https://m2.mtmt.hu/ hun 2026-10-24 04:18 JournalArticle 36410343 VALIDATED true Funding Agency and Grant Number: Semmelweis Egyetem [TKP2021-EGA-24] Funding text: The Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University is a Reference Centre of the ERN-Skin: European Reference Network on Rare and Complex Skin Diseases. The Department of Internal Medicine and Oncology, Semmelweis University is a Reference Centre of the ENDO-ERN: European Reference Network on Rare Endocrine Conditions. 0 false 2026-10-21T10:41:17.418+0000 2026-08-04T11:22:33.054+0000 2025-10-31T12:28:57.327+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-10-21T10:38:20.382+0000 2026-10-21T10:38:20.382+0000 2026-08-04T11:22:33.212+0000 true 10069305 Kondor Zóra /api/admin/10069305 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Pálla, Sára Dermatologic Features of Endocrine Tumor Syndromes-Systematic Review and Meta-Analysis true true /api/journal/2021 REVIEWED true false 2021 false 2021 true 0011-9059 1365-4632 Journal FOREIGN 65 3 464 488 464 25 2026 Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development. Alongside endocrine neoplasms, these syndromes present with diverse cutaneous manifestations, offering valuable diagnostic clues for early recognition and management. This systematic review and meta-analysis aimed to evaluate and synthesize the dermatologic features associated with these syndromes. Following PRISMA 2020 guidelines, a systematic search of MEDLINE, Cochrane Library, and Embase databases was conducted. Eligible publications included original articles, case reports, and case series with detailed dermatological descriptions of patients with the aforementioned syndromes. Data extraction and risk of bias assessment were performed independently by multiple reviewers. Statistical analyses and data visualization were conducted using program package R. A total of 217 studies comprising 833 patients were included: 276 MEN1, 48 MEN2A, 9 MEN2B, 121 CNC, and 452 PHTS cases. Distinct dermatologic patterns emerged within each syndrome: angiofibromas, collagenomas, and lipomas in MEN1; cutaneous lichen amyloidosis in MEN2A; mucosal neuromas in MEN2B; lentiginosis and cutaneous myxomas in CNC; and trichilemmomas, papillomatous papules, and acral keratoses in PHTS. Melanoma prevalence was 2.2% in PHTS and 2.5% in MEN1 patients, underscoring the need for dermatologic vigilance. This review highlights the role of dermatologic assessment in identifying endocrine tumor syndromes, with cutaneous findings often serving as early, accessible markers of systemic disease. Enhanced awareness of these manifestations can facilitate timely genetic evaluation, cancer surveillance, and multidisciplinary intervention. Trial Registration: PROSPERO registration number: CRD42024558093. Funding 2059030 /api/funding/2059030 false true true true 2025 true true true false true false NONE 2026-10-21 false 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 5 5 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 Q1 false false false false 2026-01-29T12:29:01.651+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); Farmakológiai és Gyógyszerkutatás-fejlesztési K... (SE / KSZE); Gyógyszerészi Kémiai Intézet (SE / GYTK); HUN-REN-ONKOL-TTK-HCEMM Onkogenomikai Kutatócso... (OOI); Laboratóriumi Medicina Intézet (SE / AOK / I); Országos Onkológiai Intézet 9 27 7 9 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128337674 /api/authorship/128337674 1 0.111 true false false Author 10074254 /api/author/10074254 Pálla Sára Judit true true Pálla Sára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337675 /api/authorship/128337675 2 0.111 false false false Author 10095041 /api/author/10095041 Metyovinyi Zseraldin true true Metyovinyi Zseraldin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337676 /api/authorship/128337676 3 0.111 false false false Author 10079444 /api/author/10079444 Meznerics Fanni Adél true true Meznerics Fanni Adél true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337677 /api/authorship/128337677 4 0.111 false false false Author 10032173 /api/author/10032173 Mirzahosseini Arash true 10032173 true Mirzahosseini Arash true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337678 /api/authorship/128337678 5 0.111 false false false Author 10043702 /api/author/10043702 Tőke Judit true 10043702 true Tőke Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337679 /api/authorship/128337679 6 0.111 false false false Author 10014760 /api/author/10014760 Tóth Miklós true 10014760 true Tóth Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337680 /api/authorship/128337680 7 0.111 false false false Author 10020420 /api/author/10020420 Butz Henriett true 10020420 true Butz Henriett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337681 /api/authorship/128337681 8 0.111 false false false Author 10001006 /api/author/10001006 Patócs Attila Balázs true 10001006 true Patócs Attila true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128337682 /api/authorship/128337682 9 0.111 false true true Author 10012260 /api/author/10012260 Medvecz Márta true 10012260 true Medvecz Márta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30089359 /api/publicationidentifier/30089359 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1111/ijd.70118 https://doi.org/10.1111/ijd.70118 false true PublicationIdentifier 30132294 /api/publicationidentifier/30132294 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001604118800001 https://www.webofscience.com/wos/woscc/full-record/001604118800001 true true PublicationIdentifier 30178593 /api/publicationidentifier/30178593 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105020978867 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020978867 true true PublicationIdentifier 30089358 /api/publicationidentifier/30089358 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41165034 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41165034&dopt=Abstract false true Keyword 19957 /api/keyword/19957 true 19957 true Keyword 1053476 /api/keyword/1053476 true 1053476 true Keyword 1077165 /api/keyword/1077165 true 1077165 true Keyword 1487017 /api/keyword/1487017 true 1487017 true Keyword 2827019 /api/keyword/2827019 true true Keyword 3926389 /api/keyword/3926389 true true Keyword 3926390 /api/keyword/3926390 true true SjrRating 11704669 /api/sjrrating/11704669 21 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2708 /api/classificationexternal/2708 true 2708 true Q1 FROM_LAST_YEAR true true /api/publication/36410343 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10074254"><a href="/gui2/?type=authors&mode=browse&sel=10074254" target="_blank">Pálla Sára (<span class="authorship-author-name">Pálla Sára Judit</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095041"><a href="/gui2/?type=authors&mode=browse&sel=10095041" target="_blank">Metyovinyi Zseraldin (<span class="authorship-author-name">Metyovinyi Zseraldin</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079444"><a href="/gui2/?type=authors&mode=browse&sel=10079444" target="_blank">Meznerics Fanni Adél (<span class="authorship-author-name">Meznerics Fanni Adél</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032173"><a href="/gui2/?type=authors&mode=browse&sel=10032173" target="_blank">Mirzahosseini Arash (<span class="authorship-author-name">Mirzahosseini Arash</span> <span class="authorAux-mtmt"> gyógyszerészi kémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Farmakológiai és Gyógyszerkutatás-fejlesztési Központ; <span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerészi Kémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043702"><a href="/gui2/?type=authors&mode=browse&sel=10043702" target="_blank">Tőke Judit (<span class="authorship-author-name">Tőke Judit</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Tóth Miklós (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020420"><a href="/gui2/?type=authors&mode=browse&sel=10020420" target="_blank">Butz Henriett (<span class="authorship-author-name">Butz Henriett</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Országos Onkológiai Intézet">OOI</span>/HUN-REN-ONKOL-TTK-HCEMM Onkogenomikai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001006"><a href="/gui2/?type=authors&mode=browse&sel=10001006" target="_blank">Patócs Attila (<span class="authorship-author-name">Patócs Attila Balázs</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Laboratóriumi Medicina Intézet; <span title="Országos Onkológiai Intézet">OOI</span>/HUN-REN-ONKOL-TTK-HCEMM Onkogenomikai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012260"><a href="/gui2/?type=authors&mode=browse&sel=10012260" target="_blank">Medvecz Márta ✉ (<span class="authorship-author-name">Medvecz Márta</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36410343" target="_blank">Dermatologic Features of Endocrine Tumor Syndromes-Systematic Review and Meta-Analysis</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF DERMATOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0011-9059">0011-9059</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1365-4632">1365-4632</a>)</span>: <span class="journal-volume">65</span> <span class="journal-issue">3</span> <span class="page"> pp 464-488 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1111/ijd.70118" target="_blank" href="https://doi.org/10.1111/ijd.70118"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001604118800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001604118800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105020978867" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020978867"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41165034" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41165034&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Dermatology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36410343&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36410343</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> (TKP2021-EGA-24) </div> <div class="lastModified">Utolsó módosítás: 2026.08.04. 13:22 Kondor Zóra (SE_KK_Admin5_KZ, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis Egyetem [TKP2021-EGA-24] Funding text: The Department of Dermatology, Venereology, and Dermatooncology, Semmelweis University is a Reference Centre of the ERN-Skin: European Reference Network on Rare and Complex Skin Diseases. The Department of Internal Medicine and Oncology, Semmelweis University is a Reference Centre of the ENDO-ERN: Eur...</pre> </div></div>