https://m2.mtmt.hu/ hun 2026-10-23 11:43 JournalArticle 36876458 VALIDATED true Funding: This research was funded by the Slovenian Research and Innovation Agency (ARIS) grant P1-0175. The authors also acknowledge the support of the Centre for Research Infrastructure at the University of Ljubljana, Faculty of Chemistry and Chemical Technology, which is part of the Network of Research and Infrastructural Centres UL (MRIC UL) and is also financially supported by ARIS; Infrastructure programme No. I0-0022) for the use of the Supernova diffractometer. The authors thank the mobility support for bilateral international research projects of the Hungarian Academy of Sciences and the Slovenian Academy of Sciences and Arts. EKÖP-604-SZTE University Research Scholarship Programme of the Ministry for Innovation and Technology is also acknowledged (T.P.) 0 false 2026-08-09T20:30:37.352+0000 2026-04-28T06:04:01.006+0000 2026-01-18T06:04:42.052+0000 true 10000675 Enyedy Éva Anna /api/author/10000675 Author true 10000675 2026-05-24T07:24:37.788+0000 2026-02-24T14:23:05.662+0000 true 10097128 Sass Dávid /api/admin/10097128 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Rapuš, Uroš Structure and solution biospeciation on tricarbonylrhenium(I) complexes of mercaptopyrimidines with multifaceted biological activity true true /api/journal/10011727 REVIEWED true false 10011727 false 10011727 true 1756-5901 1756-591X Journal FOREIGN 18 1 mfag002 mfag002 17 2026 In this study, we report the synthesis and detailed characterization of four novel bidentate (N, N) ligands incorporating a 2-(methylthio)pyrimidine moiety and their fac-tricarbonylrhenium(I) complexes (ReB1—ReB4 and ReB1Aq) with the general formula fac-[Re(CO)3(N, N)X]n+, with X = Cl—or H2O and n = 0 or 1. Designed to integrate biologically relevant functionalities, these complexes exhibited promising multifunctional bioactivity. Cytotoxicity assays demonstrated moderate activity (IC50 = 11–78 µM) on various human cancer cell lines, with certain derivatives showing notable selectivity toward the Colo205 line. Most of the chlorido complexes effectively inhibited the replication of Herpes simplex virus type 2, while ReB4 displayed significant antibacterial activity against Staphylococcus aureus, including methicillin-resistant strains (MIC = 12.5–25 µM), and demonstrated biofilm inhibition. Aqueous stability of these organometallic complexes was thoroughly investigated, and complexes ReB2 and ReB3 containing a pyrimidine and a thiazole ring, respectively, gradually decompose in aqueous media, correlating with a decline in anticancer activity. Ligand-exchange processes were observed, in which the chlorido co-ligands were replaced by water, thus affecting the solubility and lipophilicity. The aqua complex ReB1Aq exhibited a low chloride affinity, and the pKa of the coordinated water molecule was obtained to be ∼8. Its interaction with human serum albumin was investigated in detail and was found to be dominated by non-covalent interactions, indicating that no coordination bond formation occurs with the protein. true INTERNATIONAL 2026 true true true false true false GREEN 2026-08-09 true http://publicatio.bibl.u-szeged.hu/38852 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 8 8 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q1 false 10000675,10033330,10048770 false false false 2026-02-23T14:23:05.398+0000 Molekuláris és Analitikai Kémiai Tanszék (SZTE / TTIK / KI); Orvosi Mikrobiológiai Intézet (SZTE / SZAOK) 7 32 2 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 132954285 /api/authorship/132954285 1 0.1 true false false Rapuš Uroš true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132954286 /api/authorship/132954286 2 0.1 false false false Author 10071916 /api/author/10071916 Pivarcsik Tamás true true Pivarcsik Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132954287 /api/authorship/132954287 3 0.1 false false false Author 10033330 /api/author/10033330 Dömötör Orsolya true 10033330 true Dömötör Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true 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/api/authorship/132954292 8 0.1 false false false Turel Iztok true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132954293 /api/authorship/132954293 9 0.1 false false true Kljun Jakob true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132954294 /api/authorship/132954294 10 0.1 false true true Author 10000675 /api/author/10000675 Enyedy Éva Anna true 10000675 true Enyedy Éva A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31207015 /api/publicationidentifier/31207015 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1093/mtomcs/mfag002 https://doi.org/10.1093/mtomcs/mfag002 false true PublicationIdentifier 31278594 /api/publicationidentifier/31278594 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 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RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2506 /api/classificationexternal/2506 true 2506 true Q1 FROM_LAST_YEAR true true /api/publication/36876458 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Rapuš Uroš </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071916"><a href="/gui2/?type=authors&mode=browse&sel=10071916" target="_blank">Pivarcsik Tamás (<span class="authorship-author-name">Pivarcsik Tamás</span> <span class="authorAux-mtmt"> szervetlen kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Molekuláris és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10033330"><a href="/gui2/?type=authors&mode=browse&sel=10033330" target="_blank">Dömötör Orsolya (<span class="authorship-author-name">Dömötör Orsolya</span> <span class="authorAux-mtmt"> kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Molekuláris és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061625"><a href="/gui2/?type=authors&mode=browse&sel=10061625" target="_blank">Nové Márta (<span class="authorship-author-name">Nové Márta</span> <span class="authorAux-mtmt"> orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Molekuláris és Analitikai Kémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074488"><a href="/gui2/?type=authors&mode=browse&sel=10074488" target="_blank">Nyári József (<span class="authorship-author-name">Nyári József</span> <span class="authorAux-mtmt"> Biotechnológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048770"><a href="/gui2/?type=authors&mode=browse&sel=10048770" target="_blank">Bogdanov Anita (<span class="authorship-author-name">Bogdanov Anita</span> <span class="authorAux-mtmt"> Orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012633"><a href="/gui2/?type=authors&mode=browse&sel=10012633" target="_blank">Spengler Gabriella (<span class="authorship-author-name">Spengler Gabriella</span> <span class="authorAux-mtmt"> Orvosi mikrobiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Orvosi Mikrobiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Turel Iztok </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kljun Jakob ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000675"><a href="/gui2/?type=authors&mode=browse&sel=10000675" target="_blank">Enyedy Éva A ✉ (<span class="authorship-author-name">Enyedy Éva Anna</span> <span class="authorAux-mtmt"> Koordinációs Kémia, Bioszervetlen Kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Molekuláris és Analitikai Kémiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36876458" target="_blank">Structure and solution biospeciation on tricarbonylrhenium(I) complexes of mercaptopyrimidines with multifaceted biological activity</a></div> <div> <span class="journal-title">METALLOMICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-5901">1756-5901</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-591X">1756-591X</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">1</span> <span class="page"> Paper mfag002. 17 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1093/mtomcs/mfag002" target="_blank" href="https://doi.org/10.1093/mtomcs/mfag002"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001681222800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001681222800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105029676427" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105029676427"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41543289" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41543289&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://academic.oup.com/metallomics/advance-article/doi/10.1093/mtomcs/mfag002/8427332" target="_blank" href="https://academic.oup.com/metallomics/advance-article/doi/10.1093/mtomcs/mfag002/8427332"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="38852" target="_blank" href="http://publicatio.bibl.u-szeged.hu/38852"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Metals and Alloys&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biomaterials&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biophysics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36876458&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36876458</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.04.28. 08:04 Muhel Anna (SZTE admin5) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding: This research was funded by the Slovenian Research and Innovation Agency (ARIS) grant P1-0175. The authors also acknowledge the support of the Centre for Research Infrastructure at the University of Ljubljana, Faculty of Chemistry and Chemical Technology, which is part of the Network of Research and Infrastructural Centres UL (MRIC UL) and is also financially supported by ARIS; Infra...</pre> </div></div>