Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease

https://m2.mtmt.hu/ eng 2026-07-26 01:53 JournalArticle 37058755 VALIDATED true 0 false 2026-07-09T09:02:14.726+0000 2026-06-13T13:59:19.412+0000 2026-04-02T09:21:18.765+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true 2026-07-09T08:58:43.566+0000 2026-05-20T20:32:14.025+0000 true 521 Szuper Admin /api/admin/521 Admin Admin Szuper (admin) true false false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType Study Group (Journal Article) 104 true 10000359 true 1 /api/category/1 Category Scientific true 1 Lee, Yong-Joon Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease true true /api/journal/1394667 REVIEWED NEW ENGLAND JOURNAL OF MEDICINE 0028-4793 1533-4406 true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 394 1365 1375 1365 11 2026 Background Despite guideline recommendations, evidence from randomized trials evaluating the appropriate low-density lipoprotein (LDL) cholesterol target for secondary prevention in patients with atherosclerotic cardiovascular disease remains limited.Methods In this open-label superiority trial conducted in South Korea, we randomly assigned patients with atherosclerotic cardiovascular disease in a 1:1 ratio to a target LDL cholesterol level of less than 55 mg per deciliter (1.4 mmol per liter) (intensive-targeting group) or less than 70 mg per deciliter (1.8 mmol per liter) (conventional-targeting group). The primary end point was a composite of death from cardiovascular causes, nonfatal myocardial infarction, nonfatal stroke, any revascularization, or hospitalization for unstable angina at 3 years. Safety was also assessed.Results Of 3048 patients who underwent randomization, 1526 were assigned to the intensive-targeting group and 1522 to the conventional-targeting group. The median follow-up was 3.0 years. The median LDL cholesterol level during the trial was 56 mg per deciliter (1.4 mmol per liter) in the intensive-targeting group and 66 mg per deciliter (1.7 mmol per liter) in the conventional-targeting group. A primary end-point event occurred in 100 patients (Kaplan-Meier estimate of cumulative incidence, 6.6%) in the intensive-targeting group and in 147 patients (Kaplan-Meier estimate of cumulative incidence, 9.7%) in the conventional-targeting group (hazard ratio, 0.67; 95% confidence interval, 0.52 to 0.86; P=0.002). The incidence of prespecified safety end points was similar in the two trial groups, except for a lower incidence of creatinine elevation in the intensive-targeting group.Conclusions Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level of less than 55 mg per deciliter resulted in a lower risk of cardiovascular events at 3 years than targeting a level of less than 70 mg per deciliter. (Funded by the Cardiovascular Research Center and Yuhan; Ez-PAVE ClinicalTrials.gov number, NCT04626973.) Among patients with atherosclerotic cardiovascular disease, targeting an LDL cholesterol level below 55 mg per deciliter led to a lower 3-year risk of cardiovascular events than targeting a level below 70 mg per deciliter. 2026 true true true false false NONE 2026-07-09 false 0 0 0 0 0 0 0 0 0 0 0 0 6 6 D1 false false false false 2026-06-12T13:59:19.283+0000 14 84 0 25 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 136867954 /api/authorship/136867954 Lee, Yong-Joon 1 0.04 true false false Lee Yong-Joon true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867955 /api/authorship/136867955 Lee, Seung-Jun 2 0.04 false false false Lee Seung-Jun true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867956 /api/authorship/136867956 Kim, Jin Won 3 0.04 false false false Kim Jin Won true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867957 /api/authorship/136867957 Lee, Sang-Hyup 4 0.04 false false false Lee Sang-Hyup true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867958 /api/authorship/136867958 Kim, Gwang-Sil 5 0.04 false false false Kim Gwang-Sil true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867959 /api/authorship/136867959 Park, Jae Hyoung 6 0.04 false false false Park Jae Hyoung true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867960 /api/authorship/136867960 Cho, Jin-Man 7 0.04 false false false Cho Jin-Man true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867961 /api/authorship/136867961 Kang, Woong Chol 8 0.04 false false false Kang Woong Chol true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867962 /api/authorship/136867962 Yoon, Hyuck-Jun 9 0.04 false false false Yoon Hyuck-Jun true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867963 /api/authorship/136867963 Kim, Won Ho 10 0.04 false false false Kim Won Ho true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867964 /api/authorship/136867964 Lee, Seung-Jin 11 0.04 false false false Lee Seung-Jin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867965 /api/authorship/136867965 Lee, Jin Bae 12 0.04 false false false Lee Jin Bae true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867966 /api/authorship/136867966 Jang, Ji-Yong 13 0.04 false false false Jang Ji-Yong true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867967 /api/authorship/136867967 Shin, Sanghoon 14 0.04 false false false Shin Sanghoon true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867968 /api/authorship/136867968 Park, Ik Hyun 15 0.04 false false false Park Ik Hyun true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867969 /api/authorship/136867969 Kwon, Sung Uk 16 0.04 false false false Kwon Sung Uk true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867970 /api/authorship/136867970 Kim, Sunwon 17 0.04 false false false Kim Sunwon true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867971 /api/authorship/136867971 Hong, Sung-Jin 18 0.04 false false false Hong Sung-Jin true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867972 /api/authorship/136867972 Ahn, Chul-Min 19 0.04 false false false Ahn Chul-Min true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867973 /api/authorship/136867973 Kim, Jung-Sun 20 0.04 false false false Kim Jung-Sun true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867974 /api/authorship/136867974 Ko, Young-Guk 21 0.04 false false false Ko Young-Guk true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867975 /api/authorship/136867975 Choi, Donghoon 22 0.04 false false false Choi Donghoon true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867976 /api/authorship/136867976 Hong, Myeong-Ki 23 0.04 false false false Hong Myeong-Ki true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867977 /api/authorship/136867977 Jang, Yangsoo 24 0.04 false false false Jang Yangsoo true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 136867978 /api/authorship/136867978 Kim, Byeong-Keuk ✉ 25 0.04 false true true Kim Byeong-Keuk true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true OrgAuthorship 136867979 /api/authorship/136867979 Ez-PAVE Investigators [Collaborative Organization] 26 0.0 false false false true false false AuthorshipType 30 /api/authorshiptype/30 Collaborative Organization -29 true -29 true false true PublicationIdentifier 31786247 /api/publicationidentifier/31786247 DOI: 10.1056/NEJMoa2600283 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1056/NEJMoa2600283 https://doi.org/10.1056/NEJMoa2600283 false true PublicationIdentifier 31786248 /api/publicationidentifier/31786248 WoS: 001726645800001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001726645800001 https://www.webofscience.com/wos/woscc/full-record/001726645800001 false true PublicationIdentifier 32335514 /api/publicationidentifier/32335514 Scopus: 105035432795 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105035432795 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105035432795 false true PublicationIdentifier 31786249 /api/publicationidentifier/31786249 PubMed: 41910315 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41910315 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41910315&dopt=Abstract false true Keyword 12437 /api/keyword/12437 MANAGEMENT true 12437 true Keyword 1003521 /api/keyword/1003521 OUTCOMES true 1003521 true Keyword 1003522 /api/keyword/1003522 ATORVASTATIN true 1003522 true Keyword 1019727 /api/keyword/1019727 ezetimibe true 1019727 true Keyword 1126368 /api/keyword/1126368 statin therapy true 1126368 true SjrRating 11701408 /api/sjrrating/11701408 sjr:D1 (2026) Scopus - Medicine (miscellaneous) NEW ENGLAND JOURNAL OF MEDICINE 0028-4793 1533-4406 4 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 Scopus - Medicine (miscellaneous) true 2701 true D1 FROM_LAST_YEAR true true /api/publication/37058755 Lee Yong-Joon et al. Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease. (2026) NEW ENGLAND JOURNAL OF MEDICINE 0028-4793 1533-4406 394 1365-1375<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Lee Yong-Joon </span> ;    <span class="author-name" >Lee Seung-Jun </span> ;    <span class="author-name" >Kim Jin Won </span> ;    <span class="author-name" >Lee Sang-Hyup </span> ;    <span class="author-name" >Kim Gwang-Sil </span> ;    <span class="author-name" >Park Jae Hyoung </span> ;    <span class="author-name" >Cho Jin-Man </span> ;    <span class="author-name" >Kang Woong Chol </span> ;    <span class="author-name" >Yoon Hyuck-Jun </span> ;    <span class="author-name" >Kim Won Ho </span> ;    <span class="author-name" >Lee Seung-Jin </span> ;    <span class="author-name" >Lee Jin Bae </span> ;    <span class="author-name" >Jang Ji-Yong </span> ;    <span class="author-name" >Shin Sanghoon </span> ;    <span class="author-name" >Park Ik Hyun </span> ;    <span class="author-name" >Kwon Sung Uk </span> ;    <span class="author-name" >Kim Sunwon </span> ;    <span class="author-name" >Hong Sung-Jin </span> ;    <span class="author-name" >Ahn Chul-Min </span> ;    <span class="author-name" >Kim Jung-Sun </span> ;    <span class="author-name" >Ko Young-Guk </span> ;    <span class="author-name" >Choi Donghoon </span> ;    <span class="author-name" >Hong Myeong-Ki </span> ;    <span class="author-name" >Jang Yangsoo </span> ;    <span class="author-name" >Kim Byeong-Keuk ✉ </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-affil">Ez-PAVE Investigators</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37058755" target="_blank">Intensive LDL Cholesterol Targeting in Atherosclerotic Cardiovascular Disease</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">394</span> <span class="page"> pp 1365-1375 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2600283" target="_blank" href="https://doi.org/10.1056/NEJMoa2600283"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001726645800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001726645800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105035432795" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105035432795"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41910315" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41910315&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37058755&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 37058755</span> | <span class="status-data status-VALIDATED"> Validated </span> Citing | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Last Modified: 2026.06.13. 15:59 Éva Pécsi (MTMT Közp 2,3, admin) </div> </div></div>