https://m2.mtmt.hu/ hun 2026-09-22 08:47 JournalArticle 36411907 VALIDATED true Department of Internal Medicine II, LMU Hospital, Munich, Germany Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU, Munich, Germany Department for HPB Surgery, Clinic for General Surgery, Military Medical Academy, University of Defense, Belgrade, Serbia Department of Medical and Surgical Science (DIMEC), University of Bologna, Bologna, Italy Department of Gastroenterology, Digestive Oncology and Hepatopancreatology, HUB Erasme Hospital, ULB, Brussels, Belgium Pancreatitis Centre East, Gastrounit, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark Royal Devon University Healthcare NHS Foundation Trust, Department of Upper GI Surgery, Exeter, United Kingdom Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany German Cancer Consortium (DKTK), Partner Site Freiburg and German Cancer Research Center (DKFZ), Heidelberg, Germany Department of General, Visceral, Thoracic and Transplant Surgery, University Hospital of Giessen, Giessen, Germany Gastroenterology, Gastrointestinal Oncology and Endocrinology, University Medical Center Goettingen, Göttingen, Germany Department of Gastroenterology, Unidade Local de Saúde do Alto Ave, Guimarães, Portugal Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal ICVS/3B's, PT Government Associate Laboratory, Guimarães, Portugal I. Medical Department, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany Collegium Medicum, The Jan Kochanowski University in Kielce, Kielce, Poland Bolivian-Japanese Institute of Gastroenterology (I.G.B.J.), La Paz, Bolivia Klinik und Poliklinik für Onkologie, Gastroenterologie, Hepatologie und Pneumologie, Universitätsklinikum Leipzig, Leipzig, Germany Lviv Regional Clinical Hospital, Lviv, Ukraine Department of Clinical Medicine II, School of Medicine and Health, Technical University of Munich, TUM University Hospital, Munich, Germany Department of Internal Medicine II- Gastroenterology and Endoscopy, InnKlinikum Altötting, Altötting, Germany Department for HPB Surgery, Freeman Hospital, Newcastle University, Newcastle Upon Tyne, United Kingdom Department of Internal Medicine and Gastroenterology, University Hospital Oldenburg, Oldenburg, Germany Department of Gastroenterology and Hepatology, Navarra University Hospital, Pamplona, Spain Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary Department of Surgery #3, Poltava State Medical University, Poltava, Ukraine Division of Gastroenterology and Hepatology, Department of Internal Medicine II, Center for Advanced Research in Gastroenterology and Hepatology, “Victor Babeş” University of Medicine and Pharmacy, “Pius Brinzeu” Emergency County Hospital Timişoara, Timişoara, Romania The Center for Therapeutic Endoscopy and Endoscopic Oncology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada Department of Surgery, University Hospital Erlangen, Erlangen, Germany Division of Interdisciplinary Pancreatology, Department of Internal Medicine I, Ulm University Hospital, Ulm, Germany Institute of Molecular Oncology and Stem Cell Biology, Ulm University Hospital, Ulm, Germany Organoid Core Facility, Ulm University, Ulm, Germany Digestive Diseases Department, Hospital Clínico Universitario. Valladolid, Valladolid, Spain Department of Radiology, University Hospital, LMU Munich, Munich, Germany Export Date: 03 June 2026; Cited By: 1; Correspondence Address: G. Beyer; Department of Internal Medicine II, LMU Hospital, Munich, Germany; email: georg.beyer@med.uni-muenchen.de 0 false 2026-09-05T14:03:54.325+0000 2026-06-03T02:07:13.546+0000 2025-11-01T20:41:00.462+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-06-03T02:07:13.371+0000 2026-01-10T10:34:25.272+0000 true 10028537 Baczkó Gabriella /api/admin/10028537 Admin true 10028537 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Vornhülz, Marlies Common Practice of Percutaneous Drainage in Necrotising Pancreatitis-A Multicentre Retrospective Study (DRACULA) true true /api/journal/10029272 REVIEWED true false 10029272 false 10029272 true 2050-6406 2050-6414 Journal FOREIGN 13 10 2075 2089 2075 15 2025 Acute necrotising pancreatitis carries high mortality, especially if infected necrosis occurs. While percutaneous drainage may be required when internal drainage is not feasible, reliable guidelines for managing percutaneous drains are lacking. This study aimed to assess the common practice of percutaneous drainage therapy for infected pancreatic necrosis.This retrospective study among 29 tertiary care centres included all patients hospitalised for necrotising acute pancreatitis from 01/2016 until 12/2022 with at least one percutaneous drain. The length of hospital stay was the primary endpoint, with mortality as the secondary endpoint. Between-group comparisons were conducted using the ratio of restricted mean survival time (RMST) after adjusting for confounders.585 patients (67% male) from 29 tertiary care centres in 15 countries in Europe, Canada and Bolivia were included in the analysis. Length of hospitalisation or mortality did not differ between the flushed (n = 398) and non-flushed groups (RMST ratio 1.04, p-value = 0.42 and RMST ratio 1.05, p-value = 0.1 respectively). Mortality was significantly lower in those patients who received a combination of percutaneous and internal drains (dual-modality drainage, n = 243) as compared to those who received percutaneous drains only (RMST ratio 1.05, p-value = 0.01). Flushing with antibiotics as compared to saline was not associated with shorter length of hospital stay or lower mortality (RMST ratio 0.98, p-value = 0.78 and 0.97, p-value = 0.48 respectively).This study reveals notable differences in therapeutic concepts and flushing management for percutaneous drains. While flushing itself was not associated with a shorter length of hospitalisation or lower in-hospital mortality, a lower mortality was observed when internal and percutaneous drainage were used in combination.The study was prospectively registered in the German Clinical Trials Register (Deutsches Register Klinischer Studien, DRKS) under the registration number DRKS00032231. true 2025 true true true false false GOLD 2026-09-05 true https://doi.org/10.1002/ueg2.70133 2 0 2 1 0 2 2 2 1 2 2 1 1 1 1 0 2 1 2 1 0 1 1 Folyóiratcikk Journal Article 24 2 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 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/api/keyword/14005 true 14005 true Keyword 15103 /api/keyword/15103 true 15103 true SjrRating 11583948 /api/sjrrating/11583948 14 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2715 /api/classificationexternal/2715 true 2715 true D1 DIRECT true true /api/publication/36411907 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Vornhülz Marlies </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064235"><a href="/gui2/?type=authors&mode=browse&sel=10064235" target="_blank">Eross Bálint (<span class="authorship-author-name">Erőss Bálint Mihály</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Peter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pankreász Betegségek Intézete; <span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Transzlációs Medicina Központ; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; et al. (55) </div> <div class="autype autype-11"> Kollaborációs közreműködő: <span class="author-name" mtid="10000322"><a href="/gui2/?type=authors&mode=browse&sel=10000322" target="_blank">Laszlo Czako (<span class="authorship-author-name">Czakó László</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Belgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Valentina Ratkajec </span> </div> <div class="autype autype-29"> Kollaborációs szervezet: <span class="author-affil">DRACULA study group:</span> </div> <div><a target="_blank" href="/api/publication/36411907?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36411907" target="_blank">Common Practice of Percutaneous Drainage in Necrotising Pancreatitis-A Multicentre Retrospective Study (DRACULA)</a></div> <div> <span class="journal-title">UNITED EUROPEAN GASTROENTEROLOGY JOURNAL</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-6406">2050-6406</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2050-6414">2050-6414</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">10</span> <span class="page"> pp 2075-2089 </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/ueg2.70133" target="_blank" href="https://doi.org/10.1002/ueg2.70133"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001599642800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001599642800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105021378157" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105021378157"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41137746" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41137746&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="38744" target="_blank" href="http://publicatio.bibl.u-szeged.hu/38744"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Gastroenterology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 1 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36411907&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36411907</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Utolsó módosítás: 2026.06.03. 04:07 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Internal Medicine II, LMU Hospital, Munich, Germany Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU, Munich, Germany Department for HPB Surgery, Clinic for General Surgery, Military Medical Academy, University of Defense, Belgrade, Serbia Department of Medical and Surgical S...</pre> </div></div>