https://m2.mtmt.hu/ eng 2026-04-29 14:39 JournalArticle 36919961 VALIDATED true * Megosztott szerzőség 0 false 2026-04-27T14:55:55.534+0000 2026-04-06T14:23:18.091+0000 2026-02-03T21:11:04.778+0000 true 10064119 Das Sourav /api/author/10064119 Author Sourav Das (Pharmacy) true 10064119 2026-04-06T14:06:30.708+0000 2026-03-11T10:15:26.585+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Guba, Andrea true true /api/journal/10024432 REVIEWED PHARMACEUTICALS 1424-8247 true false 10024432 false 10024432 true 1424-8247 Journal FOREIGN 19 2 260 260 13 2026 Background/Objectives: Fluvoxamine (FLU) is a selective serotonin reuptake inhibitor and one of the most potent agonists of the sigma-1 receptor. Emerging evidence shows that FLU exerts protective effects in multiple organs, making it a promising candidate for topical ocular therapy. Developing an FLU eyedrop for glaucoma can address a significant treatment gap with potentially fewer side effects compared with conventional therapies. To optimise formulation development, precise quantification of FLU in ocular compartments such as aqueous humour, as well as systemic circulation, is essential to characterise drug absorption, ocular bioavailability, and safety. Methods: We developed and validated a UHPLC-MS method for FLU detection in aqueous humour and serum using simple sample preparation steps. Results: The 11-min-long reverse phase chromatography followed by SRM-based mass spectrometry detection provides a highly selective and sensitive FLU detection method. Our method was proved to be linear in the 0.0625–1.5 µg/mL range and was validated according to the EMA guidelines. Conclusions: The simplicity of sample preparation, the tolerable matrix effects, and the favourable detection parameters provide a robust tool for preclinical pharmacokinetic and pharmacodynamic studies of FLU’s ocular protective effects. Funding 2063234 /api/funding/2063234 (LP2021-3/2021) false true Funding 2063235 /api/funding/2063235 (STAGE 2024-1.2.3-HU-RIZONT-2024-00056) false true Funding 2063236 /api/funding/2063236 (TKP2021-EGA-24) false true true 2026 true true true false true false GOLD 2026-04-27 true https://doi.org/10.3390/ph19020260 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 Q1 false false false false 2026-02-03T14:35:56.950+0000 Biokémiai és Molekuláris Biológiai Intézet (DE / ÁOK); Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Gyermekgyógyászati Klinika (SE / AOK / K); Humán Reprodukciós Nemzeti Laboratórium (PTE); MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Molekuláris Medicina kutatócsoport (PTE / SZKK); Proteomika Szolgáltató Laboratórium (DE / ÁOK / BMBI) 10 38 7 10 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 133519734 /api/authorship/133519734 Guba, Andrea [Guba, Andrea (Metabolomika), author] Department of Biochemistry and Molecular Biology (UD); Proteomika Szolgáltató Laboratórium (UD / DBMB) 1 0.1 true false false Author 10101444 /api/author/10101444 Andrea Guba (Metabolomika) Guba Andrea true true Guba Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519735 /api/authorship/133519735 Takácsi-Nagy, Anna [Takácsi-Nagy, Anna Erzsébet (Gyógyszerészet), author] 2 0.1 false false false Author 10015365 /api/author/10015365 Anna Erzsébet Takácsi-Nagy (Gyógyszerészet) Takácsi-Nagy Anna Erzsébet true 10015365 true Takácsi-Nagy Anna true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519736 /api/authorship/133519736 Das, Sourav [Das, Sourav (Pharmacy), author] Molecular Medicine Research Group (UP / SZRC); National Laboratory for Human Reproduction (UP) 3 0.1 false false false Author 10064119 /api/author/10064119 Sourav Das (Pharmacy) Das Sourav true 10064119 true Das Sourav true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519737 /api/authorship/133519737 Szokol, Bálint [Szokol, Bálint (Gyógyszerkémia), author] 4 0.1 false false false Author 10043337 /api/author/10043337 Bálint Szokol (Gyógyszerkémia) Szokol Bálint true 10043337 true Szokol Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519738 /api/authorship/133519738 Timea, Medveczki [Medveczki, Tímea (molekuláris bioló...), author] "Lendulet" Diabetes Research Group (SU / FM / C / DP); Department of Pediatrics (SU / FM / C) 5 0.1 false false false Author 10080260 /api/author/10080260 Tímea Medveczki (molekuláris biológia, szemészet) Medveczki Tímea true true Timea Medveczki true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519739 /api/authorship/133519739 Vajna, Márton [Vajna, Márton Antal (gyógyszer-technol...), author] University Pharmacy Department of Pharmacy Admi... (SU / FP) 6 0.1 false false false Author 10020339 /api/author/10020339 Márton Antal Vajna (gyógyszer-technológia) Vajna Márton Antal true 10020339 true Vajna Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519740 /api/authorship/133519740 Kalló, Gergő [Kalló, Gergő (Proteomika), author] Department of Biochemistry and Molecular Biology (UD); Proteomika Szolgáltató Laboratórium (UD / DBMB) 7 0.1 false false false Author 10043520 /api/author/10043520 Gergő Kalló (Proteomika) Kalló Gergő true 10043520 true Kalló Gergő true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519741 /api/authorship/133519741 Fekete, Andrea [Fekete, Andrea (nefrológia, gyerm...), author] "Lendulet" Diabetes Research Group (SU / FM / C / DP); Department of Pediatrics (SU / FM / C) 8 0.1 false false false Author 10011883 /api/author/10011883 Andrea Fekete (nefrológia, gyermekgyógyászat) Fekete Andrea true 10011883 true Fekete Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519742 /api/authorship/133519742 Hodrea, Judit** [Hodrea, Judit (szemészet, diabet...), author] "Lendulet" Diabetes Research Group (SU / FM / C / DP); Department of Pediatrics (SU / FM / C) 9 0.1 false true false Author 10032759 /api/author/10032759 Judit Hodrea (szemészet, diabetológia, nephrologia) Hodrea Judit true 10032759 true Hodrea Judit true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 133519743 /api/authorship/133519743 Csősz, Éva ✉ [Csősz, Éva (Molekuláris bioló...), author] Department of Biochemistry and Molecular Biology (UD); Proteomika Szolgáltató Laboratórium (UD / DBMB) 10 0.1 false true true Author 10027545 /api/author/10027545 Éva Csősz (Molekuláris biológia, proteomika) Csősz Éva true 10027545 true Csősz Éva true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 31346276 /api/publicationidentifier/31346276 DOI: 10.3390/ph19020260 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ph19020260 https://doi.org/10.3390/ph19020260 false true PublicationIdentifier 31616133 /api/publicationidentifier/31616133 WoS: 001700173600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001700173600001 https://www.webofscience.com/wos/woscc/full-record/001700173600001 true true PublicationIdentifier 31616122 /api/publicationidentifier/31616122 Scopus: 105031267234 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105031267234 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105031267234 true true PublicationIdentifier 31560819 /api/publicationidentifier/31560819 PubMed: 41754801 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41754801 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41754801&dopt=Abstract false true PublicationIdentifier 31794261 /api/publicationidentifier/31794261 Other URL: https://www.mdpi.com/1424-8247/19/2/260 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://www.mdpi.com/1424-8247/19/2/260 https://www.mdpi.com/1424-8247/19/2/260 false true Classification 12124 /api/classification/12124 MEDICAL AND HEALTH SCIENCES true true SjrRating 11715891 /api/sjrrating/11715891 sjr:Q1 (2026) Scopus - Drug Discovery PHARMACEUTICALS 1424-8247 33 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 3002 /api/classificationexternal/3002 Scopus - Drug Discovery true 3002 true Q1 FROM_LAST_YEAR true true Reference 72072417 /api/reference/72072417 1. 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(2026) PHARMACEUTICALS 1424-8247 19 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10101444"><a href="/gui2/?type=authors&mode=browse&sel=10101444" target="_blank">Guba Andrea (<span class="authorship-author-name">Guba Andrea</span> <span class="authorAux-mtmt"> Metabolomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biochemistry and Molecular Biology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Department of Biochemistry and Molecular Biology">DBMB</span>/Proteomika Szolgáltató Laboratórium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015365"><a href="/gui2/?type=authors&mode=browse&sel=10015365" target="_blank">Takácsi-Nagy Anna (<span class="authorship-author-name">Takácsi-Nagy Anna Erzsébet</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064119"><a href="/gui2/?type=authors&mode=browse&sel=10064119" target="_blank">Das Sourav (<span class="authorship-author-name">Das Sourav</span> <span class="authorAux-mtmt"> Pharmacy</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Szentágothai Research Centre">SZRC</span>/Molecular Medicine Research Group; <span title="University of Pécs">UP</span>/National Laboratory for Human Reproduction</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043337"><a href="/gui2/?type=authors&mode=browse&sel=10043337" target="_blank">Szokol Bálint (<span class="authorship-author-name">Szokol Bálint</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080260"><a href="/gui2/?type=authors&mode=browse&sel=10080260" target="_blank">Timea Medveczki (<span class="authorship-author-name">Medveczki Tímea</span> <span class="authorAux-mtmt"> molekuláris biológia, szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Pediatrics">DP</span>/"Lendulet" Diabetes Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020339"><a href="/gui2/?type=authors&mode=browse&sel=10020339" target="_blank">Vajna Márton (<span class="authorship-author-name">Vajna Márton Antal</span> <span class="authorAux-mtmt"> gyógyszer-technológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043520"><a href="/gui2/?type=authors&mode=browse&sel=10043520" target="_blank">Kalló Gergő (<span class="authorship-author-name">Kalló Gergő</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biochemistry and Molecular Biology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Department of Biochemistry and Molecular Biology">DBMB</span>/Proteomika Szolgáltató Laboratórium</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011883"><a href="/gui2/?type=authors&mode=browse&sel=10011883" target="_blank">Fekete Andrea (<span class="authorship-author-name">Fekete Andrea</span> <span class="authorAux-mtmt"> nefrológia, gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Pediatrics">DP</span>/"Lendulet" Diabetes Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032759"><a href="/gui2/?type=authors&mode=browse&sel=10032759" target="_blank">Hodrea Judit^** (<span class="authorship-author-name">Hodrea Judit</span> <span class="authorAux-mtmt"> szemészet, diabetológia, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Pediatrics">DP</span>/"Lendulet" Diabetes Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027545"><a href="/gui2/?type=authors&mode=browse&sel=10027545" target="_blank">Csősz Éva ✉ (<span class="authorship-author-name">Csősz Éva</span> <span class="authorAux-mtmt"> Molekuláris biológia, proteomika</span>) </a> </span> <span class="author-affil"><span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/Department of Biochemistry and Molecular Biology; <span title="University of Debrecen">UD</span>/<span title="Faculty of Medicine">Faculty of Medicine</span>/<span title="Department of Biochemistry and Molecular Biology">DBMB</span>/Proteomika Szolgáltató Laboratórium</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36919961" target="_blank">UHPLC-MS-Based Analysis of Fluvoxamine in Rabbit Aqueous Humour and Serum: Method Development and Validation</a></div> <div> <span class="journal-title">PHARMACEUTICALS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1424-8247">1424-8247</a>)</span>: <span class="journal-volume">19</span> <span class="journal-issue">2</span> <span class="page"> Paper 260. 13 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ph19020260" target="_blank" href="https://doi.org/10.3390/ph19020260"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001700173600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001700173600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105031267234" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105031267234"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41754801" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41754801&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.mdpi.com/1424-8247/19/2/260" target="_blank" href="https://www.mdpi.com/1424-8247/19/2/260"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36919961&sort=publishedYear,desc&sort=title"> Number of cited publications: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36919961</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (LP2021-3/2021), (STAGE 2024-1.2.3-HU-RIZONT-2024-00056), (TKP2021-EGA-24) </div> <div class="lastModified">Last Modified: 2026.04.06. 16:23 Anna Erzsébet Takácsi-Nagy (Gyógyszerészet) </div> <pre class="comment" style="margin-top: 0; 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