https://m2.mtmt.hu/ hun 2026-09-21 21:47 JournalArticle 36437889 VALIDATED true Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States Division of Cardiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, United States Cardiology Division, Brigham and Women’s Hospital, Boston, MA, United States Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, United States Baim Institute for Clinical Research, Boston, MA, United States Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States Division of Cardiology, McGill University Hospital, Quebec, Montreal, Canada Department of Radiology, Brigham and Women’s Hospital, Boston, MA, United States Export Date: 30 June 2026; Cited By: 3; Correspondence Address: V. Juhasz; Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, United States; email: vjuhasz@mgh.harvard.edu 0 false 2026-06-30T08:26:02.734+0000 2026-06-30T08:23:23.558+0000 2025-11-16T20:41:09.241+0000 true 10077410 Juhász Vencel /api/author/10077410 Author true 2026-06-30T08:23:23.454+0000 2026-05-07T10:09:19.516+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Juhász, Vencel Atorvastatin and Aortic Stiffness During Anthracycline-Based Chemotherapy A Secondary Analysis of a Randomized Clinical Trial true true /api/journal/10062749 REVIEWED true false 10062749 false 10062749 true 2380-6583 2380-6591 Journal FOREIGN 11 1 68 76 68 9 2026 Anthracyclines, which are key to many chemotherapeutic protocols, have been associated with increased vascular stiffness, a major factor associated with cardiovascular morbidity and mortality. There is no evidence-based intervention to prevent anthracycline-associated vascular dysfunction.To investigate whether atorvastatin pretreatment is associated with attenuation of the anthracycline-induced increase in aortic stiffness.This study is a secondary analysis of a double-blind, randomized clinical trial (Statins to Prevent the Cardiotoxicity From Anthracyclines [STOP-CA]). Enrollment occurred between January 25, 2017, and September 10, 2021, with the last follow-up on October 10, 2022. Primary analyses were reported on August 8, 2023. STOP-CA was a multicenter trial across 9 academic centers in the US and Canada. Participants were patients with newly diagnosed lymphoma scheduled to undergo anthracycline-based chemotherapy with no clinical indication for a statin.Atorvastatin (40 mg, once daily) or placebo for 12 months.This subanalysis of the STOP-CA trial includes post hoc end points with cardiac magnetic resonance imaging-derived aortic arch pulse wave velocity (PWV) and aortic distensibility (AD). An intention-to-treat approach was applied. The proportions of participants with a 1 SD or more increase in PWV and a 1 SD or more decrease in ascending aortic distensibility (AAD) were calculated in each group over 12 months. An increase in PWV of 0.15 m per second or more, a previously defined annual rate in individuals of similar age, was also assessed as a secondary end point.Of the 300 participants (150 randomized to atorvastatin and 150 randomized to placebo), 152 (mean [SD] age, 51 [17] years; 72 female [47%]; 82 treated with atorvastatin) had paired PWV data, and 168 had paired AD data. The PWV values remained similar in the atorvastatin group (mean [SD], 6.5 [1.9] vs 6.5 [2.0] m per second) but increased in the placebo group (5.7 [1.8] vs 6.8 [2.0] m per second) over 12 months. A 1 SD or more increase (0.8 m per second) in PWV was observed among 4 of 82 patients (5%) with atorvastatin and 35 of 70 patients (50%) with placebo (odds ratio, 0.05; 95% CI, 0.02 to 0.16; P < .001) at 12 months. A 1 SD or more decrease (1.8 × 10-3 mm Hg-1) in AAD was observed among 6 of 88 patients (7%) with atorvastatin and in 14 of 80 patients (18%) with placebo. A 1 SD or more increase in PWV was associated with a mean left ventricular ejection fraction decline of 2.70% (95% CI, -4.65% to -0.81%; P = .006).Pretreatment with atorvastatin was associated with preservation of vascular function among patients with lymphoma undergoing anthracycline-based chemotherapy.ClinicalTrials.gov Identifier: NCT02943590. true 2025 true true true false true false NONE 2026-06-30 false 3 0 3 2 1 3 3 3 2 3 3 2 2 2 1 0 3 2 3 2 0 4 4 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 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1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128517069 /api/authorship/128517069 15 0.05263158 false false false Mousavi Negareh true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128517070 /api/authorship/128517070 16 0.05263158 false false false Redd Robert A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128517071 /api/authorship/128517071 17 0.05263158 false false false Jerosch-Herold Michael true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128517072 /api/authorship/128517072 18 0.05263158 false false false Scherrer-Crosbie Marielle true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128517073 /api/authorship/128517073 19 0.05263158 false true false Neilan Tomas G true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 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src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10077410"><a href="/gui2/?type=authors&mode=browse&sel=10077410" target="_blank">Juhász Vencel ✉ (<span class="authorship-author-name">Juhász Vencel</span> <span class="authorAux-mtmt"> Kardiológia, Sportorvostan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Zsófia D (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Quinaglia Thiago </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gilman Hannah K </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Brendel Jan M </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Suero-Abreu Giselle Alexandra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ghamari Azin </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heemelaar Julius C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neuberg Donna S </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Han Yuchi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ky Bonnie </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kwong Raymond Y </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Januzzi James L </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Asnani Aarti </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mousavi Negareh </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Redd Robert A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jerosch-Herold Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Scherrer-Crosbie Marielle </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Neilan Tomas G </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36437889" target="_blank">Atorvastatin and Aortic Stiffness During Anthracycline-Based Chemotherapy : A Secondary Analysis of a Randomized Clinical Trial.</a></div> <div> <span class="journal-title">JAMA CARDIOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2380-6583">2380-6583</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2380-6591">2380-6591</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">1</span> <span class="page"> pp 68-76 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1001/jamacardio.2025.4548" target="_blank" href="https://doi.org/10.1001/jamacardio.2025.4548"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001618151300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001618151300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105021933095" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021933095"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41205202" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41205202&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36437889&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36437889</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.30. 10:23 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cardiovascular Imaging Research Center, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, United States Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, United States Division of Cardiology, Hospit...</pre> </div></div>