https://m2.mtmt.hu/ hun 2026-09-22 00:33 JournalArticle 36915713 VALIDATED true 0 false 2026-09-09T11:47:13.624+0000 2026-07-22T09:02:57.609+0000 2026-02-02T11:33:24.808+0000 true 10019965 Ádám Adrienn /api/admin/10019965 Admin Ádám Adrienn (SE_AOK_Genetika_Admin5_ÁA, admin) true 10019965 2026-09-09T11:46:05.306+0000 2026-02-10T08:30:18.120+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Khamari, Delaram true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 27 2 976 976 19 2026 Extracellular vesicles (EVs) are emerging as key factors in maintaining cellular homeostasis, critical mediators of intercellular communication, potential biomarkers, and therapeutic tools. While small EVs have been extensively characterized, the molecular signatures of large EVs (including those generated during regulated cell death pathways) remain poorly defined. Here, we investigated the characteristics of large EVs released during apoptosis and pyroptosis by human monocytic cell lines (THP-1 and U937). Apoptosis was induced by staurosporine and blocked using the pan-caspase inhibitor Q-VD-OPh, whereas pyroptosis was triggered by LPS/nigericin and inhibited with a selective NLRP3 inhibitor. We found that both forms of regulated cell death markedly enhanced the release of large EVs. Both apoptotic and pyroptotic large EVs showed increased Annexin V binding and decreased CD9 expression compared with those released by healthy cells. Large EVs derived from apoptotic and pyroptotic cells exhibited distinct proteomic profiles. Pyroptotic large EVs carried interacting protein networks of RNA-binding proteins and chromatin-associated proteins many of which are known damage-associated molecular patterns or alarmins. In contrast, we found that a subpopulation of apoptotic large EVs was characterized by the presence of dsDNA, and active caspase-3/7. Together, our data shed light on the specific protein cargo of large EVs released by cells during apoptosis and pyroptosis. This study identifies candidate markers of large EVs released by dying cells and may enhance our understanding of the role of EVs in regulated cell death. Funding 2066491 /api/funding/2066491 (NVKP_16-1-2016-0004) Támogató: NKFIH false true Funding 2066492 /api/funding/2066492 (VEKOP-2.3.2-16-2016-00002) Támogató: NKFIH false true Funding 2066493 /api/funding/2066493 (VEKOP-2.3.3-15-2017-00016) false true Funding 2066494 /api/funding/2066494 (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium false true Funding 2066495 /api/funding/2066495 Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH false true Funding 2066496 /api/funding/2066496 (2019-2.1.7-ERA-NET-2021-00015) false true true true 2026 true true true false true false GOLD 2026-09-09 true https://real.mtak.hu/242894 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 D1 441941 false 10015596 false false false 2026-02-09T08:30:17.813+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HUN-REN Kísérleti Orvostudományi Kutatóintézet; HUN-REN-SE Transzlációs Extracelluláris Vezikul... (SE / AOK / I / GSII); Központi Laboratóriumok (HRN SZBK) 9 24 4 12 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 133474401 /api/authorship/133474401 Khamari, Delaram [Khamari, Delaram (Extracellular ves...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HUN-REN-SE Transzlációs Extracelluláris Vezikul... (SE / AOK / I / GSII) 1 0.083 true false false Author 10071730 /api/author/10071730 Khamari Delaram (Extracellular vesicles) Khamari Delaram true true Khamari Delaram true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474402 /api/authorship/133474402 Fekete, Nora [Fekete, Nóra (áramlási citometr...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 2 0.083 false false false Author 10079998 /api/author/10079998 Fekete Nóra (áramlási citometriás módszerfejlesztések, extracelluláris vezikulák vizsgálata) Fekete Nóra true true Fekete Nora true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474403 /api/authorship/133474403 Tamura, Ririka 3 0.083333336 false false false Tamura Ririka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474404 /api/authorship/133474404 Khamari, Raeeka 4 0.083333336 false false false Khamari Raeeka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474405 /api/authorship/133474405 Kittel, Agnes [Kittel, Ágnes (Sejtbiológia), szerző] HUN-REN Kísérleti Orvostudományi Kutatóintézet 5 0.083333336 false false false Author 10009113 /api/author/10009113 Kittel Ágnes (Sejtbiológia) Kittel Ágnes true 10009113 true Kittel Agnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474406 /api/authorship/133474406 Nagy, Bence [Nagy, Bence Péter (Immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 6 0.083 false false false Author 10088971 /api/author/10088971 Nagy Bence Péter (Immunológia) Nagy Bence Péter true true Nagy Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474407 /api/authorship/133474407 Menna, Luigi [Menna, Luigi (Cardiovascular di...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 7 0.083 false false false Author 10094249 /api/author/10094249 Menna Luigi (Cardiovascular diseases EVs) Menna Luigi true true Menna Luigi true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474408 /api/authorship/133474408 Darula, Zsuzsanna [Darula, Zsuzsanna (Proteomika), szerző] Központi Laboratóriumok (HRN SZBK) 8 0.083333336 false false false Author 10013561 /api/author/10013561 Darula Zsuzsanna (Proteomika) Darula Zsuzsanna true 10013561 true Darula Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474409 /api/authorship/133474409 Galinsoga, Alicia [Galinsoga, Alicia (Characterization ...), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HUN-REN-SE Transzlációs Extracelluláris Vezikul... (SE / AOK / I / GSII) 9 0.083 false false false Author 10071729 /api/author/10071729 Galinsoga Alicia (Characterization and investigation of Extracelullar vesicles) Galinsoga Alicia true true Galinsoga Alicia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474410 /api/authorship/133474410 Hunyadi-Gulyas, Eva [Hunyadi-Gulyás Éva, Csilla (Proteomika, fehér...), szerző] Központi Laboratóriumok (HRN SZBK) 10 0.083333336 false false false Author 10010811 /api/author/10010811 Hunyadi-Gulyás Éva Csilla (Proteomika, fehérje tömegspektrometria) Hunyadi-Gulyás Éva Csilla true 10010811 true Hunyadi-Gulyas Eva true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474411 /api/authorship/133474411 Bencze, Maximilien** ✉ 11 0.083 false true true Bencze Maximilien true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 133474412 /api/authorship/133474412 Buzas, Edit I. ✉ [Buzás, Edit Irén (Immunbiológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HUN-REN-SE Transzlációs Extracelluláris Vezikul... 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(2026) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 27 2<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071730"><a href="/gui2/?type=authors&mode=browse&sel=10071730" target="_blank">Khamari Delaram (<span class="authorship-author-name">Khamari Delaram</span> <span class="authorAux-mtmt"> Extracellular vesicles</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HUN-REN-SE Transzlációs Extracelluláris Vezikula Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079998"><a href="/gui2/?type=authors&mode=browse&sel=10079998" target="_blank">Fekete Nora (<span class="authorship-author-name">Fekete Nóra</span> <span class="authorAux-mtmt"> áramlási citometriás módszerfejlesztések, extra...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tamura Ririka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Khamari Raeeka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009113"><a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel Agnes (<span class="authorship-author-name">Kittel Ágnes</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil">HUN-REN Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088971"><a href="/gui2/?type=authors&mode=browse&sel=10088971" target="_blank">Nagy Bence (<span class="authorship-author-name">Nagy Bence Péter</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10094249"><a href="/gui2/?type=authors&mode=browse&sel=10094249" target="_blank">Menna Luigi (<span class="authorship-author-name">Menna Luigi</span> <span class="authorAux-mtmt"> Cardiovascular diseases EVs</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013561"><a href="/gui2/?type=authors&mode=browse&sel=10013561" target="_blank">Darula Zsuzsanna (<span class="authorship-author-name">Darula Zsuzsanna</span> <span class="authorAux-mtmt"> Proteomika</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071729"><a href="/gui2/?type=authors&mode=browse&sel=10071729" target="_blank">Galinsoga Alicia (<span class="authorship-author-name">Galinsoga Alicia</span> <span class="authorAux-mtmt"> Characterization and investigation of Extracelu...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HUN-REN-SE Transzlációs Extracelluláris Vezikula Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010811"><a href="/gui2/?type=authors&mode=browse&sel=10010811" target="_blank">Hunyadi-Gulyas Eva (<span class="authorship-author-name">Hunyadi-Gulyás Éva Csilla</span> <span class="authorAux-mtmt"> Proteomika, fehérje tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Szegedi Biológiai Kutatóközpont">HRN SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bencze Maximilien^** ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015596"><a href="/gui2/?type=authors&mode=browse&sel=10015596" target="_blank">Buzas Edit I. ✉ (<span class="authorship-author-name">Buzás Edit Irén</span> <span class="authorAux-mtmt"> Immunbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HUN-REN-SE Transzlációs Extracelluláris Vezikula Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36915713" target="_blank">Characterization of Large Extracellular Vesicles Released by Apoptotic and Pyroptotic Cells</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">2</span> <span class="page"> Paper 976. 19 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms27020976" target="_blank" href="https://doi.org/10.3390/ijms27020976"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001670600700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001670600700001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="242894" target="_blank" href="https://real.mtak.hu/242894"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105028696904" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105028696904"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41596620" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41596620&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Norvég listás folyóirat</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36915713&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36915713</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (NVKP_16-1-2016-0004) Támogató: NKFIH, (VEKOP-2.3.2-16-2016-00002) Támogató: NKFIH, (VEKOP-2.3.3-15-2017-00016), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (2019-2.1.7-ERA-NET-2021-00015) </div> <div class="lastModified">Utolsó módosítás: 2026.07.22. 11:02 Turek Márta (KOKI admin 4) </div> </div></div>