https://m2.mtmt.hu/ hun 2026-09-21 07:30 JournalArticle 36435938 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary [NKFIH FK-134267, FK-143205] Funding text: This work was supported by NKFIH FK-134267 and FK-143205 (National Research, Development and Innovation Office, Hungary). 0 false 2026-05-25T03:41:12.276+0000 2026-04-20T07:20:18.994+0000 2025-11-14T11:49:01.459+0000 true 10000786 Csala Miklós /api/author/10000786 Author Csala Miklós (Biokémia) true 10000786 2026-04-20T07:20:18.818+0000 2025-12-09T10:04:41.947+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Holczer, Marianna true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 22 10961 10961 19 2025 Proper functioning of the endoplasmic reticulum (ER) plays a key role in maintaining the internal homeostasis of the cell. A common feature of many common diseases (such as diabetes and inflammatory bowel diseases) is the induction of ER stress in cells. While some ER stress is beneficial for cellular survival, high levels of stress can lead to cell death. For this reason, many studies are focused on understanding the exact mechanism of the ER stress response. There are a variety of well-established stressors on the market that can be used to induce ER stress under laboratory conditions (i.e., thapsigargin and tunicamycin). However, new scientific results suggest that these ER stressors act very differently on the stress response mechanism and, therefore, cannot always be used reliably. By using various mathematical methods, our systems biology approach presented here seeks to answer how the well-known ER stressors affect the dynamic characteristic of the control network, specifically highlighting how we can delay the negative impact of ER stress. Furthermore, using mathematical models, we make suggestions on which ER stressors may be useful in which therapeutic treatment. Funding 2060281 /api/funding/2060281 (FK-134267) false true Funding 2060282 /api/funding/2060282 (FK-143205) false true true true 2025 true true true false true false GOLD 2026-05-25 false http://www.mdpi.com/journal/ijms 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 8 D1 false false false false 2025-12-08T10:04:41.091+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 6 10 1 6 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 128508661 /api/authorship/128508661 Holczer, Marianna [Holczer, Marianna (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.167 true false false Author 10057448 /api/author/10057448 Holczer Marianna (Biokémia) Holczer Marianna true 10057448 true Holczer Marianna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128508662 /api/authorship/128508662 Márton, Margita [Márton, Margita (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 0.167 false false false Author 10057447 /api/author/10057447 Márton Margita (Biokémia) Márton Margita true 10057447 true Márton Margita true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128508663 /api/authorship/128508663 Stiller, Ibolya [Stiller, Ibolya (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.167 false false false Author 10026775 /api/author/10026775 Stiller Ibolya (Biokémia) Stiller Ibolya true 10026775 true Stiller Ibolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128508664 /api/authorship/128508664 Lizák, Beáta [Lizák, Beáta (biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.167 false false false Author 10026029 /api/author/10026029 Lizák Beáta (biokémia, molekuláris biológia) Lizák Beáta true 10026029 true Lizák Beáta true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128508665 /api/authorship/128508665 Bánhegyi, Gábor [Bánhegyi, Gábor (Biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 5 0.167 false false false Author 10011674 /api/author/10011674 Bánhegyi Gábor (Biokémia, molekuláris biológia) Bánhegyi Gábor true 10011674 true Bánhegyi Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128508666 /api/authorship/128508666 Kapuy, Orsolya ✉ [Kapuy, Orsolya (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 6 0.167 false true true Author 10026330 /api/author/10026330 Kapuy Orsolya (Biokémia) Kapuy Orsolya true 10026330 true Kapuy Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 30164199 /api/publicationidentifier/30164199 DOI: 10.3390/ijms262210961 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms262210961 https://doi.org/10.3390/ijms262210961 false true PublicationIdentifier 30250212 /api/publicationidentifier/30250212 WoS: 001623852500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001623852500001 https://www.webofscience.com/wos/woscc/full-record/001623852500001 false true PublicationIdentifier 30290042 /api/publicationidentifier/30290042 Scopus: 105023176395 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105023176395 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105023176395 true true PublicationIdentifier 30290044 /api/publicationidentifier/30290044 PubMed: 41303444 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41303444 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41303444&dopt=Abstract true true SjrRating 11593300 /api/sjrrating/11593300 sjr:D1 (2025) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 69894893 /api/reference/69894893 1. 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(2025) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 26 22<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10057448"><a href="/gui2/?type=authors&mode=browse&sel=10057448" target="_blank">Holczer Marianna (<span class="authorship-author-name">Holczer Marianna</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057447"><a href="/gui2/?type=authors&mode=browse&sel=10057447" target="_blank">Márton Margita (<span class="authorship-author-name">Márton Margita</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026775"><a href="/gui2/?type=authors&mode=browse&sel=10026775" target="_blank">Stiller Ibolya (<span class="authorship-author-name">Stiller Ibolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026029"><a href="/gui2/?type=authors&mode=browse&sel=10026029" target="_blank">Lizák Beáta (<span class="authorship-author-name">Lizák Beáta</span> <span class="authorAux-mtmt"> biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10011674"><a href="/gui2/?type=authors&mode=browse&sel=10011674" target="_blank">Bánhegyi Gábor (<span class="authorship-author-name">Bánhegyi Gábor</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10026330"><a href="/gui2/?type=authors&mode=browse&sel=10026330" target="_blank">Kapuy Orsolya ✉ (<span class="authorship-author-name">Kapuy Orsolya</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36435938" target="_blank">Fine-Tuning of the Endoplasmic Reticulum Stress Response Mechanism Plays a Key Role in Cellular Survival—A Mathematical Study</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">22</span> <span class="page"> Paper 10961. 19 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms262210961" target="_blank" href="https://doi.org/10.3390/ijms262210961"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001623852500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001623852500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105023176395" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105023176395"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41303444" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41303444&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36435938&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36435938</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">DOI XML</span> </div> <div class="funder"> (FK-134267), (FK-143205) </div> <div class="lastModified">Utolsó módosítás: 2026.04.20. 09:20 Sonnevend Kinga (SE_AOK_OrvVegytan_Admin5_SK, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office, Hungary [NKFIH FK-134267, FK-143205] Funding text: This work was supported by NKFIH FK-134267 and FK-143205 (National Research, Development and Innovation Office, Hungary).</pre> </div></div>