https://m2.mtmt.hu/ hun 2026-10-25 16:48 JournalArticle 36920322 VALIDATED true The author(s) declared that financial support was received for this work and/or its publication. This work was funded by the International Center for Angioedema Research (ICARE) at Charite, Berlin, which supported researchers to collect, analyze and interpret the data, write the report and submit the current paper. 0 false 2026-10-22T09:23:50.096+0000 2026-10-22T09:04:57.820+0000 2026-02-04T08:23:10.989+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-10-22T09:04:58.192+0000 2026-10-22T09:04:58.192+0000 2026-02-04T08:29:07.244+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Aulenbacher, Felix Classification of angioedema types using decision tree modeling true true /api/journal/10023324 REVIEWED true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 16 1697143 1697143 10 2026 Introduction All angioedema (AE) presents with transient, localized swelling; however, the underlying causes, prognosis, and treatments vary significantly. Consequently, identifying a specific AE type is challenging.Methods We aimed to apply a machine learning (ML) model to improve AE diagnosis. Random forest (RF) ML was used to create a prediction model for diagnosing correct AE types. Development comprised a literature search to establish AE's clinical characteristics, developing and translating questions in collaboration with 12 European AE centers, and selecting, testing, validating and optimizing the established ML model. Analysis included 342 specialist-diagnosed patients with one of six AE types.Results The final optimized RF model correctly identified AE types with true positive rates of up to 94% in hereditary AE due to C1 inhibitor deficiency (C1INH), with a Percentage Accuracy of 89<middle dot>2% and a Kappa value of 81<middle dot>8% across the six AE types, with a high agreement with the diagnoses made by experts.Discussion This is the first ever reported ML algorithm designed to pre-assess to aid AE diagnosis. 2026 true true true false false GOLD 2026-10-22 false http://www.frontiersin.org/immunology 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal 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/api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522352 /api/authorship/133522352 8 0.06666667 false false false Longhurst Hilary true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522353 /api/authorship/133522353 9 0.06666667 false false false Staubach Petra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522354 /api/authorship/133522354 10 0.06666667 false false false Zanichelli Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522355 /api/authorship/133522355 11 0.06666667 false false false Aberer Werner true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522356 /api/authorship/133522356 12 0.06666667 false false false Bygum Anette true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522357 /api/authorship/133522357 13 0.06666667 false false false Van Den Elzen Mignon true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522358 /api/authorship/133522358 14 0.06666667 false false false Buttgereit Thomas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133522359 /api/authorship/133522359 15 0.06666667 false true true Magerl Markus true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31347283 /api/publicationidentifier/31347283 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/fimmu.2025.1697143 https://doi.org/10.3389/fimmu.2025.1697143 false true PublicationIdentifier 31347284 /api/publicationidentifier/31347284 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41601695&dopt=Abstract false true Keyword 12390 /api/keyword/12390 true 12390 true Keyword 1020094 /api/keyword/1020094 true 1020094 true Keyword 1020191 /api/keyword/1020191 true 1020191 true Keyword 1020191 /api/keyword/1020191 true 1020191 true Keyword 1148933 /api/keyword/1148933 true 1148933 true Keyword 1176158 /api/keyword/1176158 true 1176158 true Keyword 1245296 /api/keyword/1245296 true 1245296 true Keyword 1575636 /api/keyword/1575636 true true Keyword 3522652 /api/keyword/3522652 true true SjrRating 11695530 /api/sjrrating/11695530 37 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2403 /api/classificationexternal/2403 true 2403 true Q1 FROM_LAST_YEAR true true /api/publication/36920322 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Aulenbacher Felix </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gutsche Annika </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009711"><a href="/gui2/?type=authors&mode=browse&sel=10009711" target="_blank">Farkas Henriette (<span class="authorship-author-name">Farkas Henriette</span> <span class="authorAux-mtmt"> klinikai immunológus, allergológus</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048193"><a href="/gui2/?type=authors&mode=browse&sel=10048193" target="_blank">Kohalmi Kinga Viktoria (<span class="authorship-author-name">Kőhalmi Kinga Viktória</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Klinikai Központ (karhoz nem tartozó egységek)">KKP</span>/Reumatológiai és Immunológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kocaturk Emek </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aygoeren-Puersuen Emel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Martin Ludovic </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Longhurst Hilary </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Staubach Petra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zanichelli Andrea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aberer Werner </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bygum Anette </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Van Den Elzen Mignon </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Buttgereit Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Magerl Markus ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36920322" target="_blank">Classification of angioedema types using decision tree modeling</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">16</span> <span class="page"> Paper 1697143. 10 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fimmu.2025.1697143" target="_blank" href="https://doi.org/10.3389/fimmu.2025.1697143"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001668718700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001668718700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105028418862" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105028418862"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41601695" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41601695&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36920322&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36920322</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.10.22. 11:04 Kósáné Holecz Anna Mária (SE_KK_Reumatológia_Admin5_KHAM, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: The author(s) declared that financial support was received for this work and/or its publication. This work was funded by the International Center for Angioedema Research (ICARE) at Charite, Berlin, which supported researchers to collect, analyze and interpret the data, write the report and submit the current paper.</pre> </div></div>