https://m2.mtmt.hu/ hun 2026-08-26 04:44 JournalArticle 37040055 VALIDATED true 0 false 2026-05-18T02:13:10.396+0000 2026-05-17T18:54:03.194+0000 2026-03-28T12:49:30.478+0000 true 10003254 Barkai László /api/author/10003254 Author Barkai László (Gyermekgyógyászat) true 10003254 2026-05-17T18:54:02.820+0000 2026-04-17T06:58:26.529+0000 true 10015207 Tamássyné T. Zsuzsa /api/admin/10015207 Admin Tamássyné T. Zsuzsa (OE admin) true 10015207 2026-04-17T06:58:30.381+0000 true 10015207 Tamássyné T. Zsuzsa /api/admin/10015207 Admin Tamássyné T. Zsuzsa (OE admin) true 10015207 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Barkai, László true true /api/journal/10056704 REVIEWED BIOMEDICINES 2227-9059 true false 10056704 false 10056704 true 2227-9059 Journal FOREIGN 14 3 721 721 17 2026 Background/Objectives: The global incidence of diabetes in childhood is increasing, raising concern about its long-term effects on the developing brain. Although paediatric diabetes research has traditionally focused on microvascular and macrovascular complications, accumulating evidence indicates that the brain is also a vulnerable target. Methods: This narrative review synthesizes current knowledge on the impact of diabetes on brain health in children and adolescents, with emphasis on epidemiology, neuroimaging and cognitive outcomes, underlying mechanisms, risk and protective factors, and clinical implications. Results: In type 1 diabetes (T1D), studies consistently demonstrate subtle but measurable alterations in brain structure, including reduced growth of total, grey, and white matter volumes, alongside functional and microstructural changes. These neurobiological differences are associated with mild deficits in cognition, particularly in attention, executive function, memory, and processing speed. While clinically significant impairment affects a minority, subclinical alterations are common and may accumulate over time. Key risk factors include chronic hyperglycaemia, glycaemic variability, severe hypoglycaemia, diabetic ketoacidosis, and younger age at onset, whereas good glycaemic stability, diabetes technologies, supportive psychosocial environments, and adequate sleep appear protective. Proposed mechanisms involve oxidative stress, neuroinflammation, disrupted insulin signalling, altered cerebral metabolism, and vulnerability of the immature brain during critical developmental windows. Type 2 diabetes (T2D), increasingly diagnosed in youth, is also associated with adverse brain outcomes. Emerging data link early-onset T2D to alterations in brain structure and connectivity, poorer cognitive performance, and increased mental health burden, mediated by hyperglycaemia, insulin resistance, inflammation, and psychosocial stressors. Conclusions: Overall, childhood diabetes—both T1D and T2D—is associated with meaningful effects on brain development and function. Longitudinal and interventional studies are needed to establish causality and determine whether optimizing glycaemic control and psychosocial support can mitigate neurocognitive risk. Recognizing brain health as a potential complication of paediatric diabetes has important implications for monitoring, prevention, and clinical care. Funding 2066122 /api/funding/2066122 (TKP2021-NKTA-36) false true Funding 2066123 /api/funding/2066123 (FK- 14290) false true Funding 2066124 /api/funding/2066124 (Hungarian Diabetes Association (Grant No. 25/11/2025)) false true true 2026 true true true false true false GOLD 2026-05-18 true https://doi.org/10.3390/biomedicines14030721 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q1 false false false false 2026-04-16T06:58:26.266+0000 Egyetemi Kutató és Innovációs Központ (ÓE) 1 11 1 1 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 135902676 /api/authorship/135902676 Barkai, László ✉ [Barkai, László (Gyermekgyógyászat), szerző] Egyetemi Kutató és Innovációs Központ (ÓE) 1 1.0 true false true Author 10003254 /api/author/10003254 Barkai László (Gyermekgyógyászat) Barkai László true 10003254 true Barkai László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 31732877 /api/publicationidentifier/31732877 DOI: 10.3390/biomedicines14030721 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/biomedicines14030721 https://doi.org/10.3390/biomedicines14030721 false true PublicationIdentifier 31848558 /api/publicationidentifier/31848558 WoS: 001725850000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001725850000001 https://www.webofscience.com/wos/woscc/full-record/001725850000001 false true PublicationIdentifier 31848559 /api/publicationidentifier/31848559 Scopus: 105034372949 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105034372949 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105034372949 false true Classification 12292 /api/classification/12292 Egyes típusú diabetesz (inzulinfüggő diabetesz mellitusz) true true Classification 12215 /api/classification/12215 Klinikai orvostan true true SjrRating 11668594 /api/sjrrating/11668594 sjr:Q1 (2026) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) BIOMEDICINES 2227-9059 74 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q1 FROM_LAST_YEAR true true Reference 74053391 /api/reference/74053391 1. 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(2026) BIOMEDICINES 2227-9059 14 3<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10003254"><a href="/gui2/?type=authors&mode=browse&sel=10003254" target="_blank">Barkai László ✉ (<span class="authorship-author-name">Barkai László</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Óbudai Egyetem">ÓE</span>/Egyetemi Kutató és Innovációs Központ</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37040055" target="_blank">The Impact of Diabetes on Brain Health in Childhood</a></div> <div> <span class="journal-title">BIOMEDICINES</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2227-9059">2227-9059</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">3</span> <span class="page"> Paper 721. 17 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/biomedicines14030721" target="_blank" href="https://doi.org/10.3390/biomedicines14030721"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001725850000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001725850000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105034372949" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105034372949"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37040055&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37040055</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> (TKP2021-NKTA-36), (FK- 14290), (Hungarian Diabetes Association (Grant No. 25/11/2025)) </div> <div class="lastModified">Utolsó módosítás: 2026.05.17. 20:54 Szuper Admin (admin) </div> </div></div>