(TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium
(K131996)
(K147265)
(EKÖP-2024-86)
Szakterületek:
Endokrinológia
The obesity epidemic has led to a rise in related health conditions, with metabolic
syndrome (MS) affecting 25% of Western populations. In severe acute pancreatitis (AP),
mortality can reach 50%. Previous studies have linked MS elements to increased complications
and mortality in AP. This meta-analysis aims to identify potential risk factors and
their synergistic effects on AP outcomes.We systematically searched PubMed, Embase,
and the Cochrane Library up to November 1, 2023, and included studies based on predefined
criteria. We examined the impact of MS and its factors (obesity, hypertension, diabetes
mellitus, and hypertriglyceridemia) on AP outcomes, calculating pooled odds ratios
(OR) with 95% confidence intervals (CIs). The protocol was registered in PROSPERO
under number CRD42023471092.Out of 15,904 records, 89 studies were analyzed. Overweight
and obesity were significant risk factors for complications (local OR: 2.677, 95%CI:
1.421-5.044; systemic OR: 2.404, 95%CI: 1.481-3.901) and severe AP (BMI≥30 kg/m2,
OR: 3.058, 95%CI: 1.369-6.829). High triglyceride levels were associated with ICU
admission (OR: 2.546, 95%CI: 1.529-4.237) and severe AP (OR: 2.686, 95%CI: 1.205-5.989);
hypertension increased mortality (OR: 2.135, 95%CI: 1.870-2.437), while diabetes increased
the odds of ICU admission (OR: 1.645, 95%CI: 1.358-1.992) and severe AP (OR: 1.49,
95%CI: 1.09-2.03). We found a non-significant trend toward increased odds of severe
AP among patients with MS (OR = 1.398, 95% CI: 0.918-2.129).Individual components
of MS are risk factors for complications, severity, and mortality in AP. Lifestyle
counseling, education, and treatment of patients with obesity is crucial.https://www.crd.york.ac.uk/prospero/,
identifier CD42023471092.
