https://m2.mtmt.hu/ eng 2026-08-25 07:18 JournalArticle 36967888 VALIDATED true 0 false 2026-08-18T09:19:47.605+0000 2026-03-10T11:44:21.712+0000 2026-02-22T13:24:27.821+0000 true 10038518 Dános Kornél /api/author/10038518 Author true 10038518 2026-03-16T09:27:48.406+0000 2026-03-16T09:27:48.406+0000 2026-03-09T09:47:42.050+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dános, Kornél Association Between Nutritional Status and Extranodal Extension of Lymph Node Metastases in Head and Neck Squamous Cell Cancers true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 18 4 706 706 16 2026 Introduction: Extranodal extension (ENE) is a well-established adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC), associated with reduced survival and the need for intensified therapy. Nutritional status—commonly assessed using the Prognostic Nutritional Index (PNI) and Body Mass Index (BMI)—also influences outcomes in HNSCC. However, whether or not ENE correlates with nutritional status has not been previously investigated. Methods: We conducted a retrospective cohort study of 109 treatment-naïve HNSCC patients with pathologically confirmed nodal metastases who underwent primary tumor resection and neck dissection between 2014 and 2025 at a national tertiary center. ENE status was determined histologically. Nutritional status was evaluated using BMI, PNI, serum albumin, and percentage of weight loss at diagnosis. Statistical analyses included t-tests, Chi-square tests, ANOVA, Cox regression, Kaplan–Meier survival analysis, and Full Factorial General Linear Models. Results: ENE was present in 54.1% of patients and significantly reduced overall survival (Kaplan–Meier p = 0.006; Cox regression RR = 1.927, p = 0.008). No significant differences in BMI, PNI, weight loss, or serum albumin were observed between ENE-positive and ENE-negative groups. ENE prevalence varied significantly by tumor origin (p = 0.018), being highest in hypopharyngeal cancers (75.8%) and lowest in oral cavity tumors (25.0%). ENE status was independent of tobacco use, alcohol abuse, and all nutritional markers across TNM 8/9 subgroups. Conclusions: ENE is a strong prognostic marker in HNSCC, appearing to be independent of nutritional status. The demonstrated heterogeneity of ENE prevalence among tumor subsites supports the need for individualized management approaches. true true 2026 true true true false true false GOLD 2026-08-18 false http://www.mdpi.com/journal/nutrients/ 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 2 2 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 D1 false 10038518 false false false 2026-03-08T09:47:41.783+0000 Fül-Orr-Gégészeti és Fej-Nyaksebészeti Klinika (SE / AOK / K); Hang-, beszéd- és nyelésterápia Tanszék (SE / ETK2007) 6 11 2 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 134222436 /api/authorship/134222436 1 0.125 true false false Author 10038518 /api/author/10038518 Dános Kornél true 10038518 true Dános Kornél true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222437 /api/authorship/134222437 2 0.125 false false false Majoros Mátyás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222438 /api/authorship/134222438 3 0.125 false false false Tóth Lili true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222439 /api/authorship/134222439 4 0.125 false false false Author 10104298 /api/author/10104298 Besenczi Benedek true true Besenczi Benedek true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222440 /api/authorship/134222440 5 0.125 false false false Author 10099366 /api/author/10099366 Aouf Mohammad true true Aouf Mohammad true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222441 /api/authorship/134222441 6 0.125 false false false Author 10070353 /api/author/10070353 Horváth Angéla true true Horváth Angéla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222442 /api/authorship/134222442 7 0.125 false false false Author 10010129 /api/author/10010129 Tamás László true 10010129 true Tamás László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 134222443 /api/authorship/134222443 8 0.125 false true true Author 10096284 /api/author/10096284 Uri Imre true true Uri Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31508036 /api/publicationidentifier/31508036 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.3390/nu18040706 https://doi.org/10.3390/nu18040706 false true PublicationIdentifier 31615396 /api/publicationidentifier/31615396 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001701037900001 https://www.webofscience.com/wos/woscc/full-record/001701037900001 true true PublicationIdentifier 31605628 /api/publicationidentifier/31605628 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105031245572 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105031245572 false true PublicationIdentifier 31605629 /api/publicationidentifier/31605629 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41754223 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41754223&dopt=Abstract false true Classification 12389 /api/classification/12389 true true Keyword 1528113 /api/keyword/1528113 true true Keyword 1616005 /api/keyword/1616005 true true Keyword 2464939 /api/keyword/2464939 true true Keyword 4190854 /api/keyword/4190854 true true SjrRating 11658342 /api/sjrrating/11658342 25 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true D1 FROM_LAST_YEAR true true /api/publication/36967888 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10038518"><a href="/gui2/?type=authors&mode=browse&sel=10038518" target="_blank">Dános Kornél (<span class="authorship-author-name">Dános Kornél</span> <span class="authorAux-mtmt"> Fül-Orr-Gégészet; Fej-Nyaksebészet, Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Otorhinolaryngology, Head and Neck Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Majoros Mátyás </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tóth Lili </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10104298"><a href="/gui2/?type=authors&mode=browse&sel=10104298" target="_blank">Besenczi Benedek (<span class="authorship-author-name">Besenczi Benedek</span> <span class="authorAux-mtmt"> fül-orr-gégészet, fej-nyaksebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Otorhinolaryngology, Head and Neck Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10099366"><a href="/gui2/?type=authors&mode=browse&sel=10099366" target="_blank">Aouf Mohammad (<span class="authorship-author-name">Aouf Mohammad</span> <span class="authorAux-mtmt"> otorhinolaryngology ;Ear, Nose,Throat, Head and...</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070353"><a href="/gui2/?type=authors&mode=browse&sel=10070353" target="_blank">Horváth Angéla (<span class="authorship-author-name">Horváth Angéla</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Otorhinolaryngology, Head and Neck Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010129"><a href="/gui2/?type=authors&mode=browse&sel=10010129" target="_blank">Tamás László (<span class="authorship-author-name">Tamás László</span> <span class="authorAux-mtmt"> Fül-orr-gégészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Otorhinolaryngology, Head and Neck Surgery; <span title="Semmelweis University">SU</span>/<span title="Faculty of Health Sciences">FHS</span>/Department of Voice, Speech and Swallow Therapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10096284"><a href="/gui2/?type=authors&mode=browse&sel=10096284" target="_blank">Uri Imre ✉ (<span class="authorship-author-name">Uri Imre</span> <span class="authorAux-mtmt"> fül-orr-gégegyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Otorhinolaryngology, Head and Neck Surgery</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36967888" target="_blank">Association Between Nutritional Status and Extranodal Extension of Lymph Node Metastases in Head and Neck Squamous Cell Cancers</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">4</span> <span class="page"> Paper 706. 16 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.3390/nu18040706" target="_blank" href="https://doi.org/10.3390/nu18040706"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001701037900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001701037900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105031245572" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105031245572"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41754223" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41754223&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Food Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36967888&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36967888</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2026.03.10. 12:44 Viktória Horváth (SE_ETK_Admin5_HV, admin) </div> </div></div>