https://m2.mtmt.hu/ eng 2026-07-27 00:40 JournalArticle 36438388 ADMIN_APPROVED true 0 false 2026-06-01T13:27:10.606+0000 2026-06-01T12:48:08.570+0000 2025-11-17T08:47:52.166+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-06-01T12:48:01.170+0000 2026-06-01T12:48:01.170+0000 2026-06-01T12:48:08.775+0000 true 10045349 Fekete Rita /api/admin/10045349 Admin true 10045349 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Kadlecsik, Csaba (E)-2-Benzylidenecyclanones : Part XXI-Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Comparison of Reactivity of (E)-2-Arylidene-1-Indanone with -1-Tetralone and -1-Benzosuberone Analogs in Thia-Michael Reactions. true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 21 10573 10573 21 2025 In vitro cytotoxicity of three (E)-3-(4'-X-benzylidene)-1-indanones (2a-c) displayed lower cytotoxicity towards murine P388 and L1210 leukemic cells as well as human Molt 4/C8 and CEM T-lymphocytes than the respective six- (3a-c) and seven-membered (4a-c) analogs. To study whether thiol reactivity-as a possible basis of their mechanism of action-correlates with the observed cytotoxicities, kinetics of the non-enzyme catalyzed reactions with reduced glutathione (GSH) and N-acetylcysteine (NAC) of 2a-c were investigated. Furthermore, it was also the aim of the work to compare the thiol reactivity of the open-chain chalcones (1) and their carbocyclic analogs (2-4) with different ring sizes (n = 5-7). The reactivity of the compounds and the stereochemical outcome of the reactions were evaluated using high-pressure liquid chromatography-mass spectrometry (HPLC-MS). Molecular modeling calculations were performed to rationalize the high initial rate and low conversion of the 2a indanone in comparison with those of the carbocyclic analog tetralone (3a) and benzosuberone (4a). Thiol reactivity and cancer cell cytotoxicity showed a dependence on both the ring size and the nature of aromatic substituents. Funding 2059695 /api/funding/2059695 false true 2025 true true true false false GOLD 2026-06-01 true https://doi.org/10.3390/ijms262110573 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 10 D1 false false false false 2025-11-16T14:35:45.801+0000 Gyógyszerészi Kémiai Intézet (PTE / GYTK) 4 8 1 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128519228 /api/authorship/128519228 1 0.111 true false false Author 10104592 /api/author/10104592 Kadlecsik Csaba András true true Kadlecsik Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519229 /api/authorship/128519229 2 0.11111111 false false false Author 10098772 /api/author/10098772 Bognár Gábor true true Bognár Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519230 /api/authorship/128519230 3 0.11111111 false false false Author 10065758 /api/author/10065758 Kenari Fatemeh true true Kenari Fatemeh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519231 /api/authorship/128519231 4 0.11111111 false false false Pintér Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519232 /api/authorship/128519232 5 0.11111111 false false false Ribeiro Júlio César de Oliveira true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519233 /api/authorship/128519233 6 0.11111111 false false false Envall Mário G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519234 /api/authorship/128519234 7 0.11111111 false false false Carvalho-Silva Valter H true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519235 /api/authorship/128519235 8 0.11111111 false false false Napolitano Hamilton B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128519236 /api/authorship/128519236 9 0.111 false true true Author 10008303 /api/author/10008303 Perjési Pál true 10008303 true Perjési Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30169823 /api/publicationidentifier/30169823 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms262110573 https://doi.org/10.3390/ijms262110573 false true PublicationIdentifier 30361846 /api/publicationidentifier/30361846 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001612735200001 https://www.webofscience.com/wos/woscc/full-record/001612735200001 false true PublicationIdentifier 30361847 /api/publicationidentifier/30361847 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105021522196 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021522196 false true PublicationIdentifier 30169822 /api/publicationidentifier/30169822 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41226610 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41226610&dopt=Abstract false true Keyword 4823 /api/keyword/4823 true 4823 true Keyword 19044 /api/keyword/19044 true 19044 true Keyword 1019427 /api/keyword/1019427 true 1019427 true Keyword 1037067 /api/keyword/1037067 true 1037067 true Keyword 1133786 /api/keyword/1133786 true 1133786 true Keyword 1700658 /api/keyword/1700658 true true Keyword 3524760 /api/keyword/3524760 true true Keyword 3932583 /api/keyword/3932583 true true Keyword 3932584 /api/keyword/3932584 true true Keyword 3932585 /api/keyword/3932585 true true SjrRating 11593300 /api/sjrrating/11593300 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true /api/publication/36438388 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10104592"><a href="/gui2/?type=authors&mode=browse&sel=10104592" target="_blank">Kadlecsik Csaba (<span class="authorship-author-name">Kadlecsik Csaba András</span> <span class="authorAux-mtmt"> Kromatográfia, tömegspektrometria</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10098772"><a href="/gui2/?type=authors&mode=browse&sel=10098772" target="_blank">Bognár Gábor (<span class="authorship-author-name">Bognár Gábor</span> <span class="authorAux-mtmt"> gyógyszerész</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065758"><a href="/gui2/?type=authors&mode=browse&sel=10065758" target="_blank">Kenari Fatemeh (<span class="authorship-author-name">Kenari Fatemeh</span> <span class="authorAux-mtmt"> Gyógyszerészet</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pintér Zoltán </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ribeiro Júlio César de Oliveira </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Envall Mário G </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Carvalho-Silva Valter H </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Napolitano Hamilton B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10008303"><a href="/gui2/?type=authors&mode=browse&sel=10008303" target="_blank">Perjési Pál ✉ (<span class="authorship-author-name">Perjési Pál</span> <span class="authorAux-mtmt"> Bioorganikus kémia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmaceutical Chemistry</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36438388" target="_blank">(E)-2-Benzylidenecyclanones : Part XXI-Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Comparison of Reactivity of (E)-2-Arylidene-1-Indanone with -1-Tetralone and -1-Benzosuberone Analogs in Thia-Michael Reactions.</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">21</span> <span class="page"> Paper 10573. 21 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms262110573" target="_blank" href="https://doi.org/10.3390/ijms262110573"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001612735200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001612735200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105021522196" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021522196"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41226610" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41226610&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36438388&sort=publishedYear,desc&sort=title"> Number of cited publications: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 36438388</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (EFOP-3.6.1.-16-2016-00004) Funder: EFOP </div> <div class="lastModified">Last Modified: 2026.06.01. 14:48 Rita Fekete (PTE GYTK admin 5) </div> </div></div>