https://m2.mtmt.hu/ hun 2026-09-22 19:02 JournalArticle 36387033 VALIDATED true Funding Agency and Grant Number: Semmelweis 250+ and Stipendium Hungaricum Scholarships; National Research, Development and Innovation Fund [2024-2.1.1-EKP-2024-00004] Funding text: Houssam Aaref Abboud is grateful for the Semmelweis 250+ and Stipendium Hungaricum Scholarships. This project was supported by the 2024-2.1.1-EKOP-2024-00004 University Research Scholarship Program of the Ministry for Culture and Innovation from the source of the National Research, Development and Innovation Fund. 0 false 2026-09-21T08:10:59.448+0000 2025-11-13T11:23:35.563+0000 2025-10-18T06:15:14.413+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin true 10015206 2026-09-21T08:08:20.295+0000 2025-11-04T07:20:33.755+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Abboud, Houssam Aaref Development of Practical Low-Volume Screening Method and Pharmacokinetic Simulation of Levofloxacin-Loaded Nanofiber Inserts for Sustained Ocular Therapy true true /api/journal/10022148 REVIEWED true false 10022148 false 10022148 true 1999-4923 Journal FOREIGN 17 10 1343 1343 15 2025 Background/Objectives: Ocular drug delivery faces significant challenges due to anatomical and physiological barriers that limit drug bioavailability, particularly with conventional eye drops. Levofloxacin (LEVO), a broad-spectrum antibiotic, is widely used in the treatment of bacterial conjunctivitis, but its therapeutic efficacy is hindered by rapid precorneal clearance and short residence time. Methods: This study introduces a biorelevant 2 mL dissolution model to simulate ocular conditions better and evaluate the release kinetics of LEVO-loaded nanofibrous ophthalmic inserts. Compared to the conventional 40 mL setup, the 2 mL system demonstrated a slower and more sustained drug release profile, with kinetic modeling confirming a more controlled release behavior. Difference and similarity factor analysis further validated the distinct release profiles, highlighting the impact of dissolution volume on release dynamics. Results: Preliminary pharmacokinetic modeling suggested that the nanofiber inserts, particularly when applied twice daily, maintained levofloxacin concentrations above minimum inhibitory and bactericidal levels for extended durations across three bacterial strains (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus), potentially outperforming traditional eye drops. Conclusions: These findings suggest that small-volume dissolution testing may provide a more realistic method for evaluating ophthalmic insert formulations, though in vivo validation is needed. Moreover, the nanofibrous inserts show potential as a sustained-release alternative that warrants further investigation to improve patient compliance and therapeutic outcomes in ocular disease management. Funding 2059129 /api/funding/2059129 false true true true 2025 true true true false true false GOLD 2026-09-21 false http://www.mdpi.com/journal/pharmaceutics/ 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 4 4 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 1 1 1 D1 false false false false 2025-11-03T07:20:33.475+0000 Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK) 3 7 1 3 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128188774 /api/authorship/128188774 1 0.333 true false false Author 10094391 /api/author/10094391 Abboud Houssam true true Abboud Houssam Aaref true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128188775 /api/authorship/128188775 2 0.333 false false true Author 10002587 /api/author/10002587 Zelkó Romána true 10002587 true Zelkó Romána true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128188776 /api/authorship/128188776 3 0.333 false true true Author 10055677 /api/author/10055677 Nochta-Kazsoki Adrienn Katalin true 10055677 true Kazsoki Adrienn true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 30021913 /api/publicationidentifier/30021913 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/pharmaceutics17101343 https://doi.org/10.3390/pharmaceutics17101343 false true PublicationIdentifier 30099686 /api/publicationidentifier/30099686 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001601480200001 https://www.webofscience.com/wos/woscc/full-record/001601480200001 true true PublicationIdentifier 30099688 /api/publicationidentifier/30099688 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 105020029975 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020029975 true true PublicationIdentifier 30099687 /api/publicationidentifier/30099687 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 41155978 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41155978&dopt=Abstract true true Classification 12197 /api/classification/12197 true true SjrRating 11611771 /api/sjrrating/11611771 18 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3003 /api/classificationexternal/3003 true 3003 true D1 DIRECT true true /api/publication/36387033 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10094391"><a href="/gui2/?type=authors&mode=browse&sel=10094391" target="_blank">Abboud Houssam Aaref (<span class="authorship-author-name">Abboud Houssam</span> <span class="authorAux-mtmt"> pharmacy</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002587"><a href="/gui2/?type=authors&mode=browse&sel=10002587" target="_blank">Zelkó Romána ✉ (<span class="authorship-author-name">Zelkó Romána</span> <span class="authorAux-mtmt"> Gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055677"><a href="/gui2/?type=authors&mode=browse&sel=10055677" target="_blank">Kazsoki Adrienn ✉ (<span class="authorship-author-name">Nochta-Kazsoki Adrienn Katalin</span> <span class="authorAux-mtmt"> gyógyszertechnológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Egyetemi Gyógyszertár Gyógyszerügyi Szervezési Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36387033" target="_blank">Development of Practical Low-Volume Screening Method and Pharmacokinetic Simulation of Levofloxacin-Loaded Nanofiber Inserts for Sustained Ocular Therapy</a></div> <div> <span class="journal-title">PHARMACEUTICS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1999-4923">1999-4923</a>)</span>: <span class="journal-volume">17</span> <span class="journal-issue">10</span> <span class="page"> Paper 1343. 15 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/pharmaceutics17101343" target="_blank" href="https://doi.org/10.3390/pharmaceutics17101343"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001601480200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001601480200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="105020029975" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-105020029975"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="41155978" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=41155978&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 1 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36387033&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36387033</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="funder"> (2024-2.1.1-EKÖP-2024-00004) </div> <div class="lastModified">Utolsó módosítás: 2025.11.13. 12:23 Áncsán Gizella (SE admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Semmelweis 250+ and Stipendium Hungaricum Scholarships; National Research, Development and Innovation Fund [2024-2.1.1-EKP-2024-00004] Funding text: Houssam Aaref Abboud is grateful for the Semmelweis 250+ and Stipendium Hungaricum Scholarships. This project was supported by the 2024-2.1.1-EKOP-2024-00004 University Research Scholarship Program of th...</pre> </div></div>