https://m2.mtmt.hu/ hun 2026-05-02 17:56 BookChapter 36468793 VALIDATED true Export Date: 11 March 2026; Cited By: 0; 0 false 2026-03-12T13:10:07.490+0000 2026-03-11T13:16:28.352+0000 2025-12-03T08:01:36.327+0000 true 10088017 Szatmári Erika /api/admin/10088017 Admin Szatmári Erika (BME admin4) true 2026-03-12T08:17:25.220+0000 2026-03-12T08:17:25.220+0000 2026-01-23T09:27:55.242+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin Andódy Katalin (BME admin4) true true false true 25 25 /api/publicationtype/25 PublicationType Könyvrészlet 2 true 25 BookChapter true 10000398 Chapter true 25 25 /api/publicationtype/25 PublicationType Könyvrészlet 2 true 25 BookChapter /api/subtype/10000398 Könyvfejezet SubType Könyvfejezet (Könyvrészlet) 220 true 10000398 true 1 /api/category/1 Category Tudományos true 1 Szalai, Zsuzsanna 67 87 Chapter 4 67, Chapter 4 21 2026 This chapter focuses on the synthesis of phosphonates relevant for pharmaceutical applications due to their real or potential biological activity. The classes of compounds discussed embrace α-hydroxyphosphonates, methylenebisphosphonates, and dronic acid derivatives. The latter species are useful in the treatment of illnesses including osteoporosis or cancer diseases. The Pudovik reaction is the most common method for the synthesis of α-hydroxyphosphonates. Another pathway for their synthesis is the Abramov reaction. In addition, hydroxyphosphonates may be prepared from α-oxophosphonates by reaction with Grignard reagents, or by the oxidation of alkylphosphonates. Additional potentially bioactive compounds may be obtained by the modification of hydroxyphosphonates by acylation, alkylation, nucleophilic substitution, oxidation, rearrangement and hydrolysis. Hydroxy-methylenebisphosphonates may be obtained by the addition reaction of dialkyl phosphites or diarylphosphine oxides to the C=O group of the α-oxophosphonates. Base catalysts, for example, dialkylamines are applied in this reaction. Using less catalyst at a lower temperature, the adduct is the major component, while using more catalyst at a higher temperature, the rearranged product predominates. The outcome may also be influenced by the substitution pattern. Dronic acids are usually prepared from the corresponding carboxylic acid derivative using various phosphorus reagents, such as phosphorus trichloride and phosphorous acid. Methanesulfonic acid (MSA) and sulfolane are the most often used solvents. When using MSA, there is a need only for phosphorus trichloride. On the one hand, it forms a mixed anhydride with the carboxylic acid, on the other hand, it may form an even more active phosphorus reagent in reaction with phosphorus trichloride. In sulfolane, both phosphorus trichloride and phosphorous acid are needed. Phosphorus trichloride reacts with a carboxylic acid to form an acid chloride, and also forms a dimer or a trimer condensate with phosphorous acid. These species react with either the acid chloride or the carboxylic acid, leading to the formation of ketophosphonic acid, which is further transformed via intermediate steps to establish the dronic acid. NATIONAL 2025 true true true false false NONE 2026-03-12 false 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 25 25 false false false false 2025-12-02T08:01:42.676+0000 Szerves Kémia és Technológia Tanszék (BME / VBK) 2 12 1 2 0 true true 10002 English /api/language/10002 Angol Language Angol true 2 false true 18501 true 10023 /api/country/10023 Country Hollandia true 19 /api/city/18501 City Amsterdam, Hollandia true true 10483 true 10175 /api/country/10175 Country Egyesült Királyság / Anglia true 2151760 /api/city/10483 City London, Egyesült Királyság / Anglia true 1022850 true 14686 true 10017 /api/country/10017 Country Amerikai Egyesült Államok true 13 /api/city/14686 City Cambridge, Amerikai Egyesült Államok true 10005908 true 30258574 /api/publicationidentifier/30258574 https://doi.org/10.1016/C2024-0-00017-3 10.1016/C2024-0-00017-3 PublicationIdentifier DOI: 10.1016/C2024-0-00017-3 true 6 DOI https://doi.org/@@@ /api/publicationsource/6 DOI PlainSource DOI true true 10001 /api/publicationsourcetype/10001 PublicationSourceType DOI true true 6 true false true 30258573 /api/publicationidentifier/30258573 https://www.worldcat.org/search?q=isbn%3A9780443333743 9780443333743 PublicationIdentifier ISBN: 9780443333743 true 122 ISBN https://www.worldcat.org/search?q=isbn%3A@@@ /api/publicationsource/122 ISBN PlainSource ISBN true true 10002 /api/publicationsourcetype/10002 PublicationSourceType Egyéb true false 122 true false /api/publication/36468792 Demadis Konstantinos D.. Phosphonate Chemistry, Technology, and Applications: Synthesis, Chemistry, and Biomedical Applications. (2026) ISBN:9780443333743 true true 23 23 /api/publicationtype/23 PublicationType Könyv 3 true 23 Book false false 36468792 false true false true true 10000201 Monograph true 23 23 /api/publicationtype/23 PublicationType Könyv 3 true 23 Book /api/subtype/10000201 Szakkönyv SubType Szakkönyv (Könyv) 337 true 10000201 true Book 2026 true 1 /api/category/1 Category Tudományos true 1 false Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 128739475 /api/authorship/128739475 Szalai, Zsuzsanna [Szalai, Zsuzsanna (szerves kémia), szerző] Szerves Kémia és Technológia Tanszék (BME / VBK) 1 0.5 true false false Author 10082338 /api/author/10082338 Szalai Zsuzsanna (szerves kémia) Szalai Zsuzsanna true true Szalai Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128739476 /api/authorship/128739476 Keglevich, György [Keglevich, György (Szerves kémia, fo...), szerző] Szerves Kémia és Technológia Tanszék (BME / VBK) 2 0.5 false true false Author 1272454 /api/author/1272454 Keglevich György (Szerves kémia, foszfororganikus környezetbarát kémia) Keglevich György true 1272454 true Keglevich György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 30258575 /api/publicationidentifier/30258575 DOI: 10.1016/B978-0-443-33374-3.00040-2 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1016/B978-0-443-33374-3.00040-2 https://doi.org/10.1016/B978-0-443-33374-3.00040-2 false true PublicationIdentifier 31260149 /api/publicationidentifier/31260149 Scopus: 105027096408 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 105027096408 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027096408 false true PublicationIdentifier 30258576 /api/publicationidentifier/30258576 Egyéb URL: https://linkinghub.elsevier.com/retrieve/pii/B9780443333743000402 PlainSource 40 /api/publicationsource/40 Egyéb URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true IDENTICAL https://linkinghub.elsevier.com/retrieve/pii/B9780443333743000402 https://linkinghub.elsevier.com/retrieve/pii/B9780443333743000402 false true Classification 10293 /api/classification/10293 Kémiai tudományok true true Reference 70478017 /api/reference/70478017 1. 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(2026) Megjelent: Phosphonate Chemistry, Technology, and Applications pp. 67-87<div class="BookChapter Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10082338"><a href="/gui2/?type=authors&mode=browse&sel=10082338" target="_blank">Szalai Zsuzsanna (<span class="authorship-author-name">Szalai Zsuzsanna</span> <span class="authorAux-mtmt"> szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1272454"><a href="/gui2/?type=authors&mode=browse&sel=1272454" target="_blank">Keglevich György (<span class="authorship-author-name">Keglevich György</span> <span class="authorAux-mtmt"> Szerves kémia, foszfororganikus környezetbarát ...</span>) </a> </span> <span class="author-affil"><span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Vegyészmérnöki és Biomérnöki Kar">VBK</span>/Szerves Kémia és Technológia Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36468793" target="_blank">Synthesis of phosphonates for pharmaceutical applications</a></div> <div class="InBook"><div class="chapter-in">In:</div> <div class="authors"> <div class="autype autype-1"> <span class="author-name" >Demadis Konstantinos D. </span> (szerk.) </div> </div> <div class="booktitle"><a href="/gui2/?mode=browse&params=publication;36468792" target="_blank">Phosphonate Chemistry, Technology, and Applications : Synthesis, Chemistry, and Biomedical Applications </a></div> <span class="publishedAt">Amsterdam,</span> <span class="publishedAt">London,</span> <span class="publishedAt">Cambridge: <span class="publishers">Elsevier</span>, <span class="page"> pp 67-87 Paper Chapter 4. </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/B978-0-443-33374-3.00040-2" target="_blank" href="https://doi.org/10.1016/B978-0-443-33374-3.00040-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105027096408" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105027096408"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://linkinghub.elsevier.com/retrieve/pii/B9780443333743000402" target="_blank" href="https://linkinghub.elsevier.com/retrieve/pii/B9780443333743000402"> Egyéb URL </a> </span> </span> <span class="bookchapter-ids">Befoglaló link(ek):</span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:black" title="10.1016/C2024-0-00017-3" target="_blank" href="https://doi.org/10.1016/C2024-0-00017-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <span class="isbnOrIssn"> ISBN: </span> <a style="color:black" title="9780443333743" target="_blank" href="https://www.worldcat.org/search?q=isbn%3A9780443333743"> 9780443333743 </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36468793&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 25 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36468793</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="long-book-mtid">Befoglaló: 36468792</span> Forrás Idéző | <span class="type-subtype">Könyvrészlet ( Könyvfejezet ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DOI XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.03.11. 14:16 Szatmári Erika (BME admin4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 11 March 2026; Cited By: 0;</pre> </div> </div>