https://m2.mtmt.hu/ hun 2026-09-21 00:18 JournalArticle 36898500 VALIDATED true Funding Agency and Grant Number: American Heart Association [CDA1048544]; National Heart, Lung, and Blood Institute [R01HL163775]; American Federation for Aging Research; Presbyterian Health Foundation; National Institute on Aging [R03AG095868, K01AG073613] Funding text: This work was supported by grants from the American Heart Association (CDA1048544 to PB), the National Institute on Aging (K01AG073613 and R03AG095868 to PB and R01HL163775 to MS), as well as the Seed grant from Presbyterian Health Foundation, Pilot grant from Harold Hamm Diabetes Center (HHDC), and OUHSC College of Medicine Alumni Association (COMAA) to PB. This research was conducted while PB was an AFAR Grant for Junior Faculty awardee, supported by the WoodNext Foundation, a component fund administered by Greater Houston Community Foundation. 0 false 2026-08-27T12:27:53.795+0000 2026-05-16T03:21:24.848+0000 2026-01-26T10:31:59.188+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-08-27T12:26:26.804+0000 2026-05-16T03:21:24.820+0000 true 521 Szuper Admin /api/admin/521 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Otu-Boakye, Sarah Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 48 2 1735 1750 1735 16 2026 Dysregulation in lipid metabolism is increasingly recognized as a key contributor to age-related diseases, including neurodegeneration and cerebrovascular dysfunction. While prior studies have largely focused on glial cells, the impact of lipid dysregulation on brain endothelial aging remains poorly understood. In this study, we conducted a secondary analysis of single-cell transcriptomic data from young and aged mouse brains, with a specific focus on endothelial cells (ECs). Our analyses revealed that aging promotes lipid droplet accumulation in brain ECs. These lipid-laden brain ECs exhibit a transcriptomic signature indicative of impaired blood-brain barrier function, increased cellular senescence, and inflammation in aging. Furthermore, lipid accumulation is associated with an altered metabolic phenotype characterized by increased fatty acid oxidation and decreased glycolysis and impaired mitochondrial electron transport chain activity in the ECs of the aging brain. We have also validated lipid accumulation in aged ECs in vivo. Collectively, our findings indicate that lipid accumulation may drive structural, functional, and metabolic impairments in the brain ECs, likely contributing to cerebrovascular aging. Understanding the mechanisms underlying lipid accumulation-induced endothelial dysfunction may offer novel therapeutic strategies for mitigating microvascular dysfunction and cognitive decline in aging. true 2026 true true true false true false NONE 2026-08-27 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 D1 false false false false 2026-04-26T09:41:20.347+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Gyermekgyógyászati Klinika (SE / AOK / K); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI) 2 21 3 8 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 133341443 /api/authorship/133341443 1 0.125 true false false Otu-Boakye Sarah true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341444 /api/authorship/133341444 2 0.125 false false false Natarajan Duraipandy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341445 /api/authorship/133341445 3 0.125 false false false Plakkot Bhuvana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341446 /api/authorship/133341446 4 0.125 false false false Raghavendiran Ilakiya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341447 /api/authorship/133341447 5 0.125 false false false Author 10103748 /api/author/10103748 Hoppa Paulina true true Hoppa Paulina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341448 /api/authorship/133341448 6 0.125 false false false Author 10071509 /api/author/10071509 Kiss Tamás true true Kiss Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341449 /api/authorship/133341449 7 0.125 false false false Subramanian Madhan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 133341450 /api/authorship/133341450 8 0.125 false true true Balasubramanian Priya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31276305 /api/publicationidentifier/31276305 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s11357-025-01986-y https://doi.org/10.1007/s11357-025-01986-y false true PublicationIdentifier 31276306 /api/publicationidentifier/31276306 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001662248300001 https://www.webofscience.com/wos/woscc/full-record/001662248300001 false true PublicationIdentifier 31276308 /api/publicationidentifier/31276308 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105027780160 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027780160 false true PublicationIdentifier 31276307 /api/publicationidentifier/31276307 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41543825 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41543825&dopt=Abstract false true Keyword 1002283 /api/keyword/1002283 true 1002283 true Keyword 1014859 /api/keyword/1014859 true 1014859 true Keyword 1528399 /api/keyword/1528399 true true Keyword 1713626 /api/keyword/1713626 true true Keyword 4177854 /api/keyword/4177854 true true SjrRating 11734232 /api/sjrrating/11734232 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3401 /api/classificationexternal/3401 true 3401 true D1 FROM_LAST_YEAR true true /api/publication/36898500 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Otu-Boakye Sarah </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Natarajan Duraipandy </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Plakkot Bhuvana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raghavendiran Ilakiya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10103748"><a href="/gui2/?type=authors&mode=browse&sel=10103748" target="_blank">Hoppa Paulina (<span class="authorship-author-name">Hoppa Paulina</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss Tamas (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Subramanian Madhan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian Priya ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36898500" target="_blank">Lipid-laden endothelial cells exhibit a transcriptomic signature linked to blood-brain barrier dysfunction, metabolic reprogramming, and increased inflammation in the aging brain</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">48</span> <span class="journal-issue">2</span> <span class="page"> pp 1735-1750 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01986-y" target="_blank" href="https://doi.org/10.1007/s11357-025-01986-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001662248300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001662248300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105027780160" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027780160"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41543825" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41543825&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36898500&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36898500</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.16. 05:21 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: American Heart Association [CDA1048544]; National Heart, Lung, and Blood Institute [R01HL163775]; American Federation for Aging Research; Presbyterian Health Foundation; National Institute on Aging [R03AG095868, K01AG073613] Funding text: This work was supported by grants from the American Heart Association (CDA1048544 to PB), the National Institute ...</pre> </div></div>