https://m2.mtmt.hu/ hun 2026-07-27 13:53 JournalArticle 37105328 VALIDATED true 0 false 2026-05-22T13:57:11.114+0000 2026-05-21T07:17:21.357+0000 2026-05-02T10:51:56.918+0000 true 10082788 Frankó Máté /api/admin/10082788 Admin true 2026-05-22T13:56:02.087+0000 2026-05-21T07:17:20.376+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Helwa‐Shalom, Omer Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model true true /api/journal/2743 REVIEWED true false 2743 false 2743 true 0736-0266 1554-527X Journal FOREIGN 44 4 e70190 e70190 12 2026 Osteochondral injuries are common, painful, and lack natural healing abilities. Previous studies demonstrated that recombinant human amelogenin promotes osteochondral repair in rat knee injuries, including improved defect filling and formation of hyaline cartilage. Here, we aimed to evaluate the efficacy and safety of Remelix®, a novel recombinant human amelogenin–based product, in a large animal goat model. Acute osteochondral injuries were created in the weight‐bearing region of the medial femoral condyle in thirteen goats. Seven goats received Remelix® at a protein concentration of 0.5 mg/mL, with the contralateral knee applied with PX 407 carrier alone. An additional six goats received Remelix® at 0.25 mg/mL, while contralateral knees were treated with normal saline. Potential adverse effects, along with evaluation of osteochondral healing were assessed. Healing was assessed 24 weeks post‐treatment using magnetic resonance imaging (MRI), macroscopic evaluation, and histological and immunohistochemical analyses. No adverse effects were observed. Both Remelix® concentrations resulted in substantial healing of cartilage and subchondral bone. Histological analyses demonstrated improved tidemark formation, predominantly hyaline cartilage filling in the deeper layers of the defect with extension toward the superficial zone, and reduced subchondral bone abnormalities. MRI and macroscopic evaluations revealed a continuous repair surface with good integration at the defect margins. In contrast, PX 407 and saline‐treated control knees exhibited inferior repair, characterized by mainly fibrous cartilage, heterogeneous MRI signal intensity, and lower histological scores. Overall, Remelix® substantially improved osteochondral healing in a goat model without observable adverse effects, supporting its potential for further evaluation in human clinical studies. true true 2026 true true true false false NONE 2026-05-22 false 0 0 0 0 0 0 0 0 0 0 0 0 4 4 Q2 false false false false 2026-07-31T10:52:14.436+0000 4 27 0 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 137697792 /api/authorship/137697792 1 0.083333336 true false false Helwa‐Shalom Omer true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 137697793 /api/authorship/137697793 2 0.083333336 false false false Nevo Hani true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 137697794 /api/authorship/137697794 3 0.083333336 false false false Nasrawy Tarek true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 137697795 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;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nasrawy Tarek </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galiner Masha </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yusef Azraq </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ben‐David Keren </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Markowitz Shany Ivon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gellman Yechiel N. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Beyth Shaul </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sacks Hagit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Blumenfeld Anat </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Haze Amir ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37105328" target="_blank">Recombinant Human Amelogenin Protein Enhances Healing of Osteochondral Injury in a Goat Model</a></div> <div> <span class="journal-title">JOURNAL OF ORTHOPAEDIC RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0736-0266">0736-0266</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1554-527X">1554-527X</a>)</span>: <span class="journal-volume">44</span> <span class="journal-issue">4</span> <span class="page"> Paper e70190. 12 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1002/jor.70190" target="_blank" href="https://doi.org/10.1002/jor.70190"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001732202900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001732202900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105034818898" target="_blank" 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