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      <title>Néhány gondolat a szérum-kreatininszint, -transzaminázaktivitás és -albuminszint meghatározások módszertanáról</title>
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      <abstractText>A modern orvostudomány fejlődése ellenére a klasszikus laboratóriumi paraméterek továbbra is a klinikai döntéshozatal fő pillérei. A közlemény négy, rutinszerűen mért analitra fókuszál: szérum-kreatininszint, májtranszamináz-aktivitások, albuminszint. Ezek 2024-ben a magyarországi laboratóriumi meghatározások több mint 15%-át tették ki. A szérum-kreatininszint mérését a laboratóriumok kétféle módszerrel mérik: Jaffé- vagy enzimatikus módszerrel. Bár mindkettő alkalmas a glomerulusfiltrációs ráta (GFR) becslésére, az eredmények 5–14%-kal eltérhetnek egymástól. A szakmai állásfoglalás szerint mindkét módszer használható, de a leleten jelölni kell az alkalmazott technikát. A transzamináz-aktivitások (GOT/AST, GPT/ALT) meghatározásakor kritikus a piridoxál-foszfát (B6-vitamin) jelenléte a reagensben. Ennek hiányában a mért értékek 15–30%-kal alacsonyabbak lehetnek. Ez téves diagnózishoz vezethet, különösen a májfibrosis becslésére szolgáló FIB4-pontszám számításakor. Ezért piridoxál-foszfátot tartalmazó reagensek alkalmazása javasolt a transzamináz-aktivitások mérésére. Az albumin mérésére a brómkrezolzöld helyett brómkrezolvörös reagens használata javasolt, mivel az előbbi májbetegségben és veseelégtelenségben pontatlan eredményeket ad. A módszerváltásokat a klinikusokkal egyeztetve kell végrehajtani, illetve oda kell figyelni arra is, hogy a vizsgálatok LOINC-kódja (egységes nevezéktanon alapuló kódrendszer) változhat. Orv Hetil. 2026; 167(6): 211–216. | Despite advances in modern medicine, classic laboratory parameters are still crucial pillars of clinical decision-making.
The report focuses on four routinely measured analytes: serum creatinine levels, liver transaminase activities and al-
bumin levels. In 2024, these accounted for more than 15% of laboratory determinations in Hungary. Laboratories
measure serum creatinine levels using two methods: the Jaffé or the enzymatic method. Although both are suitable
for estimating the glomerular filtration rate (GFR), the results may differ by 5–14% from each other. According to
the professional opinion, both methods can be used, but they should be indicated on the report. The presence of
pyridoxal phosphate (vitamin B6) in the reagent is critical for the determination of transaminase activities (GOT/
AST, GPT/ALT). In its absence, the measured values may be 15–30% lower, which may lead to misdiagnosis, espe-
cially when calculating the FIB4 score for estimating the severity of liver fibrosis. Therefore, the use of reagents
containing pyridoxal phosphate is recommended for measuring transaminase activities. In the case of albumin deter-
mination, the use of bromocresol red reagent is recommended instead of bromocresol green, as the former gives
inaccurate results in liver disease and renal failure. Method changes should be made in consultation with clinicians,
and it should be noted that the LOINC codes (an international standard for parameter identification) for the tests
may change.</abstractText>
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          <doi>10.1080/09674845.2011.11730338</doi>
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      <label>Vásárhelyi Barna et al. Néhány gondolat a szérum-kreatininszint, -transzaminázaktivitás és -albuminszint meghatározások módszertanáról. (2026) ORVOSI HETILAP 0030-6002 1788-6120 167 6 211-216</label><template>&lt;div class=&quot;JournalArticle Publication short-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10003195&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10003195&quot; target=&quot;_blank&quot;&gt;Vásárhelyi, Barna ✉&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; mtid=&quot;10022095&quot;&gt; &lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10022095&quot; target=&quot;_blank&quot;&gt;Bereczky, Zsuzsanna&lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; ; &lt;span class=&quot;author-name&quot; &gt; Miseta, Attila &lt;/span&gt; &lt;span class=&quot;author-type&quot;&gt; &lt;/span&gt; &lt;/div &gt;&lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36932110&quot; mtid=&quot;36932110&quot; target=&quot;_blank&quot;&gt;Néhány gondolat a szérum-kreatininszint, -transzaminázaktivitás és -albuminszint meghatározások módszertanáról&lt;/a&gt;&lt;/div&gt; &lt;div class=&quot;pub-info&quot;&gt; &lt;span class=&quot;journal-title&quot;&gt;ORVOSI HETILAP&lt;/span&gt; &lt;span class=&quot;journal-volume&quot;&gt;167&lt;/span&gt; : &lt;span class=&quot;journal-issue&quot;&gt;6&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp. 211-216. , 6 p. &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2026)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-end&quot;&gt;&lt;div class=&quot;identifier-list&quot;&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1556/650.2026.33490&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1556/650.2026.33490&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot; Green &quot;&gt; 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PubMed &lt;/a&gt; &lt;/span&gt; &lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;short-pub-prop-list&quot;&gt; &lt;span class=&quot;short-pub-mtid&quot;&gt; Publication:36932110 &lt;/span&gt; &lt;span class=&quot;status-holder&quot;&gt;&lt;span class=&quot;status-data status-ADMIN_APPROVED&quot;&gt; Admin approved &lt;/span&gt;&lt;/span&gt; &lt;span class=&quot;pub-core&quot;&gt;Core Citing &lt;/span&gt; &lt;span class=&quot;pub-type&quot;&gt;Journal Article (Survey paper ) &lt;/span&gt; &lt;!-- &amp;&amp; !record.category.scientific --&gt; &lt;span class=&quot;pub-category&quot;&gt;Scientific&lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;/div&gt;</template><template2>&lt;div class=&quot;JournalArticle Publication long-list&quot;&gt; &lt;div class=&quot;authors&quot;&gt; &lt;img title=&quot;Forrásközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-core-icon.png&quot;&gt; &lt;img title=&quot;Idézőközlemény&quot; style=&quot;float: left&quot; src=&quot;/frontend/resources/grid/publication-citation-icon.png&quot;&gt; &lt;div class=&quot;autype autype0&quot;&gt; &lt;span class=&quot;author-name&quot; mtid=&quot;10003195&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10003195&quot; target=&quot;_blank&quot;&gt;Vásárhelyi Barna ✉ (&lt;span class=&quot;authorship-author-name&quot;&gt;Vásárhelyi Barna&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; gyermekgyógyászat&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; mtid=&quot;10022095&quot;&gt;&lt;a href=&quot;/gui2/?type=authors&amp;mode=browse&amp;sel=10022095&quot; target=&quot;_blank&quot;&gt;Bereczky Zsuzsanna (&lt;span class=&quot;authorship-author-name&quot;&gt;Bereczky Zsuzsanna&lt;/span&gt; &lt;span class=&quot;authorAux-mtmt&quot;&gt; véralvadás&lt;/span&gt;) &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;author-affil&quot;&gt;&lt;span title=&quot;University of Debrecen&quot;&gt;UD&lt;/span&gt;/&lt;span title=&quot;Faculty of Medicine&quot;&gt;Faculty of Medicine&lt;/span&gt;/&lt;span title=&quot;Department of Laboratory Medicine&quot;&gt;DLM&lt;/span&gt;/Klinikai Laboratóriumi Kutató Tanszék&lt;/span&gt; ;&amp;nbsp;&amp;nbsp;&amp;nbsp; &lt;span class=&quot;author-name&quot; &gt;Miseta Attila &lt;/span&gt; &lt;/div&gt; &lt;/div&gt; &lt;div class=&quot;title&quot;&gt;&lt;a href=&quot;/gui2/?mode=browse&amp;params=publication;36932110&quot; target=&quot;_blank&quot;&gt;Néhány gondolat a szérum-kreatininszint, -transzaminázaktivitás és -albuminszint meghatározások módszertanáról&lt;/a&gt;&lt;/div&gt; &lt;div&gt; &lt;span class=&quot;journal-title&quot;&gt;ORVOSI HETILAP&lt;/span&gt; &lt;span class=&quot;journal-issn&quot;&gt;(&lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/0030-6002&quot;&gt;0030-6002&lt;/a&gt; &lt;a target=&quot;_blank&quot; href=&quot;https://portal.issn.org/resource/ISSN/1788-6120&quot;&gt;1788-6120&lt;/a&gt;)&lt;/span&gt;: &lt;span class=&quot;journal-volume&quot;&gt;167&lt;/span&gt; &lt;span class=&quot;journal-issue&quot;&gt;6&lt;/span&gt; &lt;span class=&quot;page&quot;&gt; pp 211-216 &lt;/span&gt; &lt;span class=&quot;year&quot;&gt;(2026)&lt;/span&gt; &lt;/div&gt; &lt;div class=&quot;pub-footer&quot;&gt;  &lt;span class=&quot;language&quot; xmlns=&quot;http://www.w3.org/1999/html&quot;&gt;Language: Hungarian | &lt;/span&gt; &lt;span class=&quot;identifiers&quot;&gt; &lt;span class=&quot;id identifier oa_GOLD&quot; title=&quot; Gold &quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;10.1556/650.2026.33490&quot; target=&quot;_blank&quot; href=&quot;https://doi.org/10.1556/650.2026.33490&quot;&gt; DOI &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_GREEN&quot; title=&quot; Green &quot;&gt; &lt;a style=&quot;color:black&quot; title=&quot;233573&quot; target=&quot;_blank&quot; href=&quot;https://real.mtak.hu/233573&quot;&gt; REAL &lt;/a&gt; &lt;/span&gt; &lt;span class=&quot;id identifier oa_none&quot; title=&quot;none&quot;&gt; &lt;a style=&quot;color:blue&quot; title=&quot;001684269300001&quot; target=&quot;_blank&quot; href=&quot;https://www.webofscience.com/wos/woscc/full-record/001684269300001&quot;&gt; WoS &lt;/a&gt; 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