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      <title>Miért nem fenyegeti a ketoacidosis a teljes hasnyálmirigy-eltávolításon átesett betegeket?</title>
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      <abstractText>Klinikai megfigyelésünk szerint a pancreatectomián átesett betegekben nem alakul ki diabeteses ketoacidosis, amely az inzulinhiányos diabetes leggyakoribb akut életveszélyes szövődménye. A teljes hasnyálmirigy-eltávolításon átesett páciensek cukorbetegsége az inzulin, glükagon és emésztőenzimek teljes hiánya miatt extrém mértékben labilis. A munkacsoport számos, hasnyálmirigy-eltávolításon átesett diabeteses személyt gondoz, a gyakori súlyos társbetegségek, onkológiai kezelések ellenére azonban diabeteses ketoacidosis gyakorlatilag nem fordul elő. Véleményünk szerint ennek hátterében a glükagon hiánya áll. A szerzők összefoglalják a glükagon diabeteses ketoacidosisban betöltött szerepét, valamint a glükagonszintet befolyásoló diabeteskezeléseknek a ketoacidosis kialakulásával való kapcsolatát. Orv Hetil. 2025; 166(43): 1683–1688. | Based on our clinical observations, diabetic ketoacidosis, which is the most common acute life-threatening complica-
tion of insulin-deficient diabetes, does not develop in pancreatectomy patients. The diabetes developing after total
pancreatectomy is extremely labile due to the complete lack of insulin, glucagon, and digestive enzymes. Our work-
ing group takes care of many patients after total pancreatectomy who, despite unstable diabetes and/or severe co-
morbidities from cancer treatment, do not develop diabetic ketoacidosis. In our opinion, the background to this is
the lack of glucagon. The authors summarize the role of glucagon in diabetic ketoacidosis and the relationship be-
tween diabetes treatments that affect glucagon levels and the development of ketoacidosis.</abstractText>
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