https://m2.mtmt.hu/ hun 2026-10-23 11:43 JournalArticle 37217203 VALIDATED true Cited by: 0; All Open Access; Gold Open Access; Green Open Access 0 false 2026-08-10T15:38:13.757+0000 2026-05-22T07:35:33.411+0000 2026-05-19T09:36:55.278+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 2026-06-03T01:59:43.394+0000 2026-05-19T12:44:43.740+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Frank, Nóra true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 15 9 3532 3532 14 2026 Background: Outpatient palliative care effectively alleviates symptom burden in advanced cancer patients, yet data from Central-Eastern Europe remain scarce. This retrospective study examined changes in revised Edmonton Symptom Assessment Scale (ESAS) scores from initial outpatient palliative consultation to first follow-up in Hungarian cancer patients, assessing clinically meaningful improvement and inter-symptom associations. Methods: Revised ESAS scores from 119 patients attending an outpatient palliative care clinic (2017-2020) were analyzed using paired baseline and first follow-up assessments (7-30 days). Symptom changes (Time 2-Time 1) were evaluated using Wilcoxon signed-rank tests. Clinically meaningful improvement was assessed with minimal clinically important difference thresholds (0.5× baseline SD). Sankey diagrams visualized symptom transitions, and multivariable linear regression examined inter-symptom associations. Results: Baseline pain was highest (mean 6.29, median 7), followed by fatigue, sleep disorder, and impaired well-being. At follow-up, significant reductions were observed in pain (mean 4.52, p = 0.001), nausea, dyspnea, constipation, sleep disorder, depression, and anxiety (all p < 0.05). Sankey diagrams showed shifts from severe to mild/moderate pain (50% to 24%) and constipation. Clinically meaningful improvement occurred in pain, nausea, and constipation, with 59-65% achieving ≥1-point pain reduction. Regression analyses showed that pain reduction was associated with concurrent improvements in sleep disorder (β = 0.31), depression (β = 0.20), fatigue (β = 0.20), and anxiety (β = 0.14), while dyspnea reduction was associated with concurrent improvements in depression (β = 0.22) and anxiety (β = 0.14). Conclusions: Outpatient palliative care in Hungarian cancer patients resulted in clinically meaningful symptom reductions, particularly pain and dyspnea. Improvements in these core symptoms were associated with concurrent improvements in other symptom domains, underscoring the clinical relevance of inter-symptom associations and supporting early, integrated outpatient palliative care and symptom cluster-based management. 2026 true true true false false GOLD 2026-08-10 true https://doi.org/10.3390/jcm15093532 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2 false false false false 2026-05-18T12:44:43.593+0000 Alapellátási Intézet (PTE / ÁOK); Egészségtudományi Doktori Iskola (PTE / DI); Egészségügyi Technológiaértékelési és Farmakoök... (PTE / GYTK); Orvosi Népegészségtani Intézet (PTE / ÁOK) 5 17 4 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 138603945 /api/authorship/138603945 Frank, Nóra [Frank, Nóra (Háziorvostan), szerző] Alapellátási Intézet (PTE / ÁOK); Egészségtudományi Doktori Iskola (PTE / DI) 1 0.2 true false false Author 10064676 /api/author/10064676 Frank Nóra (Háziorvostan) Frank Nóra true 10064676 true Frank Nóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 138603946 /api/authorship/138603946 Busa, Csilla [Busa, Csilla (Egészségtudomány), szerző] Alapellátási Intézet (PTE / ÁOK) 2 0.2 false false false Author 10028586 /api/author/10028586 Busa Csilla (Egészségtudomány) Busa Csilla true 10028586 true Busa Csilla true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 138603947 /api/authorship/138603947 Sághy, Eszter [Sághy, Eszter (Biostatisztika), szerző] Egészségügyi Technológiaértékelési és Farmakoök... (PTE / GYTK) 3 0.2 false false false Author 10099657 /api/author/10099657 Sághy Eszter (Biostatisztika) Sághy Eszter true true Sághy Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 138603948 /api/authorship/138603948 Pozsgai, Éva ✉ [Pozsgai, Éva (Orvostudomány), szerző] Orvosi Népegészségtani Intézet (PTE / ÁOK); Alapellátási Intézet (PTE / ÁOK) 4 0.2 false false true Author 10021082 /api/author/10021082 Pozsgai Éva (Orvostudomány) Pozsgai Éva true 10021082 true Pozsgai Éva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 138603949 /api/authorship/138603949 Csikós, Ágnes [Csikós, Ágnes (Palliatív orvoslás), szerző] Alapellátási Intézet (PTE / ÁOK); Egészségtudományi Doktori Iskola (PTE / DI) 5 0.2 false true false Author 10016696 /api/author/10016696 Csikós Ágnes (Palliatív orvoslás) Csikós Ágnes true 10016696 true Csikós Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 32226491 /api/publicationidentifier/32226491 DOI: 10.3390/jcm15093532 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/jcm15093532 https://doi.org/10.3390/jcm15093532 false true PublicationIdentifier 32226492 /api/publicationidentifier/32226492 WoS: 001763678800001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001763678800001 https://www.webofscience.com/wos/woscc/full-record/001763678800001 false true PublicationIdentifier 32254867 /api/publicationidentifier/32254867 Scopus: 105038403699 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105038403699 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105038403699 true true PublicationIdentifier 32226490 /api/publicationidentifier/32226490 PubMed: 42123265 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 42123265 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=42123265&dopt=Abstract false true Keyword 15104 /api/keyword/15104 dyspnea true 15104 true Keyword 1099335 /api/keyword/1099335 Pain Management true 1099335 true Keyword 1415424 /api/keyword/1415424 Symptom Assessment true 1415424 true Keyword 1528669 /api/keyword/1528669 minimal clinically important difference true true Keyword 2057399 /api/keyword/2057399 ESAS true true Keyword 2110319 /api/keyword/2110319 Symptom clusters true true Keyword 2836623 /api/keyword/2836623 cancer symptoms true true Keyword 4282160 /api/keyword/4282160 early symptom management true true Keyword 4282161 /api/keyword/4282161 interrelated symptoms true true Keyword 4282162 /api/keyword/4282162 outpatient palliative care true true SjrRating 11701992 /api/sjrrating/11701992 sjr:Q2 (2026) Scopus - Medicine (miscellaneous) JOURNAL OF CLINICAL MEDICINE 2077-0383 638 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true Q2 FROM_LAST_YEAR true true /api/publication/37217203 Frank Nóra et al. Symptom Improvement and Interrelated ESAS Domains Following Outpatient Palliative Care in Hungarian Cancer Patients.. (2026) JOURNAL OF CLINICAL MEDICINE 2077-0383 15 9<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064676"><a href="/gui2/?type=authors&mode=browse&sel=10064676" target="_blank">Frank Nóra (<span class="authorship-author-name">Frank Nóra</span> <span class="authorAux-mtmt"> Háziorvostan</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Alapellátási Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Doktori Iskolák">DI</span>/Egészségtudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028586"><a href="/gui2/?type=authors&mode=browse&sel=10028586" target="_blank">Busa Csilla (<span class="authorship-author-name">Busa Csilla</span> <span class="authorAux-mtmt"> Egészségtudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Alapellátási Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099657"><a href="/gui2/?type=authors&mode=browse&sel=10099657" target="_blank">Sághy Eszter (<span class="authorship-author-name">Sághy Eszter</span> <span class="authorAux-mtmt"> Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egészségügyi Technológiaértékelési és Farmakoökonómiai Kutatóközpont</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021082"><a href="/gui2/?type=authors&mode=browse&sel=10021082" target="_blank">Pozsgai Éva ✉ (<span class="authorship-author-name">Pozsgai Éva</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Orvosi Népegészségtani Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Alapellátási Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10016696"><a href="/gui2/?type=authors&mode=browse&sel=10016696" target="_blank">Csikós Ágnes (<span class="authorship-author-name">Csikós Ágnes</span> <span class="authorAux-mtmt"> Palliatív orvoslás</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Alapellátási Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Doktori Iskolák">DI</span>/Egészségtudományi Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37217203" target="_blank">Symptom Improvement and Interrelated ESAS Domains Following Outpatient Palliative Care in Hungarian Cancer Patients.</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">9</span> <span class="page"> Paper 3532. 14 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/jcm15093532" target="_blank" href="https://doi.org/10.3390/jcm15093532"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001763678800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001763678800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105038403699" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105038403699"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="42123265" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=42123265&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37217203</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.22. 09:35 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited by: 0; All Open Access; Gold Open Access; Green Open Access</pre> </div></div>