800543 /api/reference/75800543 24. Chen, E.Y., Tan, C.M., Kou, Y., Duan, Q., Wang, Z., Meirelles, G.V., Clark, N.R., and Ma’ayan, A. (2013). Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool. BMC Bioinform., 14., DOI: 10.1186/1471-2105-14-128 24 10.1186/1471-2105-14-128 false true Reference 75800544 /api/reference/75800544 25. Rusinova 2013: Interferome v2.0: An updated database of annotated interferon-regulated genes., Nucleic Acids Res., 41, p. D1040, DOI: 10.1093/nar/gks1215 25 10.1093/nar/gks1215 false true Reference 75800545 /api/reference/75800545 26. Love 2014: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2., Genome Biol., 15, p. 550, DOI: 10.1186/s13059-014-0550-8 26 10.1186/s13059-014-0550-8 false true Reference 75800546 /api/reference/75800546 27. Weinstein 1997: An information-intensive approach to the molecular pharmacology of cancer., Science, 275, p. 343, DOI: 10.1126/science.275.5298.343 27 10.1126/science.275.5298.343 false true Reference 75800547 /api/reference/75800547 28. Szklarczyk 2019: STRING v11: Protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets., Nucleic Acids Res., 47, p. D607, DOI: 10.1093/nar/gky1131 28 10.1093/nar/gky1131 false true Reference 75800548 /api/reference/75800548 29. Arai 2015: Mitochondria-targeted fluorescent thermometer monitors intracellular temperature gradient., Chem. Commun., 51, p. 8044, DOI: 10.1039/C5CC01088H 29 10.1039/C5CC01088H false true Reference 75800549 /api/reference/75800549 30. Lane, N. (2018). Hot mitochondria?. PLoS Biol., 16., DOI: 10.1371/journal.pbio.2005113 30 10.1371/journal.pbio.2005113 false true Reference 75800550 /api/reference/75800550 31. Karabatsiakis 2014: Mitochondrial respiration in peripheral blood mononuclear cells correlates with depressive subsymptoms and severity of major depression., Transl. Psychiatry, 4, p. e397, DOI: 10.1038/tp.2014.44 31 10.1038/tp.2014.44 false true Reference 75800551 /api/reference/75800551 32. Gao 2017: CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential., Stem Cells, 35, p. 1799, DOI: 10.1002/stem.2635 32 10.1002/stem.2635 false true Reference 75800552 /api/reference/75800552 33. Dwyer 1995: Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes., J. Lipid Res., 36, p. 1211, DOI: 10.1016/S0022-2275(20)41129-0 33 10.1016/S0022-2275(20)41129-0 false true Reference 75800553 /api/reference/75800553 34. Chen 2019: Thermal stress induces glycolytic beige fat formation via a myogenic state., Nature, 565, p. 180, DOI: 10.1038/s41586-018-0801-z 34 10.1038/s41586-018-0801-z false true Reference 75800554 /api/reference/75800554 35. Oselka 2025: Using weight-for-age as a screening tool for metabolic syndrome in apparently healthy adolescents., Pediatr. Res., 97, p. 994, DOI: 10.1038/s41390-024-03465-0 35 10.1038/s41390-024-03465-0 false true Reference 75800555 /api/reference/75800555 36. Yu 2019: Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages., J. Clin. Investig., 129, p. 2485, DOI: 10.1172/JCI125646 36 10.1172/JCI125646 false true Reference 75800556 /api/reference/75800556 37. Shan 2021: Cold-responsive adipocyte progenitors couple adrenergic signaling to immune cell activation to promote beige adipocyte accrual., Genes. Dev., 35, p. 1333, DOI: 10.1101/gad.348762.121 37 10.1101/gad.348762.121 false true Reference 75800557 /api/reference/75800557 38. Blondin 2020: Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation., Cell Metab., 32, p. 287, DOI: 10.1016/j.cmet.2020.07.005 38 10.1016/j.cmet.2020.07.005 false true Reference 75800558 /api/reference/75800558 39. Ali 2010: Caspase 3 inactivates biologically active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation., Biochem. Biophys. Res. Commun., 391, p. 1512, DOI: 10.1016/j.bbrc.2009.12.107 39 10.1016/j.bbrc.2009.12.107 false true Reference 75800559 /api/reference/75800559 40. Ishida 2024: Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans., Int. J. Obes., 48, p. 1110, DOI: 10.1038/s41366-024-01522-6 40 10.1038/s41366-024-01522-6 false true Reference 75800560 /api/reference/75800560 41. Stunff 1997: In vivo resistance of lipolysis to epinephrine. A new feature of childhood onset obesity., J. Clin. Investig., 99, p. 2568, DOI: 10.1172/JCI119444 41 10.1172/JCI119444 false true Reference 75800561 /api/reference/75800561 42. Cero 2021: β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis., JCI Insight, 6, p. e139160, DOI: 10.1172/jci.insight.139160 42 10.1172/jci.insight.139160 false true Reference 75800562 /api/reference/75800562 43. Straat 2023: Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue., Cell Rep. Med., 4, p. 100942, DOI: 10.1016/j.xcrm.2023.100942 43 10.1016/j.xcrm.2023.100942 false true Reference 75800563 /api/reference/75800563 44. Krief 1993: Tissue distribution of beta 3-adrenergic receptor mRNA in man., J. Clin. Investig., 91, p. 344, DOI: 10.1172/JCI116191 44 10.1172/JCI116191 false true Reference 75800564 /api/reference/75800564 45. Shin 2017: Lipolysis in brown adipocytes is not essential for cold-induced thermogenesis in mice., Cell Metab., 26, p. 764, DOI: 10.1016/j.cmet.2017.09.002 45 10.1016/j.cmet.2017.09.002 false true Reference 75800565 /api/reference/75800565 46. Markussen 2022: Lipolysis regulates major transcriptional programs in brown adipocytes., Nat. Commun., 13, p. 3956, DOI: 10.1038/s41467-022-31525-8 46 10.1038/s41467-022-31525-8 false true Reference 75800566 /api/reference/75800566 47. Arner 1999: Catecholamine-induced lipolysis in obesity., Int. J. Obes. Relat. Metab. Disord. J. Int. Assoc. Study Obes., 23, p. 10, DOI: 10.1038/sj.ijo.0800789 47 10.1038/sj.ijo.0800789 false true Reference 75800567 /api/reference/75800567 48. Carel 1999: Resistance to the lipolytic action of epinephrine: A new feature of protein Gs deficiency., J. Clin. Endocrinol. Metab., 84, p. 4127, DOI: 10.1210/jcem.84.11.6145 48 10.1210/jcem.84.11.6145 false true Reference 75800568 /api/reference/75800568 49. Eliakim 2006: Reduced exercise-associated response of the GH-IGF-I axis and catecholamines in obese children and adolescents., J. Appl. Physiol., 100, p. 1630, DOI: 10.1152/japplphysiol.01072.2005 49 10.1152/japplphysiol.01072.2005 false true Reference 75800569 /api/reference/75800569 50. Landgraf 2015: Evidence of early alterations in adipose tissue biology and function and its association with obesity-related inflammation and insulin resistance in children., Diabetes, 64, p. 1249, DOI: 10.2337/db14-0744 50 10.2337/db14-0744 false true Reference 75800570 /api/reference/75800570 51. Zhou 2020: Interleukin (IL)-33: An orchestrator of immunity from host defence to tissue homeostasis., Clin. Transl. Immunol., 9, p. e1146, DOI: 10.1002/cti2.1146 51 10.1002/cti2.1146 false true Reference 75800571 /api/reference/75800571 52. Cayrol 2018: Interleukin-33 (IL-33): A nuclear cytokine from the IL-1 family., Immunol. Rev., 281, p. 154, DOI: 10.1111/imr.12619 52 10.1111/imr.12619 false true Reference 75800572 /api/reference/75800572 53. Misawa, T., Wagner, M., and Koyasu, S. (2022). ILC2s and Adipose Tissue Homeostasis: Progress to Date and the Road Ahead. Front. Immunol., 13., DOI: 10.3389/fimmu.2022.876029 53 10.3389/fimmu.2022.876029 false true Reference 75800573 /api/reference/75800573 54. Röszer, T. (2020). M2 Macrophages in the Metabolic Organs and in the Neuroendocrine System. The M2 Macrophage, Springer International Publishing., DOI: 10.1007/978-3-030-50480-9_9 54 10.1007/978-3-030-50480-9_9 false true Reference 75800574 /api/reference/75800574 55. Holl 2019: STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI., Brain Behav. Immun., 81, p. 228, DOI: 10.1016/j.bbi.2019.06.019 55 10.1016/j.bbi.2019.06.019 false true Reference 75800575 /api/reference/75800575 56. Miller 2010: Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice., Circ. Res., 107, p. 650, DOI: 10.1161/CIRCRESAHA.110.218867 56 10.1161/CIRCRESAHA.110.218867 false true Reference 75800576 /api/reference/75800576 57. Wang 2024: Adipose-tissue Treg cells restrain differentiation of stromal adipocyte precursors to promote insulin sensitivity and metabolic homeostasis., Immunity, 57, p. 1345, DOI: 10.1016/j.immuni.2024.04.002 57 10.1016/j.immuni.2024.04.002 false true Reference 75800577 /api/reference/75800577 58. Lee 2015: Activated type 2 innate lymphoid cells regulate beige fat biogenesis., Cell, 160, p. 74, DOI: 10.1016/j.cell.2014.12.011 58 10.1016/j.cell.2014.12.011 false true Reference 75800578 /api/reference/75800578 59. Lin 2021: The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit., Sci. Immunol., 6, p. eabg9698, DOI: 10.1126/sciimmunol.abg9698 59 10.1126/sciimmunol.abg9698 false true Reference 75800579 /api/reference/75800579 60. Ding 2016: IL-33-driven ILC2/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity., J. Endocrinol., 231, p. 35, DOI: 10.1530/JOE-16-0229 60 10.1530/JOE-16-0229 false true Reference 75800580 /api/reference/75800580 61. Goldberg 2021: IL-33 causes thermogenic failure in aging by expanding dysfunctional adipose ILC2., Cell Metab., 33, p. 2277, DOI: 10.1016/j.cmet.2021.08.004 61 10.1016/j.cmet.2021.08.004 false true Reference 75800581 /api/reference/75800581 62. Song 2017: Induction of thermogenic adipocytes: Molecular targets and thermogenic small molecules., Exp. Mol. Med., 49, p. e353, DOI: 10.1038/emm.2017.70 62 10.1038/emm.2017.70 false true Reference 75800582 /api/reference/75800582 63. Kumari 2016: IRF3 promotes adipose inflammation and insulin resistance and represses browning., J. Clin. Investig., 126, p. 2839, DOI: 10.1172/JCI86080 63 10.1172/JCI86080 false true Reference 75800583 /api/reference/75800583 64. Wang 2013: Interferon regulatory factor 7 deficiency prevents diet-induced obesity and insulin resistance., Am. J. Physiol. Endocrinol. Metab., 305, p. E485, DOI: 10.1152/ajpendo.00505.2012 64 10.1152/ajpendo.00505.2012 false true Reference 75800584 /api/reference/75800584 65. Kissig 2017: PRDM16 represses the type I interferon response in adipocytes to promote mitochondrial and thermogenic programing., EMBO J., 36, p. 1528, DOI: 10.15252/embj.201695588 65 10.15252/embj.201695588 false true Reference 75800585 /api/reference/75800585 66. Chen 2024: Interleukin-33: Expression, regulation and function in adipose tissues., Int. Immunopharmacol., 143, p. 113285, DOI: 10.1016/j.intimp.2024.113285 66 10.1016/j.intimp.2024.113285 false true Reference 75800586 /api/reference/75800586 67. Joshi, A.D., Oak, S.R., Hartigan, A.J., Finn, W.G., Kunkel, S.L., Duffy, K.E., Das, A., and Hogaboam, C.M. (2010). Interleukin-33 contributes to both M1 and M2 chemokine marker expression in human macrophages. BMC Immunol., 11., DOI: 10.1186/1471-2172-11-52 67 10.1186/1471-2172-11-52 false true Reference 75800587 /api/reference/75800587 68. Zeyda 2013: Severe obesity increases adipose tissue expression of interleukin-33 and its receptor ST2, both predominantly detectable in endothelial cells of human adipose tissue., Int. J. Obes., 37, p. 658, DOI: 10.1038/ijo.2012.118 68 10.1038/ijo.2012.118 false true Reference 75800588 /api/reference/75800588 69. Pereira 2023: Interleukin-33 inhibits glucose uptake in human adipocytes and its expression in adipose tissue is elevated in insulin resistance and type 2 diabetes., Cytokine, 161, p. 156080, DOI: 10.1016/j.cyto.2022.156080 69 10.1016/j.cyto.2022.156080 false true Reference 75800589 /api/reference/75800589 70. Romanelli 2020: Viral and Nonviral Transfer of Genetic Materials to Adipose Tissues: Toward a Gold Standard Approach., Diabetes, 69, p. 2581, DOI: 10.2337/dbi20-0036 70 10.2337/dbi20-0036 false true Reference 75800590 /api/reference/75800590 71. Wang 2025: Adipose tissue-targeting nanomedicines for obesity pharmacotherapy., Trends Endocrinol. Metab., 36, p. 1127, DOI: 10.1016/j.tem.2025.03.010 71 10.1016/j.tem.2025.03.010 false true Reference 75800591 /api/reference/75800591 72. Tiwari 2024: Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy., Gene Ther., 31, p. 445, DOI: 10.1038/s41434-024-00471-z 72 10.1038/s41434-024-00471-z false true Reference 75800592 /api/reference/75800592 73. Herrera 2000: Lipid metabolism in the fetus and the newborn., Diabetes/Metab. Res. Rev., 16, p. 202, DOI: 10.1002/1520-7560(200005/06)16:3&lt;202::AID-DMRR116&gt;3.0.CO;2-# 73 10.1002/1520-7560(200005/06)16:3&lt;202::AID-DMRR116&gt;3.0.CO;2-# false true Reference 75800593 /api/reference/75800593 74. Draper, H.H. (1990). Energy Metabolism of the Newborn Infant. Advances in Nutritional Research, Springer., DOI: 10.1007/978-1-4613-0611-5 74 10.1007/978-1-4613-0611-5 false true Reference 75800594 /api/reference/75800594 75. Persson 1974: Carbohydrate and Lipid Metabolism in the Newborn Infant., Acta Anaesthesiol. Scand., 18, p. 50, DOI: 10.1111/j.1399-6576.1974.tb00706.x 75 10.1111/j.1399-6576.1974.tb00706.x false true Reference 75800595 /api/reference/75800595 76. Poissonnet 1984: The chronology of adipose tissue appearance and distribution in the human fetus., Early Hum. Dev., 10, p. 1, DOI: 10.1016/0378-3782(84)90106-3 76 10.1016/0378-3782(84)90106-3 false true Reference 75800596 /api/reference/75800596 77. Badr, M.Z. (2019). Isolation and Characterization of Adipose Tissue Macrophages. Nuclear Receptors: Methods and Experimental Protocols, Springer. 77 false true Reference 75800597 /api/reference/75800597 78. Hoang, A.C., Yu, H., and Röszer, T. (2021). Transcriptional Landscaping Identifies a Beige Adipocyte Depot in the Newborn Mouse. Cells, 10., DOI: 10.3390/cells10092368 78 10.3390/cells10092368 false true Reference 75800598 /api/reference/75800598 79. Radványi, Á., Gyurina, K., Rácz, E., Kovács, I., Méhes, G., and Röszer, T. (2024). Adipose Tissue Macrophages of the Human Fetus. Cells, 13., DOI: 10.3390/cells13211787 79 10.3390/cells13211787 false true Reference 75800599 /api/reference/75800599 80. Larsson 2015: A stringent validation of mouse adipose tissue identity markers., Am. J. Physiol. Endocrinol. Metab., 308, p. E1085, DOI: 10.1152/ajpendo.00023.2015 80 10.1152/ajpendo.00023.2015 false true /api/publication/37322302 Gyurina Katalin et al. Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes. (2026) CELLS 2073-4409 15 11 p. 1000<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071216"><a href="/gui2/?type=authors&mode=browse&sel=10071216" target="_blank">Gyurina Katalin (<span class="authorship-author-name">Gyurina Katalin</span> <span class="authorAux-mtmt"> gyermekkori elhízás molekuláris biológiai vizsg...</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087195"><a href="/gui2/?type=authors&mode=browse&sel=10087195" target="_blank">Radványi Ádám (<span class="authorship-author-name">Radványi Ádám</span> <span class="authorAux-mtmt"> gyermeksebészet, obesitológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043792"><a href="/gui2/?type=authors&mode=browse&sel=10043792" target="_blank">Sasi-Szabó László (<span class="authorship-author-name">Sasi Szabó László András</span> <span class="authorAux-mtmt"> sebészet, gyermeksebészet</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038322"><a href="/gui2/?type=authors&mode=browse&sel=10038322" target="_blank">Felszeghy Enikő (<span class="authorship-author-name">Felszeghy Enikő</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, endokrinológia</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rácz Emese </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011299"><a href="/gui2/?type=authors&mode=browse&sel=10011299" target="_blank">Méhes Gábor (<span class="authorship-author-name">Méhes Gábor</span> <span class="authorAux-mtmt"> haematopathologia, molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Pathology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="205"><a href="/gui2/?type=authors&mode=browse&sel=205" target="_blank">Kádár Andrea (<span class="authorship-author-name">Kádár Andrea</span> <span class="authorAux-mtmt"> Integratív neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012354"><a href="/gui2/?type=authors&mode=browse&sel=10012354" target="_blank">Fekete Csaba (<span class="authorship-author-name">Fekete Csaba</span> <span class="authorAux-mtmt"> Neuroendokrinológia</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Institute of Experimental Medicine">HUN-REN IEM</span>/Integratív Neuroendokrinológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Röszer Tamás </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37322302" target="_blank">Lim Homeobox 8 Is Essential for Beta Adrenergic Stimulation of Thermogenesis in Human Adipocytes</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">11</span> <span class="page"> p. 1000. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/cells15111000" target="_blank" href="https://doi.org/10.3390/cells15111000"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="239506" target="_blank" href="https://real.mtak.hu/239506"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001789843900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001789843900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105041275122" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105041275122"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="42274594" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=42274594&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="https://www.mdpi.com/2073-4409/15/11/1000" target="_blank" href="https://www.mdpi.com/2073-4409/15/11/1000"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37322302&sort=publishedYear,desc&sort=title"> Number of cited publications: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 37322302</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> János Bolyai Research Scholarship(BO/00227/23), National Research, Development and Innovation Office, Hungary(NKFIH-142939), National Research, Development and Innovation Office, Hungary(152378) </div> <div class="lastModified">Last Modified: 2026.10.20. 03:05 Admin Szuper (admin) </div> </div></div>