(TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium
(K131996)
(K147265)
(EKÖP-2024-11)
The prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in the past
20 years. Most T2DM cases are preventable if risk factors are eliminated early. Hypertriglyceridemia
(HTG) is also a potential but modifiable risk factor, and has a high prevalence as
well. We aimed to investigate the dose-dependent effect of HTG on the development
of T2DM.We carried out a systematic search in three databases (MEDLINE, Embase, and
CENTRAL) on 9 November 2023. We investigated an adult population with different triglyceride
levels (exposure). The outcome of interest was the development of T2DM. Pooled hazard
ratio (HR), odds ratio (OR), and mean differences (MDs) with 95% confidence intervals
(CIs) were calculated using a random-effects model. Risk of bias was assessed with
the Quality In Prognosis Studies (QUIPS) tool. The protocol was registered in PROSPERO
(CRD42023471288).We identified 31,098 articles and included 101 in our meta-analysis.
We found that people with HTG had more than a 1.5-fold higher risk (HR: 1.73 [1.31;
2.29]) of developing T2DM. Those who had their TG levels between 1.7 and 2.3 mmol/L
had a 42% higher risk (HR: 1.42 [1.13; 1.79]), while those with TG levels above 2.3
mmol/L had an even higher risk for T2DM (HR: 1.82 [1.18; 2.87]) compared with patients
with TG levels below 1.7 mmol/L. When investigating the hypertriglyceridemic waist
phenotype, we found that only those with increased waist circumference had a higher
risk in both sex groups among the different phenotype groups (female: HR: 2.86 [1.59;
5.14], male: HR: 3.31 [1.57; 7.27]).HTG is a dose-dependent risk factor for T2DM.
Elevated waist circumference may have an even more important role in the development
of T2DM than HTG.https://www.crd.york.ac.uk/prospero/, identifier CRD42023471288.
