https://m2.mtmt.hu/ eng 2026-10-25 17:08 JournalArticle 36490553 VALIDATED true * Megosztott szerzőség 0 false 2026-10-09T17:02:11.132+0000 2026-03-11T07:52:03.667+0000 2025-12-12T20:49:46.148+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-06-13T09:59:24.522+0000 2026-01-30T12:46:25.951+0000 true 10097129 Vékony-Pap Lili /api/admin/10097129 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Creanga-Murariu, Ioana Multifaced roles of cannabinoid therapy in cancer : balancing analgesia, antitumor potential, and systemic toxicity true true /api/journal/10026753 REVIEWED true false 10026753 false 10026753 true 1663-9812 Journal FOREIGN 16 1691893 1691893 18 2025 Cannabinoids hold promise in oncology for symptom relief and antitumor effects, though concerns about safety and efficacy persist. This study assessed the impact of JWH-182 and phytocannabinoids NC1 - Cannabixir® Medium dried flowers and NC2 - Cannabixir® THC full extract, in a murine breast cancer model with paclitaxel-induced peripheral neuropathy (CIPN).Female BALB/c mice with breast tumors received paclitaxel alone or combined with cannabinoids, and outcomes included pain sensitivity, tumor progression (imaging and histopathology), cachexia (body weight, food intake, imaging), as well as hematological and organ toxicity profiles.All cannabinoids alleviated neuropathic pain, with NC1 most effective for central and thermal protection (72% and 100%, p < 0.0001), NC2 showing strong central and mechanical benefit (>60% and >33%), and JWH-182 intermediate (∼50%). Tumor growth was not significantly altered, but metastasis incidence was 41.7% for NC1, 58.3% for NC2, compared with 70% for PTX, suggesting antitumoral activity. Effects on cachexia were modest, JWH-182 tended to improve food intake, whereas NC1 and NC2 reduced it, yet body weight remained stable and significant muscle loss was observed only with NC2 (p < 0.05). Hematology showed immunomodulatory effects, with cannabinoids reversing lymphopenia (p = 0.0005), raising monocytes and neutrophils, and partly restoring platelets. Toxicity was highest with NC2 (renal and hepatic injury), moderate with NC1, and lowest for kidney with JWH-182 but with greater hepatic inflammation.Cannabinoids show potential in oncology by relieving CIPN and influencing tumor dynamics, with mostly neutral effects on cachexia. GMP-certified formulations enhance translational value, though safety concerns warrant further study. 2025 true true true false true false GOLD 2026-10-09 false https://www.frontiersin.org/journals/pharmacology 2 0 2 0 0 2 2 2 2 2 2 0 0 0 2 0 2 0 2 0 0 0 0 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 2 0 2 0 Q1 false false false false 2025-12-14T10:15:17.669+0000 Interdiszciplináris Kutatásfejlesztési és Innov... (SZTE); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 2 27 4 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128874764 /api/authorship/128874764 1 0.059 true false false Author 10089643 /api/author/10089643 Creanga-Murariu Ioana true true Creanga-Murariu Ioana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128874765 /api/authorship/128874765 2 0.059 true false false Ciorpac Mitica true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128874766 /api/authorship/128874766 3 0.05882353 false false false Gogu Raluca-Maria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128874767 /api/authorship/128874767 4 0.05882353 false false false Pricope Cosmin-Vasilica true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 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/api/publication/36490553 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10089643"><a href="/gui2/?type=authors&mode=browse&sel=10089643" target="_blank">Creanga-Murariu Ioana (<span class="authorship-author-name">Creanga-Murariu Ioana</span> <span class="authorAux-mtmt"> pharmacology</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ciorpac Mitica<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gogu Raluca-Maria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pricope Cosmin-Vasilica </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bild Veronica </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ababei Daniela-Carmen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Filipiuc Leontina-Elena </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szilagyi Andrei </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Josan Claudiu-Laurentiu </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Caruntu Irina-Draga </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lozneanu Ludmila </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Timofte Andrei </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Solcan Carmen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scripcariu Dragos-Viorel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Peter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="University of Szeged">SZTE</span>/Centre of Excellence for Interdisciplinary Research, Development and Innovation</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Alexa-Stratulat Teodora ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tamba Bogdan-Ionel </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36490553" target="_blank">Multifaced roles of cannabinoid therapy in cancer : balancing analgesia, antitumor potential, and systemic toxicity</a></div> <div> <span class="journal-title">FRONTIERS IN PHARMACOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1663-9812">1663-9812</a>)</span>: <span class="journal-volume">16</span> <span class="page"> Paper 1691893. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fphar.2025.1691893" target="_blank" href="https://doi.org/10.3389/fphar.2025.1691893"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001631705900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001631705900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105024013860" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105024013860"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41357884" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41357884&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://www.frontiersin.org/articles/10.3389/fphar.2025.1691893/full" target="_blank" href="https://www.frontiersin.org/articles/10.3389/fphar.2025.1691893/full"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 2</span> | Independent citation: 0 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 2 | Number of citations in Scopus:&nbsp;2 | WoS/Scopus assigned:&nbsp;2 | Number of citations with DOI:&nbsp;2 </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36490553</span> | <span class="status-data status-VALIDATED"> Validated </span> Core | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2026.03.11. 08:52 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: * Megosztott szerzőség</pre> </div></div>