https://m2.mtmt.hu/ hun 2026-09-21 15:49 JournalArticle 36400762 VALIDATED true 0 false 2026-07-24T10:37:37.670+0000 2025-12-28T17:51:29.429+0000 2025-10-27T14:39:06.997+0000 true 10065652 Kovács Klaudia Ágota /api/admin/10065652 Admin Kovács Klaudia Ágota (TE 5 admin) false 2026-05-19T12:29:38.502+0000 2026-05-19T12:29:38.502+0000 2025-11-12T13:38:17.490+0000 true 10101429 Lipták Fruzsina /api/admin/10101429 Admin Lipták Fruzsina (admin) true 2025-12-28T17:51:29.410+0000 true 521 Szuper Admin /api/admin/521 Admin Szuper Admin (admin) true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin (MTMT Központi admin) Lévayné Deseő Katalin true 10025544 true 2026-05-20T07:50:30.926+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Fazekas, Fruzsina true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 26 20 9987 9987 18 2025 Imaging of intracellular messengers, like calcium, is one of the most reliable methods to follow real-time changes in several aspects of cellular activity, like receptor activation. However, the analysis could be influenced and biased by several factors like the location, shape, and size of the regions of interest (ROIs) and by the detection and correction of the movement of the preparation. Programs which are provided by the manufacturers are expensive and cannot be shared by collaborators. Many self-made programs have been implemented lately which have in-built cell recognizer ROI identification functions. These programs focus on the soma of the cells and neglect the processes, because in full tissue preparation finding cells is still challenging. Subcellular imaging experiments are still rare. To the best of our knowledge there is no program which can automatically define ROIs for subcellular imaging experiments even in single indicated cells with complex morphology. We developed and validated a program to address this gap using simple and understandable mathematical methods for ROI determination and simple statistics for movement correction. Validation experiments were conducted on cochlear Deiters’ cells. Deiters’ cells have processed morphology which connects two fluid compartments in the cochlea. Because of the function and the fine morphology of the cell, it could be interesting to examine the subcellular Ca2+ handling mechanisms of it. Test impulses were activated by ATP. With some limitations the program successfully fulfilled its purpose. As a free, easily understandable, and open-source program, we hope it will help to analyze and plan subcellular experiments. Funding 2058985 /api/funding/2058985 SRF-001(SRF-001) Támogató: ÁTE false true Funding 2058986 /api/funding/2058986 (2024-2.1.1-EKÖP-2024-00018) Támogató: NKFIH false true Funding 2058987 /api/funding/2058987 (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium false true true INTERNATIONAL 2025 true true true false true false GOLD 2026-07-24 true https://real.mtak.hu/243165 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 3 3 D1 false false false false 2025-11-11T13:38:17.130+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Molekuláris Farmakológia Kutatócsoport (HRN KOKI); Orálbiológiai Tanszék (SE / FOK); Zoológiai tanszék (ÁTE / BI) 3 19 4 3 0 true 10025544 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 128287459 /api/authorship/128287459 Fazekas, Fruzsina [Fazekas , Fruzsina (sejtbiológia; szá...), szerző] Orálbiológiai Tanszék (SE / FOK); Zoológiai tanszék (ÁTE / BI) 1 0.333 true false false Author 10089421 /api/author/10089421 Fazekas Fruzsina (sejtbiológia; számítógépes biologia (computational biology)) Fazekas Fruzsina true true Fazekas Fruzsina true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128287460 /api/authorship/128287460 Zelles, Tibor [Zelles, Tibor (Idegtudományok), szerző] Molekuláris Farmakológia Kutatócsoport (HRN KOKI); Orálbiológiai Tanszék (SE / FOK); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 2 0.333 false false false Author 10000028 /api/author/10000028 Zelles Tibor (Idegtudományok) Zelles Tibor true 10000028 true Zelles Tibor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 128287461 /api/authorship/128287461 Berekméri, Eszter ✉ [Berekméri, Eszter, szerző] Orálbiológiai Tanszék (SE / FOK); Zoológiai tanszék (ÁTE / BI); Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I) 3 0.333 false true true Author 10052116 /api/author/10052116 Berekméri Eszter Berekméri Eszter true 10052116 true Berekméri Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 30062112 /api/publicationidentifier/30062112 DOI: 10.3390/ijms26209987 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms26209987 https://doi.org/10.3390/ijms26209987 false true PublicationIdentifier 30133032 /api/publicationidentifier/30133032 WoS: 001603754600001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001603754600001 https://www.webofscience.com/wos/woscc/full-record/001603754600001 false true PublicationIdentifier 32685566 /api/publicationidentifier/32685566 REAL: 243165 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL https://real.mtak.hu/@@@ true true 36 true GOLD true 243165 https://real.mtak.hu/243165 false true PublicationIdentifier 30133033 /api/publicationidentifier/30133033 Scopus: 105020210859 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105020210859 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020210859 false true PublicationIdentifier 30062113 /api/publicationidentifier/30062113 PubMed: 41155282 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41155282 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41155282&dopt=Abstract false true SjrRating 11593300 /api/sjrrating/11593300 sjr:D1 (2025) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 5 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 69323578 /api/reference/69323578 1. 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(2025) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 26 20<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10089421"><a href="/gui2/?type=authors&mode=browse&sel=10089421" target="_blank">Fazekas Fruzsina (<span class="authorship-author-name">Fazekas Fruzsina</span> <span class="authorAux-mtmt"> sejtbiológia; számítógépes biologia (computatio...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Biológiai Intézet">BI</span>/Zoológiai tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000028"><a href="/gui2/?type=authors&mode=browse&sel=10000028" target="_blank">Zelles Tibor (<span class="authorship-author-name">Zelles Tibor</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil"><span title="HUN-REN Kísérleti Orvostudományi Kutatóintézet">HRN KOKI</span>/Molekuláris Farmakológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052116"><a href="/gui2/?type=authors&mode=browse&sel=10052116" target="_blank">Berekméri Eszter ✉ (<span class="authorship-author-name">Berekméri Eszter</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Állatorvostudományi Egyetem">ÁTE</span>/<span title="Biológiai Intézet">BI</span>/Zoológiai tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36400762" target="_blank">A Semi-Automatic Tool for the Standardized Analysis of Fluorescent Intensity Changes in Polarized Cells</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">20</span> <span class="page"> Paper 9987. 18 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms26209987" target="_blank" href="https://doi.org/10.3390/ijms26209987"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001603754600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001603754600001"> WoS </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="243165" target="_blank" href="https://real.mtak.hu/243165"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105020210859" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020210859"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41155282" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41155282&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36400762&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36400762</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="funder"> SRF-001(SRF-001) Támogató: ÁTE, (2024-2.1.1-EKÖP-2024-00018) Támogató: NKFIH, (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium </div> <div class="lastModified">Utolsó módosítás: 2025.12.28. 18:51 Szuper Admin (admin) </div> <div class="lockedBy">Központi kezelésű 2026.05.20. 09:50 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>