https://m2.mtmt.hu/ hun 2026-09-22 12:51 JournalArticle 36874105 VALIDATED true 0 false 2026-07-17T05:46:36.847+0000 2026-05-11T07:23:04.971+0000 2026-01-16T10:39:29.484+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-07-17T05:45:30.005+0000 2026-02-16T10:33:25.927+0000 true 10022176 Laczik Cecilia /api/admin/10022176 Admin true 10022176 Admin 10099440 /api/admin/10099440 Csernyik Rita true true 2026-05-11T05:33:12.697+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Chung, Man-Kyo Tooth Pulp Afferents and Transient Receptor Potential (TRP) Ion Channels as Key Regulators of Pulp Homeostasis, Inflammation, and Pain true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 27 1 182 182 39 2026 Dental pain often arises from the compromised integrity of the tooth pulp due to dental injury or caries. The dentin-pulp complex has long been considered to be central to the unique biology of dental pain. Most trigeminal ganglion afferents projecting into tooth pulp are myelinated neurons, which lose their myelination at the site of peripheral dentin innervation. The pulpal afferents likely combine multiple internal and external stimuli to mediate nociception and maintain pulp homeostasis. Transient receptor potential (TRP) ion channels in neurons and odontoblasts, along with mechanosensitive ion channels such as Piezo, form a key molecular hub for pulpal nociception by sensing thermal, chemical, and hydrodynamic stimuli. Among these, TRP vanilloid 1 (TRPV1) mediates nociception and the release of calcitonin-gene-related peptides (CGRPs), while TRP canonical 5 (TRPC5) mediates cold pain. TRP melastatin 8 (TRPM8) mediates the transduction of hyperosmotic stimuli. Pulpitis elevates endogenous TRPV1 and TRPA1 agonists, while inflammatory mediators sensitize TRP channels, amplifying pain. CGRP recruits immune cells and promotes bacterial clearance and reparative dentinogenesis, yet the roles of TRP channels in these processes remain unclear. Future studies should use advanced multi-omics and in vivo or organotypic models in animal and human teeth to define TRP channel contributions to pain, immune responses, and regeneration. Understanding neuronal and non-neuronal TRP channel interactions and their integration with other ion channels may enable novel analgesic and regenerative strategies in dentistry. true true 2026 true true true false true false GOLD 2026-07-17 false http://www.mdpi.com/journal/ijms 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 14 14 D1 441941 false false false false 2026-01-15T10:43:29.849+0000 Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 1 5 1 3 0 true 10099440 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 132895424 /api/authorship/132895424 1 0.33333334 true false true Chung Man-Kyo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132895425 /api/authorship/132895425 2 0.33333334 false false false Raman Swarnalakshmi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 132895426 /api/authorship/132895426 3 0.333 false true true Author 10064548 /api/author/10064548 Szállási Árpád true 10064548 true Szallasi Arpad true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 31200441 /api/publicationidentifier/31200441 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms27010182 https://doi.org/10.3390/ijms27010182 false true PublicationIdentifier 31200442 /api/publicationidentifier/31200442 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001657440400001 https://www.webofscience.com/wos/woscc/full-record/001657440400001 false true PublicationIdentifier 31437308 /api/publicationidentifier/31437308 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105027006892 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027006892 true true PublicationIdentifier 31200443 /api/publicationidentifier/31200443 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41516061 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41516061&dopt=Abstract false true Keyword 72 /api/keyword/72 true 72 true Keyword 860 /api/keyword/860 true 860 true Keyword 996 /api/keyword/996 true 996 true Keyword 1211 /api/keyword/1211 true 1211 true Keyword 2031 /api/keyword/2031 true 2031 true Keyword 1008926 /api/keyword/1008926 true 1008926 true Keyword 1009320 /api/keyword/1009320 true 1009320 true Keyword 1027370 /api/keyword/1027370 true 1027370 true Keyword 1027391 /api/keyword/1027391 true 1027391 true Keyword 1027393 /api/keyword/1027393 true 1027393 true Keyword 1493330 /api/keyword/1493330 true true Keyword 1507699 /api/keyword/1507699 true true Keyword 1713744 /api/keyword/1713744 true true Keyword 1714886 /api/keyword/1714886 true true Keyword 1958423 /api/keyword/1958423 true true Keyword 4173219 /api/keyword/4173219 true true Keyword 4173220 /api/keyword/4173220 true true PredatorRating 11781719 /api/predatorrating/11781719 RatingType 10033 /api/ratingtype/10033 norveg true true 441941 true true SjrRating 11676124 /api/sjrrating/11676124 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 FROM_LAST_YEAR true true /api/publication/36874105 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Chung Man-Kyo ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Raman Swarnalakshmi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064548"><a href="/gui2/?type=authors&mode=browse&sel=10064548" target="_blank">Szallasi Arpad ✉ (<span class="authorship-author-name">Szállási Árpád</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36874105" target="_blank">Tooth Pulp Afferents and Transient Receptor Potential (TRP) Ion Channels as Key Regulators of Pulp Homeostasis, Inflammation, and Pain</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">1</span> <span class="page"> Paper 182. 39 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms27010182" target="_blank" href="https://doi.org/10.3390/ijms27010182"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001657440400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001657440400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105027006892" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027006892"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41516061" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41516061&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Norvég listás folyóirat</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36874105&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 14 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36874105</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.11. 09:23 Csernyik Rita (MTMT központi admin) </div> <div class="lockedBy">Központi kezelésű 2026.05.11. 07:33 Csernyik Rita (MTMT központi admin) </div> </div></div>