https://m2.mtmt.hu/ hun 2026-09-22 04:40 JournalArticle 36403869 VALIDATED true Funding Agency and Grant Number: National Institute on Aging; Technical Services Unit of the Department of Comparative Medicine at OUHSC Funding text: The authors thank the Technical Services Unit of the Department of Comparative Medicine at OUHSC for assistance with hematology analyses and the Institutional Research Core Facility at OUHSC for their help with the construction of cDNA libraries and next-generation sequencing. A GPT-based AI grammar check was used to improve the English of the manuscript. Illustrations in Figs. 1 and 7 were created using BioRender. 0 false 2026-08-26T08:38:30.934+0000 2026-04-16T10:06:44.997+0000 2025-10-28T13:47:44.855+0000 true 10058020 Fekete Mónika /api/author/10058020 Author true 10058020 2026-08-26T08:33:47.414+0000 2026-04-09T07:40:46.028+0000 true 10085578 Fi Tamás /api/admin/10085578 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gulej, Rafal Irradiation-induced brain senescence accelerates cardiac aging via systemic mechanisms: insights from transcriptomic profiling true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 48 1 951 971 951 21 2026 Aging is characterized by a coordinated functional decline across multiple organs. While cell-autonomous mechanisms contribute to local aging phenotypes, the systemic synchronicity of aging suggests a major role for cell non-autonomous drivers. Emerging evidence implicates the hypothalamus—a central regulator of neuroendocrine and homeostatic functions—as a potential source of circulating pro-geronic signals. A hallmark of brain aging is the accumulation of senescent cells, particularly in microglia and brain microvascular endothelial cells, including within the hypothalamus, which contributes to a heightened state of neuroinflammation and altered systemic signaling. Here, we tested the hypothesis that brain senescence and its associated inflammatory milieu promote peripheral aging by reshaping the systemic environment. To model this, we employed targeted whole-brain irradiation (WBI) in young mice—a well-established method to induce widespread brain cellular senescence and neuroinflammation, mimicking changes seen in natural aging. Two months after WBI, we performed transcriptomic profiling of the heart to evaluate remote, cell non-autonomous effects. Cardiac RNA sequencing revealed a striking overlap in gene expression changes between WBI-treated young mice and naturally aged controls. Notably, several gene sets associated with fundamental cellular and molecular mechanisms of aging were concordantly dysregulated in both groups, with strong enrichment for pathways related to mitochondrial metabolism, immune activation, interferon signaling, and extracellular matrix remodeling. These findings demonstrate that localized brain senescence is sufficient to induce aging-like transcriptomic remodeling in peripheral organs, likely mediated by circulating factors. Our findings establish brain senescence as a key orchestrator of systemic aging—a mechanism that may contribute to accelerated aging trajectories in individuals with lifestyle-associated increased brain senescence and neuroinflammation, as well as in cancer survivors exposed to senescence-inducing treatments such as whole-brain irradiation. Funding 2059141 /api/funding/2059141 false true Funding 2059142 /api/funding/2059142 false true Funding 2059143 /api/funding/2059143 false true Funding 2059144 /api/funding/2059144 false true true true 2025 true true true false true false NONE 2026-08-26 false 3 0 3 1 2 3 3 3 3 3 3 1 1 1 2 0 3 1 3 1 0 21 21 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 3 1 3 1 D1 false 10052983 false false false 2026-01-26T13:48:00.544+0000 Doktori Iskola (SE); Gyermekgyógyászati Klinika (SE / AOK / K); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); MTA-SE Lendület Diabétesz Kutatócsoport (SE / AOK / K / GYGYK); Megelőző Orvostani és Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I) 12 47 6 16 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128301915 /api/authorship/128301915 1 0.063 true false false Author 10092932 /api/author/10092932 Gulej Rafal true true Gulej Rafal true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301916 /api/authorship/128301916 2 0.063 true false false Author 10052983 /api/author/10052983 Patai Roland true 10052983 true Patai Roland true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301917 /api/authorship/128301917 3 0.063 true false false Author 10071509 /api/author/10071509 Kiss Tamás true true Kiss Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301918 /api/authorship/128301918 4 0.063 true false false Chandragiri Siva Sai true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301919 /api/authorship/128301919 5 0.0625 false false false Ekambaram Shoba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301920 /api/authorship/128301920 6 0.0625 false false false Nagaraja Raghavendra Yelahanka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301921 /api/authorship/128301921 7 0.063 false false false Author 10075082 /api/author/10075082 Nagy Dorina true true Nagy Dorina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301922 /api/authorship/128301922 8 0.0625 false false false Kordestan Kiana Vali true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301923 /api/authorship/128301923 9 0.063 false false false Author 10066688 /api/author/10066688 Lakat Tamás true true Lakat Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301924 /api/authorship/128301924 10 0.063 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini Stefano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301925 /api/authorship/128301925 11 0.063 false false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301926 /api/authorship/128301926 12 0.063 false false true Author 10090858 /api/author/10090858 Ungvári Anna Sára true true Ungvari Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301927 /api/authorship/128301927 13 0.063 false false false Author 10095385 /api/author/10095385 Yabluchanskiy Andriy true true Yabluchanskiy Andriy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301928 /api/authorship/128301928 14 0.063 false false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyo Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301929 /api/authorship/128301929 15 0.063 false false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128301930 /api/authorship/128301930 16 0.063 false true false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30070632 /api/publicationidentifier/30070632 PlainSource 6 /api/publicationsource/6 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true Reference 69370216 /api/reference/69370216 92 10.3109/0284186X.2014.969845 false true Reference 69370217 /api/reference/69370217 93 10.1200/JCO.2012.46.6086 false true Reference 69370218 /api/reference/69370218 94 10.1038/s43018-024-00745-w false true Reference 69370219 /api/reference/69370219 95 10.1016/S1470-2045(16)30215-7 false true Reference 69370220 /api/reference/69370220 96 10.1007/s11357-020-00286-x false true Reference 69370221 /api/reference/69370221 97 10.1007/s11357-020-00185-1 false true /api/publication/36403869 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10092932"><a href="/gui2/?type=authors&mode=browse&sel=10092932" target="_blank">Gulej Rafal (<span class="authorship-author-name">Gulej Rafal</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052983"><a href="/gui2/?type=authors&mode=browse&sel=10052983" target="_blank">Patai Roland<sup>*</sup> (<span class="authorship-author-name">Patai Roland</span> <span class="authorAux-mtmt"> neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071509"><a href="/gui2/?type=authors&mode=browse&sel=10071509" target="_blank">Kiss Tamas<sup>*</sup> (<span class="authorship-author-name">Kiss Tamás</span> <span class="authorAux-mtmt"> bioinformatika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet ; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chandragiri Siva Sai<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ekambaram Shoba </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Nagaraja Raghavendra Yelahanka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075082"><a href="/gui2/?type=authors&mode=browse&sel=10075082" target="_blank">Nagy Dorina (<span class="authorship-author-name">Nagy Dorina</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Klinikai Kórélettani Intézet">KKI</span>/HUN-REN-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kordestan Kiana Vali </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10066688"><a href="/gui2/?type=authors&mode=browse&sel=10066688" target="_blank">Lakat Tamas (<span class="authorship-author-name">Lakat Tamás</span> <span class="authorAux-mtmt"> Diabetológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Gyermekgyógyászati Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Gyermekgyógyászati Klinika">GYGYK</span>/MTA-SE Lendület Diabétesz Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10090858"><a href="/gui2/?type=authors&mode=browse&sel=10090858" target="_blank">Ungvari Anna ✉ (<span class="authorship-author-name">Ungvári Anna Sára</span> <span class="authorAux-mtmt"> népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10095385"><a href="/gui2/?type=authors&mode=browse&sel=10095385" target="_blank">Yabluchanskiy Andriy (<span class="authorship-author-name">Yabluchanskiy Andriy</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyo Zoltan (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/Doktori Iskola; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Megelőző Orvostani és Népegészségtani Intézet </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36403869" target="_blank">Irradiation-induced brain senescence accelerates cardiac aging via systemic mechanisms: insights from transcriptomic profiling</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">48</span> <span class="journal-issue">1</span> <span class="page"> pp 951-971 </span> <span class="year">(2026)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-025-01953-7" target="_blank" href="https://doi.org/10.1007/s11357-025-01953-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001599829200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001599829200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105019674229" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105019674229"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41139380" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41139380&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019674229&doi=10.1007%2Fs11357-025-01953-7&partnerID=40&md5=c2be99dd3c94ca2381523e9ad5e611b2" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-105019674229&doi=10.1007%2Fs11357-025-01953-7&partnerID=40&md5=c2be99dd3c94ca2381523e9ad5e611b2"> Egyéb URL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="https://link.springer.com/10.1007/s11357-025-01953-7" target="_blank" href="https://link.springer.com/10.1007/s11357-025-01953-7"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Aging&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 1 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36403869&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 21 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36403869</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (TKP2021-NKTA-47), Nemzeti Kardiovaszkuláris Laboratórium(RRF-2.3.1-21-2022-00003) Támogató: NKFIH, (135784) Támogató: NKFIH, (EKÖP-2024–2) Támogató: New National Excellence Program </div> <div class="lastModified">Utolsó módosítás: 2026.04.16. 12:06 Fi Tamás (SE_AOK_Nepegeszsegtan_Admin5_FT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Institute on Aging; Technical Services Unit of the Department of Comparative Medicine at OUHSC Funding text: The authors thank the Technical Services Unit of the Department of Comparative Medicine at OUHSC for assistance with hematology analyses and the Institutional Research Core Facility at OUHSC for their help with the construction of cDN...</pre> </div></div>