https://m2.mtmt.hu/ hun 2026-08-26 14:40 JournalArticle 37050637 APPROVED true Laboratory of Pharmacology of Natural and Synthetic Products, Institute of Biological Sciences, Federal University of Goiás, GO, Goiânia, Brazil Theoretical and Structural Chemistry Group of Anápolis, State University of Goias, GO, Brazil Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary Export Date: 16 June 2026; Cited By: 1; Correspondence Address: J.O. Fajemiroye; Laboratory of Pharmacology of Natural and Synthetic Products, Institute of Biological Sciences, Federal University of Goiás, Goiânia, GO, Brazil; email: jamesfajemiroye@ufg.br 0 false 2026-06-16T10:41:04.871+0000 2026-06-16T09:51:05.244+0000 2026-03-30T08:43:34.976+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-06-16T09:51:05.206+0000 true true true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ogbu, John Ihayi Cannabidiol in Epilepsy : Restoring Locomotion and Seizure Control true true /api/journal/10040087 REVIEWED true false 10040087 false 10040087 true 1871-5273 1996-3181 Journal FOREIGN 2026 Epilepsy remains a global challenge, with about one-third of affected patients being resistant to treatment. Seizures and motor abnormalities characterized by movement difficulties are common in epilepsy, highlighting the need for treatments that can both improve motor outcomes and control seizures. The therapeutic potential of Cannabidiol (CBD) in this regard necessitates a review that explores its effects and underlying mechanisms of action. This study reviewed studies from major scientific databases on the use of CBD in animal and human models of epilepsy. We also integrated tools of network pharmacology and molecular modeling to investigate how CBD may interact with various biological targets. The cannabinoid broadly demonstrates minimal or no changes in motor outcomes, reinforcing its low toxicity and tolerability. Evidence suggests that CBD has potential for seizure control by prolonging the time to seizure onset and decreasing seizure severity. The antiepileptic effects of CBD involve the modulation of multiple targets or genes. This multitarget interaction network may underlie its neuroprotective effects by regulating endocannabinoid signaling, neurotransmission, inflammation, and metabolic pathways. Chemical bonding between CBD and key protein residues reinforces evidence supporting its interaction with these targets. Despite the limited clinical data and algorithmic constraints of network pharmacology, the present findings reveal the potential of CBD to improve epileptic outcomes. The multitarget mechanisms of this phytocannabinoid offer valuable insights that may guide and advance epilepsy research. 2026 true true true false false PAY 2026-06-16 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 Q2 false false false false 2026-06-29T07:21:08.888+0000 Gyógyszerészi Kémiai Intézet (PTE / GYTK) 1 6 1 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 136059752 /api/authorship/136059752 1 0.125 true false false Ogbu John Ihayi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059753 /api/authorship/136059753 2 0.125 false false false Mendes Rosa Thysia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059754 /api/authorship/136059754 3 0.125 false false false Nakao de Aguiar Antônio Sérgio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059755 /api/authorship/136059755 4 0.125 false false false Borges Leonardo Luiz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059756 /api/authorship/136059756 5 0.125 false false false Author 10008303 /api/author/10008303 Perjési Pál true 10008303 true Perjesi Pal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059757 /api/authorship/136059757 6 0.125 false false false Napolitano Hamilton Barbosa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059758 /api/authorship/136059758 7 0.125 false false false Filho Alberto Souza Sá true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 136059759 /api/authorship/136059759 8 0.125 false true true Fajemiroye James Oluwagbamigbe true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31759662 /api/publicationidentifier/31759662 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.2174/0118715273398370251129105507 https://doi.org/10.2174/0118715273398370251129105507 false true PublicationIdentifier 32506416 /api/publicationidentifier/32506416 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001783870900001 https://www.webofscience.com/wos/woscc/full-record/001783870900001 false true PublicationIdentifier 32507494 /api/publicationidentifier/32507494 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105040793985 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105040793985 false true PublicationIdentifier 31759661 /api/publicationidentifier/31759661 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41833036 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41833036&dopt=Abstract false true Keyword 1548 /api/keyword/1548 true 1548 true Keyword 1008990 /api/keyword/1008990 true 1008990 true Keyword 1132310 /api/keyword/1132310 true 1132310 true Keyword 4205500 /api/keyword/4205500 true true SjrRating 11702065 /api/sjrrating/11702065 772 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true Q2 FROM_LAST_YEAR true true /api/publication/37050637 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Ogbu John Ihayi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mendes Rosa Thysia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nakao de Aguiar Antônio Sérgio </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Borges Leonardo Luiz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008303"><a href="/gui2/?type=authors&mode=browse&sel=10008303" target="_blank">Perjesi Pal (<span class="authorship-author-name">Perjési Pál</span> <span class="authorAux-mtmt"> Bioorganikus kémia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Napolitano Hamilton Barbosa </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Filho Alberto Souza Sá </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fajemiroye James Oluwagbamigbe ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37050637" target="_blank">Cannabidiol in Epilepsy : Restoring Locomotion and Seizure Control</a></div> <div> <span class="journal-title">CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1871-5273">1871-5273</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1996-3181">1996-3181</a>)</span>: <span class="journal-volume"></span> <span class="page"> </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.2174/0118715273398370251129105507" target="_blank" href="https://doi.org/10.2174/0118715273398370251129105507"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001783870900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001783870900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105040793985" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105040793985"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41833036" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41833036&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37050637</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.16. 11:51 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Laboratory of Pharmacology of Natural and Synthetic Products, Institute of Biological Sciences, Federal University of Goiás, GO, Goiânia, Brazil Theoretical and Structural Chemistry Group of Anápolis, State University of Goias, GO, Brazil Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, Hungary Export Date: ...</pre> </div></div>