Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections
worldwide. Its role in infection-associated cancers, such as gastric cancer and mucosa-associated
lymphoid tissue (MALT) lymphoma is well known. However, mitochondrial alterations
in these malignancies are less documented. Mitochondria are key organelles, maintaining
cellular homeostasis under normal and pathological conditions. They regulate complex
cellular processes and play a key role in carcinogenesis and cancer progression in
H. pylori-associated malignancies. This review summarizes the role of mitochondrial
stress in H. pylori infection, gastric cancer, and MALT lymphoma.
