https://m2.mtmt.hu/ hun 2026-09-22 22:35 JournalArticle 36367426 VALIDATED true 0 false 2026-05-25T02:23:36.148+0000 2025-12-19T09:25:31.109+0000 2025-10-07T10:54:04.052+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2025-12-19T09:25:30.829+0000 2025-10-07T10:57:34.664+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Masri, Iraqi Hiba Patients with langerhans cell histiocytosis and hypothalamic-pituitary involvement: insights from the HEROS study cohort true true /api/journal/10007652 REVIEWED true false 10007652 false 10007652 true 1386-341X 1573-7403 Journal FOREIGN 28 5 104 104 6 2025 Purpose Langerhans cell histiocytosis (LCH) is a rare disease involving multiple organs, including the endocrine system. This multicenter study aimed to characterize patients with hypothalamic- pituitary involvement in LCH. Methods The Hypopituitarism European NeuroEndocrine Association (ENEA) Rare Etiologies Observational Study (HEROS) platform invited ENEA members to include patients with rare pituitary diseases like LCH. Demographic data, presenting symptoms, hormonal profile, imaging tests, treatment, and prognosis were retrieved. Results Forty-eight patients (58% males) were included. Age at diagnosis was 22 +/- 16.1 years, with 58% diagnosed as adults (> 18 years). The mean follow-up was 15.8 +/- 10.6 years, 46% of the patients initially presented with bone lesions, 42% with lung involvement, and five were incidentally diagnosed. At diagnosis, 69% of the patients had arginine vasopressin deficiency (AVD), 42% had central hypogonadism, 25% hypothyroidism, and 12.5% hypocortisolism. Magnetic resonance imaging (MRI) was available in 41 patients, 73% of whom had pathology of the posterior pituitary/pituitary stalk. Visual disturbances were reported in only one patient. Diagnosis was histopathologically confirmed in all patients, mainly from extra-pituitary lesions. Transcranial biopsy was performed in five patients, and two underwent transsphenoidal intervention. During follow-up, 27% of the patients developed new AVD and five acquired new anterior pituitary hormone deficiency. There was no disease-related mortality during follow-up. Conclusions Patients with LCH and hypothalamic-pituitary involvement remained clinically stable during long-term follow-up. However, new hormonal deficits may develop years after diagnosis, with most patients ultimately experiencing AVD. true true 2025 true true true false true false NONE 2026-05-25 false 1 0 1 0 0 1 1 1 0 1 1 0 0 0 1 0 1 0 1 0 0 1 1 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2026 0 1 0 1 0 Q2 false false false false 2025-10-06T10:57:34.518+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K) 1 9 1 12 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 128026472 /api/authorship/128026472 1 0.083 true false true Masri Iraqi Hiba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026473 /api/authorship/128026473 2 0.083333336 false false false Tsoli Marina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026474 /api/authorship/128026474 3 0.083333336 false false false Colao Annamaria true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026475 /api/authorship/128026475 4 0.083333336 false false false Ferone Diego true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026476 /api/authorship/128026476 5 0.083 false false false Author 10014760 /api/author/10014760 Tóth Miklós DUPLUM true 10014760 true Toth Miklos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026477 /api/authorship/128026477 6 0.083333336 false false false Pigarova Ekaterina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026478 /api/authorship/128026478 7 0.083333336 false false false Akirov Amit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026479 /api/authorship/128026479 8 0.083333336 false false false Baraf Lior true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026480 /api/authorship/128026480 9 0.083333336 false false false Greenman Yona true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026481 /api/authorship/128026481 10 0.083333336 false false false Doknic Mirjana true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026482 /api/authorship/128026482 11 0.083333336 false false false Kaltsas Gregory true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 128026483 /api/authorship/128026483 12 0.083333336 false true false Shimon Ilan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 29958354 /api/publicationidentifier/29958354 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1007/s11102-025-01576-3 https://doi.org/10.1007/s11102-025-01576-3 false true PublicationIdentifier 29958355 /api/publicationidentifier/29958355 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001582362400002 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/api/keyword/1531380 true true Keyword 1564198 /api/keyword/1564198 true true Keyword 1953865 /api/keyword/1953865 true true SjrRating 11580005 /api/sjrrating/11580005 43 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1310 /api/classificationexternal/1310 true 1310 true Q2 DIRECT true true /api/publication/36367426 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Masri Iraqi Hiba ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tsoli Marina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Colao Annamaria </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ferone Diego </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014760"><a href="/gui2/?type=authors&mode=browse&sel=10014760" target="_blank">Toth Miklos (<span class="authorship-author-name">Tóth Miklós</span> <span class="authorAux-mtmt"> Belgyógyászat, Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Belgyógyászati és Onkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pigarova Ekaterina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akirov Amit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Baraf Lior </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Greenman Yona </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doknic Mirjana </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kaltsas Gregory </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shimon Ilan </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;36367426" target="_blank">Patients with langerhans cell histiocytosis and hypothalamic-pituitary involvement: insights from the HEROS study cohort</a></div> <div> <span class="journal-title">PITUITARY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1386-341X">1386-341X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1573-7403">1573-7403</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">5</span> <span class="page"> Paper 104. 6 p. </span> <span class="year">(2025)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11102-025-01576-3" target="_blank" href="https://doi.org/10.1007/s11102-025-01576-3"> DOI </a> </span> <span class="id identifier oa_none" title="none"> 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style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;36367426&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 36367426</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS TAGGED</span> </div> <div class="lastModified">Utolsó módosítás: 2025.12.19. 10:25 Szuper Admin (admin) </div> </div></div>