https://m2.mtmt.hu/ hun 2026-09-22 03:49 JournalArticle 36463729 VALIDATED true Funding Agency and Grant Number: International Excellence Research Cooperation Program [2024-1.2.3-HU-RIZONT]; Hungarian National Scientific Research Fund [OTKA-138223]; European Union [2.3.1-21-2022-00003] Funding text: This research was funded by the International Excellence Research Cooperation Program 2024-1.2.3-HU-RIZONT and supported by the Hungarian National Scientific Research Fund (OTKA-138223). This study was also supported by project no. 2.3.1-21-2022-00003 'National Heart Laboratory, Hungary', implemented with the support of the European Union. 0 false 2026-08-10T20:25:49.940+0000 2025-12-09T11:57:58.356+0000 2025-11-29T18:33:02.961+0000 true 10026589 Tichy Rita /api/admin/10026589 Admin Tichy Rita (SE_KK_Admin5_TR, admin) true 10026589 2026-03-27T10:22:02.993+0000 2026-03-27T10:22:02.993+0000 2025-12-01T13:24:49.939+0000 true 10097128 Sass Dávid /api/admin/10097128 Admin Sass Dávid (SZTE admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Itani, Nadja true true /api/journal/10051562 REVIEWED CELLS 2073-4409 true false 10051562 false 10051562 true 2073-4409 Journal FOREIGN 14 22 1748 1748 13 2025 Through binding to complementary mRNAs, microRNAs (miRNAs) mediate gene silencing. The stability and half-life of microRNAs are controlled by two isoforms of the RNA-binding protein Roquin. This study aimed at identifying the role of Roquin to miRNA-dependent regulation of the transcriptome in the post-ischemic heart. Both Roquin isoforms are highly conserved between rats and humans and constitutively expressed in cardiomyocytes. In both cell species, hypoxia induces a down-regulation of Roquin-1 and Roquin-2. An integrative miRNA-and-mRNA analysis (MMIA) identified miR-23b-5p as a potential interaction partner of Roquins. The open data bank TargetScan8.0 suggests that the transcription factor ZBTB20 is a potential target of miR-23b-5p. The level of expression of ZBTB20 correlated with the functional recovery of rat hearts after myocardial infarction. Moreover, the down-regulation of Roquin-2 in AC16 cells by siRNA under normoxic conditions was associated with an up-regulation of miR-23b-5p and a down-regulation of ZBTB20. Furthermore, in the case of hypoxia-dependent down-regulation of Roquin, the subsequent down-regulation of ZBTB20 was reversed with the help of an antagomir against miR-23b-5p. In conclusion, hypoxia-induced down-regulation of the two Roquin isoforms was associated with an increased stability of miR-23b-5p, a Roquin-2-dependent miRNA, which subsequently led to silencing of the transcription factor ZBTB20. 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(SE / KSZE) 2 20 3 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 128715095 /api/authorship/128715095 Itani, Nadja 1 0.16666667 true false false Itani Nadja true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128715096 /api/authorship/128715096 Schreckenberg, Rolf 2 0.16666667 false false false Schreckenberg Rolf true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128715097 /api/authorship/128715097 Schulz, Rainer 3 0.16666667 false false false Schulz Rainer true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128715098 /api/authorship/128715098 Bencsik, Peter [Bencsik, Péter (Experimentális ka...), szerző] Farmakológiai és Farmakoterápiai Intézet (SZTE / SZAOK) 4 0.16666667 false false false Author 10022542 /api/author/10022542 Bencsik Péter (Experimentális kardiológia) Bencsik Péter true 10022542 true Bencsik Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128715099 /api/authorship/128715099 Ferdinandy, Peter [Ferdinandy, Péter (Farmakológia, mol...), szerző] Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE) 5 0.167 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter (Farmakológia, molekuláris medicina) Ferdinandy Péter true 10010125 true Ferdinandy Peter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128715100 /api/authorship/128715100 Schlüter, Klaus-Dieter ✉ 6 0.167 false true true Schlüter Klaus-Dieter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 30245104 /api/publicationidentifier/30245104 DOI: 10.3390/cells14221748 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/cells14221748 https://doi.org/10.3390/cells14221748 false true PublicationIdentifier 30250641 /api/publicationidentifier/30250641 WoS: 001623586400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001623586400001 https://www.webofscience.com/wos/woscc/full-record/001623586400001 true true PublicationIdentifier 30254140 /api/publicationidentifier/30254140 Scopus: 105022916743 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105022916743 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105022916743 true true PublicationIdentifier 30250661 /api/publicationidentifier/30250661 PubMed: 41294801 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41294801 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41294801&dopt=Abstract true true PublicationIdentifier 32441473 /api/publicationidentifier/32441473 SZTE Publicatio: 40250 SwordSource 90 /api/publicationsource/90 SZTE Publicatio PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 40250 http://publicatio.bibl.u-szeged.hu/40250 false true SjrRating 11560399 /api/sjrrating/11560399 sjr:Q1 (2025) Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) CELLS 2073-4409 38 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1301 /api/classificationexternal/1301 Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous) true 1301 true Q1 DIRECT true true Reference 70373723 /api/reference/70373723 1. 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(2025) CELLS 2073-4409 14 22<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Itani Nadja </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schreckenberg Rolf </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schulz Rainer </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10022542"><a href="/gui2/?type=authors&mode=browse&sel=10022542" target="_blank">Bencsik Peter (<span class="authorship-author-name">Bencsik Péter</span> <span class="authorAux-mtmt"> Experimentális kardiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Farmakológiai és Farmakoterápiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Peter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schlüter Klaus-Dieter ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36463729" target="_blank">Roquin Modulates Cardiac Post-Infarct Remodeling via microRNA Stability Control</a></div> <div> <span class="journal-title">CELLS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2073-4409">2073-4409</a>)</span>: <span class="journal-volume">14</span> <span class="journal-issue">22</span> <span class="page"> Paper 1748. 13 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/cells14221748" target="_blank" href="https://doi.org/10.3390/cells14221748"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001623586400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001623586400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105022916743" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105022916743"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41294801" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41294801&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="40250" target="_blank" href="http://publicatio.bibl.u-szeged.hu/40250"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36463729&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36463729</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (2024-1.2.3-HU-RIZONT), (OTKA-138223), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2025.12.09. 12:57 Baczkó Gabriella (SZTE SZAOK admin5 Szemészeti Klinika) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: International Excellence Research Cooperation Program [2024-1.2.3-HU-RIZONT]; Hungarian National Scientific Research Fund [OTKA-138223]; European Union [2.3.1-21-2022-00003] Funding text: This research was funded by the International Excellence Research Cooperation Program 2024-1.2.3-HU-RIZONT and supported by the Hungarian National Scientific Resear...</pre> </div></div>