https://m2.mtmt.hu/ hun 2026-04-30 05:40 JournalArticle 36444536 VALIDATED true Funding Agency and Grant Number: CAMS Innovation Fund for Medical Sciences [2019-I2M-5-038] Funding text: This study was supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-038). 0 false 2026-01-24T09:37:50.339+0000 2026-01-01T05:46:48.013+0000 2025-11-19T16:15:27.389+0000 true 10039927 Ella Krisztina /api/author/10039927 Author true 10039927 2026-01-01T09:04:28.488+0000 2026-01-01T05:46:47.125+0000 true 521 Szuper Admin /api/admin/521 Admin true false false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Chi, Yanting Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome true true /api/journal/10015686 REVIEWED true false 10015686 false 10015686 true 1756-8935 1756-8935 Journal FOREIGN 18 1 70 70 16 2025 Background/PurposeSj & ouml;gren's syndrome (SS) is a chronic systemic autoimmune disease characterized by lymphocytic infiltration and formation of lymphoepithelial lesions (LEL) in exocrine glands, leading to secretory dysfunction. DNA methylation, a dynamically regulated epigenetic mark, has been increasingly recognized as a key regulatory mechanism in the pathogenesis of autoimmune diseases including SS, and holds promise for identifying novel diagnostic and therapeutic strategies.MethodsReduced representation bisulfite sequencing (RRBS) was performed on 4 cases of SS and 3 controls to profile genome-wide DNA methylation patterns. Differentially methylated regions (DMRs) and associated differentially methylated genes (DMGs) were detected, followed by functional enrichment analysis. Integration with transcriptomic data (GSE40611) was performed to identify overlapping epigenetic and transcriptional changes.ResultsA total of 29,462 DMRs were detected, with 24,116 hypermethylated and 5,346 hypomethylated regions, indicating an overall increase in methylation levels of SS, and DMGs located in gene promoter regions were significantly enriched in pathways related to immune response, transcriptional regulation, and inflammation. Nine hub genes (LCP2, BTK, LAPTM5, ARHGAP9, IKZF1, WDFY4, CSF2RB, ARHGAP25, DOCK8) were identified, which displayed promoter hyper-or hypomethylation, indicating the complex epigenetic regulatory mechanisms.ConclusionThis study reveals extensive DNA methylation alterations in SS, providing new insights into the epigenetic mechanisms underlying pathogenesis. Moreover, these findings suggest potential biomarkers or therapeutic targets for further investigation to elucidate detailed molecular mechanisms of SS. 2025 true true true false false GOLD 2026-01-24 false http://www.epigeneticsandchromatin.com/home 0 0 0 0 0 0 0 0 0 0 0 0 4 4 Q1 false false false false 2026-02-17T16:16:01.601+0000 19 53 0 4 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128549012 /api/authorship/128549012 1 0.25 true false false Chi Yanting true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128549013 /api/authorship/128549013 2 0.25 false false false Qin Zhiming true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128549014 /api/authorship/128549014 3 0.25 false false false Qiu Jingjing true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128549015 /api/authorship/128549015 4 0.25 false true true Li Binbin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30186811 /api/publicationidentifier/30186811 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1186/s13072-025-00637-y https://doi.org/10.1186/s13072-025-00637-y false true PublicationIdentifier 30186812 /api/publicationidentifier/30186812 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001600871500001 https://www.webofscience.com/wos/woscc/full-record/001600871500001 false true PublicationIdentifier 30186814 /api/publicationidentifier/30186814 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true 105019782393 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105019782393 false true PublicationIdentifier 30186813 /api/publicationidentifier/30186813 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41146282 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41146282&dopt=Abstract false true Keyword 64 /api/keyword/64 true 64 true Keyword 1005240 /api/keyword/1005240 true 1005240 true Keyword 1029050 /api/keyword/1029050 true 1029050 true Keyword 1034819 /api/keyword/1034819 true 1034819 true Keyword 1190720 /api/keyword/1190720 true 1190720 true Keyword 1633642 /api/keyword/1633642 true true Keyword 2380658 /api/keyword/2380658 true true Keyword 3388356 /api/keyword/3388356 true true SjrRating 11584377 /api/sjrrating/11584377 49 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1311 /api/classificationexternal/1311 true 1311 true Q1 FROM_LAST_YEAR true true /api/publication/36444536 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Chi Yanting </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Qin Zhiming </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Qiu Jingjing </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li Binbin ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36444536" target="_blank">Integrated study of DNA methylation and transcriptome: a new perspective for exploring the pathogenesis of Sjögren's syndrome</a></div> <div> <span class="journal-title">EPIGENETICS & CHROMATIN</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-8935">1756-8935</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-8935">1756-8935</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">1</span> <span class="page"> Paper 70. 16 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1186/s13072-025-00637-y" target="_blank" href="https://doi.org/10.1186/s13072-025-00637-y"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001600871500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001600871500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="105019782393" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105019782393"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41146282" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41146282&dopt=Abstract"> PubMed </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36444536&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36444536</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.01.01. 06:46 Szuper Admin (admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: CAMS Innovation Fund for Medical Sciences [2019-I2M-5-038] Funding text: This study was supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-038).</pre> </div></div>