https://m2.mtmt.hu/ hun 2026-10-23 11:43 JournalArticle 36710206 VALIDATED true Export Date: 03 June 2026; Cited By: 0; Correspondence Address: E. Pandur; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, Pécs, H-7624, Hungary; email: pandur.edina@gytk.pte.hu 0 false 2026-09-13T21:26:38.583+0000 2026-06-03T02:15:00.093+0000 2025-12-29T12:20:24.073+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-06-03T02:14:59.945+0000 2025-12-29T16:17:58.722+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Horváth, Adrienn Iron, the Essential Micronutrient: A Comprehensive Review of Regulatory Pathways of Iron Metabolism true true /api/journal/10016563 REVIEWED true false 10016563 false 10016563 true 2072-6643 Journal FOREIGN 18 109 109 27 2026 Iron constitutes an essential micronutrient in living organisms. All iron is absorbed into the body through dietary intake, except for exogenous therapeutic sources. Dietary iron is typically categorized as either heme or nonheme iron. Nonheme iron is essential for regulating iron in the body, as it exists in various forms, including soluble iron, storage iron within ferritin, and iron found in the catalytic centers of a wide range of proteins. Iron homeostasis is carefully managed to ensure that sufficient iron is available for critical biological processes while preventing the harmful effects that can arise from excess iron. The small peptide hormone hepcidin is the main regulator of iron homeostasis. Hepcidin and other iron regulatory molecules are regulated by various signaling pathways, such as IL-6/JAK-STAT, BMP/SMAD, and MAPK. Alterations in regulatory pathways may occur in response to iron accumulation or deficiency. Iron overload in the body can activate JAK/STAT, BMP/SMAD and MAPK pathways, leading to the initiation hepcidin synthesis. Conversely, in iron deficiency, as in hypoxic conditions or EPO-mediated signaling pathways, HAMP synthesis in the nucleus is reduced. Thus, this review provides an update on the possible regulatory pathways that play a role in iron regulation and may be potential therapeutic targets. 2025 true true true false false GOLD 2026-09-13 true https://doi.org/10.3390/nu18010109 11 0 10 9 0 11 10 1 0 1 1 1 1 10 1 0 11 10 10 9 0 11 11 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 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10066876 /api/author/10066876 Jánosa Gergely true true Jánosa Gergely true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 131353770 /api/authorship/131353770 5 0.2 false true true Author 10019183 /api/author/10019183 Pandur Edina true 10019183 true Pandur Edina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30825872 /api/publicationidentifier/30825872 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/nu18010109 https://doi.org/10.3390/nu18010109 false true PublicationIdentifier 31199848 /api/publicationidentifier/31199848 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001657553200001 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/api/keyword/1013269 true 1013269 true Keyword 1524793 /api/keyword/1524793 true true Keyword 1531845 /api/keyword/1531845 true true Keyword 1761333 /api/keyword/1761333 true true Keyword 2295792 /api/keyword/2295792 true true SjrRating 11658342 /api/sjrrating/11658342 25 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1106 /api/classificationexternal/1106 true 1106 true D1 FROM_LAST_YEAR true true /api/publication/36710206 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064729"><a href="/gui2/?type=authors&mode=browse&sel=10064729" target="_blank">Horváth Adrienn (<span class="authorship-author-name">Horváth Adrienn</span> <span class="authorAux-mtmt"> Gyógyszertudomány</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10088315"><a href="/gui2/?type=authors&mode=browse&sel=10088315" target="_blank">Tamási Kitti (<span class="authorship-author-name">Tamási Kitti</span> <span class="authorAux-mtmt"> biológia tudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059999"><a href="/gui2/?type=authors&mode=browse&sel=10059999" target="_blank">Pap Ramóna (<span class="authorship-author-name">Pap Ramóna</span> <span class="authorAux-mtmt"> Gyógyszerészi biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066876"><a href="/gui2/?type=authors&mode=browse&sel=10066876" target="_blank">Jánosa Gergely (<span class="authorship-author-name">Jánosa Gergely</span> <span class="authorAux-mtmt"> Orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019183"><a href="/gui2/?type=authors&mode=browse&sel=10019183" target="_blank">Pandur Edina ✉ (<span class="authorship-author-name">Pandur Edina</span> <span class="authorAux-mtmt"> Gyógyszerészi biológia</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Biológia Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36710206" target="_blank">Iron, the Essential Micronutrient: A Comprehensive Review of Regulatory Pathways of Iron Metabolism</a></div> <div> <span class="journal-title">NUTRIENTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6643">2072-6643</a>)</span>: <span class="journal-volume">18</span> <span class="page"> Paper 109. 27 p. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/nu18010109" target="_blank" href="https://doi.org/10.3390/nu18010109"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001657553200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001657553200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105026972284" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105026972284"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41515226" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41515226&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Food Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Nutrition and Dietetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 10 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36710206&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36710206</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.03. 04:15 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 03 June 2026; Cited By: 0; Correspondence Address: E. Pandur; Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Pécs, Pécs, H-7624, Hungary; email: pandur.edina@gytk.pte.hu</pre> </div></div>