https://m2.mtmt.hu/ hun 2026-10-25 08:58 JournalArticle 36455719 VALIDATED true Funding Agency and Grant Number: Ministry of Culture and Innovation; National Research, Development and Innovation Office [TKP2021-EGA-02]; National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program [National Tumor Biology Laboratory] [2022-2.1.1-NL-2022-00010]; National Research, Development and Innovation Office Funding text: This research was funded by the Ministry of Culture and Innovation and the National Research, Development and Innovation Office under Grant Nr. TKP2021-EGA-02.The project was implemented with support from the National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program [National Tumor Biology Laboratory (2022-2.1.1-NL-2022-00010) ] Grant Agreement with the National Research, Development and Innovation Office. 0 false 2026-05-19T15:04:23.675+0000 2026-05-19T15:02:51.521+0000 2025-11-25T14:46:15.421+0000 true 10072271 Andódy Katalin /api/admin/10072271 Admin true 2026-05-19T15:02:51.230+0000 2026-01-14T12:08:43.075+0000 true 10101957 Pirmann Tamás /api/admin/10101957 Admin true 2026-01-16T10:46:47.612+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szegedi, Domonkos Quality of density deformations in patient anatomy during synthetic CT guided online adaptive radiation therapy for pelvic cancer true true /api/journal/10004858 REVIEWED true false 10004858 false 10004858 true 1507-1367 2083-4640 Journal FOREIGN 30 5 649 656 649 8 2025 Background: Online adaptive radiotherapy (oART) with cone-beam computed tomography (CBCT) enables real-time plan adaptation to daily anatomical changes in the patient. Synthetic CTs (sCTs), generated by deforming planning CTs (pCTs) to CBCTs, are crucial for precise dose calculations. However, variations such as gaseous volumes in the pelvis may impact alignment accuracy. Materials and methods: This retrospective study analyzed 90 treatment fractions for nine patients with cancer in the pelvic region, treated with CBCT-guided oART on the Ethos system. SCTs were generated and compared to corresponding CBCTs using similarity metrics, focusing on bony structures, external body contours, and gaseous volumes. Symmetric differences and Dice Similarity Coefficients (DSC) were calculated to evaluate the registration accuracy. Results: Bony structure deformations were minor (average volume change 0.2%, DSC 0.89). External body contours on sCTs aligned closely with CBCT (mean deviation 1.0 ± 0.4%), while gaseous volumes exhibited lower alignment (DSC < 0.5 in many fractions). Gaseous volume discrepancies were independent of the pCT and showed time-dependent variability, emphasizing the challenges in adapting density maps. Only a small portion of the gaseous volume differences overlapped with the planning target volume (PTV), suggesting limited direct impact on dose calculation. Conclusions: CBCT-based sCT adaptation effectively aligns external contours but does not accurately handle gaseous volumes, which may vary in great extent. Minimizing the time between CBCT acquisition and treatment is crucial to maintain alignment accuracy. Advanced imaging solutions enabling direct dose calculation without involving sCT generation could further enhance dose reconstruction but may not resolve the time-sensitive nature of gaseous volume changes. © 2025 Greater Poland Cancer Centre. Funding 2060020 /api/funding/2060020 false true Funding 2060053 /api/funding/2060053 false true true NATIONAL 2025 true true true false true false GOLD 2026-05-19 true https://doi.org/10.5603/rpor.108009 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2025-11-24T16:12:30.165+0000 Fizikai Tudományok Doktori Iskola (BME / EHBDT); Nukleáris Technika Tanszék (BME / TTK / NTI); Onkológiai Tanszék (SE / AOK / K); Országos Onkológiai Intézet 5 17 4 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128670178 /api/authorship/128670178 1 0.2 true false true Author 10075032 /api/author/10075032 Szegedi Domonkos true true Szegedi Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128670179 /api/authorship/128670179 2 0.2 false false false Author 10042823 /api/author/10042823 Stelczer Gábor true 10042823 true Stelczer Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128670180 /api/authorship/128670180 3 0.2 false false false Author 10044386 /api/author/10044386 Major Tibor true 10044386 true Major Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128670181 /api/authorship/128670181 4 0.2 false false false Author 10013883 /api/author/10013883 Takácsi-Nagy Zoltán true 10013883 true Takácsi-Nagy Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128670182 /api/authorship/128670182 5 0.2 false true false Author 10018107 /api/author/10018107 Pesznyák Csilla true 10018107 true Pesznyák Csilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30221405 /api/publicationidentifier/30221405 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.5603/rpor.108009 https://doi.org/10.5603/rpor.108009 false true PublicationIdentifier 31199494 /api/publicationidentifier/31199494 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001654802400001 https://www.webofscience.com/wos/woscc/full-record/001654802400001 false true PublicationIdentifier 30221404 /api/publicationidentifier/30221404 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105021497999 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021497999 false true PublicationIdentifier 31199495 /api/publicationidentifier/31199495 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 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true 1486788 true Keyword 1510190 /api/keyword/1510190 true true Keyword 1510751 /api/keyword/1510751 true true Keyword 1864206 /api/keyword/1864206 true true Keyword 2002324 /api/keyword/2002324 true true Keyword 2188248 /api/keyword/2188248 true true Keyword 2549817 /api/keyword/2549817 true true Keyword 2824042 /api/keyword/2824042 true true Keyword 3937330 /api/keyword/3937330 true true SjrRating 11618807 /api/sjrrating/11618807 156 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2741 /api/classificationexternal/2741 true 2741 true Q2 DIRECT true true /api/publication/36455719 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10075032"><a href="/gui2/?type=authors&mode=browse&sel=10075032" target="_blank">Szegedi Domonkos ✉ (<span class="authorship-author-name">Szegedi Domonkos</span> <span class="authorAux-mtmt"> orvosi fizikus</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Egyetemi Habilitációs Bizottság és Doktori Tanács">EHBDT</span>/Fizikai Tudományok Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042823"><a href="/gui2/?type=authors&mode=browse&sel=10042823" target="_blank">Stelczer Gábor (<span class="authorship-author-name">Stelczer Gábor</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Nukleáris Technikai Intézet">NTI</span>/Nukleáris Technika Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044386"><a href="/gui2/?type=authors&mode=browse&sel=10044386" target="_blank">Major Tibor (<span class="authorship-author-name">Major Tibor</span> <span class="authorAux-mtmt"> klinikai sugárfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013883"><a href="/gui2/?type=authors&mode=browse&sel=10013883" target="_blank">Takácsi-Nagy Zoltán (<span class="authorship-author-name">Takácsi-Nagy Zoltán</span> <span class="authorAux-mtmt"> Sugárterápia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Onkológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018107"><a href="/gui2/?type=authors&mode=browse&sel=10018107" target="_blank">Pesznyák Csilla (<span class="authorship-author-name">Pesznyák Csilla</span> <span class="authorAux-mtmt"> Orvosfizika</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Budapesti Műszaki és Gazdaságtudományi Egyetem">BME</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Nukleáris Technikai Intézet">NTI</span>/Nukleáris Technika Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36455719" target="_blank">Quality of density deformations in patient anatomy during synthetic CT guided online adaptive radiation therapy for pelvic cancer</a></div> <div> <span class="journal-title">REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1507-1367">1507-1367</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2083-4640">2083-4640</a>)</span>: <span class="journal-volume">30</span> <span class="journal-issue">5</span> <span class="page"> pp 649-656 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.5603/rpor.108009" target="_blank" href="https://doi.org/10.5603/rpor.108009"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001654802400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001654802400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105021497999" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021497999"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41503558" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41503558&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q4</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36455719&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36455719</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (National Tumor Biology Laboratory (2022–2.1.1-NL-2022-00010))), (TKP-2021-EGA-02) </div> <div class="lastModified">Utolsó módosítás: 2026.05.19. 17:02 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Ministry of Culture and Innovation; National Research, Development and Innovation Office [TKP2021-EGA-02]; National Research, Development and Innovation Fund of the Ministry of Culture and Innovation under the National Laboratories Program [National Tumor Biology Laboratory] [2022-2.1.1-NL-2022-00010]; National Research, Development and Innovation Office ...</pre> </div></div>