https://m2.mtmt.hu/ hun 2026-05-02 06:55 JournalArticle 36913927 VALIDATED true 0 false 2026-02-01T17:40:26.902+0000 2026-02-01T17:37:06.887+0000 2026-02-01T17:34:37.251+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 2026-02-01T17:37:07.135+0000 2026-02-01T17:37:07.135+0000 2026-02-01T17:37:07.126+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin true 10015544 false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chang, Chun-Hung Obesity and autonomic dysfunction in schizophrenia: Associations with symptom severity and onset subtypes true true /api/journal/2814 REVIEWED true false 2814 false 2814 true 0022-3956 1879-1379 Journal FOREIGN 191 77 86 77 10 2025 Background: Schizophrenia (SCZ) is associated with elevated cardiometabolic risk, including obesity and autonomic dysfunction. Reduced heart rate variability (HRV), reflecting impaired autonomic nervous system (ANS) function, is linked to increased mortality. Methods: Seventy inpatients with SCZ were evaluated using the Positive and Negative Syndrome Scale (PANSS). HRV was measured via a standardized 5-min protocol evaluating ANS balance, vagal activity (VAG), and standard deviation of normal-to-normal intervals (SDNN). HRV data from 112 age-matched healthy controls were included for comparison. Results: SCZ patients exhibited significantly reduced SDNN compared to controls (17.8 ms vs. 40.5 ms, p < 0.001). Older individuals with obesity exhibited higher HRV than younger, non-obese patients (SDNN: 27.8 ms vs. 14.3 ms, p = 0.019). Early-onset SCZ patients with BMI <24 showed higher PANSS-N (28.3 vs. 22.1, p = 0.012) and PANSS-G scores (41.0 vs. 35.9, p = 0.049) without HRV differences. Conversely, late-onset cases, especially among non-obese patients, was associated with better ANS and VAG indices (ANS: PCC = 0.643, p = 0.01; VAG, PCC = 0.581, p = 0.023). Males had higher white blood cell counts, while females with BMI <24 showed higher PANSS-N scores (p < 0.05). Use of long-acting injectable antipsychotics was linked to higher PANSS-S in non-obese patients (7.4 vs. 4.1, p = 0.036). Conclusion: Autonomic dysfunction is evident in SCZ, particularly in younger, non-obese individuals, and correlates with symptom severity and onset patterns. HRV and ANS metrics may serve as physiomarkers for risk stratification and personalized care. 2026 true true true false false NONE 2026-02-01 false 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q1 false false false false 2026-01-31T17:37:06.828+0000 5 16 0 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 133443993 /api/authorship/133443993 1 0.2 true false false Chang Chun-Hung true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133443994 /api/authorship/133443994 2 0.2 false false false Tsai Hsin-Chi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133443995 /api/authorship/133443995 3 0.2 false false false Wu Sheng-Nan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133443996 /api/authorship/133443996 4 0.2 false false false Tan Han-Ru true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133443997 /api/authorship/133443997 5 0.2 false true true Liu Wen-Chun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31325971 /api/publicationidentifier/31325971 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true 10.1016/j.jpsychires.2025.09.025 https://doi.org/10.1016/j.jpsychires.2025.09.025 false true PublicationIdentifier 31325972 /api/publicationidentifier/31325972 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true 001584985100001 https://www.webofscience.com/wos/woscc/full-record/001584985100001 false true PublicationIdentifier 31325974 /api/publicationidentifier/31325974 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 105017807976 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105017807976 false true PublicationIdentifier 31325973 /api/publicationidentifier/31325973 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true 40974732 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40974732&dopt=Abstract false true Keyword 307 /api/keyword/307 true 307 true Keyword 599 /api/keyword/599 true 599 true Keyword 4805 /api/keyword/4805 true 4805 true Keyword 4817 /api/keyword/4817 true 4817 true Keyword 5854 /api/keyword/5854 true 5854 true Keyword 14105 /api/keyword/14105 true 14105 true Keyword 14206 /api/keyword/14206 true 14206 true Keyword 17892 /api/keyword/17892 true 17892 true Keyword 1009059 /api/keyword/1009059 true 1009059 true Keyword 1044605 /api/keyword/1044605 true 1044605 true Keyword 1057172 /api/keyword/1057172 true 1057172 true Keyword 1068314 /api/keyword/1068314 true 1068314 true Keyword 2400883 /api/keyword/2400883 true true SjrRating 11560889 /api/sjrrating/11560889 13 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2803 /api/classificationexternal/2803 true 2803 true Q1 FROM_LAST_YEAR true true /api/publication/36913927 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Chang Chun-Hung </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsai Hsin-Chi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Wu Sheng-Nan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tan Han-Ru </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu Wen-Chun ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36913927" target="_blank">Obesity and autonomic dysfunction in schizophrenia: Associations with symptom severity and onset subtypes</a></div> <div> <span class="journal-title">JOURNAL OF PSYCHIATRIC RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0022-3956">0022-3956</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1879-1379">1879-1379</a>)</span>: <span class="journal-volume">191</span> <span class="page"> pp 77-86 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/j.jpsychires.2025.09.025" target="_blank" href="https://doi.org/10.1016/j.jpsychires.2025.09.025"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="001584985100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001584985100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105017807976" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105017807976"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="40974732" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=40974732&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36913927&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36913927</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.02.01. 18:37 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> </div></div>