https://m2.mtmt.hu/ hun 2026-10-23 06:14 JournalArticle 36437689 VALIDATED true Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary from the National Research [TKP2021-EGA]; National Research, Development and Innovation Fund of Hungary [STAGE 2024-1.2.3-HU-RIZONT-2024-00056]; Hungarian Academy of Sciences [LP2021-3/2021] Funding text: This work was funded by the following grants: Project no. TKP2021-EGA-24 has been implemented with support from the Ministry of Innovation and Technology of Hungary from the National Research, Development and Innovation Fund, financed under the TKP2021-EGA (Thematic Excellence Programme 2021-Health Subprogramme) funding scheme. The work was also supported by the STAGE 2024-1.2.3-HU-RIZONT-2024-00056 grant of the National Research, Development and Innovation Fund of Hungary and the MTA-SE "Lendulet" Research Grant LP2021-3/2021 of the Hungarian Academy of Sciences. 0 false 2026-09-28T09:45:38.894+0000 2026-04-02T10:10:58.016+0000 2025-11-16T16:43:14.256+0000 true 10015546 Berhidi Anna /api/admin/10015546 Admin true 10015546 2026-06-09T08:28:28.239+0000 2026-02-25T08:22:04.682+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Tóth, Ákos R Novel Sigma-1 receptor agonist alleviates renal ischemic injury by targeting apoptotic and inflammatory pathways true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 15 1 39762 39762 12 2025 Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury, yet its mechanisms remain unclear, and effective treatments are lacking. We previously showed that the Sigma-1 receptor (S1R) agonist fluvoxamine protects against IRI and IRI-induced graft injury during transplantation. Here, we developed a novel compound, 'VCC904125', with potent S1R affinity and minimal blood-brain barrier penetration to mitigate renal IRI without psychoactive side effects. Mice were treated with VCC904125 before clamping the left renal pedicles, followed by contralateral nephrectomy. VCC904125 markedly alleviated BUN and serum creatinine levels, KIM-1 and NGAL expression, and structural damage at both 24 and 48 h after reperfusion. S1R activation by VCC904125 targets key pathways underlying IRI, including apoptosis and inflammation. VCC904125 treatment impeded the apoptotic p53-Bax pathway and influenced CaMKII-NF-κB signaling, resulting in diminished proinflammatory cytokine expression. In the ex vivo model, kidneys were perfused and stored in an HTK preservation solution supplemented with VCC904125 to simulate cold storage conditions before transplantation. VCC904125 ameliorated structural injury profoundly after cold ischemia. Taken together, S1R activation by VCC904125 decreases renal IRI via ameliorating apoptotic and inflammatory pathways. These results highlight the therapeutic promise of S1R activation in mitigating cold and warm ischemia and improving transplant outcomes. Funding 2059630 /api/funding/2059630 false true Funding 2059631 /api/funding/2059631 false true Funding 2059632 /api/funding/2059632 false true true NATIONAL 2025 true true true false true false GOLD 2026-09-28 true https://doi.org/10.1038/s41598-025-23459-0 1 0 1 0 0 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 6 6 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 0 1 0 Q1 A nemzetközi false 10043337,10032730 false false false 2025-11-25T08:08:12.195+0000 Gyermekgyógyászati Klinika (SE / AOK / K); MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... (SE / AOK / K) 10 31 4 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128516392 /api/authorship/128516392 1 0.091 true false false Author 10071755 /api/author/10071755 Tóth Ákos Roland true true Tóth Ákos R true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516393 /api/authorship/128516393 2 0.091 false false false Author 10066688 /api/author/10066688 Lakat Tamás true true Lakat Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516394 /api/authorship/128516394 3 0.091 false false false Author 10052727 /api/author/10052727 Budai András true 10052727 true Budai András true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516395 /api/authorship/128516395 4 0.091 false false false Author 10102342 /api/author/10102342 Kállay Hanga true true Kállay Hanga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516396 /api/authorship/128516396 5 0.091 false false false Author 10043337 /api/author/10043337 Szokol Bálint true 10043337 true Szokol Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516397 /api/authorship/128516397 6 0.091 false false false Author 10020375 /api/author/10020375 Wágner László József true 10020375 true Wágner László J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516398 /api/authorship/128516398 7 0.091 false false false Author 10003054 /api/author/10003054 Őrfi László true 10003054 true Őrfi László true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516399 /api/authorship/128516399 8 0.09090909 false false false Kreko Marcell true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516400 /api/authorship/128516400 9 0.091 false false false Author 10015517 /api/author/10015517 Szabó Attila true 10015517 true Szabó Attila J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516401 /api/authorship/128516401 10 0.091 false true false Author 10011883 /api/author/10011883 Fekete Andrea true 10011883 true Fekete Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128516402 /api/authorship/128516402 11 0.091 false true true Author 10032730 /api/author/10032730 Hosszú Ádám true 10032730 true Hosszú Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30168221 /api/publicationidentifier/30168221 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-025-23459-0 https://doi.org/10.1038/s41598-025-23459-0 false true PublicationIdentifier 30222813 /api/publicationidentifier/30222813 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001614478300001 https://www.webofscience.com/wos/woscc/full-record/001614478300001 true true PublicationIdentifier 30222829 /api/publicationidentifier/30222829 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105021838453 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021838453 true true PublicationIdentifier 30168220 /api/publicationidentifier/30168220 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41238634 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41238634&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Classification 12304 /api/classification/12304 true true Keyword 64 /api/keyword/64 true 64 true Keyword 68 /api/keyword/68 true 68 true Keyword 300 /api/keyword/300 true 300 true Keyword 1869 /api/keyword/1869 true 1869 true Keyword 1001653 /api/keyword/1001653 true 1001653 true Keyword 1009833 /api/keyword/1009833 true 1009833 true Keyword 1029629 /api/keyword/1029629 true 1029629 true Keyword 1030756 /api/keyword/1030756 true 1030756 true Keyword 1314656 /api/keyword/1314656 true 1314656 true Keyword 2271540 /api/keyword/2271540 true true MtaRating 519359 /api/mtarating/519359 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19359 true MtaRating 11551161 /api/mtarating/11551161 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11736329 /api/sjrrating/11736329 24 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/36437689 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071755"><a href="/gui2/?type=authors&mode=browse&sel=10071755" target="_blank">Tóth Ákos R (<span class="authorship-author-name">Tóth Ákos Roland</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066688"><a href="/gui2/?type=authors&mode=browse&sel=10066688" target="_blank">Lakat Tamás (<span class="authorship-author-name">Lakat Tamás</span> <span class="authorAux-mtmt"> Diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052727"><a href="/gui2/?type=authors&mode=browse&sel=10052727" target="_blank">Budai András (<span class="authorship-author-name">Budai András</span> <span class="authorAux-mtmt"> Sebészet, Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10102342"><a href="/gui2/?type=authors&mode=browse&sel=10102342" target="_blank">Kállay Hanga (<span class="authorship-author-name">Kállay Hanga</span> <span class="authorAux-mtmt"> gyermekgyógyászat, nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043337"><a href="/gui2/?type=authors&mode=browse&sel=10043337" target="_blank">Szokol Bálint (<span class="authorship-author-name">Szokol Bálint</span> <span class="authorAux-mtmt"> Gyógyszerkémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020375"><a href="/gui2/?type=authors&mode=browse&sel=10020375" target="_blank">Wágner László J (<span class="authorship-author-name">Wágner László József</span> <span class="authorAux-mtmt"> Transzplantáció</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003054"><a href="/gui2/?type=authors&mode=browse&sel=10003054" target="_blank">Őrfi László (<span class="authorship-author-name">Őrfi László</span> <span class="authorAux-mtmt"> Szerves- és Gyógyszerkémia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kreko Marcell </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015517"><a href="/gui2/?type=authors&mode=browse&sel=10015517" target="_blank">Szabó Attila J (<span class="authorship-author-name">Szabó Attila</span> <span class="authorAux-mtmt"> Gyermekgyógyászat, nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011883"><a href="/gui2/?type=authors&mode=browse&sel=10011883" target="_blank">Fekete Andrea<sup>**</sup> (<span class="authorship-author-name">Fekete Andrea</span> <span class="authorAux-mtmt"> nefrológia, gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032730"><a href="/gui2/?type=authors&mode=browse&sel=10032730" target="_blank">Hosszú Ádám ✉ (<span class="authorship-author-name">Hosszú Ádám</span> <span class="authorAux-mtmt"> nephrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36437689" target="_blank">Novel Sigma-1 receptor agonist alleviates renal ischemic injury by targeting apoptotic and inflammatory pathways</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">1</span> <span class="page"> Paper 39762. 12 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-025-23459-0" target="_blank" href="https://doi.org/10.1038/s41598-025-23459-0"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001614478300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001614478300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105021838453" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021838453"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41238634" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41238634&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36437689&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36437689</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma, (STAGE 2024-1.2.3-HU-RIZONT-2024-00056), (LP2021-3/2021) </div> <div class="lastModified">Utolsó módosítás: 2026.04.02. 12:10 Cseh Éva (SE_AOK_Adm5_1GyermekgyCsehÉva, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Ministry of Innovation and Technology of Hungary from the National Research [TKP2021-EGA]; National Research, Development and Innovation Fund of Hungary [STAGE 2024-1.2.3-HU-RIZONT-2024-00056]; Hungarian Academy of Sciences [LP2021-3/2021] Funding text: This work was funded by the following grants: Project no. TKP2021-EGA-24 has been implemented with...</pre> </div></div>