https://m2.mtmt.hu/ hun 2026-07-28 04:47 JournalArticle 37026755 VALIDATED true Early edition published: 17 March 2026 Open access funding provided by Semmelweis University. This research was funded by grants from the Hungarian National Research, Development and Innovation Office (K143321 and 150826 to M.K.) and the Thematic Excellence Programme (TKP2021-EGA-23) of the Ministry for Innovation and Technology in Hungary. This research is supported by the NRDI Office (OTKA K 138472). Gábor Szebényi acknowledges the financial support received through the János Bolyai Scholarship of the Hungarian Academy of Sciences. 0 false 2026-07-13T06:21:30.875+0000 2026-07-13T06:19:53.557+0000 2026-03-24T08:20:17.579+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-07-13T06:19:53.835+0000 2026-07-13T06:19:53.835+0000 2026-04-08T11:25:43.886+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin true 2026-05-21T23:33:51.168+0000 true 521 Szuper Admin /api/admin/521 Admin true true true true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Antal, Sarolta Combined effects of ageing and type 2 diabetes mellitus on human dental mechanics true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN Early edition 14 2026 Dental collagen, a protein subject to essentially zero turnover, is highly susceptible to the accumulation of advanced glycation end-products (AGEs) due to elevated blood glucose in type 2 diabetes mellitus (T2DM). Progressive loss of collagen's structural stability likely increases the risk of tooth decay and fracture complicating the proper fixation of dental restorations. Our study aimed at investigating the structural and mechanical alterations in T2DM-affected teeth by measuring the stiffness and detecting micro-traumas and fractures. By using computed tomography (CT) and static compression tests, caries-free human molars and front teeth from healthy and T2DM patients were analyzed. Our results revealed a significantly reduced enamel/dentin ratio and larger dentin crack sizes in T2DM molars compared to controls, indicating increased susceptibility to mechanical damage. Although statistical analysis showed age as a dominant factor in tooth deterioration, T2DM was associated with a clinically relevant increase in dentin fracture size, suggesting that diabetes aggravates tooth fragility. Our findings underscore the importance of the cooperative effect of age and diabetes in dental biomechanics which bears significant implications in restorative treatments. Altogether, while ageing significantly affects tooth mechanical stability, T2DM contributes to additional structural weakening, particularly in molars, due to altered mechanical properties and higher occurrence of dental wears. 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Veres Dániel true 10031347 true Veres Dániel Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 135120887 /api/authorship/135120887 7 0.125 false false false Author 10013879 /api/author/10013879 Kellermayer Miklós true 10013879 true Kellermayer Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 135120888 /api/authorship/135120888 8 0.125 false true true Author 10038534 /api/author/10038534 Haluszka Dóra true 10038534 true Haluszka Dóra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31694891 /api/publicationidentifier/31694891 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1007/s11357-026-02202-1 https://doi.org/10.1007/s11357-026-02202-1 false true PublicationIdentifier 31694892 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ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 FROM_LAST_YEAR true true /api/publication/37026755 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10104717"><a href="/gui2/?type=authors&mode=browse&sel=10104717" target="_blank">Antal Sarolta ✉ (<span class="authorship-author-name">Antal Sarolta</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089556"><a href="/gui2/?type=authors&mode=browse&sel=10089556" target="_blank">Haba Kata Sára (<span class="authorship-author-name">Haba Kata Sára</span> <span class="authorAux-mtmt"> Diabétesz hatása a szájüregi egészségre</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Fogpótlástani Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028662"><a href="/gui2/?type=authors&mode=browse&sel=10028662" target="_blank">Szebényi Gábor (<span class="authorship-author-name">Szebényi Gábor</span> <span class="authorAux-mtmt"> Gépészeti Tudományok</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Gépészmérnöki Kar">GPK</span>/Polimertechnika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088679"><a href="/gui2/?type=authors&mode=browse&sel=10088679" target="_blank">Horváth Ildikó (<span class="authorship-author-name">Horváth Ildikó</span> <span class="authorAux-mtmt"> Biofizika, Sugárbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013859"><a href="/gui2/?type=authors&mode=browse&sel=10013859" target="_blank">Krisztián Szigeti (<span class="authorship-author-name">Szigeti Krisztián</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031347"><a href="/gui2/?type=authors&mode=browse&sel=10031347" target="_blank">Veres Dániel Sándor (<span class="authorship-author-name">Veres Dániel</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013879"><a href="/gui2/?type=authors&mode=browse&sel=10013879" target="_blank">Kellermayer Miklós (<span class="authorship-author-name">Kellermayer Miklós</span> <span class="authorAux-mtmt"> Biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038534"><a href="/gui2/?type=authors&mode=browse&sel=10038534" target="_blank">Haluszka Dóra ✉ (<span class="authorship-author-name">Haluszka Dóra</span> <span class="authorAux-mtmt"> mikroszkópia, kisérleti orvostudomány,nanomedicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;37026755" target="_blank">Combined effects of ageing and type 2 diabetes mellitus on human dental mechanics</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">Early edition</span> <span class="page"> 14 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1007/s11357-026-02202-1" target="_blank" href="https://doi.org/10.1007/s11357-026-02202-1"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001716329000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001716329000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105033295911" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105033295911"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41845133" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41845133&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;37026755&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 37026755</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (K143321), (K150826), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, (K 138472), (János Bolyai Research Scholarship) </div> <div class="lastModified">Utolsó módosítás: 2026.07.13. 08:19 Fülöp Tamás (BME GPK admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Early edition published: 17 March 2026 Open access funding provided by Semmelweis University. This research was funded by grants from the Hungarian National Research, Development and Innovation Office (K143321 and 150826 to M.K.) and the Thematic Excellence Programme (TKP2021-EGA-23) of the Ministry for Innovation and Technology in Hungary. This research is supported by the NRDI Office (OTKA K ...</pre> </div></div>